LOCUS       NM_001006118            1882 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens RNA binding motif protein Y-linked family 1 member E
            (RBMY1E), mRNA.
ACCESSION   NM_001006118
VERSION     NM_001006118.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1882)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1882)
  AUTHORS   Tsuei,D.J., Hsu,H.C., Lee,P.H., Jeng,Y.M., Pu,Y.S., Chen,C.N.,
            Lee,Y.C., Chou,W.C., Chang,C.J., Ni,Y.H. and Chang,M.H.
  TITLE     RBMY, a male germ cell-specific RNA-binding protein, activated in
            human liver cancers and transforms rodent fibroblasts
  JOURNAL   Oncogene 23 (34), 5815-5822 (2004)
   PUBMED   15184870
REFERENCE   3  (bases 1 to 1882)
  AUTHORS   Skaletsky,H., Kuroda-Kawaguchi,T., Minx,P.J., Cordum,H.S.,
            Hillier,L., Brown,L.G., Repping,S., Pyntikova,T., Ali,J., Bieri,T.,
            Chinwalla,A., Delehaunty,A., Delehaunty,K., Du,H., Fewell,G.,
            Fulton,L., Fulton,R., Graves,T., Hou,S.F., Latrielle,P.,
            Leonard,S., Mardis,E., Maupin,R., McPherson,J., Miner,T., Nash,W.,
            Nguyen,C., Ozersky,P., Pepin,K., Rock,S., Rohlfing,T., Scott,K.,
            Schultz,B., Strong,C., Tin-Wollam,A., Yang,S.P., Waterston,R.H.,
            Wilson,R.K., Rozen,S. and Page,D.C.
  TITLE     The male-specific region of the human Y chromosome is a mosaic of
            discrete sequence classes
  JOURNAL   Nature 423 (6942), 825-837 (2003)
   PUBMED   12815422
REFERENCE   4  (bases 1 to 1882)
  AUTHORS   Chai,N.N., Zhou,H., Hernandez,J., Najmabadi,H., Bhasin,S. and
            Yen,P.H.
  TITLE     Structure and organization of the RBMY genes on the human Y
            chromosome: transposition and amplification of an ancestral
            autosomal hnRNPG gene
  JOURNAL   Genomics 49 (2), 283-289 (1998)
   PUBMED   9598316
REFERENCE   5  (bases 1 to 1882)
  AUTHORS   Prosser,J., Inglis,J.D., Condie,A., Ma,K., Kerr,S., Thakrar,R.,
            Taylor,K., Cameron,J.M. and Cooke,H.J.
  TITLE     Degeneracy in human multicopy RBM (YRRM), a candidate
            spermatogenesis gene
  JOURNAL   Mamm Genome 7 (11), 835-842 (1996)
   PUBMED   8875892
REFERENCE   6  (bases 1 to 1882)
  AUTHORS   Ma,K., Inglis,J.D., Sharkey,A., Bickmore,W.A., Hill,R.E.,
            Prosser,E.J., Speed,R.M., Thomson,E.J., Jobling,M., Taylor,K. et
            al.
  TITLE     A Y chromosome gene family with RNA-binding protein homology:
            candidates for the azoospermia factor AZF controlling human
            spermatogenesis
  JOURNAL   Cell 75 (7), 1287-1295 (1993)
   PUBMED   8269511
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007322.4.
            
            On Apr 1, 2021 this sequence version replaced NM_001006118.2.
            
            Summary: This gene encodes a protein containing an RNA-binding
            motif in the N-terminus and four SRGY (serine, arginine, glycine,
            tyrosine) boxes in the C-terminus. Multiple copies of this gene are
            found in the AZFb azoospermia factor region of chromosome Y and the
            encoded protein is thought to be involved in spermatogenesis. Most
            copies of this locus are pseudogenes, although six highly similar
            copies have full-length ORFs and are considered functional. Four
            functional copies of this gene are found within inverted repeat
            IR2; two functional copies of this gene are found in palindrome P3,
            along with two copies of PTPN13-like, Y-linked. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.134962.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA1970526 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382659.7/ ENSP00000372105.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               AC007322.4         69839-69951         c
            114-226             AC007322.4         67865-67977         c
            227-330             AC007322.4         67285-67388         c
            331-508             AC007322.4         64088-64265         c
            509-661             AC007322.4         62020-62172         c
            662-776             AC007322.4         59895-60009         c
            777-887             AC007322.4         58829-58939         c
            888-998             AC007322.4         58277-58387         c
            999-1109            AC007322.4         57732-57842         c
            1110-1220           AC007322.4         56700-56810         c
            1221-1309           AC007322.4         56525-56613         c
            1310-1882           AC007322.4         55541-56113         c
FEATURES             Location/Qualifiers
     source          1..1882
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="Y"
                     /map="Yq11.223"
     gene            1..1882
                     /gene="RBMY1E"
                     /note="RNA binding motif protein Y-linked family 1 member
                     E"
                     /db_xref="GeneID:378950"
                     /db_xref="HGNC:HGNC:23916"
     exon            1..113
                     /gene="RBMY1E"
                     /inference="alignment:Splign:2.1.0"
     exon            114..226
                     /gene="RBMY1E"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1608
                     /gene="RBMY1E"
                     /codon_start=1
                     /product="RNA-binding motif protein, Y chromosome, family
                     1 member E"
                     /protein_id="NP_001006118.2"
                     /db_xref="CCDS:CCDS35481.1"
                     /db_xref="GeneID:378950"
                     /db_xref="HGNC:HGNC:23916"
                     /translation="MVEADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDRT
                     SKSRGFAFITFENPADAKNAAKDMNGKSLHGKAIKVEQAKKPSFQSGGRRRPPASSRN
                     RSPSGSLRSARGSRGGTRGWLPSQEGHLDDGGYTPDLKMSYSRGLIPVKRGPSSRSGG
                     PPPKKSAPSAVARSNSWMGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATN
                     DGNHPSCQETRDYAPPSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPSRGHA
                     YRDYGHSRRDESYSRGYRNRRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHP
                     SSRETRDYAPPHRDYAYRDYGHSSWDEHSSRGYSYHDGYGEALGRDHSEHLSGSSYRD
                     ALQRYGTAHGAPPARGPRMSYGGSTCHAYSNTRDRYGRSWESYSSCGDFHYCDREHVC
                     RKDQRNPPSLGRVLPDPREACGSSSYVASIVDGGESRSEKGDSSRY"
     exon            227..330
                     /gene="RBMY1E"
                     /inference="alignment:Splign:2.1.0"
     exon            331..508
                     /gene="RBMY1E"
                     /inference="alignment:Splign:2.1.0"
     exon            509..661
                     /gene="RBMY1E"
                     /inference="alignment:Splign:2.1.0"
     exon            662..776
                     /gene="RBMY1E"
                     /inference="alignment:Splign:2.1.0"
     exon            777..887
                     /gene="RBMY1E"
                     /inference="alignment:Splign:2.1.0"
     exon            888..998
                     /gene="RBMY1E"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1109
                     /gene="RBMY1E"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1220
                     /gene="RBMY1E"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1309
                     /gene="RBMY1E"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1882
                     /gene="RBMY1E"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggaagctc cagctgtccc tcccgcagtt ggccctgtgg tgttccgaag ccggttacgt
       61 acggcctgag ggccaggcga acctcaggct ctttgtccta ctaaaaagcg cagcacaatg
      121 gtagaagcag atcatcctgg caagcttttc attggtggcc tcaatagaga aaccaatgag
      181 aagatgctta aagcagtatt tgggaaacat ggtcccatat cagaagttct tttgataaag
      241 gatcgaacca gcaaatccag aggctttgca tttattactt ttgagaaccc tgcagatgct
      301 aagaatgctg ccaaagatat gaatggaaag tctttgcatg gaaaagcaat aaaagtagaa
      361 caagccaaga aaccatcttt tcaaagtggt ggtaggcgga gaccaccagc ttcttcgaga
      421 aacagaagcc cttcaggaag tctgagatct gcaagaggaa gccgtggagg aacaagaggg
      481 tggcttccct cacaagaagg gcacctggat gatggtggat acactcctga tctcaagatg
      541 agttattcta ggggactcat tccagttaaa agaggtccat cttcaagaag tggaggtcct
      601 cctccgaaaa aatctgctcc ttctgctgtg gcaagaagca atagttggat gggaagccaa
      661 ggtcccatgt cacaaagaag agagaattat ggagttcctc cacgcagagc gacaatatct
      721 tcctggagaa atgatcgcat gtcaacaaga catgatggtt atgcaactaa cgatggaaat
      781 catccaagtt gccaagaaac gagggattat gctccaccat ctagaggcta tgcataccgt
      841 gataatggtc attctaatcg ggatgaacat tcctctagag gatatagaaa tcatcgaagt
      901 tcccgagaaa ctagggatta tgctccacca tctagaggcc atgcataccg tgattatggt
      961 cattctcgtc gggatgaaag ttattctaga ggatacagaa atcgtcgaag ttcccgagaa
     1021 actagggagt atgctccacc atctagaggc catggatacc gtgattatgg tcattctcgt
     1081 cgacatgaaa gttattctag aggatataga aatcatccaa gttcccgaga aaccagggat
     1141 tatgctccac cacatagaga ctatgcatac cgtgattatg gtcattctag ttgggatgaa
     1201 cattcctcta gaggatatag ttatcatgat ggctacggtg aggcccttgg tagagatcat
     1261 tctgaacatc taagtggaag ttcttataga gatgcacttc agagatacgg gaccgctcat
     1321 ggtgcaccac ctgcaagagg gcctcggatg tcctatggtg gaagcacctg ccacgcatat
     1381 agtaatacac gagatagata tggcagaagt tgggagagtt actcgagctg tggtgatttt
     1441 cattattgtg atcgtgagca tgtttgcaga aaagaccaaa ggaatccgcc ttctctgggt
     1501 agggtgctcc ctgatcctcg tgaagcatgt ggtagctcaa gttatgtggc atctatagta
     1561 gatggtgggg agagtcgatc tgaaaaagga gactcgagca gatattaaag caagcattga
     1621 aagtaatagt tattgcatac caatccttgt ttgcaaatca aaaattgaaa tgttatttct
     1681 gcattgttac ctgcatatta ctgaaagaaa catgttggtt ttgtggagag aggtagatac
     1741 taacttcctc catgaatttt ttgaggtatt caaaggaaaa ggaattgttt tcaaagtaat
     1801 ttcatacttg ttgatgctat ttgaaaagtg tttagatgta atatctacct taaaattttc
     1861 acaataaaat ttgacatgta ct
//
