LOCUS       NM_014469               2151 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens RBMX like 2 (RBMXL2), mRNA.
ACCESSION   NM_014469
VERSION     NM_014469.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2151)
  AUTHORS   Ouyang,Y.Q., zur Hausen,A., Orlowska-Volk,M., Jager,M.,
            Bettendorf,H., Hirschfeld,M., Tong,X.W. and Stickeler,E.
  TITLE     Expression levels of hnRNP G and hTra2-beta1 correlate with
            opposite outcomes in endometrial cancer biology
  JOURNAL   Int J Cancer 128 (9), 2010-2019 (2011)
   PUBMED   20607830
  REMARK    GeneRIF: nuclear hnRNP G level as well as hTra2-beta1 level were
            independent prognostic factors for endometrial cancer
            progression-free survival
REFERENCE   2  (bases 1 to 2151)
  AUTHORS   Kanhoush,R., Beenders,B., Perrin,C., Moreau,J., Bellini,M. and
            Penrad-Mobayed,M.
  TITLE     Novel domains in the hnRNP G/RBMX protein with distinct roles in
            RNA binding and targeting nascent transcripts
  JOURNAL   Nucleus 1 (1), 109-122 (2010)
   PUBMED   21327109
  REMARK    GeneRIF: The initial recruitment of hnRNP G to nascent pre-mRNAs is
            independent of its sequence-specific RNA binding properties.
REFERENCE   3  (bases 1 to 2151)
  AUTHORS   Liu,Y., Bourgeois,C.F., Pang,S., Kudla,M., Dreumont,N., Kister,L.,
            Sun,Y.H., Stevenin,J. and Elliott,D.J.
  TITLE     The germ cell nuclear proteins hnRNP G-T and RBMY activate a
            testis-specific exon
  JOURNAL   PLoS Genet 5 (11), e1000707 (2009)
   PUBMED   19893608
  REMARK    GeneRIF: germ cell-specific RBMY and hnRNP G-T proteins were more
            efficient in stimulating TLE4-T incorporation than somatically
            expressed hnRNP G protein.
REFERENCE   4  (bases 1 to 2151)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   5  (bases 1 to 2151)
  AUTHORS   Maymon,B.B., Paz,G., Elliott,D.J., Lifschitz-Mercer,B., Yogev,L.,
            Kleiman,S.E., Botchan,A., Hauser,R., Schreiber,L. and Yavetz,H.
  TITLE     Localization of the germ cell-specific protein, hnRNP G-T, in
            testicular biopsies of azoospermic men
  JOURNAL   Acta Histochem 104 (3), 255-261 (2002)
   PUBMED   12389739
  REMARK    GeneRIF: Heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) is
            a germ cell-specific protein expressed most prominently during
            meiosis
REFERENCE   6  (bases 1 to 2151)
  AUTHORS   Elliott,D.J., Venables,J.P., Newton,C.S., Lawson,D., Boyle,S.,
            Eperon,I.C. and Cooke,H.J.
  TITLE     An evolutionarily conserved germ cell-specific hnRNP is encoded by
            a retrotransposed gene
  JOURNAL   Hum Mol Genet 9 (14), 2117-2124 (2000)
   PUBMED   10958650
REFERENCE   7  (bases 1 to 2151)
  AUTHORS   Venables,J.P., Elliott,D.J., Makarova,O.V., Makarov,E.M.,
            Cooke,H.J. and Eperon,I.C.
  TITLE     RBMY, a probable human spermatogenesis factor, and other hnRNP G
            proteins interact with Tra2beta and affect splicing
  JOURNAL   Hum Mol Genet 9 (5), 685-694 (2000)
   PUBMED   10749975
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC100875.3.
            
            On May 17, 2019 this sequence version replaced NM_014469.4.
            
            Summary: This gene belongs to the HNRPG subfamily of ubiquitously
            expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The
            hnRNPs are RNA binding proteins and they complex with heterogeneous
            nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs
            in the nucleus and appear to influence pre-mRNA processing and
            other aspects of mRNA metabolism and transport. While all of the
            hnRNPs are present in the nucleus, some seem to shuttle between the
            nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic
            acid binding properties. The protein encoded by this gene has two
            RRM domains that bind RNAs. This gene is intronless and is thought
            to be derived from a processed retroposon. However, unlike many
            retroposon-derived genes, this gene is not a pseudogene. The
            encoded protein has similarity to HNRPG and RBMY proteins and it is
            suggested to replace HNRPG protein function during meiotic prophase
            or act as a germ cell-specific splicing regulator. It primarily
            localizes to the nuclei of meiotic spermatocytes. This gene is a
            candidate for autosomal male infertility. [provided by RefSeq, Jul
            2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC057796.1, AK292271.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306904.7/ ENSP00000304139.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2151              AC100875.3         67063-69213         c
FEATURES             Location/Qualifiers
     source          1..2151
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..2151
                     /gene="RBMXL2"
                     /gene_synonym="HNRNPG-T; HNRNPGT; HNRPGT"
                     /note="RBMX like 2"
                     /db_xref="GeneID:27288"
                     /db_xref="HGNC:HGNC:17886"
                     /db_xref="MIM:605444"
     exon            1..2151
                     /gene="RBMXL2"
                     /gene_synonym="HNRNPG-T; HNRNPGT; HNRPGT"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1302
                     /gene="RBMXL2"
                     /gene_synonym="HNRNPG-T; HNRNPGT; HNRPGT"
                     /note="heterogeneous nuclear ribonucleoprotein G T;
                     testes-specific heterogenous nuclear ribonucleoprotein
                     G-T; hnRNP G-T; testis-specific heterogeneous nuclear
                     ribonucleoprotein G-T; RNA binding motif protein, X-linked
                     like 2"
                     /codon_start=1
                     /product="RNA-binding motif protein, X-linked-like-2"
                     /protein_id="NP_055284.3"
                     /db_xref="CCDS:CCDS7777.1"
                     /db_xref="GeneID:27288"
                     /db_xref="HGNC:HGNC:17886"
                     /db_xref="MIM:605444"
                     /translation="MVEADRPGKLFIGGLNLETDEKALEAEFGKYGRIVEVLLMKDRE
                     TNKSRGFAFVTFESPADAKAAARDMNGKSLDGKAIKVAQATKPAFESSRRGPPPPRSR
                     GRPRFLRGTRGGGGGPRRSPSRGGPDDDGGYTADFDLRPSRAPMPMKRGPPPRRVGPP
                     PKRAAPSGPARSSGGGMRGRALAVRGRDGYSGPPRREPLPPRRDPYLGPRDEGYSSRD
                     GYSSRDYREPRGFAPSPGEYTHRDYGHSSVRDDCPLRGYSDRDGYGGRDRDYGDHLSR
                     GSHREPFESYGELRGAAPGRGTPPSYGGGGRYEEYRGYSPDAYSGGRDSYSSSYGRSD
                     RYSRGRHRVGRPDRGLSLSMERGCPPQRDSYSRSGCRVPRGGGRLGGRLERGGGRSRY
                     "
     regulatory      1643..1648
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBMXL2"
                     /gene_synonym="HNRNPG-T; HNRNPGT; HNRPGT"
                     /note="hexamer: GATAAA"
     polyA_site      1673
                     /gene="RBMXL2"
                     /gene_synonym="HNRNPG-T; HNRNPGT; HNRPGT"
                     /note="major polyA site"
     regulatory      1869..1874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBMXL2"
                     /gene_synonym="HNRNPG-T; HNRNPGT; HNRPGT"
                     /note="hexamer: AGTAAA"
     regulatory      1882..1887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBMXL2"
                     /gene_synonym="HNRNPG-T; HNRNPGT; HNRPGT"
                     /note="hexamer: AGTAAA"
     polyA_site      1891
                     /gene="RBMXL2"
                     /gene_synonym="HNRNPG-T; HNRNPGT; HNRPGT"
                     /note="major polyA site"
     polyA_site      1903
                     /gene="RBMXL2"
                     /gene_synonym="HNRNPG-T; HNRNPGT; HNRPGT"
                     /note="major polyA site"
ORIGIN      
        1 ggactcggcg actaggcgcc gcctgaccag taggagccgc cctcgacgag cgagctcgaa
       61 ggctgcgact ggcgccgcct caccgcctcc caccgccact gaccgaccgt tcgaccggca
      121 aacatggttg aagcggatcg cccggggaag ctgttcattg ggggcctcaa cctcgaaacc
      181 gacgagaaag ccctcgaagc cgagtttggc aagtatggcc gcatcgtcga ggtgctcctg
      241 atgaaagacc gagaaaccaa caagtcgagg ggcttcgcgt tcgtcacctt tgaaagcccc
      301 gcagacgcca aggccgccgc cagagacatg aacggcaagt ccctggatgg taaggccatc
      361 aaggtggccc aggccaccaa accggcgttc gagagcagcc ggcggggccc gccgcctccc
      421 cgcagccgcg gtcgcccgag gttcctgcgc ggaacccgcg ggggtggcgg cggcccgcgg
      481 cgttccccat cccggggcgg gcccgatgat gacggcggct acacggcgga tttcgacctg
      541 cggccctcca gggccccgat gcccatgaag cgtgggccgc cgccgcgcag ggtcggccca
      601 ccccccaaga gggccgcgcc gtcgggcccg gctcgcagca gcggcggtgg aatgcgcggg
      661 agggccctgg ccgtgcgggg gcgagacggc tactcaggcc caccgcgccg ggagccgctg
      721 cccccgcgcc gcgaccccta cctgggcccg cgggatgagg gctactcgtc cagagacggc
      781 tactcgagcc gagactaccg cgaaccccgg ggttttgccc cctcgcccgg agagtacacc
      841 caccgcgatt acggccactc cagtgtccgg gacgactgtc ccttgagagg ctacagcgac
      901 cgagacggct acggaggtcg cgaccgtgac tacggggatc atctgagcag aggctcccat
      961 cgagagccct ttgagagcta cggagagctg cgcggcgccg ccccaggacg ggggacaccg
     1021 ccatcttacg gaggaggagg ccgctacgag gagtaccggg gctactcacc cgatgcctac
     1081 agcggcggcc gcgacagtta cagcagcagt tatggccgga gcgaccgcta ctcgaggggc
     1141 cgacaccggg tgggcagacc agatcgtggg ctctctctgt ccatggaaag gggctgccct
     1201 ccccagcgtg attcttacag ccggtcaggc tgcagggtgc ccaggggcgg aggccgtcta
     1261 ggaggccgct tggagagagg aggaggccgg agcagatact aagcaggaac agacttggga
     1321 ccaaaaatcc cttttcaacg aaactaacaa aaagaagaac ctgttgtatg gtaactaccc
     1381 aaggactagt acaaggaaga gttgttttta ccttttaaga atttcctgtt aagatcgtct
     1441 ccatttttat gcttttggga gaaaaaactt aaaattcgtt tagtttagtt ttggaattgt
     1501 taacgtttct ttcaacaagc tcctgttaaa agtatatgaa cctgagtact agtcttctta
     1561 catttacaag tagaaattcg attaatggct tcttcccttg taaattttct tgataaatga
     1621 ggcaaacagt tctaagatct ttgataaaca tctgctcacc taaaatggaa aaacggatca
     1681 ttctgctcat ttaaaccaac tagattttgg gtggagagtg ggagggattg gtgtatgcta
     1741 ctcttaagat ttcagggtat ctttcaaact gaatctttgt ttccagtatt aaaaagcaaa
     1801 caaccagcaa caacaacaac aaaagtgatt tagatcaaat gtttatgtaa agaaaattat
     1861 tttcactcag taaatctgaa aagtaaatgg ataatgttgg ccatgttttg cctttttgct
     1921 ttttctttgg gaatctacag gatcacctgt cccctcactc ccaaaagtac tatctatgtt
     1981 ttgaacaaca gtggaatact atatcaaagg tttggccaac caaccacaaa gctacaaaac
     2041 aagcaaatcc caaatccttc aattgatagc attcattttc actaccaaca aatttattaa
     2101 gaaacaagta gaaaataaat cagtggtcga cttggggacc gtaatggctt c
//
