LOCUS       NM_002139               2012 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens RNA binding motif protein X-linked (RBMX), transcript
            variant 1, mRNA.
ACCESSION   NM_002139
VERSION     NM_002139.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2012)
  AUTHORS   Johansson,J., Lideus,S., Frykholm,C., Gunnarsson,C., Mihalic,F.,
            Gudmundsson,S., Ekvall,S., Molin,A.M., Pham,M., Vihinen,M.,
            Lagerstedt-Robinson,K., Nordgren,A., Jemth,P., Ameur,A.,
            Anneren,G., Wilbe,M. and Bondeson,M.L.
  TITLE     Gustavson syndrome is caused by an in-frame deletion in RBMX
            associated with potentially disturbed SH3 domain interactions
  JOURNAL   Eur J Hum Genet 32 (3), 333-341 (2024)
   PUBMED   37277488
  REMARK    GeneRIF: Gustavson syndrome is caused by an in-frame deletion in
            RBMX associated with potentially disturbed SH3 domain interactions.
REFERENCE   2  (bases 1 to 2012)
  AUTHORS   Yan,Q., Zeng,P., Huang,S., Tan,C., Zhou,X., Qiao,J., Zhao,X.,
            Feng,L., Zhu,Z., Zhang,G., Hu,H. and Chen,C.
  TITLE     [RBMX overexpression inhibits proliferation, migration, invasion
            and glycolysis of human bladder cancer cells by downregulating
            PKM2]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 44 (1), 9-16 (2024)
   PUBMED   38293971
  REMARK    GeneRIF: [RBMX overexpression inhibits proliferation, migration,
            invasion and glycolysis of human bladder cancer cells by
            downregulating PKM2].
REFERENCE   3  (bases 1 to 2012)
  AUTHORS   Sheng,Y., Lei,K., Sun,C., Liu,J., Tu,Z., Zhu,X. and Huang,K.
  TITLE     Aberrant RBMX expression is relevant for cancer prognosis and
            immunotherapy response
  JOURNAL   Aging (Albany NY) 16 (1), 226-245 (2024)
   PUBMED   38214653
  REMARK    GeneRIF: Aberrant RBMX expression is relevant for cancer prognosis
            and immunotherapy response.
REFERENCE   4  (bases 1 to 2012)
  AUTHORS   Liu,J., Zheng,T., Chen,D., Huang,J., Zhao,Y., Ma,W. and Liu,H.
  TITLE     RBMX involves in telomere stability maintenance by regulating TERRA
            expression
  JOURNAL   PLoS Genet 19 (9), e1010937 (2023)
   PUBMED   37756323
  REMARK    GeneRIF: RBMX involves in telomere stability maintenance by
            regulating TERRA expression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2012)
  AUTHORS   Zheng,Y., Niu,X., Xue,W., Li,L., Geng,Q., Fan,Z. and Zhao,J.
  TITLE     The Role of Alternative Splicing Factors hnRNP G and Fox-2 in the
            Progression and Prognosis of Esophageal Cancer
  JOURNAL   Dis Markers 2022, 3043737 (2022)
   PUBMED   36466711
  REMARK    GeneRIF: The Role of Alternative Splicing Factors hnRNP G and Fox-2
            in the Progression and Prognosis of Esophageal Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2012)
  AUTHORS   Mazeyrat,S., Saut,N., Mattei,M.G. and Mitchell,M.J.
  TITLE     RBMY evolved on the Y chromosome from a ubiquitously transcribed
            X-Y identical gene
  JOURNAL   Nat Genet 22 (3), 224-226 (1999)
   PUBMED   10391207
REFERENCE   7  (bases 1 to 2012)
  AUTHORS   Delbridge,M.L., Lingenfelter,P.A., Disteche,C.M. and Graves,J.A.
  TITLE     The candidate spermatogenesis gene RBMY has a homologue on the
            human X chromosome
  JOURNAL   Nat Genet 22 (3), 223-224 (1999)
   PUBMED   10391206
REFERENCE   8  (bases 1 to 2012)
  AUTHORS   Venables,J.P., Vernet,C., Chew,S.L., Elliott,D.J., Cowmeadow,R.B.,
            Wu,J., Cooke,H.J., Artzt,K. and Eperon,I.C.
  TITLE     T-STAR/ETOILE: a novel relative of SAM68 that interacts with an
            RNA-binding protein implicated in spermatogenesis
  JOURNAL   Hum Mol Genet 8 (6), 959-969 (1999)
   PUBMED   10332027
REFERENCE   9  (bases 1 to 2012)
  AUTHORS   Soulard,M., Della Valle,V., Siomi,M.C., Pinol-Roma,S., Codogno,P.,
            Bauvy,C., Bellini,M., Lacroix,J.C., Monod,G., Dreyfuss,G. et al.
  TITLE     hnRNP G: sequence and characterization of a glycosylated
            RNA-binding protein
  JOURNAL   Nucleic Acids Res 21 (18), 4210-4217 (1993)
   PUBMED   7692398
REFERENCE   10 (bases 1 to 2012)
  AUTHORS   Le Coniat,M., Soulard,M., Della Valle,V., Larsen,C.J. and Berger,R.
  TITLE     Localization of the human gene encoding heterogeneous nuclear RNA
            ribonucleoprotein G (hnRNP-G) to chromosome 6p12
  JOURNAL   Hum Genet 88 (5), 593-595 (1992)
   PUBMED   1551662
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM147410.1, DC337568.1 and
            BC007435.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002139.3.
            
            Summary: This gene belongs to the RBMY gene family which includes
            candidate Y chromosome spermatogenesis genes. This gene, an active
            X chromosome homolog of the Y chromosome RBMY gene, is widely
            expressed whereas the RBMY gene evolved a male-specific function in
            spermatogenesis. Pseudogenes of this gene, found on chromosomes 1,
            4, 9, 11, and 6, were likely derived by retrotransposition from the
            original gene. Alternatively spliced transcript variants encoding
            different isoforms have been identified. A snoRNA gene (SNORD61) is
            found in one of its introns. [provided by RefSeq, Sep 2009].
            
            Transcript Variant: This variant (1) represents the more frequently
            occurring transcript and it encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.785239.1,
                                           SRR3476690.256439.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320676.11/ ENSP00000359645.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               BM147410.1         56-209
            155-184             DC337568.1         155-184
            185-2012            BC007435.2         176-2003
FEATURES             Location/Qualifiers
     source          1..2012
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.3"
     gene            1..2012
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; MRXS11; MRXSG;
                     MRXSH; RBMXP1; RBMXRT; RNMX"
                     /note="RNA binding motif protein X-linked"
                     /db_xref="GeneID:27316"
                     /db_xref="HGNC:HGNC:9910"
                     /db_xref="MIM:300199"
     exon            1..129
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; MRXS11; MRXSG;
                     MRXSH; RBMXP1; RBMXRT; RNMX"
                     /inference="alignment:Splign:2.1.0"
     exon            130..264
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; MRXS11; MRXSG;
                     MRXSH; RBMXP1; RBMXRT; RNMX"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1331
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; MRXS11; MRXSG;
                     MRXSH; RBMXP1; RBMXRT; RNMX"
                     /note="isoform 1 is encoded by transcript variant 1;
                     heterogeneous nuclear ribonucleoprotein G; hnRNP G;
                     glycoprotein p43; RNA-binding motif protein, X chromosome"
                     /codon_start=1
                     /product="RNA-binding motif protein, X chromosome isoform
                     1"
                     /protein_id="NP_002130.2"
                     /db_xref="CCDS:CCDS14661.1"
                     /db_xref="GeneID:27316"
                     /db_xref="HGNC:HGNC:9910"
                     /db_xref="MIM:300199"
                     /translation="MVEADRPGKLFIGGLNTETNEKALEAVFGKYGRIVEVLLMKDRE
                     TNKSRGFAFVTFESPADAKDAARDMNGKSLDGKAIKVEQATKPSFESGRRGPPPPPRS
                     RGPPRGLRGGRGGSGGTRGPPSRGGHMDDGGYSMNFNMSSSRGPLPVKRGPPPRSGGP
                     PPKRSAPSGPVRSSSGMGGRAPVSRGRDSYGGPPRREPLPSRRDVYLSPRDDGYSTKD
                     SYSSRDYPSSRDTRDYAPPPRDYTYRDYGHSSSRDDYPSRGYSDRDGYGRDRDYSDHP
                     SGGSYRDSYESYGNSRSAPPTRGPPPSYGGSSRYDDYSSSRDGYGGSRDSYSSSRSDL
                     YSSGRDRVGRQERGLPPSMERGYPPPRDSYSSSSRGAPRGGGRGGSRSDRGGGRSRY"
     exon            265..371
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; MRXS11; MRXSG;
                     MRXSH; RBMXP1; RBMXRT; RNMX"
                     /inference="alignment:Splign:2.1.0"
     exon            372..543
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; MRXS11; MRXSG;
                     MRXSH; RBMXP1; RBMXRT; RNMX"
                     /inference="alignment:Splign:2.1.0"
     exon            544..696
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; MRXS11; MRXSG;
                     MRXSH; RBMXP1; RBMXRT; RNMX"
                     /inference="alignment:Splign:2.1.0"
     exon            697..811
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; MRXS11; MRXSG;
                     MRXSH; RBMXP1; RBMXRT; RNMX"
                     /inference="alignment:Splign:2.1.0"
     exon            812..937
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; MRXS11; MRXSG;
                     MRXSH; RBMXP1; RBMXRT; RNMX"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1020
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; MRXS11; MRXSG;
                     MRXSH; RBMXP1; RBMXRT; RNMX"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..2012
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; MRXS11; MRXSG;
                     MRXSH; RBMXP1; RBMXRT; RNMX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1590..1595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; MRXS11; MRXSG;
                     MRXSH; RBMXP1; RBMXRT; RNMX"
                     /note="hexamer: AGTAAA"
     polyA_site      1613
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; MRXS11; MRXSG;
                     MRXSH; RBMXP1; RBMXRT; RNMX"
                     /note="major polyA site"
     regulatory      1989..1994
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; MRXS11; MRXSG;
                     MRXSH; RBMXP1; RBMXRT; RNMX"
                     /note="hexamer: AATAAA"
     polyA_site      2012
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; MRXS11; MRXSG;
                     MRXSH; RBMXP1; RBMXRT; RNMX"
                     /note="major polyA site"
ORIGIN      
        1 ctcgttgcgc agtagtgcta gcggcttcgc ggttcggtcc tcgcacccgg cagccgccac
       61 tggtgctgag ctgctaggaa gcccctatcg ccgagctcgt tggagcttga acccattgtc
      121 acccctccga ctcaccggcc caaaaaaaaa aaaacatggt tgaagcagat cgcccaggaa
      181 agctcttcat tggtgggctt aatacggaaa caaatgagaa agctcttgaa gcagtatttg
      241 gcaaatatgg acgaatagtg gaagtactct tgatgaaaga ccgtgaaacc aacaaatcaa
      301 gaggatttgc ttttgtcacc tttgaaagcc cagcagacgc taaggatgca gccagagaca
      361 tgaatggaaa gtcattagat ggaaaagcca tcaaggtgga acaagccacc aaaccatcat
      421 ttgaaagtgg tagacgtgga ccgcctccac ctccaagaag tagaggccct ccaagaggtc
      481 ttagaggtgg aagaggagga agtggaggaa ccaggggacc tccctcacgg ggaggacaca
      541 tggatgacgg tggatattcc atgaatttta acatgagttc ttccagggga ccactcccag
      601 taaaaagagg accaccacca agaagtgggg gtcctcctcc taagagatct gcaccttcag
      661 gaccagttcg cagtagcagt ggaatgggag gaagagctcc tgtatcacgt ggaagagata
      721 gttatggagg tccacctcga agggaaccgc tgccctctcg tagagatgtt tatttgtccc
      781 caagagatga tgggtattct actaaagaca gctattcaag cagagattac ccaagttctc
      841 gtgatactag agattatgca ccaccaccac gagattatac ttaccgtgat tatggtcatt
      901 ccagttcacg tgatgactat ccatcaagag gatatagcga tagagatgga tatggtcgtg
      961 atcgtgacta ttcagatcat ccaagtggag gttcctacag agattcatat gagagttatg
     1021 gtaactcacg tagtgctcca cctacacgag ggcccccgcc atcttatggt ggaagcagtc
     1081 gctatgatga ttacagcagc tcacgtgacg gatatggtgg aagtcgagac agttactcaa
     1141 gcagccgaag tgatctctac tcaagtggtc gtgatcgggt tggcagacaa gaaagagggc
     1201 ttcccccttc tatggaaagg gggtaccctc ctccacgtga ttcctacagc agttcaagcc
     1261 gcggagcacc aagaggtggt ggccgtggag gaagccgatc tgatagaggg ggaggcagaa
     1321 gcagatacta gaaacaaaca aaactttgga ccaaaatccc agttcaaaga aacaaaaagt
     1381 ggaaactatt ctatcataac tacccaagga ctactaaaag gaaaaattgt gttacttttt
     1441 ttaaattccc tgttaagttc ccctccataa tttttatgtt cttgtgagga aaaaagtaaa
     1501 acatgtttaa ttttatttga ctttcgcatt gcttttcaac aagcaaatgt taaatgtgtt
     1561 aagacttgta ctagtgttgt aactttccaa gtaaaagtat cccctaaagg ccacttccta
     1621 tctgattttt cccagcaaat gaggcaggca attctaagat cttccacaaa acatctagcc
     1681 atctaaaatg gagagatgaa tcattctacc tatacaaaca agctagctat tagagggtgg
     1741 ttggggtatg ctactcataa gatttcaggg tgtcttccaa ctgaaatctc aatgttctca
     1801 gtacgaaaaa cctgaaatca catgcctatg taaggaaagt gctattcacc cagtaaaccc
     1861 aaaaaagcaa atggataatg ctggccattt tgcctttctg acatttcctt gggaatctgc
     1921 aagaacctcc cctttccctt cccccaataa gaccatttaa gtgtgtgtta aacaactaca
     1981 gaatactaaa taaaaagttt ggccaaaacc aa
//
