LOCUS       NM_001006121            1921 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens RNA binding motif protein Y-linked family 1 member B
            (RBMY1B), transcript variant 1, mRNA.
ACCESSION   NM_001006121
VERSION     NM_001006121.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1921)
  AUTHORS   Kido,T., Tabatabai,Z.L., Chen,X. and Lau,Y.C.
  TITLE     Potential dual functional roles of the Y-linked RBMY in
            hepatocarcinogenesis
  JOURNAL   Cancer Sci 111 (8), 2987-2999 (2020)
   PUBMED   32473614
  REMARK    GeneRIF: Potential dual functional roles of the Y-linked RBMY in
            hepatocarcinogenesis.
REFERENCE   2  (bases 1 to 1921)
  AUTHORS   Tsuei,D.J., Hsu,H.C., Lee,P.H., Jeng,Y.M., Pu,Y.S., Chen,C.N.,
            Lee,Y.C., Chou,W.C., Chang,C.J., Ni,Y.H. and Chang,M.H.
  TITLE     RBMY, a male germ cell-specific RNA-binding protein, activated in
            human liver cancers and transforms rodent fibroblasts
  JOURNAL   Oncogene 23 (34), 5815-5822 (2004)
   PUBMED   15184870
REFERENCE   3  (bases 1 to 1921)
  AUTHORS   Skaletsky,H., Kuroda-Kawaguchi,T., Minx,P.J., Cordum,H.S.,
            Hillier,L., Brown,L.G., Repping,S., Pyntikova,T., Ali,J., Bieri,T.,
            Chinwalla,A., Delehaunty,A., Delehaunty,K., Du,H., Fewell,G.,
            Fulton,L., Fulton,R., Graves,T., Hou,S.F., Latrielle,P.,
            Leonard,S., Mardis,E., Maupin,R., McPherson,J., Miner,T., Nash,W.,
            Nguyen,C., Ozersky,P., Pepin,K., Rock,S., Rohlfing,T., Scott,K.,
            Schultz,B., Strong,C., Tin-Wollam,A., Yang,S.P., Waterston,R.H.,
            Wilson,R.K., Rozen,S. and Page,D.C.
  TITLE     The male-specific region of the human Y chromosome is a mosaic of
            discrete sequence classes
  JOURNAL   Nature 423 (6942), 825-837 (2003)
   PUBMED   12815422
REFERENCE   4  (bases 1 to 1921)
  AUTHORS   Venables,J.P., Elliott,D.J., Makarova,O.V., Makarov,E.M.,
            Cooke,H.J. and Eperon,I.C.
  TITLE     RBMY, a probable human spermatogenesis factor, and other hnRNP G
            proteins interact with Tra2beta and affect splicing
  JOURNAL   Hum Mol Genet 9 (5), 685-694 (2000)
   PUBMED   10749975
REFERENCE   5  (bases 1 to 1921)
  AUTHORS   Chai,N.N., Zhou,H., Hernandez,J., Najmabadi,H., Bhasin,S. and
            Yen,P.H.
  TITLE     Structure and organization of the RBMY genes on the human Y
            chromosome: transposition and amplification of an ancestral
            autosomal hnRNPG gene
  JOURNAL   Genomics 49 (2), 283-289 (1998)
   PUBMED   9598316
REFERENCE   6  (bases 1 to 1921)
  AUTHORS   Prosser,J., Inglis,J.D., Condie,A., Ma,K., Kerr,S., Thakrar,R.,
            Taylor,K., Cameron,J.M. and Cooke,H.J.
  TITLE     Degeneracy in human multicopy RBM (YRRM), a candidate
            spermatogenesis gene
  JOURNAL   Mamm Genome 7 (11), 835-842 (1996)
   PUBMED   8875892
REFERENCE   7  (bases 1 to 1921)
  AUTHORS   Ma,K., Inglis,J.D., Sharkey,A., Bickmore,W.A., Hill,R.E.,
            Prosser,E.J., Speed,R.M., Thomson,E.J., Jobling,M., Taylor,K. et
            al.
  TITLE     A Y chromosome gene family with RNA-binding protein homology:
            candidates for the azoospermia factor AZF controlling human
            spermatogenesis
  JOURNAL   Cell 75 (7), 1287-1295 (1993)
   PUBMED   8269511
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010141.2.
            
            On May 17, 2019 this sequence version replaced NM_001006121.3.
            
            Summary: This gene encodes a protein containing an RNA-binding
            motif in the N-terminus and four SRGY (serine, arginine, glycine,
            tyrosine) boxes in the C-terminus. This protein likely functions as
            a splicing factor during spermatogenesis. Multiple closely related
            paralogs of this gene are found in a gene cluster in the AZFb
            azoospermia factor region of chromosome Y. Most of these related
            copies are thought to be pseudogenes, though several likely encode
            functional proteins. [provided by RefSeq, Mar 2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000383020.7/ ENSP00000372484.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               AC010141.2         53455-53602
            149-261             AC010141.2         55464-55576
            262-365             AC010141.2         56051-56154
            366-543             AC010141.2         59174-59351
            544-696             AC010141.2         61267-61419
            697-811             AC010141.2         63430-63544
            812-922             AC010141.2         64500-64610
            923-1033            AC010141.2         65052-65162
            1034-1144           AC010141.2         65597-65707
            1145-1255           AC010141.2         66629-66739
            1256-1344           AC010141.2         66827-66915
            1345-1921           AC010141.2         67327-67903
FEATURES             Location/Qualifiers
     source          1..1921
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="Y"
                     /map="Yq11.223"
     gene            1..1921
                     /gene="RBMY1B"
                     /gene_synonym="RBMY1D"
                     /note="RNA binding motif protein Y-linked family 1 member
                     B"
                     /db_xref="GeneID:378948"
                     /db_xref="HGNC:HGNC:23914"
     exon            1..148
                     /gene="RBMY1B"
                     /gene_synonym="RBMY1D"
                     /inference="alignment:Splign:2.1.0"
     exon            149..261
                     /gene="RBMY1B"
                     /gene_synonym="RBMY1D"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1643
                     /gene="RBMY1B"
                     /gene_synonym="RBMY1D"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RNA-binding motif protein, Y chromosome, family 1 member
                     B; RNA-binding motif protein, Y chromosome, family 1
                     member D"
                     /codon_start=1
                     /product="RNA-binding motif protein, Y chromosome, family
                     1 member B isoform 1"
                     /protein_id="NP_001006121.1"
                     /db_xref="CCDS:CCDS35479.1"
                     /db_xref="GeneID:378948"
                     /db_xref="HGNC:HGNC:23914"
                     /translation="MVEADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDRT
                     SKSRGFAFITFENPADAKNAAKDMNGKSLHGKAIKVEQAKKPSFQSGGRRRPPASSRN
                     RSPSGSLRSARGSRGGTRGWLPSQEGHLDDGGYTPDLKMSYSRGLIPVKRGPSSRSGG
                     PPPKKSAPSAVARSNSWMGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATN
                     DGNHPSCQETRDYAPPSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPSRGHA
                     YRDYGHSRRDESYSRGYRNRRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHP
                     SSRETRDYAPPHRDYAYRDYGHSSWDEHSSRGYSYHDGYGEALGRDHSEHLSGSSYRD
                     ALQRYGTSHGAPPARGPRMSYGGSTCHAYSNTRDRYGRSWESYSSCGDFHYCDREHVC
                     RKDQRNPPSLGRVLPDPREAYGSSSYVASIVDGGESRSEKGDSSRY"
     exon            262..365
                     /gene="RBMY1B"
                     /gene_synonym="RBMY1D"
                     /inference="alignment:Splign:2.1.0"
     exon            366..543
                     /gene="RBMY1B"
                     /gene_synonym="RBMY1D"
                     /inference="alignment:Splign:2.1.0"
     exon            544..696
                     /gene="RBMY1B"
                     /gene_synonym="RBMY1D"
                     /inference="alignment:Splign:2.1.0"
     exon            697..811
                     /gene="RBMY1B"
                     /gene_synonym="RBMY1D"
                     /inference="alignment:Splign:2.1.0"
     exon            812..922
                     /gene="RBMY1B"
                     /gene_synonym="RBMY1D"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1033
                     /gene="RBMY1B"
                     /gene_synonym="RBMY1D"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1144
                     /gene="RBMY1B"
                     /gene_synonym="RBMY1D"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1255
                     /gene="RBMY1B"
                     /gene_synonym="RBMY1D"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1344
                     /gene="RBMY1B"
                     /gene_synonym="RBMY1D"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1921
                     /gene="RBMY1B"
                     /gene_synonym="RBMY1D"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atttccgggc acggcttccg gcgtccttcc ctctcaggga agctccagct gtccctcccg
       61 cagttggccc tgtggtgttc cgaagccggt tacgtacggc ctgagggcca ggcgaacctc
      121 aggctctttg tcctactaaa aagcgcagca caatggtaga agcagatcat cctggcaagc
      181 ttttcattgg tggcctcaat agagaaacca atgagaagat gcttaaagca gtatttggga
      241 aacatggtcc catatcagaa gttcttttga taaaggatcg aaccagcaaa tccagaggct
      301 ttgcatttat tacttttgag aaccctgcag atgctaagaa tgctgccaaa gatatgaatg
      361 gaaagtcttt gcatggaaaa gcaataaaag tagaacaagc caagaaacca tcttttcaaa
      421 gtggtggtag gcggagacca ccagcttctt cgagaaacag aagcccttca ggaagtctga
      481 gatctgcaag aggaagccgt ggaggaacaa gagggtggct tccctcacaa gaagggcacc
      541 tggatgatgg tggatacact cctgatctca agatgagtta ttctagggga ctcattccag
      601 ttaaaagagg tccatcttca agaagtggag gtcctcctcc gaaaaaatct gctccttctg
      661 ctgtggcaag aagcaatagt tggatgggaa gccaaggtcc catgtcacaa agaagagaga
      721 attatggagt tcctccacgc agagcgacaa tatcttcctg gagaaatgat cgcatgtcaa
      781 caagacatga tggttatgca actaacgatg gaaatcatcc aagttgccaa gaaacgaggg
      841 attatgctcc accatctaga ggctatgcat accgtgataa tggtcattct aatcgggatg
      901 aacattcctc tagaggatat agaaatcatc gaagttcccg agaaactagg gattatgctc
      961 caccatctag aggccatgca taccgtgatt atggtcattc tcgtcgggat gaaagttatt
     1021 ctagaggata cagaaatcgt cgaagttccc gagaaactag ggagtatgct ccaccatcta
     1081 gaggccatgg ataccgtgat tatggtcatt ctcgtcgaca tgaaagttat tctagaggat
     1141 atagaaatca tccaagttcc cgagaaacca gggattatgc tccaccacat agagactatg
     1201 cataccgtga ttatggtcat tctagttggg atgaacattc ctctagagga tatagttatc
     1261 atgatggcta cggtgaggcc cttggtagag atcattctga acatctaagt ggaagttctt
     1321 atagagatgc acttcagaga tacgggacct ctcatggtgc accacctgca agagggcctc
     1381 ggatgtctta tggtggaagc acctgccacg catatagtaa tacacgagat agatatggca
     1441 gaagttggga gagttactcg agctgtggtg attttcatta ttgtgatcgt gagcatgttt
     1501 gcagaaaaga ccaaaggaat ccgccttctc tgggtagggt gctccctgat cctcgtgaag
     1561 catatggtag ctcaagttat gtggcatcta tagtagatgg tggggagagt cgatctgaaa
     1621 aaggagactc gagcagatat taaagcaagc attgaaagta atagttattg cataccaatc
     1681 cttgtttgca aatcaaaaat tgaaatgtta tttctgcatt gttacctgca tattactgaa
     1741 agaaacatgt tggttttgtg gagagaggta gatactaact tcctccatga attttttgag
     1801 gtattcaaag gaaaaggaat tgttttcaaa gtaatttcat acttgttgat gctatttgaa
     1861 aagtgtttag atgtaatatc taccttaaaa ttttcacaat aaaatttgac atgtactgca
     1921 a
//
