LOCUS       NM_001130992            1792 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens retinol binding protein 1 (RBP1), transcript variant
            2, mRNA.
ACCESSION   NM_001130992
VERSION     NM_001130992.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1792)
  AUTHORS   Fu,L.L., Yan,M., Yu,X., Shao,M., Gosau,M., Friedrich,R.E.,
            Vollkommer,T., Smeets,R., Feng,H.C. and Xu,L.
  TITLE     Retinol-binding protein type 1 expression predicts poor prognosis
            in head and neck squamous cell carcinoma
  JOURNAL   BMC Cancer 24 (1), 1277 (2024)
   PUBMED   39407127
  REMARK    GeneRIF: Retinol-binding protein type 1 expression predicts poor
            prognosis in head and neck squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1792)
  AUTHORS   Zalesak-Kravec,S., Huang,W., Jones,J.W., Yu,J., Alloush,J.,
            Defnet,A.E., Moise,A.R. and Kane,M.A.
  TITLE     Role of cellular retinol-binding protein, type 1 and retinoid
            homeostasis in the adult mouse heart: A multi-omic approach
  JOURNAL   FASEB J 36 (4), e22242 (2022)
   PUBMED   35253263
  REMARK    GeneRIF: Role of cellular retinol-binding protein, type 1 and
            retinoid homeostasis in the adult mouse heart: A multi-omic
            approach.
REFERENCE   3  (bases 1 to 1792)
  AUTHORS   Li,H., Lei,Y., Li,S., Li,F. and Lei,J.
  TITLE     MicroRNA-20a-5p inhibits the autophagy and cisplatin resistance in
            ovarian cancer via regulating DNMT3B-mediated DNA methylation of
            RBP1
  JOURNAL   Reprod Toxicol 109, 93-100 (2022)
   PUBMED   34990753
  REMARK    GeneRIF: MicroRNA-20a-5p inhibits the autophagy and cisplatin
            resistance in ovarian cancer via regulating DNMT3B-mediated DNA
            methylation of RBP1.
REFERENCE   4  (bases 1 to 1792)
  AUTHORS   Yu,J., Perri,M., Jones,J.W., Pierzchalski,K., Ceaicovscaia,N.,
            Cione,E. and Kane,M.A.
  TITLE     Altered RBP1 Gene Expression Impacts Epithelial Cell Retinoic Acid,
            Proliferation, and Microenvironment
  JOURNAL   Cells 11 (5), 792 (2022)
   PUBMED   35269414
  REMARK    GeneRIF: Altered RBP1 Gene Expression Impacts Epithelial Cell
            Retinoic Acid, Proliferation, and Microenvironment.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1792)
  AUTHORS   Wu,W., Wang,Y., Niu,C., Wahafu,A., Huo,L., Guo,X., Xiang,J., Li,X.,
            Xie,W., Bai,X., Wang,M. and Wang,J.
  TITLE     Retinol binding protein 1-dependent activation of NF- kappaB
            signaling enhances the malignancy of non-glioblastomatous diffuse
            gliomas
  JOURNAL   Cancer Sci 113 (2), 517-528 (2022)
   PUBMED   34866280
  REMARK    GeneRIF: Retinol binding protein 1-dependent activation of NF-
            kappaB signaling enhances the malignancy of non-glioblastomatous
            diffuse gliomas.
REFERENCE   6  (bases 1 to 1792)
  AUTHORS   Siegenthaler,G., Tomatis,I., Chatellard-Gruaz,D., Jaconi,S.,
            Eriksson,U. and Saurat,J.H.
  TITLE     Expression of CRABP-I and -II in human epidermal cells. Alteration
            of relative protein amounts is linked to the state of
            differentiation
  JOURNAL   Biochem J 287 (Pt 2) (Pt 2), 383-389 (1992)
   PUBMED   1332671
REFERENCE   7  (bases 1 to 1792)
  AUTHORS   Herr,F.M. and Ong,D.E.
  TITLE     Differential interaction of lecithin-retinol acyltransferase with
            cellular retinol binding proteins
  JOURNAL   Biochemistry 31 (29), 6748-6755 (1992)
   PUBMED   1322170
REFERENCE   8  (bases 1 to 1792)
  AUTHORS   Astrom,A., Tavakkol,A., Pettersson,U., Cromie,M., Elder,J.T. and
            Voorhees,J.J.
  TITLE     Molecular cloning of two human cellular retinoic acid-binding
            proteins (CRABP). Retinoic acid-induced expression of CRABP-II but
            not CRABP-I in adult human skin in vivo and in skin fibroblasts in
            vitro
  JOURNAL   J Biol Chem 266 (26), 17662-17666 (1991)
   PUBMED   1654334
REFERENCE   9  (bases 1 to 1792)
  AUTHORS   Wei,L.N., Mertz,J.R., Goodman,D.S. and Nguyen-Huu,M.C.
  TITLE     Cellular retinoic acid- and cellular retinol-binding proteins:
            complementary deoxyribonucleic acid cloning, chromosomal
            assignment, and tissue specific expression
  JOURNAL   Mol Endocrinol 1 (8), 526-534 (1987)
   PUBMED   2856408
REFERENCE   10 (bases 1 to 1792)
  AUTHORS   Colantuoni,V., Cortese,R., Nilsson,M., Lundvall,J., Bavik,C.O.,
            Eriksson,U., Peterson,P.A. and Sundelin,J.
  TITLE     Cloning and sequencing of a full length cDNA corresponding to human
            cellular retinol-binding protein
  JOURNAL   Biochem Biophys Res Commun 130 (1), 431-439 (1985)
   PUBMED   2992469
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK309492.1, BX092411.1,
            W72800.1, AA887145.1, AC046134.8, AI359782.1 and AI130945.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001130992.2.
            
            Summary: This gene encodes the carrier protein involved in the
            transport of retinol (vitamin A alcohol) from the liver storage
            site to peripheral tissue. Vitamin A is a fat-soluble vitamin
            necessary for growth, reproduction, differentiation of epithelial
            tissues, and vision. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Aug 2008].
            
            Transcript Variant: This variant (2) includes an alternate exon,
            compared to variant 1, that causes a frameshift. The resulting
            protein (isoform b) has a distinct C-terminus, compared to isoform
            a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK309492.1, ERR4352442.369177.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2145245
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1197              AK309492.1         88-1284
            1198-1230           BX092411.1         679-711
            1231-1400           AK309492.1         1318-1487
            1401-1463           W72800.1           352-414             c
            1464-1602           AA887145.1         188-326             c
            1603-1603           AC046134.8         150915-150915
            1604-1787           AI359782.1         106-289             c
            1788-1792           AI130945.1         64-68               c
FEATURES             Location/Qualifiers
     source          1..1792
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q23"
     gene            1..1792
                     /gene="RBP1"
                     /gene_synonym="CRABP-I; CRBP; CRBP1; CRBPI; hCRBP1; RBPC"
                     /note="retinol binding protein 1"
                     /db_xref="GeneID:5947"
                     /db_xref="HGNC:HGNC:9919"
                     /db_xref="MIM:180260"
     exon            1..283
                     /gene="RBP1"
                     /gene_synonym="CRABP-I; CRBP; CRBP1; CRBPI; hCRBP1; RBPC"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..498
                     /gene="RBP1"
                     /gene_synonym="CRABP-I; CRBP; CRBP1; CRBPI; hCRBP1; RBPC"
                     /EC_number="2.7.7.1"
                     /note="isoform b is encoded by transcript variant 2;
                     retinol-binding protein 1, cellular; cellular retinol
                     binding protein 1; cellular retinol-binding protein I"
                     /codon_start=1
                     /product="retinol-binding protein 1 isoform b"
                     /protein_id="NP_001124464.1"
                     /db_xref="CCDS:CCDS46926.1"
                     /db_xref="GeneID:5947"
                     /db_xref="HGNC:HGNC:9919"
                     /db_xref="MIM:180260"
                     /translation="MDPPAGFVRAGNPAVAAPQSPLSPEGAHFRAAHHPRSTGSRCPG
                     SLQPSRPLVANWLQSLPEMPVDFTGYWKMLVNENFEEYLRALDVNVALRKIANLLKPD
                     KEIVQDGDHMIIRTLSTFRNYIMDFQVGKEFEEDLTGIDDRKCMAGVQSRDLSSL"
     exon            284..462
                     /gene="RBP1"
                     /gene_synonym="CRABP-I; CRBP; CRBP1; CRBPI; hCRBP1; RBPC"
                     /inference="alignment:Splign:2.1.0"
     exon            463..1792
                     /gene="RBP1"
                     /gene_synonym="CRABP-I; CRBP; CRBP1; CRBPI; hCRBP1; RBPC"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1792
                     /gene="RBP1"
                     /gene_synonym="CRABP-I; CRBP; CRBP1; CRBPI; hCRBP1; RBPC"
                     /note="major polyA site"
ORIGIN      
        1 aagcggggag gagcgaccgc tacaatggat cctcccgcag gctttgtgcg cgctgggaat
       61 ccagctgtcg ccgccccgca gagccccctg tccccggagg gcgctcattt ccgggccgcc
      121 caccacccgc gtagcaccgg cagccgctgt cccggcagtc tccagccgtc ccgcccgctt
      181 gtggccaact ggctccagtc actccccgaa atgccagtcg acttcactgg gtactggaag
      241 atgttggtca acgagaattt cgaggagtac ctgcgcgccc tcgacgtcaa tgtggccttg
      301 cgcaaaatcg ccaacttgct gaagccagac aaagagatcg tgcaggacgg tgaccatatg
      361 atcatccgca cgctgagcac ttttaggaac tacatcatgg acttccaggt tgggaaggag
      421 tttgaggagg atctgacagg catagatgac cgcaagtgca tggctggagt gcaatcgcgt
      481 gatctcagct cactgtaacc tctgcctccc gggttcaagc aattctcctg cctcagcctc
      541 ccaagtagct gggattacag tcacacgcca ccacacctgg ataattttgt atttttggta
      601 gagacagggt ttcactatgt tggtcaggct ggtctcaaac tcctgagctc aggtgatcca
      661 tctgcctcag cctcccaaaa tgctgggatt acaagtgtga gccactacac ctggttcttc
      721 tttccactgt ttgctaactc ccatggtgtt ttctggcatc acttccagca ttatttctag
      781 ccttacctct tccaggaagc cttccctgat gggcctctgt ctctacctta aaggctgtcg
      841 aggtgccttc tgacttccat aacctccagc atttgtctac cagtacttac cattctgctg
      901 gaattctctg tcttcttacc ttcttctcag ataatctgtg agccctcaag agcaggccac
      961 tgaccttact tccctctctc cagcacctac agctggtgca taggaggtgt gaaacccatg
     1021 attgctgaat gccgttccct tgcacagaac cacgtggtga attcctattg ctcagtcaag
     1081 ggtcagttta aagcagggaa ctgcagagca cagtcatcaa gagcatgagc tctagagcca
     1141 aatctcatct ccccacttca cggctgggtg aacttcaggc ctcagtctcc acatttgtaa
     1201 aatgatgaga agcatacctg ctctaggagg ttgtcaggag tcaactggta tgacatatac
     1261 tttgcctagt accctgccca gcacataatg ttgggcatta tcattatcat aacaacacat
     1321 gttgttatga tattgattat ggtgactgat aatgacagca atgctatcac tcccaccagg
     1381 gagccttccc tgacccccca ggctgggttg cgggccgtca tccctcccag catatagcac
     1441 agaggtgtca ttgccttctc tccaggctga gctaccccat gacagagctt ctgtgcagcc
     1501 cagccttagg gccaccctaa gtgctaggtc cctgggatga atgagtgcag ttccacaggg
     1561 ccctgtgacc ttctccagtc ctgttcccac ctccttatcc agaaccttgg ccttgagcac
     1621 tccaatggtt taaactgact ctaggaactt tctgaattgt ttaaggaaaa ataactataa
     1681 catgtcaagt ttattagtct taacattttc tcattttgtc ttaataattg tgttatcatt
     1741 tgctgttagc tttttcatgg tattagaatt gcattctttc atgctcacaa aa
//
