LOCUS       NM_001006117            1946 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens RNA binding motif protein Y-linked family 1 member J
            (RBMY1J), mRNA.
ACCESSION   NM_001006117
VERSION     NM_001006117.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1946)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1946)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1946)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1946)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   5  (bases 1 to 1946)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   6  (bases 1 to 1946)
  AUTHORS   Tsuei,D.J., Hsu,H.C., Lee,P.H., Jeng,Y.M., Pu,Y.S., Chen,C.N.,
            Lee,Y.C., Chou,W.C., Chang,C.J., Ni,Y.H. and Chang,M.H.
  TITLE     RBMY, a male germ cell-specific RNA-binding protein, activated in
            human liver cancers and transforms rodent fibroblasts
  JOURNAL   Oncogene 23 (34), 5815-5822 (2004)
   PUBMED   15184870
REFERENCE   7  (bases 1 to 1946)
  AUTHORS   Skaletsky,H., Kuroda-Kawaguchi,T., Minx,P.J., Cordum,H.S.,
            Hillier,L., Brown,L.G., Repping,S., Pyntikova,T., Ali,J., Bieri,T.,
            Chinwalla,A., Delehaunty,A., Delehaunty,K., Du,H., Fewell,G.,
            Fulton,L., Fulton,R., Graves,T., Hou,S.F., Latrielle,P.,
            Leonard,S., Mardis,E., Maupin,R., McPherson,J., Miner,T., Nash,W.,
            Nguyen,C., Ozersky,P., Pepin,K., Rock,S., Rohlfing,T., Scott,K.,
            Schultz,B., Strong,C., Tin-Wollam,A., Yang,S.P., Waterston,R.H.,
            Wilson,R.K., Rozen,S. and Page,D.C.
  TITLE     The male-specific region of the human Y chromosome is a mosaic of
            discrete sequence classes
  JOURNAL   Nature 423 (6942), 825-837 (2003)
   PUBMED   12815422
REFERENCE   8  (bases 1 to 1946)
  AUTHORS   Chai,N.N., Zhou,H., Hernandez,J., Najmabadi,H., Bhasin,S. and
            Yen,P.H.
  TITLE     Structure and organization of the RBMY genes on the human Y
            chromosome: transposition and amplification of an ancestral
            autosomal hnRNPG gene
  JOURNAL   Genomics 49 (2), 283-289 (1998)
   PUBMED   9598316
REFERENCE   9  (bases 1 to 1946)
  AUTHORS   Prosser,J., Inglis,J.D., Condie,A., Ma,K., Kerr,S., Thakrar,R.,
            Taylor,K., Cameron,J.M. and Cooke,H.J.
  TITLE     Degeneracy in human multicopy RBM (YRRM), a candidate
            spermatogenesis gene
  JOURNAL   Mamm Genome 7 (11), 835-842 (1996)
   PUBMED   8875892
REFERENCE   10 (bases 1 to 1946)
  AUTHORS   Ma,K., Inglis,J.D., Sharkey,A., Bickmore,W.A., Hill,R.E.,
            Prosser,E.J., Speed,R.M., Thomson,E.J., Jobling,M., Taylor,K. et
            al.
  TITLE     A Y chromosome gene family with RNA-binding protein homology:
            candidates for the azoospermia factor AZF controlling human
            spermatogenesis
  JOURNAL   Cell 75 (7), 1287-1295 (1993)
   PUBMED   8269511
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007320.3.
            
            On Jul 21, 2021 this sequence version replaced NM_001006117.3.
            
            Summary: This gene encodes a protein containing an RNA-binding
            motif in the N-terminus and four SRGY (serine, arginine, glycine,
            tyrosine) boxes in the C-terminus. This protein likely functions as
            a splicing factor during spermatogenesis. Multiple closely related
            paralogs of this gene are found in a gene cluster in the AZFb
            azoospermia factor region of chromosome Y. Most of these related
            copies are thought to be pseudogenes, though several likely encode
            functional proteins. [provided by RefSeq, Mar 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000250831.6/ ENSP00000250831.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               AC007320.3         141123-141295
            174-286             AC007320.3         143157-143269
            287-390             AC007320.3         143738-143841
            391-568             AC007320.3         146865-147042
            569-721             AC007320.3         148958-149110
            722-836             AC007320.3         151121-151235
            837-947             AC007320.3         152191-152301
            948-1058            AC007320.3         152742-152852
            1059-1169           AC007320.3         153287-153397
            1170-1280           AC007320.3         154321-154431
            1281-1369           AC007320.3         154518-154606
            1370-1946           AC007320.3         155018-155594
FEATURES             Location/Qualifiers
     source          1..1946
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="Y"
                     /map="Yq11.223"
     gene            1..1946
                     /gene="RBMY1J"
                     /note="RNA binding motif protein Y-linked family 1 member
                     J"
                     /db_xref="GeneID:378951"
                     /db_xref="HGNC:HGNC:23917"
     exon            1..173
                     /gene="RBMY1J"
                     /inference="alignment:Splign:2.1.0"
     exon            174..286
                     /gene="RBMY1J"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..1668
                     /gene="RBMY1J"
                     /note="Y chromosome RNA recognition motif 2"
                     /codon_start=1
                     /product="RNA-binding motif protein, Y chromosome, family
                     1 member F/J"
                     /protein_id="NP_001006117.2"
                     /db_xref="CCDS:CCDS35484.1"
                     /db_xref="GeneID:378951"
                     /db_xref="HGNC:HGNC:23917"
                     /translation="MVEADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDRT
                     SKSRGFAFITFENPADAKNAAKDMNGTSLHGKAIKVEQAKKPSFQSGGRRRPPASSRN
                     RSPSGSLRSARGSSGGTRGWLPSHEGHLDDGGYTPDLKMSYSRGLIPVKRGPSSRSGG
                     PPPKKSAPSAVARSNSWMGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATN
                     DGNHPSCQETRDYAPPSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPSRGHA
                     YRDYGHSRRDESYSRGYRNHRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHP
                     SSRETRDYAPPHRDYAYRDYGHSSWDEHSSRGYSYHDGYGEALGRDHSEHLSGSSYRD
                     ALQRYGTSHGAPPARGPRMSYGGSTCHAYSNTRDRYGRSWESYSSCGDFHYCDREHVC
                     RKDQRNPPSLGRVLPDPREAYGSSSYVASIVDGGESRSEKGDSSRY"
     exon            287..390
                     /gene="RBMY1J"
                     /inference="alignment:Splign:2.1.0"
     exon            391..568
                     /gene="RBMY1J"
                     /inference="alignment:Splign:2.1.0"
     exon            569..721
                     /gene="RBMY1J"
                     /inference="alignment:Splign:2.1.0"
     exon            722..836
                     /gene="RBMY1J"
                     /inference="alignment:Splign:2.1.0"
     exon            837..947
                     /gene="RBMY1J"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1058
                     /gene="RBMY1J"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1169
                     /gene="RBMY1J"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1280
                     /gene="RBMY1J"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1369
                     /gene="RBMY1J"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1946
                     /gene="RBMY1J"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgattggcc gctggaggta ggcgggattt ccgggcacgg cttccggcgt ccttccctct
       61 cagggtagct ccagctgtcc ctcccgcagt tggccctgtg gtgttccgaa gccggttacg
      121 tacgcctgag ggccaggcga acctcaggct ctttgtccta ctaaaaagcg cagcacaatg
      181 gtagaagcag atcatcctgg caagcttttc attggtggcc tcaatagaga aaccaatgag
      241 aagatgctta aagcagtatt tgggaaacat ggtcccatat cagaagttct tttgataaag
      301 gatcgaacca gcaaatccag aggctttgca tttattactt ttgagaaccc tgcagatgct
      361 aagaatgctg cgaaagatat gaatggaacg tctttgcatg gaaaagcaat aaaagtagaa
      421 caagccaaga aaccatcttt tcaaagtggt ggtaggcgga gaccaccagc ttcttcgaga
      481 aacagaagcc cttcaggaag tctgagatct gcaagaggaa gcagtggagg aacaagaggg
      541 tggcttccct cacatgaagg gcacctggat gatggtggat acactcctga tctcaagatg
      601 agttattcta ggggactcat tccagttaaa agaggtccat cttcaagaag tggaggtcct
      661 cctccgaaaa aatctgctcc ttctgctgtg gcaagaagca atagttggat gggaagccaa
      721 ggtcccatgt cacaaagaag agagaattat ggagttcctc cacgcagagc gacaatatct
      781 tcctggagaa atgatcgcat gtcaacaaga catgatggtt atgcaactaa cgatggaaat
      841 catccaagtt gccaagaaac gagggattat gctccaccat ctagaggcta tgcataccgt
      901 gataatggtc attctaatcg ggatgaacat tcctctagag gatatagaaa tcatcgaagt
      961 tcccgagaaa ctagggatta tgctccacca tctagaggcc atgcataccg tgattatggt
     1021 cattctcgtc gggatgaaag ttattctaga ggatacagaa atcatcgaag ttcccgagaa
     1081 actagggagt atgctccacc atctagaggc catggatacc gtgattatgg tcattctcgt
     1141 cgacatgaaa gttattctag aggatataga aatcatccaa gttcccgaga aaccagggat
     1201 tatgctccac cacatagaga ctatgcatac cgtgattatg gtcattctag ttgggatgaa
     1261 cattcctcta gaggatatag ttatcatgat ggctacggtg aggcccttgg tagagatcat
     1321 tctgaacatc taagtggaag ttcttataga gatgcacttc agagatacgg gacctctcat
     1381 ggtgcaccac ctgcaagagg gcctcggatg tcttatggtg gaagcacctg ccacgcatat
     1441 agtaatacac gagatagata tggcagaagt tgggagagtt actcgagctg tggtgatttt
     1501 cattattgtg atcgtgagca tgtttgcaga aaagaccaaa ggaatccgcc ttctctgggt
     1561 agggtgctcc ctgatcctcg tgaagcatat ggtagctcaa gttatgtggc atctatagta
     1621 gatggtgggg agagtcgatc tgaaaaagga gactcgagca gatattaaag caagcattga
     1681 aaataatagt tattgcatac caatccttgt ttgcaaatca aaaattgaaa tgttatttct
     1741 gcattgttac ctgcatatta ctgaaagaaa catgttggtt ttgtggagag aggtagatac
     1801 taacttcctc catgaatttt ttgaggtatt caaaggaaaa ggaattgttt tcaaagtaat
     1861 ttcatacttg ttgatgctat ttgaaaagtg tttagatgta atatctacct taaaattttc
     1921 acaataaaat tttacatgta ctgcaa
//
