LOCUS       NM_016024               1823 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens RNA binding motif protein X-linked 2 (RBMX2), mRNA.
ACCESSION   NM_016024
VERSION     NM_016024.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1823)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1823)
  AUTHORS   Laine,P., Rowell,W.J., Paulin,L., Kujawa,S., Raterman,D.,
            Mayhew,G., Wendt,J., Burgess,D.L., Partonen,T., Paunio,T.,
            Auvinen,P. and Ekholm,J.M.
  TITLE     Alu element in the RNA binding motif protein, X-linked 2 (RBMX2)
            gene found to be linked to bipolar disorder
  JOURNAL   PLoS One 16 (12), e0261170 (2021)
   PUBMED   34914762
  REMARK    GeneRIF: Alu element in the RNA binding motif protein, X-linked 2
            (RBMX2) gene found to be linked to bipolar disorder.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1823)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1823)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1823)
  AUTHORS   van der Feltz,C. and Hoskins,A.A.
  TITLE     Structural and functional modularity of the U2 snRNP in pre-mRNA
            splicing
  JOURNAL   Crit Rev Biochem Mol Biol 54 (5), 443-465 (2019)
   PUBMED   31744343
  REMARK    Review article
REFERENCE   6  (bases 1 to 1823)
  AUTHORS   Zhang,X., Yan,C., Zhan,X., Li,L., Lei,J. and Shi,Y.
  TITLE     Structure of the human activated spliceosome in three
            conformational states
  JOURNAL   Cell Res 28 (3), 307-322 (2018)
   PUBMED   29360106
REFERENCE   7  (bases 1 to 1823)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   8  (bases 1 to 1823)
  AUTHORS   Hegele,A., Kamburov,A., Grossmann,A., Sourlis,C., Wowro,S.,
            Weimann,M., Will,C.L., Pena,V., Luhrmann,R. and Stelzl,U.
  TITLE     Dynamic protein-protein interaction wiring of the human spliceosome
  JOURNAL   Mol Cell 45 (4), 567-580 (2012)
   PUBMED   22365833
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY112998.1, BC063517.1 and AA905143.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_016024.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292855.1, SRR1803615.261966.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305536.11/ ENSP00000339090.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-331               HY112998.1         40-370
            332-1510            BC063517.1         318-1496
            1511-1682           AA905143.1         144-315             c
            1683-1823           AA905143.1         2-142               c
FEATURES             Location/Qualifiers
     source          1..1823
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.1"
     gene            1..1823
                     /gene="RBMX2"
                     /gene_synonym="CGI-79; Snu17"
                     /note="RNA binding motif protein X-linked 2"
                     /db_xref="GeneID:51634"
                     /db_xref="HGNC:HGNC:24282"
     exon            1..51
                     /gene="RBMX2"
                     /gene_synonym="CGI-79; Snu17"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1015
                     /gene="RBMX2"
                     /gene_synonym="CGI-79; Snu17"
                     /codon_start=1
                     /product="RNA-binding motif protein, X-linked 2"
                     /protein_id="NP_057108.2"
                     /db_xref="CCDS:CCDS43993.1"
                     /db_xref="GeneID:51634"
                     /db_xref="HGNC:HGNC:24282"
                     /translation="MNPLTKVKLINELNEREVQLGVADKVSWHSEYKDSAWIFLGGLP
                     YELTEGDIICVFSQYGEIVNINLVRDKKTGKSKGFCFLCYEDQRSTILAVDNFNGIKI
                     KGRTIRVDHVSNYRAPKDSEEIDDVTRQLQEKGCGARTPSPSLSESSEDEKPTKKHKK
                     DKKEKKKKKKEKEKADREVQAEQPSSSSPRRKTVKEKDDTGPKKHSSKNSERAQKSEP
                     REGQKLPKSRTAYSGGAEDLERELKKEKPKHEHKSSSRREAREEKTRIRDRGRSSDAH
                     SSWYNGRSEGRSYRSRSRSRDKSHRHKRARRSRERESSNPSDRWRH"
     exon            52..167
                     /gene="RBMX2"
                     /gene_synonym="CGI-79; Snu17"
                     /inference="alignment:Splign:2.1.0"
     exon            168..219
                     /gene="RBMX2"
                     /gene_synonym="CGI-79; Snu17"
                     /inference="alignment:Splign:2.1.0"
     exon            220..349
                     /gene="RBMX2"
                     /gene_synonym="CGI-79; Snu17"
                     /inference="alignment:Splign:2.1.0"
     exon            350..527
                     /gene="RBMX2"
                     /gene_synonym="CGI-79; Snu17"
                     /inference="alignment:Splign:2.1.0"
     exon            528..1823
                     /gene="RBMX2"
                     /gene_synonym="CGI-79; Snu17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1489..1494
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBMX2"
                     /gene_synonym="CGI-79; Snu17"
                     /note="hexamer: ATTAAA"
     polyA_site      1510
                     /gene="RBMX2"
                     /gene_synonym="CGI-79; Snu17"
                     /note="major polyA site"
     regulatory      1803..1808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBMX2"
                     /gene_synonym="CGI-79; Snu17"
                     /note="hexamer: CATAAA"
     polyA_site      1823
                     /gene="RBMX2"
                     /gene_synonym="CGI-79; Snu17"
ORIGIN      
        1 ctttcccggg cgctgattcc tgagtgctga gcgcgaaccc gaggagatga accctttaac
       61 taaggtgaag ctgatcaacg agctgaatga acgagaggtc cagcttgggg tggccgataa
      121 ggtgtcctgg cactccgagt acaaggacag cgcctggatc ttcctgggag ggcttcctta
      181 tgaactgact gaaggggaca tcatctgtgt gttctcacaa tatggggaga ttgttaacat
      241 taatctcgtg cgggacaaga aaactgggaa atccaaagga ttctgtttcc tctgctatga
      301 agaccagagg agcacaattc tggccgtcga caattttaat gggatcaaga tcaaaggaag
      361 aactatccga gtggatcatg tgtctaacta tcgggctcct aaggactcag aagaaataga
      421 tgatgtgacc agacaactcc aggagaaggg ctgtggggct cgtaccccct caccaagttt
      481 gtctgagagc tctgaagatg aaaaaccaac aaaaaagcac aaaaaagaca aaaaggaaaa
      541 aaagaaaaaa aagaaagaaa aagagaaagc cgaccgggag gtacaggcag agcaaccatc
      601 ctcttcgtca cccagacgca agacagtaaa ggaaaaggat gacactggcc ctaagaagca
      661 cagcagcaag aactcagaga gagctcagaa gtcagagccc agggaggggc agaagctccc
      721 caaatccagg acggcctact ctggtggagc agaggaccta gagagggagc tgaagaagga
      781 gaaacccaag cacgagcaca agtcctcaag caggagggag gcaagagaag aaaagaccag
      841 gattagggac agagggcgga gctcagatgc acattctagc tggtataatg ggcgttctga
      901 agggcgtagt tatagaagta gaagtaggag ccgagataaa tcccataggc ataaaagggc
      961 ccgacgctcc cgggagcggg agtcttcgaa tcccagtgac cgttggcgtc actgaagact
     1021 tcagctgcac agtagatttg gaaataatta tgttttttaa atgcagtcaa attcagttgg
     1081 gtggttacta tttttgtatc taaaacttct ggggctggat tcttttaatc ccttgactat
     1141 ttagagtcat tgggagggct gcagtttcaa cagctagata tcctggatat tgtttgcacc
     1201 atccattgtc cctgtaccag agtatgtatc ctgaactttg gttcataaat atggctcttg
     1261 aacccataga ccccagttga agatggaatt ttcaggaaag ggaaaatact agataattct
     1321 agaattctag tcttcgtgtt agatgtttat agcccagcat cttgggacct ttccagttac
     1381 taggtttgga cagcttgatg tgaacgaatg ggataggatt tttaaaatca gccagctcca
     1441 tgcccaaacc ttcctgtttg cagaactttt taatgtcttt tctttttcat taaaactttt
     1501 ttgttcgata tgcctctttc cacatttttt ccttgcaatg tatttattat ttatttgtat
     1561 ttaggtgaaa ttcacataac ataaagttaa ccattttaaa gggaacaatt cagtggcatt
     1621 tggtactgaa catccacagt gttgtgtaac cattgcctct gtctagttcc aaaacatttt
     1681 ttatcatccc aaaatgaaac cctgtagcca ttaaacaaga gctccccgtt tcctccctcc
     1741 tccctgtccc tagcaaccac cagtggactt cctgtttatg ggtttgccta ttctggatct
     1801 ttcataaaaa tggaattaca caa
//
