LOCUS       NM_005058               1921 bp    mRNA    linear   PRI 10-OCT-2024
DEFINITION  Homo sapiens RNA binding motif protein Y-linked family 1 member A1
            (RBMY1A1), transcript variant 1, mRNA.
ACCESSION   NM_005058
VERSION     NM_005058.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1921)
  AUTHORS   Chua,H.H., Chang,M.H., Chen,Y.H., Tsuei,D.J., Jeng,Y.M., Lee,P.H.
            and Ni,Y.H.
  TITLE     PIM1-Induced Cytoplasmic Expression of RBMY Mediates Hepatocellular
            Carcinoma Metastasis
  JOURNAL   Cell Mol Gastroenterol Hepatol 15 (1), 121-152 (2023)
   PUBMED   36191855
  REMARK    GeneRIF: PIM1-Induced Cytoplasmic Expression of RBMY Mediates
            Hepatocellular Carcinoma Metastasis.
REFERENCE   2  (bases 1 to 1921)
  AUTHORS   Kido,T., Tabatabai,Z.L., Chen,X. and Lau,Y.C.
  TITLE     Potential dual functional roles of the Y-linked RBMY in
            hepatocarcinogenesis
  JOURNAL   Cancer Sci 111 (8), 2987-2999 (2020)
   PUBMED   32473614
  REMARK    GeneRIF: Potential dual functional roles of the Y-linked RBMY in
            hepatocarcinogenesis.
REFERENCE   3  (bases 1 to 1921)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1921)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1921)
  AUTHORS   Kovacs,I.A., Luck,K., Spirohn,K., Wang,Y., Pollis,C., Schlabach,S.,
            Bian,W., Kim,D.K., Kishore,N., Hao,T., Calderwood,M.A., Vidal,M.
            and Barabasi,A.L.
  TITLE     Network-based prediction of protein interactions
  JOURNAL   Nat Commun 10 (1), 1240 (2019)
   PUBMED   30886144
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1921)
  AUTHORS   Elliott,D.J., Millar,M.R., Oghene,K., Ross,A., Kiesewetter,F.,
            Pryor,J., McIntyre,M., Hargreave,T.B., Saunders,P.T., Vogt,P.H.,
            Chandley,A.C. and Cooke,H.
  TITLE     Expression of RBM in the nuclei of human germ cells is dependent on
            a critical region of the Y chromosome long arm
  JOURNAL   Proc Natl Acad Sci U S A 94 (8), 3848-3853 (1997)
   PUBMED   9108067
REFERENCE   7  (bases 1 to 1921)
  AUTHORS   Delbridge,M.L., Harry,J.L., Toder,R., O'Neill,R.J., Ma,K.,
            Chandley,A.C. and Graves,J.A.
  TITLE     A human candidate spermatogenesis gene, RBM1, is conserved and
            amplified on the marsupial Y chromosome
  JOURNAL   Nat Genet 15 (2), 131-136 (1997)
   PUBMED   9020837
  REMARK    Erratum:[Nat Genet 1997 Apr;15(4):411]
REFERENCE   8  (bases 1 to 1921)
  AUTHORS   Prosser,J., Inglis,J.D., Condie,A., Ma,K., Kerr,S., Thakrar,R.,
            Taylor,K., Cameron,J.M. and Cooke,H.J.
  TITLE     Degeneracy in human multicopy RBM (YRRM), a candidate
            spermatogenesis gene
  JOURNAL   Mamm Genome 7 (11), 835-842 (1996)
   PUBMED   8875892
REFERENCE   9  (bases 1 to 1921)
  AUTHORS   Ma,K., Inglis,J.D., Sharkey,A., Bickmore,W.A., Hill,R.E.,
            Prosser,E.J., Speed,R.M., Thomson,E.J., Jobling,M., Taylor,K. et
            al.
  TITLE     A Y chromosome gene family with RNA-binding protein homology:
            candidates for the azoospermia factor AZF controlling human
            spermatogenesis
  JOURNAL   Cell 75 (7), 1287-1295 (1993)
   PUBMED   8269511
REFERENCE   10 (bases 1 to 1921)
  AUTHORS   Fan,Y. and Silber,S.J.
  TITLE     Y Chromosome Infertility
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301513
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB107177.1, X76059.1 and
            BX119894.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_005058.3.
            
            Summary: This gene encodes a protein containing an RNA-binding
            motif in the N-terminus and four SRGY (serine, arginine, glycine,
            tyrosine) boxes in the C-terminus. This protein is thought to
            function as a splicing regulator during spermatogenesis. Multiple
            closely related paralogs of this gene are found in a gene cluster
            in the AZFb azoospermia factor region of chromosome Y. Most of
            these related copies are thought to be pseudogenes, though several
            likely encode functional proteins. [provided by RefSeq, Mar 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X76059.1, BC146853.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382707.6/ ENSP00000372154.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               CB107177.1         1-151
            152-1913            X76059.1           117-1878
            1914-1921           BX119894.1         398-405
FEATURES             Location/Qualifiers
     source          1..1921
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="Y"
                     /map="Yq11.223"
     gene            1..1921
                     /gene="RBMY1A1"
                     /gene_synonym="RBM; RBM1; RBM2; RBMY; RBMY1C; YRRM1;
                     YRRM2"
                     /note="RNA binding motif protein Y-linked family 1 member
                     A1"
                     /db_xref="GeneID:5940"
                     /db_xref="HGNC:HGNC:9912"
                     /db_xref="MIM:400006"
     exon            1..148
                     /gene="RBMY1A1"
                     /gene_synonym="RBM; RBM1; RBM2; RBMY; RBMY1C; YRRM1;
                     YRRM2"
                     /inference="alignment:Splign:2.1.0"
     exon            149..261
                     /gene="RBMY1A1"
                     /gene_synonym="RBM; RBM1; RBM2; RBMY; RBMY1C; YRRM1;
                     YRRM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1643
                     /gene="RBMY1A1"
                     /gene_synonym="RBM; RBM1; RBM2; RBMY; RBMY1C; YRRM1;
                     YRRM2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RNA-binding motif protein, Y chromosome, family 1 member
                     A1/C; RNA-binding motif protein 2; Y chromosome RNA
                     recognition motif 1; Y chromosome RNA recognition motif 2"
                     /codon_start=1
                     /product="RNA-binding motif protein, Y chromosome, family
                     1 member A1 isoform 1"
                     /protein_id="NP_005049.1"
                     /db_xref="CCDS:CCDS14796.1"
                     /db_xref="GeneID:5940"
                     /db_xref="HGNC:HGNC:9912"
                     /db_xref="MIM:400006"
                     /translation="MVEADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDRT
                     SKSRGFAFITFENPADAKNAAKDMNGKSLHGKAIKVEQAKKPSFQSGGRRRPPASSRN
                     RSPSGSLRSARGSRGGTRGWLPSHEGHLDDGGYTPDLKMSYSRGLIPVKRGPSSRSGG
                     PPPKKSAPSAVARSNSWMGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATN
                     DGNHPSCQETRDYAPPSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPSRGHA
                     YRDYGHSRRDESYSRGYRNRRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHP
                     SSRETRDYAPPHRDYAYRDYGHSSWDEHSSRGYSYHDGYGEALGRDHSEHLSGSSYRD
                     ALQRYGTSHGAPPARGPRMSYGGSTCHAYSNTRDRYGRSWESYSSCGDFHYCDREHVC
                     RKDQRNPPSLGRVLPDPREACGSSSYVASIVDGGESRSEKGDSSRY"
     exon            262..365
                     /gene="RBMY1A1"
                     /gene_synonym="RBM; RBM1; RBM2; RBMY; RBMY1C; YRRM1;
                     YRRM2"
                     /inference="alignment:Splign:2.1.0"
     exon            366..543
                     /gene="RBMY1A1"
                     /gene_synonym="RBM; RBM1; RBM2; RBMY; RBMY1C; YRRM1;
                     YRRM2"
                     /inference="alignment:Splign:2.1.0"
     exon            544..696
                     /gene="RBMY1A1"
                     /gene_synonym="RBM; RBM1; RBM2; RBMY; RBMY1C; YRRM1;
                     YRRM2"
                     /inference="alignment:Splign:2.1.0"
     exon            697..811
                     /gene="RBMY1A1"
                     /gene_synonym="RBM; RBM1; RBM2; RBMY; RBMY1C; YRRM1;
                     YRRM2"
                     /inference="alignment:Splign:2.1.0"
     exon            812..922
                     /gene="RBMY1A1"
                     /gene_synonym="RBM; RBM1; RBM2; RBMY; RBMY1C; YRRM1;
                     YRRM2"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1033
                     /gene="RBMY1A1"
                     /gene_synonym="RBM; RBM1; RBM2; RBMY; RBMY1C; YRRM1;
                     YRRM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1144
                     /gene="RBMY1A1"
                     /gene_synonym="RBM; RBM1; RBM2; RBMY; RBMY1C; YRRM1;
                     YRRM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1255
                     /gene="RBMY1A1"
                     /gene_synonym="RBM; RBM1; RBM2; RBMY; RBMY1C; YRRM1;
                     YRRM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1344
                     /gene="RBMY1A1"
                     /gene_synonym="RBM; RBM1; RBM2; RBMY; RBMY1C; YRRM1;
                     YRRM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1921
                     /gene="RBMY1A1"
                     /gene_synonym="RBM; RBM1; RBM2; RBMY; RBMY1C; YRRM1;
                     YRRM2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atttccgggc acggcttccg gcgtccttcc ctctcaggga agctccagct gtccctcccg
       61 cagttggccc tgtggtgttc cgaagccggt tacgtacggc ctgagggcca ggcgaacctc
      121 aggctctttg tcctactaaa aagcgcagca caatggtaga agcagatcat cctggcaagc
      181 ttttcattgg tggcctcaat agagaaacca atgagaagat gcttaaagca gtatttggga
      241 aacatggtcc catatcagaa gttcttttga taaaggatcg aaccagcaaa tccagaggct
      301 ttgcatttat tacttttgag aaccctgcag atgctaagaa tgctgccaaa gatatgaatg
      361 gaaagtcttt gcatggaaaa gcaataaaag tagaacaagc caagaaacca tcttttcaaa
      421 gtggtggtag gcggagacca ccagcttctt cgagaaacag aagcccttca ggaagtctga
      481 gatctgcaag aggaagccgt ggaggaacaa gagggtggct tccctcacat gaagggcacc
      541 tggatgatgg tggatacact cctgatctca agatgagtta ttctagggga ctcattccag
      601 ttaaaagagg tccatcttca agaagtggag gtcctcctcc gaaaaaatct gctccttctg
      661 ctgtggcaag aagcaatagt tggatgggaa gccaaggtcc catgtcacaa agaagagaga
      721 attatggagt tcctccacgc agagcgacaa tatcttcctg gagaaatgat cgcatgtcaa
      781 caagacatga tggttatgca actaacgatg gaaatcatcc aagttgccaa gaaacgaggg
      841 attatgctcc accatctaga ggctatgcat accgtgataa tggtcattct aatcgggatg
      901 aacattcctc tagaggatat agaaatcatc gaagttcccg agaaactagg gattatgctc
      961 caccatctag aggccatgca taccgtgatt atggtcattc tcgtcgggat gaaagttatt
     1021 ctagaggata cagaaatcgt cgaagttccc gagaaactag ggagtatgct ccaccatcta
     1081 gaggccatgg ataccgtgat tatggtcatt ctcgtcgaca tgaaagttat tctagaggat
     1141 atagaaatca tccaagttcc cgagaaacca gggattatgc tccaccacat agagactatg
     1201 cataccgtga ttatggtcat tctagttggg atgaacattc ctctagagga tatagttatc
     1261 atgatggcta cggtgaggcc cttggtagag atcattctga acatctaagt ggaagttctt
     1321 atagagatgc acttcagaga tacgggacct ctcatggtgc accacctgca agagggcctc
     1381 ggatgtctta tggtggaagc acctgccacg catatagtaa tacacgagat agatatggca
     1441 gaagttggga gagttactcg agctgtggtg attttcatta ttgtgatcgt gagcatgttt
     1501 gcagaaaaga ccaaaggaat ccgccttctc tgggtagggt gctccctgat cctcgtgaag
     1561 catgtggtag ctcaagttat gtggcatcta tagtagatgg tggggagagt cgatctgaaa
     1621 aaggagactc gagcagatat taaagcaagc attgaaaata atagttattg cataccaatc
     1681 cttgtttgca aatcaaaaat tgaaatgtta tttctgcatt gttacctgca tattactgaa
     1741 agaaacatgt tggttttgtg gagagaggta gatactaact tcctccatga attttttgag
     1801 gtattcaaag gaaaaggaat tgttttcaaa gtaatttcat acttgttgat gctatttgaa
     1861 aagtgtttag atgtaatatc taccttaaaa ttttcacaat aaaatttgac atgtactgca
     1921 a
//
