LOCUS       NM_001130993            1954 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens retinol binding protein 1 (RBP1), transcript variant
            3, mRNA.
ACCESSION   NM_001130993
VERSION     NM_001130993.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1954)
  AUTHORS   Fu,L.L., Yan,M., Yu,X., Shao,M., Gosau,M., Friedrich,R.E.,
            Vollkommer,T., Smeets,R., Feng,H.C. and Xu,L.
  TITLE     Retinol-binding protein type 1 expression predicts poor prognosis
            in head and neck squamous cell carcinoma
  JOURNAL   BMC Cancer 24 (1), 1277 (2024)
   PUBMED   39407127
  REMARK    GeneRIF: Retinol-binding protein type 1 expression predicts poor
            prognosis in head and neck squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1954)
  AUTHORS   Zalesak-Kravec,S., Huang,W., Jones,J.W., Yu,J., Alloush,J.,
            Defnet,A.E., Moise,A.R. and Kane,M.A.
  TITLE     Role of cellular retinol-binding protein, type 1 and retinoid
            homeostasis in the adult mouse heart: A multi-omic approach
  JOURNAL   FASEB J 36 (4), e22242 (2022)
   PUBMED   35253263
  REMARK    GeneRIF: Role of cellular retinol-binding protein, type 1 and
            retinoid homeostasis in the adult mouse heart: A multi-omic
            approach.
REFERENCE   3  (bases 1 to 1954)
  AUTHORS   Li,H., Lei,Y., Li,S., Li,F. and Lei,J.
  TITLE     MicroRNA-20a-5p inhibits the autophagy and cisplatin resistance in
            ovarian cancer via regulating DNMT3B-mediated DNA methylation of
            RBP1
  JOURNAL   Reprod Toxicol 109, 93-100 (2022)
   PUBMED   34990753
  REMARK    GeneRIF: MicroRNA-20a-5p inhibits the autophagy and cisplatin
            resistance in ovarian cancer via regulating DNMT3B-mediated DNA
            methylation of RBP1.
REFERENCE   4  (bases 1 to 1954)
  AUTHORS   Yu,J., Perri,M., Jones,J.W., Pierzchalski,K., Ceaicovscaia,N.,
            Cione,E. and Kane,M.A.
  TITLE     Altered RBP1 Gene Expression Impacts Epithelial Cell Retinoic Acid,
            Proliferation, and Microenvironment
  JOURNAL   Cells 11 (5), 792 (2022)
   PUBMED   35269414
  REMARK    GeneRIF: Altered RBP1 Gene Expression Impacts Epithelial Cell
            Retinoic Acid, Proliferation, and Microenvironment.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1954)
  AUTHORS   Wu,W., Wang,Y., Niu,C., Wahafu,A., Huo,L., Guo,X., Xiang,J., Li,X.,
            Xie,W., Bai,X., Wang,M. and Wang,J.
  TITLE     Retinol binding protein 1-dependent activation of NF- kappaB
            signaling enhances the malignancy of non-glioblastomatous diffuse
            gliomas
  JOURNAL   Cancer Sci 113 (2), 517-528 (2022)
   PUBMED   34866280
  REMARK    GeneRIF: Retinol binding protein 1-dependent activation of NF-
            kappaB signaling enhances the malignancy of non-glioblastomatous
            diffuse gliomas.
REFERENCE   6  (bases 1 to 1954)
  AUTHORS   Siegenthaler,G., Tomatis,I., Chatellard-Gruaz,D., Jaconi,S.,
            Eriksson,U. and Saurat,J.H.
  TITLE     Expression of CRABP-I and -II in human epidermal cells. Alteration
            of relative protein amounts is linked to the state of
            differentiation
  JOURNAL   Biochem J 287 (Pt 2) (Pt 2), 383-389 (1992)
   PUBMED   1332671
REFERENCE   7  (bases 1 to 1954)
  AUTHORS   Herr,F.M. and Ong,D.E.
  TITLE     Differential interaction of lecithin-retinol acyltransferase with
            cellular retinol binding proteins
  JOURNAL   Biochemistry 31 (29), 6748-6755 (1992)
   PUBMED   1322170
REFERENCE   8  (bases 1 to 1954)
  AUTHORS   Astrom,A., Tavakkol,A., Pettersson,U., Cromie,M., Elder,J.T. and
            Voorhees,J.J.
  TITLE     Molecular cloning of two human cellular retinoic acid-binding
            proteins (CRABP). Retinoic acid-induced expression of CRABP-II but
            not CRABP-I in adult human skin in vivo and in skin fibroblasts in
            vitro
  JOURNAL   J Biol Chem 266 (26), 17662-17666 (1991)
   PUBMED   1654334
REFERENCE   9  (bases 1 to 1954)
  AUTHORS   Wei,L.N., Mertz,J.R., Goodman,D.S. and Nguyen-Huu,M.C.
  TITLE     Cellular retinoic acid- and cellular retinol-binding proteins:
            complementary deoxyribonucleic acid cloning, chromosomal
            assignment, and tissue specific expression
  JOURNAL   Mol Endocrinol 1 (8), 526-534 (1987)
   PUBMED   2856408
REFERENCE   10 (bases 1 to 1954)
  AUTHORS   Colantuoni,V., Cortese,R., Nilsson,M., Lundvall,J., Bavik,C.O.,
            Eriksson,U., Peterson,P.A. and Sundelin,J.
  TITLE     Cloning and sequencing of a full length cDNA corresponding to human
            cellular retinol-binding protein
  JOURNAL   Biochem Biophys Res Commun 130 (1), 431-439 (1985)
   PUBMED   2992469
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK309492.1, DC394326.1,
            AC046134.8, CN479224.1, DB324655.1 and AW451931.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001130993.2.
            
            Summary: This gene encodes the carrier protein involved in the
            transport of retinol (vitamin A alcohol) from the liver storage
            site to peripheral tissue. Vitamin A is a fat-soluble vitamin
            necessary for growth, reproduction, differentiation of epithelial
            tissues, and vision. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Aug 2008].
            
            Transcript Variant: This variant (3) includes an alternate exon,
            compared to variant 1, that causes a frameshift. The resulting
            protein (isoform c) has a distinct C-terminus, compared to isoform
            a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK301684.1, SRR6380198.22577.19
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145245, SAMEA2145544
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-462               AK309492.1         88-549
            463-580             DC394326.1         440-557
            581-1292            AC046134.8         151333-152044
            1293-1513           CN479224.1         464-684             c
            1514-1747           DB324655.1         213-446             c
            1748-1952           AW451931.1         17-221              c
            1953-1954           AC046134.8         152705-152706
FEATURES             Location/Qualifiers
     source          1..1954
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q23"
     gene            1..1954
                     /gene="RBP1"
                     /gene_synonym="CRABP-I; CRBP; CRBP1; CRBPI; hCRBP1; RBPC"
                     /note="retinol binding protein 1"
                     /db_xref="GeneID:5947"
                     /db_xref="HGNC:HGNC:9919"
                     /db_xref="MIM:180260"
     exon            1..283
                     /gene="RBP1"
                     /gene_synonym="CRABP-I; CRBP; CRBP1; CRBPI; hCRBP1; RBPC"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..486
                     /gene="RBP1"
                     /gene_synonym="CRABP-I; CRBP; CRBP1; CRBPI; hCRBP1; RBPC"
                     /EC_number="2.7.7.1"
                     /note="isoform c is encoded by transcript variant 3;
                     retinol-binding protein 1, cellular; cellular retinol
                     binding protein 1; cellular retinol-binding protein I"
                     /codon_start=1
                     /product="retinol-binding protein 1 isoform c"
                     /protein_id="NP_001124465.1"
                     /db_xref="CCDS:CCDS46925.1"
                     /db_xref="GeneID:5947"
                     /db_xref="HGNC:HGNC:9919"
                     /db_xref="MIM:180260"
                     /translation="MDPPAGFVRAGNPAVAAPQSPLSPEGAHFRAAHHPRSTGSRCPG
                     SLQPSRPLVANWLQSLPEMPVDFTGYWKMLVNENFEEYLRALDVNVALRKIANLLKPD
                     KEIVQDGDHMIIRTLSTFRNYIMDFQVGKEFEEDLTGIDDRKCMSETGFSS"
     exon            284..462
                     /gene="RBP1"
                     /gene_synonym="CRABP-I; CRBP; CRBP1; CRBPI; hCRBP1; RBPC"
                     /inference="alignment:Splign:2.1.0"
     exon            463..1954
                     /gene="RBP1"
                     /gene_synonym="CRABP-I; CRBP; CRBP1; CRBPI; hCRBP1; RBPC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1933..1938
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBP1"
                     /gene_synonym="CRABP-I; CRBP; CRBP1; CRBPI; hCRBP1; RBPC"
                     /note="hexamer: ATTAAA"
     polyA_site      1954
                     /gene="RBP1"
                     /gene_synonym="CRABP-I; CRBP; CRBP1; CRBPI; hCRBP1; RBPC"
                     /note="major polyA site"
ORIGIN      
        1 aagcggggag gagcgaccgc tacaatggat cctcccgcag gctttgtgcg cgctgggaat
       61 ccagctgtcg ccgccccgca gagccccctg tccccggagg gcgctcattt ccgggccgcc
      121 caccacccgc gtagcaccgg cagccgctgt cccggcagtc tccagccgtc ccgcccgctt
      181 gtggccaact ggctccagtc actccccgaa atgccagtcg acttcactgg gtactggaag
      241 atgttggtca acgagaattt cgaggagtac ctgcgcgccc tcgacgtcaa tgtggccttg
      301 cgcaaaatcg ccaacttgct gaagccagac aaagagatcg tgcaggacgg tgaccatatg
      361 atcatccgca cgctgagcac ttttaggaac tacatcatgg acttccaggt tgggaaggag
      421 tttgaggagg atctgacagg catagatgac cgcaagtgca tgagtgaaac tggcttttcc
      481 tcttgaatgt gctgactttt gattccagcc ccccaggaat ggatcagaga agaggagccg
      541 ctacccaccc actcatcagc ctggcctcag gggcagctca tggacttttt agccagagag
      601 aaccgggttc aagttatggc tcaagcccta accccttggt gatgggctgg ttacttatag
      661 aagcctaatt tttatcagct ctaaagcttg aagatttagt gaaacattgt ggaaagctcc
      721 cagcacagta cctggcacct ggcaggttct ctgtcatctc ccctactttt ccctcctgat
      781 cacttattta acacaagcac cagatgctga aaaccctcta attgtcccag gaacacacat
      841 accctcaaag ggagaagcac actttcaaat caaactccag gatttgcatc ttttagcaat
      901 ttccattatg cggagaaagt atctactcac tgtctggttt tgaaatttta ccccaaatcg
      961 aaagagcatg ggttttggtg tcagacctgg gtcggtcctg gctctggcct ttgcaggcag
     1021 tatcaccacg ggcaaggctt cacctctcat aacctggctg tggaaccaca gaaacaacag
     1081 aattcagtcc cagccctcca gaggtggatc cgtaaacaga gggactacta gggctgggtg
     1141 gagggctgtg agtgatccaa catcccctgc tcttgagagt ggtgttttag catgggagtg
     1201 ttaatgaatg tcacaagttt cttgatacca aatagagttc ctaccatttg caggtcatac
     1261 cggtcactgc caagagatgg cttatttagt gggaattgtc tggcactcct agtataagtc
     1321 acctaagtgg ggcaagtggg ccttgaaaca tccctgggag acactcactc aggctgcctg
     1381 tgggagctgg gctttttgtg tcactctccc atgcagcagt gacggctggg gtttctaagt
     1441 ggtcagagga gctggaaaat ggcttctgaa gtaacagtcc cttgtcatag tggtacaaag
     1501 atgtcttcat tcatctgttg gcacatgtct ctgggtaaac tgccggcaag gccaaagtga
     1561 tgggggttat tattagtttt taatagaaaa gttagactgg cttcactttc caaccagctt
     1621 ccctagttcc agcccatttg cagacttttg ggtggtctgt gggatgaaaa tttcttgtga
     1681 ggaggtgagc tgaagatggc catccctcct ggttgctctt ggattgtctg ggcttcattt
     1741 ctaaggcggt cccagagccc atgtgggggt tgggggaagc agcattgtct agcccctttg
     1801 gtttgtaccc atgttcaccc cacccccaca gccacctgcc ttttctgtgg gacttgaaaa
     1861 gcatcaggaa tatcttccta cctgaaattc ttccattaga ccctgattaa ttggattaat
     1921 ctaggaaacc agattaaatg accatttaac gacc
//
