LOCUS       NM_002899                807 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens retinol binding protein 1 (RBP1), transcript variant
            1, mRNA.
ACCESSION   NM_002899
VERSION     NM_002899.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 807)
  AUTHORS   Fu,L.L., Yan,M., Yu,X., Shao,M., Gosau,M., Friedrich,R.E.,
            Vollkommer,T., Smeets,R., Feng,H.C. and Xu,L.
  TITLE     Retinol-binding protein type 1 expression predicts poor prognosis
            in head and neck squamous cell carcinoma
  JOURNAL   BMC Cancer 24 (1), 1277 (2024)
   PUBMED   39407127
  REMARK    GeneRIF: Retinol-binding protein type 1 expression predicts poor
            prognosis in head and neck squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 807)
  AUTHORS   Zalesak-Kravec,S., Huang,W., Jones,J.W., Yu,J., Alloush,J.,
            Defnet,A.E., Moise,A.R. and Kane,M.A.
  TITLE     Role of cellular retinol-binding protein, type 1 and retinoid
            homeostasis in the adult mouse heart: A multi-omic approach
  JOURNAL   FASEB J 36 (4), e22242 (2022)
   PUBMED   35253263
  REMARK    GeneRIF: Role of cellular retinol-binding protein, type 1 and
            retinoid homeostasis in the adult mouse heart: A multi-omic
            approach.
REFERENCE   3  (bases 1 to 807)
  AUTHORS   Li,H., Lei,Y., Li,S., Li,F. and Lei,J.
  TITLE     MicroRNA-20a-5p inhibits the autophagy and cisplatin resistance in
            ovarian cancer via regulating DNMT3B-mediated DNA methylation of
            RBP1
  JOURNAL   Reprod Toxicol 109, 93-100 (2022)
   PUBMED   34990753
  REMARK    GeneRIF: MicroRNA-20a-5p inhibits the autophagy and cisplatin
            resistance in ovarian cancer via regulating DNMT3B-mediated DNA
            methylation of RBP1.
REFERENCE   4  (bases 1 to 807)
  AUTHORS   Yu,J., Perri,M., Jones,J.W., Pierzchalski,K., Ceaicovscaia,N.,
            Cione,E. and Kane,M.A.
  TITLE     Altered RBP1 Gene Expression Impacts Epithelial Cell Retinoic Acid,
            Proliferation, and Microenvironment
  JOURNAL   Cells 11 (5), 792 (2022)
   PUBMED   35269414
  REMARK    GeneRIF: Altered RBP1 Gene Expression Impacts Epithelial Cell
            Retinoic Acid, Proliferation, and Microenvironment.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 807)
  AUTHORS   Wu,W., Wang,Y., Niu,C., Wahafu,A., Huo,L., Guo,X., Xiang,J., Li,X.,
            Xie,W., Bai,X., Wang,M. and Wang,J.
  TITLE     Retinol binding protein 1-dependent activation of NF- kappaB
            signaling enhances the malignancy of non-glioblastomatous diffuse
            gliomas
  JOURNAL   Cancer Sci 113 (2), 517-528 (2022)
   PUBMED   34866280
  REMARK    GeneRIF: Retinol binding protein 1-dependent activation of NF-
            kappaB signaling enhances the malignancy of non-glioblastomatous
            diffuse gliomas.
REFERENCE   6  (bases 1 to 807)
  AUTHORS   Siegenthaler,G., Tomatis,I., Chatellard-Gruaz,D., Jaconi,S.,
            Eriksson,U. and Saurat,J.H.
  TITLE     Expression of CRABP-I and -II in human epidermal cells. Alteration
            of relative protein amounts is linked to the state of
            differentiation
  JOURNAL   Biochem J 287 (Pt 2) (Pt 2), 383-389 (1992)
   PUBMED   1332671
REFERENCE   7  (bases 1 to 807)
  AUTHORS   Herr,F.M. and Ong,D.E.
  TITLE     Differential interaction of lecithin-retinol acyltransferase with
            cellular retinol binding proteins
  JOURNAL   Biochemistry 31 (29), 6748-6755 (1992)
   PUBMED   1322170
REFERENCE   8  (bases 1 to 807)
  AUTHORS   Astrom,A., Tavakkol,A., Pettersson,U., Cromie,M., Elder,J.T. and
            Voorhees,J.J.
  TITLE     Molecular cloning of two human cellular retinoic acid-binding
            proteins (CRABP). Retinoic acid-induced expression of CRABP-II but
            not CRABP-I in adult human skin in vivo and in skin fibroblasts in
            vitro
  JOURNAL   J Biol Chem 266 (26), 17662-17666 (1991)
   PUBMED   1654334
REFERENCE   9  (bases 1 to 807)
  AUTHORS   Wei,L.N., Mertz,J.R., Goodman,D.S. and Nguyen-Huu,M.C.
  TITLE     Cellular retinoic acid- and cellular retinol-binding proteins:
            complementary deoxyribonucleic acid cloning, chromosomal
            assignment, and tissue specific expression
  JOURNAL   Mol Endocrinol 1 (8), 526-534 (1987)
   PUBMED   2856408
REFERENCE   10 (bases 1 to 807)
  AUTHORS   Colantuoni,V., Cortese,R., Nilsson,M., Lundvall,J., Bavik,C.O.,
            Eriksson,U., Peterson,P.A. and Sundelin,J.
  TITLE     Cloning and sequencing of a full length cDNA corresponding to human
            cellular retinol-binding protein
  JOURNAL   Biochem Biophys Res Commun 130 (1), 431-439 (1985)
   PUBMED   2992469
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC356836.1, BC121052.2 and
            AC046134.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_002899.4.
            
            Summary: This gene encodes the carrier protein involved in the
            transport of retinol (vitamin A alcohol) from the liver storage
            site to peripheral tissue. Vitamin A is a fat-soluble vitamin
            necessary for growth, reproduction, differentiation of epithelial
            tissues, and vision. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Aug 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.401675.1,
                                           DRR138519.518906.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2145245
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000672186.1/ ENSP00000500931.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               DC356836.1         88-261
            175-663             BC121052.2         20-508
            664-807             AC046134.8         159536-159679
FEATURES             Location/Qualifiers
     source          1..807
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q23"
     gene            1..807
                     /gene="RBP1"
                     /gene_synonym="CRABP-I; CRBP; CRBP1; CRBPI; hCRBP1; RBPC"
                     /note="retinol binding protein 1"
                     /db_xref="GeneID:5947"
                     /db_xref="HGNC:HGNC:9919"
                     /db_xref="MIM:180260"
     exon            1..283
                     /gene="RBP1"
                     /gene_synonym="CRABP-I; CRBP; CRBP1; CRBPI; hCRBP1; RBPC"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..618
                     /gene="RBP1"
                     /gene_synonym="CRABP-I; CRBP; CRBP1; CRBPI; hCRBP1; RBPC"
                     /EC_number="2.7.7.1"
                     /note="isoform a is encoded by transcript variant 1;
                     retinol-binding protein 1, cellular; cellular retinol
                     binding protein 1; cellular retinol-binding protein I"
                     /codon_start=1
                     /product="retinol-binding protein 1 isoform a"
                     /protein_id="NP_002890.2"
                     /db_xref="CCDS:CCDS3110.2"
                     /db_xref="GeneID:5947"
                     /db_xref="HGNC:HGNC:9919"
                     /db_xref="MIM:180260"
                     /translation="MDPPAGFVRAGNPAVAAPQSPLSPEGAHFRAAHHPRSTGSRCPG
                     SLQPSRPLVANWLQSLPEMPVDFTGYWKMLVNENFEEYLRALDVNVALRKIANLLKPD
                     KEIVQDGDHMIIRTLSTFRNYIMDFQVGKEFEEDLTGIDDRKCMTTVSWDGDKLQCVQ
                     KGEKEGRGWTQWIEGDELHLEMRVEGVVCKQVFKKVQ"
     exon            284..462
                     /gene="RBP1"
                     /gene_synonym="CRABP-I; CRBP; CRBP1; CRBPI; hCRBP1; RBPC"
                     /inference="alignment:Splign:2.1.0"
     exon            463..564
                     /gene="RBP1"
                     /gene_synonym="CRABP-I; CRBP; CRBP1; CRBPI; hCRBP1; RBPC"
                     /inference="alignment:Splign:2.1.0"
     exon            565..807
                     /gene="RBP1"
                     /gene_synonym="CRABP-I; CRBP; CRBP1; CRBPI; hCRBP1; RBPC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      785..790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBP1"
                     /gene_synonym="CRABP-I; CRBP; CRBP1; CRBPI; hCRBP1; RBPC"
                     /note="hexamer: AATAAA"
     polyA_site      807
                     /gene="RBP1"
                     /gene_synonym="CRABP-I; CRBP; CRBP1; CRBPI; hCRBP1; RBPC"
                     /note="major polyA site"
ORIGIN      
        1 aagcggggag gagcgaccgc tacaatggat cctcccgcag gctttgtgcg cgctgggaat
       61 ccagctgtcg ccgccccgca gagccccctg tccccggagg gcgctcattt ccgggccgcc
      121 caccacccgc gtagcaccgg cagccgctgt cccggcagtc tccagccgtc ccgcccgctt
      181 gtggccaact ggctccagtc actccccgaa atgccagtcg acttcactgg gtactggaag
      241 atgttggtca acgagaattt cgaggagtac ctgcgcgccc tcgacgtcaa tgtggccttg
      301 cgcaaaatcg ccaacttgct gaagccagac aaagagatcg tgcaggacgg tgaccatatg
      361 atcatccgca cgctgagcac ttttaggaac tacatcatgg acttccaggt tgggaaggag
      421 tttgaggagg atctgacagg catagatgac cgcaagtgca tgacaacagt gagctgggac
      481 ggagacaagc tccagtgtgt gcagaagggt gagaaggagg ggcgtggctg gacccagtgg
      541 atcgagggtg atgagctgca cctggagatg agagtggaag gtgtggtctg caagcaagta
      601 ttcaagaagg tgcagtgagg cccaggcaga caaccttgtc ccaaggaatc agcaggatgt
      661 gtgggccagg atccccctct ttgcacagca tgaggcaaaa atgtccagcc acccccaggc
      721 atctgttagc agagtctgtc tcttggcttt gtcacttttc cttttcttaa aacaaagcca
      781 tgccaataaa gtgatctgtg ttcaaaa
//
