LOCUS       NM_019610               4656 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens RBMX like 1 (RBMXL1), transcript variant 2, mRNA.
ACCESSION   NM_019610
VERSION     NM_019610.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4656)
  AUTHORS   Prieto,C., Nguyen,D.T.T., Liu,Z., Wheat,J., Perez,A., Gourkanti,S.,
            Chou,T., Barin,E., Velleca,A., Rohwetter,T., Chow,A., Taggart,J.,
            Savino,A.M., Hoskova,K., Dhodapkar,M., Schurer,A., Barlowe,T.S.,
            Vu,L.P., Leslie,C., Steidl,U., Rabadan,R. and Kharas,M.G.
  TITLE     Transcriptional control of CBX5 by the RNA binding proteins RBMX
            and RBMXL1 maintains chromatin state in myeloid leukemia
  JOURNAL   Nat Cancer 2, 741-757 (2021)
   PUBMED   34458856
  REMARK    GeneRIF: Transcriptional control of CBX5 by the RNA binding
            proteins RBMX and RBMXL1 maintains chromatin state in myeloid
            leukemia.
REFERENCE   2  (bases 1 to 4656)
  AUTHORS   Martins-de-Souza,D., Gattaz,W.F., Schmitt,A., Rewerts,C.,
            Maccarrone,G., Dias-Neto,E. and Turck,C.W.
  TITLE     Prefrontal cortex shotgun proteome analysis reveals altered calcium
            homeostasis and immune system imbalance in schizophrenia
  JOURNAL   Eur Arch Psychiatry Clin Neurosci 259 (3), 151-163 (2009)
   PUBMED   19165527
REFERENCE   3  (bases 1 to 4656)
  AUTHORS   Marques,A.C., Dupanloup,I., Vinckenbosch,N., Reymond,A. and
            Kaessmann,H.
  TITLE     Emergence of young human genes after a burst of retroposition in
            primates
  JOURNAL   PLoS Biol 3 (11), e357 (2005)
   PUBMED   16201836
REFERENCE   4  (bases 1 to 4656)
  AUTHORS   Emerson,J.J., Kaessmann,H., Betran,E. and Long,M.
  TITLE     Extensive gene traffic on the mammalian X chromosome
  JOURNAL   Science 303 (5657), 537-540 (2004)
   PUBMED   14739461
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC397531.1, BC012942.1,
            BF901720.1 and AL832785.1.
            
            On Aug 13, 2020 this sequence version replaced NM_019610.5.
            
            Summary: This gene represents a retrogene of RNA binding motif
            protein, X-linked (RBMX), which is located on chromosome X. While
            all introns in the coding sequence have been processed out compared
            to the RBMX locus, the ORF is intact and there is specific evidence
            for transcription at this location. The preservation of the ORF by
            purifying selection in all Old World monkeys carrying it suggests
            that this locus is likely to be functional, possibly during male
            meiosis when X chromosomal genes are silenced or during haploid
            stages of spermatogenesis. This gene shares 5' exon structure with
            the cysteine conjugate-beta lyase 2 locus on chromosome 1, but the
            coding sequences are non-overlapping. Alternative splicing results
            in two transcript variants. [provided by RefSeq, Jun 2009].
            
            Transcript Variant: This variant (2) lacks an exon in the 5' UTR
            compared to variant 1. Both variants 1 and 2 encode the same
            protein.
            
            CCDS Note: This CCDS represents a retrogene of RBMX (RNA binding
            motif protein, X-linked), which is located on chromosome X. While
            all introns in the coding sequence have been processed out compared
            to the RBMX locus, the ORF is intact and there is specific evidence
            for transcription at this location. Studies in PMID:16201836
            indicate that this locus is likely to be functional because the ORF
            has been preserved by purifying selection in all six Old World
            primates carrying this retrogene. Given that X chromosomal genes in
            mammals can generate a statistically significant excess of
            autosomal retrogenes relative to genes on other chromosomes
            (PMID:14739461), it is possible that this retrogene may be
            functional during male meiosis when X chromosomal genes are
            silenced or during haploid stages of spermatogenesis
            (PMID:16201836). In addition, it should be noted that this
            retrogene shares its first non-coding exon with the cysteine
            conjugate-beta lyase 2 (CCBL2) locus on chromosome 1, but the
            coding sequences are non-overlapping.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832554.1, BC012942.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                DC397531.1         399-408
            11-1816             BC012942.1         1-1806
            1817-1841           BF901720.1         413-437
            1842-3687           BC012942.1         1832-3677
            3688-4656           AL832785.1         2960-3928
FEATURES             Location/Qualifiers
     source          1..4656
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.2"
     gene            1..4656
                     /gene="RBMXL1"
                     /gene_synonym="RBM1"
                     /note="RBMX like 1"
                     /db_xref="GeneID:494115"
                     /db_xref="HGNC:HGNC:25073"
     exon            1..45
                     /gene="RBMXL1"
                     /gene_synonym="RBM1"
                     /inference="alignment:Splign:2.1.0"
     exon            46..4656
                     /gene="RBMXL1"
                     /gene_synonym="RBM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..1458
                     /gene="RBMXL1"
                     /gene_synonym="RBM1"
                     /note="heterogeneous nuclear ribonucleoprotein G-like 1;
                     RNA binding motif protein, X-linked like 1"
                     /codon_start=1
                     /product="RNA binding motif protein, X-linked-like-1"
                     /protein_id="NP_062556.2"
                     /db_xref="CCDS:CCDS716.1"
                     /db_xref="GeneID:494115"
                     /db_xref="HGNC:HGNC:25073"
                     /translation="MVEADRPGKLFIGGLNTETNEKALETVFGKYGRIVEVLLIKDRE
                     TNKSRGFAFVTFESPADAKDAARDMNGKSLDGKAIKVEQATKPSFERGRHGPPPPPRS
                     RGPPRGFGAGRGGSGGTRGPPSRGGHMDDGGYSMNFNMSSSRGPLPVKRGPPPRSGGP
                     SPKRSAPSGLVRSSSGMGGRAPLSRGRDSYGGPPRREPLPSRRDVYLSPRDDGYSTKD
                     SYSSRDYPSSRDTRDYAPPPRDYTYRDYGHSSSRDDYPSRGYGDRDGYGRDRDYSDHP
                     SGGSYRDSYESYGNSRSAPLTRGPPPSYGGSSRYDDYSSSRDGYGGSRDSYSSSRSDL
                     YSSCDRVGRQERGLPPSVERGYPSSRDSYSSSSRGAPRGAGPGGSRSDRGGGRSRY"
     regulatory      4636..4641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBMXL1"
                     /gene_synonym="RBM1"
                     /note="hexamer: ATTAAA"
     polyA_site      4656
                     /gene="RBMXL1"
                     /gene_synonym="RBM1"
                     /note="major polyA site"
ORIGIN      
        1 agtcgggact cgagcctagg gaggcgaggt tcccgcaccg gataggaaca ttctgttgtt
       61 ttcctctgcc atctagtggc aaaagaaagt aattttcctg gttttttgaa tggatagcca
      121 taccttaaaa agcatccaga ttgcgcagta gtgctagcgg cttcgcggtt cagtcctcct
      181 aactgacagc cgccactggt gctgagctgc taggaagccc ctgtcggcga gcttgttgga
      241 gcttgaaccc actgtcaccc ctccgactca ccggcaaaaa aaaaaatggt tgaagcagat
      301 cgcccaggaa agctcttcat tggtgggctt aatacggaaa caaatgagaa agctcttgaa
      361 acagtatttg gcaaatatgg acgaatagtg gaagtactct tgataaaaga ccgtgaaacc
      421 aacaaatcaa gaggatttgc ttttgtcacc tttgaaagcc cagcagacgc taaggatgca
      481 gccagagaca tgaatggaaa gtcattagat ggaaaagcca tcaaggtgga acaagccacc
      541 aaaccatcat ttgaaagagg tagacatgga ccgcccccac ctccaagaag tagaggtcct
      601 ccaagaggtt ttggagctgg aagaggagga agtggaggaa ccaggggacc tccttcacga
      661 ggaggacaca tggatgatgg tggatattcc atgaatttta acatgagttc ttccagggga
      721 ccactcccag taaaaagagg accaccacca agaagtgggg gtccttctcc taagagatct
      781 gcaccttcag gactagttcg cagcagcagt ggaatgggag gaagagctcc tctatcacgt
      841 ggaagagata gttatggagg tccacctcga agggaaccgc tcccctctcg tagagatgtt
      901 tatttgtccc caagagatga tgggtattct actaaagaca gctattcaag cagagattac
      961 ccaagttctc gtgatacaag agattatgca ccaccaccac gagattatac ttaccgtgat
     1021 tatggtcatt ccagttcacg tgatgactat ccatcaagag gctatggcga tagagatgga
     1081 tatggtcgtg atcgtgacta ttcagatcat ccaagtggag gttcctacag agattcatat
     1141 gagagttatg gtaactcacg tagtgctcca cttacacgag ggcccccgcc atcttatggt
     1201 ggaagcagtc gctatgatga ttatagcagc tcacgtgatg gatatggtgg aagtcgagac
     1261 agttactcaa gcagccgaag tgatctctac tcaagttgtg acagggttgg cagacaagaa
     1321 agagggcttc ccccttctgt agaaaggggg tacccttctt cacgtgattc ctacagcagt
     1381 tcaagccgcg gagcaccaag aggtgctggc cctggaggaa gccgatctga tagaggggga
     1441 ggcagaagca gatactagaa acaaacaaaa ctttggacca aaatcccagt tcaaagaaac
     1501 aaaaaaaaga gtggaaacta ttctatcata actacccaag gactactaaa aggaaaaatt
     1561 gtgttacctt ttttaaattc cctgttaagt cccttccgta atttttatgt tcttgtgagg
     1621 aaaaaagtaa aacatgttta attttatttg actttatgac attgcttttc aacaagcaaa
     1681 tgttaaatgt gttaagcctt gtagtactag tgttgtaact ttccaagtaa aggtgtccct
     1741 aaagaccact tcctatctgg tttttcccag taaatgaggc aagcaattct aagatcttcc
     1801 acaaaacatc tagccaacta aaatggagag atgaatcatt ctgcctatac aaacaagcta
     1861 gctattagag ggtggttgga gtatgctact cataagattt cagggtgttt tctaactgaa
     1921 atctcactgt tctcagtatg caaaacctga aatcagatgc ctatgtaagg aaagtgctat
     1981 tcacccagta aacccaaaaa aagcaaatgg ataatgctgg ccattttgcc tttctgacat
     2041 ttccttggga atctgcaaga acctcccctt tcccctccca caataagacc atttaagtgt
     2101 gtgctaaaca actacggaat actaaataaa aagtttggcc aaaaccaacc atgaagctgc
     2161 aaaggtgctt gctcttactc tttcaaattt ttgcaactct aatgtctcac ttttaaagga
     2221 acagcttgat tgcaaaggag aaaatagata agcaatgaat ttatctccaa cttcctaaag
     2281 gcttatgact tctaaaaagt gaatctatca gcattccaca tcagatttaa agcatcaaat
     2341 gcctgtgaaa cagcaaagat ggttgaagat tgtgctcatt atgtttgtgg agtgctgatt
     2401 gattcacagt agataacgct ggcagtaaga gaaatcaaat gctaagagtt gttgaagcag
     2461 aaggcggctg attgttggta agtcagtgca gttgcataag cagtgctgtc agaattggtt
     2521 tggtgcaggc aatagatttt gccttcaagg gttcctgtgg atctcaggaa ggcatcagtg
     2581 ttgattaaca ctcataacta gggagtgagt ggtagttact taagtaattg accaaatgga
     2641 aaaggggaag taattaagga aattggtaag tggaggtagt caggaggttc tcgtggtcct
     2701 ttacacagat tttacagctt tgggtttcat tttgtttagc taaagtcatg gggacaactc
     2761 ttcaatttag aacttaagat gaattataaa aatgatggat ataagtggta gctctatctg
     2821 gtgaagtgtc ttgtcagtaa gtgaaacatt tttttgtggt ggcttatcca caaacagttt
     2881 agttgtagaa taaaacttat gagtgacatc tggaaagtaa caaccatgct aagatggcaa
     2941 acacactgga aacaattggg ccacttggct ttcttttgct gtattgtttt ataagcctgc
     3001 tttacctccc cgtcttggaa acaagtttta gtttattgct ttggagacta gagccaatag
     3061 tgtaatgttc tcaaaggaaa cagacttgag ttgttggatt agaggaacta actcaacttc
     3121 taattttttt tgttgtaatt atggcactgt catgttttaa catttgcaac tagggatagt
     3181 aagtacaaca tttttaactc tcatttggca gactactact aatcacagac cacaagggta
     3241 atgaccaaat ttatgtggtt gttacacttc catagttgtc ttagccgaat ccttccatat
     3301 tcttatgatt acttgggtta aagcttctgt gaggaccttt tggctcttaa gatatcctaa
     3361 atatttaaaa tatttagata tcctaaatat aggatataga gtttgtacca aatatgaatg
     3421 aatattgttc aaagcaagga gtatgttaaa atgaccagac acctgtttga taaatagttt
     3481 actgaactag cagacgtgtg gaaaaagaat cagatcttga ttcttctggg tttatactgg
     3541 ttgtaaaaca gaatgatatt agaaaatgtt ttccttgttt aagtggtagt tgaacataga
     3601 acttgggtat tatagatcac ttttcacttt ttggaatgtt ttgtattgaa acttaataca
     3661 actttaacat ggcaaaaaaa aaaaaaatcc aaaatctatg agataatttt gttaaagttg
     3721 gcttgcttgg gcgggtgctt ggtccagagg gagaaaagaa ggcatgattt cagaatactc
     3781 tggcagcttt ttaaattcag ctttatcaag ttacagtaaa ctgtatctgt ttagaattac
     3841 aactcaatgg ttattttgac agatgtatat gccatgaagc cactgtcacc atcaacatgc
     3901 agaacacttc catcgccccc aaaagattcc tcaagttcct ttgcagtcca tccctcacgc
     3961 tgctgatttg tctttgtcac catatattag tttgctttgt ggtggtgttt agtattttat
     4021 ataaatggga ttgtgtagca tgtacttttt tgtttatggt ttctttcaca cacaatgact
     4081 ttgaaattca ccaggttgca gtgtatcagt agcttattcc ttttattgct gagtagtgtc
     4141 ccattatgtg aatatgccat tatttgtttt tctactcacc tgttgatgga ccttgggatt
     4201 gtttccagtt tggggctact gtgaataaaa ctgttaggaa catttgtgta caagccactg
     4261 tgtagacata ggttttcctt tctcttgggt aaatacctac cagtaaaatg gttgggttgc
     4321 atggcagatt tatgtttaat aaagtaactg ccaaactgtt tgttttccaa aggggctata
     4381 cccttttata ttcccaccag ggttgtatag agttccaact gccaacactc agttttcagc
     4441 cattctgatg ggaatctagt ggtatctcat tgtggtttta ttttcatttc cccgggtgac
     4501 taatgctggt aagcatcttt taaggtactt tttggccagt tgtatatttt ctgtgaagtg
     4561 gctgtcaaat cttttgccca cttttaattg gattgtttgt cttattgagt tgtaaaagtt
     4621 ctttatatat actgtattaa agtcctttgt aagaca
//
