LOCUS       NM_152585               1862 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens RNA binding motif protein Y-linked family 1 member F
            (RBMY1F), transcript variant 1, mRNA.
ACCESSION   NM_152585
VERSION     NM_152585.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1862)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1862)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1862)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1862)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   5  (bases 1 to 1862)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   6  (bases 1 to 1862)
  AUTHORS   Skaletsky,H., Kuroda-Kawaguchi,T., Minx,P.J., Cordum,H.S.,
            Hillier,L., Brown,L.G., Repping,S., Pyntikova,T., Ali,J., Bieri,T.,
            Chinwalla,A., Delehaunty,A., Delehaunty,K., Du,H., Fewell,G.,
            Fulton,L., Fulton,R., Graves,T., Hou,S.F., Latrielle,P.,
            Leonard,S., Mardis,E., Maupin,R., McPherson,J., Miner,T., Nash,W.,
            Nguyen,C., Ozersky,P., Pepin,K., Rock,S., Rohlfing,T., Scott,K.,
            Schultz,B., Strong,C., Tin-Wollam,A., Yang,S.P., Waterston,R.H.,
            Wilson,R.K., Rozen,S. and Page,D.C.
  TITLE     The male-specific region of the human Y chromosome is a mosaic of
            discrete sequence classes
  JOURNAL   Nature 423 (6942), 825-837 (2003)
   PUBMED   12815422
REFERENCE   7  (bases 1 to 1862)
  AUTHORS   Venables,J.P., Elliott,D.J., Makarova,O.V., Makarov,E.M.,
            Cooke,H.J. and Eperon,I.C.
  TITLE     RBMY, a probable human spermatogenesis factor, and other hnRNP G
            proteins interact with Tra2beta and affect splicing
  JOURNAL   Hum Mol Genet 9 (5), 685-694 (2000)
   PUBMED   10749975
REFERENCE   8  (bases 1 to 1862)
  AUTHORS   Chai,N.N., Zhou,H., Hernandez,J., Najmabadi,H., Bhasin,S. and
            Yen,P.H.
  TITLE     Structure and organization of the RBMY genes on the human Y
            chromosome: transposition and amplification of an ancestral
            autosomal hnRNPG gene
  JOURNAL   Genomics 49 (2), 283-289 (1998)
   PUBMED   9598316
REFERENCE   9  (bases 1 to 1862)
  AUTHORS   Prosser,J., Inglis,J.D., Condie,A., Ma,K., Kerr,S., Thakrar,R.,
            Taylor,K., Cameron,J.M. and Cooke,H.J.
  TITLE     Degeneracy in human multicopy RBM (YRRM), a candidate
            spermatogenesis gene
  JOURNAL   Mamm Genome 7 (11), 835-842 (1996)
   PUBMED   8875892
REFERENCE   10 (bases 1 to 1862)
  AUTHORS   Ma,K., Inglis,J.D., Sharkey,A., Bickmore,W.A., Hill,R.E.,
            Prosser,E.J., Speed,R.M., Thomson,E.J., Jobling,M., Taylor,K. et
            al.
  TITLE     A Y chromosome gene family with RNA-binding protein homology:
            candidates for the azoospermia factor AZF controlling human
            spermatogenesis
  JOURNAL   Cell 75 (7), 1287-1295 (1993)
   PUBMED   8269511
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC023342.3.
            
            On May 6, 2020 this sequence version replaced NM_152585.2.
            
            Summary: This gene encodes a protein containing an RNA-binding
            motif in the N-terminus and four SRGY (serine, arginine, glycine,
            tyrosine) boxes in the C-terminus. Multiple copies of this gene are
            found in the AZFb azoospermia factor region of chromosome Y and the
            encoded protein is thought to be involved in spermatogenesis. Most
            copies of this locus are pseudogenes, although six highly similar
            copies have full-length ORFs and are considered functional. Four
            functional copies of this gene are found within inverted repeat
            IR2; two functional copies of this gene are found in palindrome P3,
            along with two copies of PTPN13-like, Y-linked. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030018.2, SRR5189667.347794.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303766.12/ ENSP00000307155.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                AC023342.3         50312-50400         c
            90-202              AC023342.3         48338-48450         c
            203-306             AC023342.3         47768-47871         c
            307-484             AC023342.3         44571-44748         c
            485-637             AC023342.3         42503-42655         c
            638-752             AC023342.3         40378-40492         c
            753-863             AC023342.3         39312-39422         c
            864-974             AC023342.3         38761-38871         c
            975-1085            AC023342.3         38216-38326         c
            1086-1196           AC023342.3         37182-37292         c
            1197-1285           AC023342.3         37007-37095         c
            1286-1862           AC023342.3         36019-36595         c
FEATURES             Location/Qualifiers
     source          1..1862
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="Y"
                     /map="Yq11.223"
     gene            1..1862
                     /gene="RBMY1F"
                     /gene_synonym="YRRM2"
                     /note="RNA binding motif protein Y-linked family 1 member
                     F"
                     /db_xref="GeneID:159163"
                     /db_xref="HGNC:HGNC:23974"
     exon            1..89
                     /gene="RBMY1F"
                     /gene_synonym="YRRM2"
                     /inference="alignment:Splign:2.1.0"
     exon            90..202
                     /gene="RBMY1F"
                     /gene_synonym="YRRM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1584
                     /gene="RBMY1F"
                     /gene_synonym="YRRM2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RNA-binding motif protein, Y chromosome, family 1 member
                     F/J; y chromosome RNA recognition motif 2"
                     /codon_start=1
                     /product="RNA-binding motif protein, Y chromosome, family
                     1 member F/J isoform 1"
                     /protein_id="NP_689798.1"
                     /db_xref="CCDS:CCDS35483.1"
                     /db_xref="GeneID:159163"
                     /db_xref="HGNC:HGNC:23974"
                     /translation="MVEADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDRT
                     SKSRGFAFITFENPADAKNAAKDMNGTSLHGKAIKVEQAKKPSFQSGGRRRPPASSRN
                     RSPSGSLRSARGSSGGTRGWLPSHEGHLDDGGYTPDLKMSYSRGLIPVKRGPSSRSGG
                     PPPKKSAPSAVARSNSWMGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATN
                     DGNHPSCQETRDYAPPSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPSRGHA
                     YRDYGHSRRDESYSRGYRNHRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHP
                     SSRETRDYAPPHRDYAYRDYGHSSWDEHSSRGYSYHDGYGEALGRDHSEHLSGSSYRD
                     ALQRYGTSHGAPPARGPRMSYGGSTCHAYSNTRDRYGRSWESYSSCGDFHYCDREHVC
                     RKDQRNPPSLGRVLPDPREAYGSSSYVASIVDGGESRSEKGDSSRY"
     exon            203..306
                     /gene="RBMY1F"
                     /gene_synonym="YRRM2"
                     /inference="alignment:Splign:2.1.0"
     exon            307..484
                     /gene="RBMY1F"
                     /gene_synonym="YRRM2"
                     /inference="alignment:Splign:2.1.0"
     exon            485..637
                     /gene="RBMY1F"
                     /gene_synonym="YRRM2"
                     /inference="alignment:Splign:2.1.0"
     exon            638..752
                     /gene="RBMY1F"
                     /gene_synonym="YRRM2"
                     /inference="alignment:Splign:2.1.0"
     exon            753..863
                     /gene="RBMY1F"
                     /gene_synonym="YRRM2"
                     /inference="alignment:Splign:2.1.0"
     exon            864..974
                     /gene="RBMY1F"
                     /gene_synonym="YRRM2"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1085
                     /gene="RBMY1F"
                     /gene_synonym="YRRM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1196
                     /gene="RBMY1F"
                     /gene_synonym="YRRM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1285
                     /gene="RBMY1F"
                     /gene_synonym="YRRM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1862
                     /gene="RBMY1F"
                     /gene_synonym="YRRM2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagttggcc ctgtggtgtt ccgaagccgg ttacgtacgg cctgagggcc aggcgaacct
       61 caggctcttt gtcctactaa aaagcgcagc acaatggtag aagcagatca tcctggcaag
      121 cttttcattg gtggcctcaa tagagaaacc aatgagaaga tgcttaaagc agtatttggg
      181 aaacatggtc ccatatcaga agttcttttg ataaaggatc gaaccagcaa atccagaggc
      241 tttgcattta ttacttttga gaaccctgca gatgctaaga atgctgcgaa agatatgaat
      301 ggaacgtctt tgcatggaaa agcaataaaa gtagaacaag ccaagaaacc atcttttcaa
      361 agtggtggta ggcggagacc accagcttct tcgagaaaca gaagcccttc aggaagtctg
      421 agatctgcaa gaggaagcag tggaggaaca agagggtggc ttccctcaca tgaagggcac
      481 ctggatgatg gtggatacac tcctgatctc aagatgagtt attctagggg actcattcca
      541 gttaaaagag gtccatcttc aagaagtgga ggtcctcctc cgaaaaaatc tgctccttct
      601 gctgtggcaa gaagcaatag ttggatggga agccaaggtc ccatgtcaca aagaagagag
      661 aattatggag ttcctccacg cagagcgaca atatcttcct ggagaaatga tcgcatgtca
      721 acaagacatg atggttatgc aactaacgat ggaaatcatc caagttgcca agaaacgagg
      781 gattatgctc caccatctag aggctatgca taccgtgata atggtcattc taatcgggat
      841 gaacattcct ctagaggata tagaaatcat cgaagttccc gagaaactag ggattatgct
      901 ccaccatcta gaggccatgc ataccgtgat tatggtcatt ctcgtcggga tgaaagttat
      961 tctagaggat acagaaatca tcgaagttcc cgagaaacta gggagtatgc tccaccatct
     1021 agaggccatg gataccgtga ttatggtcat tctcgtcgac atgaaagtta ttctagagga
     1081 tatagaaatc atccaagttc ccgagaaacc agggattatg ctccaccaca tagagactat
     1141 gcataccgtg attatggtca ttctagttgg gatgaacatt cctctagagg atatagttat
     1201 catgatggct acggtgaggc ccttggtaga gatcattctg aacatctaag tggaagttct
     1261 tatagagatg cacttcagag gtacgggacc tctcatggtg caccacctgc aagagggcct
     1321 cggatgtctt atggtggaag cacctgccac gcatatagta atacacgaga tagatatggc
     1381 agaagttggg agagttactc gagctgtggt gattttcatt attgtgatcg tgagcatgtt
     1441 tgcagaaaag accaaaggaa tccgccttct ctgggtaggg tgctccctga tcctcgtgaa
     1501 gcatatggta gctcaagtta tgtggcatct atagtagatg gtggggagag tcgatctgaa
     1561 aaaggagact cgagcagata ttaaagcaag cattgaaaat aatagttatt gcataccaat
     1621 ccttgtttgc aaatcaaaaa ttgaaatgtt atttctgcat tgttacctgc atattactga
     1681 aagaaacatg ttggttttgt ggagagaggt agatactaac ttcctccatg aattttttga
     1741 ggtattcaaa ggaaaaggaa ttgttttcaa agtaatttca tacttgttga tgctatttga
     1801 aaagtgttta gatgtaatat ctaccttaaa attttcacaa taaaatttta catgtactgc
     1861 aa
//
