LOCUS       NM_001003793            8449 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens RNA binding motif single stranded interacting protein
            3 (RBMS3), transcript variant 1, mRNA.
ACCESSION   NM_001003793
VERSION     NM_001003793.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8449)
  AUTHORS   Li,Y., Wang,S., Li,G., Gao,C., Cui,Z., Cong,M., Hu,J., Zhang,M.,
            Jin,X., Sun,H. and Kong,D.
  TITLE     The RNA-binding protein RBMS3 inhibits the progression of colon
            cancer by regulating the stability of LIMS1 mRNA
  JOURNAL   Cancer Med 13 (7), e7129 (2024)
   PUBMED   38618967
  REMARK    GeneRIF: The RNA-binding protein RBMS3 inhibits the progression of
            colon cancer by regulating the stability of LIMS1 mRNA.
REFERENCE   2  (bases 1 to 8449)
  AUTHORS   Gornicki,T., Lambrinow,J., Mrozowska,M., Romanowicz,H., Smolarz,B.,
            Piotrowska,A., Gomulkiewicz,A., Podhorska-Okolow,M., Dziegiel,P.
            and Grzegrzolka,J.
  TITLE     Expression of RBMS3 in Breast Cancer Progression
  JOURNAL   Int J Mol Sci 24 (3), 2866 (2023)
   PUBMED   36769184
  REMARK    GeneRIF: Expression of RBMS3 in Breast Cancer Progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8449)
  AUTHORS   Zhou,Y., Liang,Z., Xia,Y., Li,S., Liang,J., Hu,Z., Tang,C.,
            Zhao,Q., Gong,Q. and Ouyang,Y.
  TITLE     Disruption of RBMS3 suppresses PD-L1 and enhances antitumor immune
            activities and therapeutic effects of auranofin against
            triple-negative breast cancer
  JOURNAL   Chem Biol Interact 369, 110260 (2023)
   PUBMED   36414028
  REMARK    GeneRIF: Disruption of RBMS3 suppresses PD-L1 and enhances
            antitumor immune activities and therapeutic effects of auranofin
            against triple-negative breast cancer.
REFERENCE   4  (bases 1 to 8449)
  AUTHORS   Wang,M., Fu,X., Wang,W., Zhang,Y., Jiang,Z., Gu,Y., Chu,M., Shao,Y.
            and Li,S.
  TITLE     Comprehensive bioinformatics analysis confirms RBMS3 as the central
            candidate biological target for ovarian cancer
  JOURNAL   Med Eng Phys 110, 103883 (2022)
   PUBMED   36075788
  REMARK    GeneRIF: Comprehensive bioinformatics analysis confirms RBMS3 as
            the central candidate biological target for ovarian cancer.
REFERENCE   5  (bases 1 to 8449)
  AUTHORS   Block,C.J., Mitchell,A.V., Wu,L., Glassbrook,J., Craig,D., Chen,W.,
            Dyson,G., DeGracia,D., Polin,L., Ratnam,M., Gibson,H. and Wu,G.
  TITLE     RNA binding protein RBMS3 is a common EMT effector that modulates
            triple-negative breast cancer progression via stabilizing PRRX1
            mRNA
  JOURNAL   Oncogene 40 (46), 6430-6442 (2021)
   PUBMED   34608266
  REMARK    GeneRIF: RNA binding protein RBMS3 is a common EMT effector that
            modulates triple-negative breast cancer progression via stabilizing
            PRRX1 mRNA.
REFERENCE   6  (bases 1 to 8449)
  AUTHORS   Broderick,P., Wang,Y., Vijayakrishnan,J., Matakidou,A., Spitz,M.R.,
            Eisen,T., Amos,C.I. and Houlston,R.S.
  TITLE     Deciphering the impact of common genetic variation on lung cancer
            risk: a genome-wide association study
  JOURNAL   Cancer Res 69 (16), 6633-6641 (2009)
   PUBMED   19654303
REFERENCE   7  (bases 1 to 8449)
  AUTHORS   Meigs,J.B., Manning,A.K., Fox,C.S., Florez,J.C., Liu,C.,
            Cupples,L.A. and Dupuis,J.
  TITLE     Genome-wide association with diabetes-related traits in the
            Framingham Heart Study
  JOURNAL   BMC Med Genet 8 Suppl 1 (Suppl 1), S16 (2007)
   PUBMED   17903298
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 8449)
  AUTHORS   Kiel,D.P., Demissie,S., Dupuis,J., Lunetta,K.L., Murabito,J.M. and
            Karasik,D.
  TITLE     Genome-wide association with bone mass and geometry in the
            Framingham Heart Study
  JOURNAL   BMC Med Genet 8 Suppl 1 (Suppl 1), S14 (2007)
   PUBMED   17903296
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 8449)
  AUTHORS   Fritz,D. and Stefanovic,B.
  TITLE     RNA-binding protein RBMS3 is expressed in activated hepatic
            stellate cells and liver fibrosis and increases expression of
            transcription factor Prx1
  JOURNAL   J Mol Biol 371 (3), 585-595 (2007)
   PUBMED   17586524
  REMARK    GeneRIF: These results suggest that RBMS3, by binding Prx1 mRNA in
            a sequence-specific manner, controls Prx1 expression and indirectly
            collagen synthesis.
REFERENCE   10 (bases 1 to 8449)
  AUTHORS   Penkov,D., Ni,R., Else,C., Pinol-Roma,S., Ramirez,F. and Tanaka,S.
  TITLE     Cloning of a human gene closely related to the genes coding for the
            c-myc single-strand binding proteins
  JOURNAL   Gene 243 (1-2), 27-36 (2000)
   PUBMED   10675610
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC012262.15, AY236871.1,
            AK097311.1, AC097633.2 and CA448021.1.
            
            On May 17, 2019 this sequence version replaced NM_001003793.2.
            
            Summary: This gene encodes an RNA-binding protein that belongs to
            the c-myc gene single-strand binding protein family. These proteins
            are characterized by the presence of two sets of ribonucleoprotein
            consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and
            RNP2, originally described in RNA binding proteins, and required
            for DNA binding. These proteins have been implicated in such
            diverse functions as DNA replication, gene transcription, cell
            cycle progression and apoptosis. The encoded protein was isolated
            by virtue of its binding to an upstream element of the alpha2(I)
            collagen promoter. The observation that this protein localizes
            mostly in the cytoplasm suggests that it may be involved in a
            cytoplasmic function such as controlling RNA metabolism, rather
            than transcription. Multiple alternatively spliced transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Apr 2010].
            
            Transcript Variant: This variant (1), also known as DD23-L, encodes
            the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.90682.1,
                                           SRR1803617.233707.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000383767.7/ ENSP00000373277.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-381               AC012262.15        120451-120831
            382-1973            AY236871.1         1-1592
            1974-2996           AK097311.1         468-1490
            2997-7765           AC097633.2         63263-68031
            7766-8449           CA448021.1         27-710              c
FEATURES             Location/Qualifiers
     source          1..8449
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p24.1"
     gene            1..8449
                     /gene="RBMS3"
                     /note="RNA binding motif single stranded interacting
                     protein 3"
                     /db_xref="GeneID:27303"
                     /db_xref="HGNC:HGNC:13427"
                     /db_xref="MIM:605786"
     exon            1..686
                     /gene="RBMS3"
                     /inference="alignment:Splign:2.1.0"
     CDS             612..1925
                     /gene="RBMS3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RNA-binding protein; RNA binding motif, single stranded
                     interacting protein"
                     /codon_start=1
                     /product="RNA-binding motif, single-stranded-interacting
                     protein 3 isoform 1"
                     /protein_id="NP_001003793.1"
                     /db_xref="CCDS:CCDS33724.1"
                     /db_xref="GeneID:27303"
                     /db_xref="HGNC:HGNC:13427"
                     /db_xref="MIM:605786"
                     /translation="MGKRLDQPQMYPQYTYYYPHYLQTKQSYAPAPHPMAPPSPSTNS
                     SSNNSSNNSSGEQLSKTNLYIRGLPPGTTDQDLIKLCQPYGKIVSTKAILDKNTNQCK
                     GYGFVDFDSPAAAQKAVASLKANGVQAQMAKQQEQDPTNLYISNLPISMDEQELENML
                     KPFGHVISTRILRDANGVSRGVGFARMESTEKCEVVIQHFNGKYLKTPPGIPAPSEPL
                     LCKFADGGQKKRQNQSKYTQNGRPWPREGEAGMALTYDPTAAIQNGFYSSPYSIATNR
                     MIPQTSITPFIAASPVSTYQVQSTSWMPHPPYVMQPTGAVITPTMDHPMSMQPANMMG
                     PLTQQMNHLSLGTTGTIQSQDRIMILHQLLCQYMTAAAPMQGTYIPQYTPVPPTAVSI
                     EGVVADTSPQTVAPSSQDTSGQQQQIAVDTSNEHAPAYSYQQSKP"
     exon            687..859
                     /gene="RBMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            860..918
                     /gene="RBMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1010
                     /gene="RBMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1168
                     /gene="RBMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1248
                     /gene="RBMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1355
                     /gene="RBMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1402
                     /gene="RBMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1499
                     /gene="RBMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1550
                     /gene="RBMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1661
                     /gene="RBMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1709
                     /gene="RBMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1790
                     /gene="RBMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1918
                     /gene="RBMS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..8449
                     /gene="RBMS3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6521..6526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBMS3"
                     /note="hexamer: AATAAA"
     polyA_site      6545
                     /gene="RBMS3"
     regulatory      8433..8438
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBMS3"
                     /note="hexamer: AATGAA"
     polyA_site      8449
                     /gene="RBMS3"
                     /note="major polyA site"
ORIGIN      
        1 atgtcactct gggagggaga cagcagcaac taagctgtac aaggtttttt tttttttttt
       61 ttcttccttt ttttcttttt ttttttcttt ttcccctttc tttttctttc tttctttctt
      121 tttctttctt tctttctctt tctctctctc ttttttcttt ttctttaagg tggggaaaga
      181 gacaaccaag agacaggaag ctgatctgca aggattcgga gttgtgctaa aaggactttg
      241 atttttttcc ccctttacga acgctggcaa ttgacatcac tacagacagc ctggttagag
      301 aacaaactgc ctcatcccaa gtggaccccg gcagctgggg gaagccaggc aagatctggg
      361 aaggctgtgt gtgggtgttt tttctacaga tctcactcct cgcccttttt ttttttcctt
      421 tggtgtgtgt tttttgtttt gttttgtttt ttaaaaaaat tcttgctgtg ttggaactag
      481 cgagtggtgg agtctctgaa gcctcatcag tcaccgggac tgtcaggaat agtggtttaa
      541 gaggaagctc ggcctggggc actataccct gtcatccagt tccctgcctc ggagataaag
      601 attccagcta catgggcaaa cgcctggatc agccacaaat gtacccccag tacacttact
      661 actatcctca ttatctccaa accaagcagt cctatgcacc agctccccac cccatggctc
      721 ctcccagccc cagcacaaac agcagcagca acaacagcag caacaacagc agcggggaac
      781 agttgagtaa aaccaacctg tacattcgag gcctcccacc aggcaccact gaccaggacc
      841 taatcaagct gtgccaaccg tatggaaaaa ttgtatctac aaaggcaatt cttgacaaaa
      901 acacaaatca gtgcaaaggt tatggttttg tagattttga cagtcctgca gccgcacaga
      961 aagcggtagc atctctcaag gcaaatggcg tgcaggcaca gatggctaag caacaagagc
     1021 aagacccaac aaacctatac atctcaaatc tccccatttc tatggatgag caggagcttg
     1081 agaatatgct gaaacccttt ggacatgtca tttccacaag aatactaaga gacgctaatg
     1141 gagtcagcag aggtgttggc tttgccagaa tggagtctac tgaaaaatgt gaagtggtaa
     1201 ttcaacattt taatggaaaa tatctgaaaa caccaccagg catcccagcc cccagtgagc
     1261 ctttgctgtg caaattcgct gatggaggac aaaagaagcg acagaatcaa agcaaatata
     1321 cccagaatgg gaggccttgg cccagggaag gagaggctgg catggctttg acctatgacc
     1381 ccacagctgc catacagaat ggattttatt cttcaccgta cagtattgca accaaccgca
     1441 tgattccaca gacatctatc acgccattca ttgctgcttc ccctgtctcc acataccagg
     1501 tccagagtac ttcatggatg cctcatccgc catacgttat gcaaccaaca ggtgctgtga
     1561 ttacaccaac catggaccat cccatgtcaa tgcagccagc caacatgatg ggcccactga
     1621 cacagcagat gaatcacctt tcgttgggca caacaggaac gattcaatcc caagacagga
     1681 ttatgatact ccaccagctg ttgtgtcagt atatgactgc tgctgctcct atgcaaggga
     1741 cctacattcc tcagtacacg cctgtgcctc cgacagctgt ttctattgaa ggtgttgttg
     1801 ctgatacctc tccccagaca gtggcacctt catcccagga caccagtggt cagcagcaac
     1861 agatagcagt ggacacatcc aacgaacatg cacctgcata ttcttaccaa cagtctaaac
     1921 cataaacagg actgaagaat gtctgtctga atctttgcct tgaatgaaga aacttcattg
     1981 aacaagaagt tggcttccag tttgcacaga cgtcaatgga atgcattttt ttgttgttgt
     2041 tgttgttttt tttttagtgt tataccttac ccaatgaaag caaagttttt atgtgctgtg
     2101 caaatggtct tcatgtggtc tgacaattta tttttgccat cattttttta attaaagaaa
     2161 aaatttccag aagaggaaaa aaaaactaca aaaaacaaaa cattgaaggt tgatatttta
     2221 tgtggaagaa catttgaatt gaattcagaa tttttctgaa ggtgtagata cttttttttt
     2281 ttttttaaca gaaaacctga tgtcaagagg tgggcaatag aaatggaaac aaattgtctt
     2341 cctcaataat taagctactt tctctttttc ccttcttgtt ttaatctagt gggtttttta
     2401 ttttattttt tcttagaaat atgtaggtaa ggtttatctt gaatcttaat tgccttaatt
     2461 ttaaggacgt caaaggctct cgaggcaagc tgtcaacgtc ttgttgaaaa caaaaatcaa
     2521 gaaagaattg aaatactgtg ccggctttca ctggcacaga agtttaagac tatgagtttt
     2581 tagggtgaag aaaaaactgt acagtttaaa tgaaaatgtt tttcttcatt tgaagaaaat
     2641 ttgttgataa accatggcaa ctgcaagaat tggaaaaatg ctgggacttt tcatgaactt
     2701 tgtcttaagt gttgacatga atcattctaa aaggctaaaa cattttacag taaagttatt
     2761 aaggttggtt taaaaacaac tgcattagaa ataatgcgtg tttggggggc agaatgcaga
     2821 tttttttaat ttacaaagcg tgatcgctag caaaagcatt agtgcttttt atctgcagtc
     2881 ttttttatga gctttacaaa gtttttagtc agctttgctt gtcacattgc aaaacctagc
     2941 ttaagagcat taaaaaaaaa aacttaagta gataggagct tatggtcaaa aagtgcaaaa
     3001 aaaaaaacaa aaaaaaagca atagatagag aaattgttga caatttctgt agtctttcct
     3061 agttgtgatc aaattcagcc tatggatggc ctattttata ccaaagatga agtgacaccc
     3121 tattacagtc cagaagatag aggttgtttt cgtttctttt ctttttaaaa aaaaaaaaat
     3181 ttatttgacc gacatggccg gaccagttct ttctttgttg tttgtttaaa ctaccttcca
     3241 ctggtgtttt acatagtgca aaaaaaaaaa gagggtgggg ggagttgtct ctcttttctt
     3301 taaatgtgta ttcattgata gcagaagctt gtacctgctg tgtttagcag tttcagcatg
     3361 aagagttctg gatatgaact gattcataga gccaagtggc tttaaattct gtgagctttt
     3421 ctggtttctc actagctgtc ttgaatagtg aaacctgtat tgatggccac tagtaaacca
     3481 agatgcttat ttaacaggtg gaatattctt tatatgaaat ttcagctaaa gacactttct
     3541 ggacctggtc tgaaaggtca tttgtcaaaa aagcttaggg atattctgtg aaatggtgag
     3601 tggtctcctg gaaaggtctc attgtatttg aacaatagtc ttccctctaa attacaacac
     3661 ctctgggttt tgtctttaca cctctgtctt tgtcatcacc taccatgaat agtcaccttg
     3721 gttttgcaaa tggggagggg gtatcatctt tttgcctgtt ttcactgtat ttttgtatat
     3781 tggtgttgcc gaaagaactt tttctttcag tttaattctt tgaggcatgt aggaccaata
     3841 agattgagaa ttctattggt ggaatttagg gaagtcctta aaatgctagt tgacaatcaa
     3901 ggaacagtat gatttatatc aataagaacc aaaagaatta ggtttgatca atcatttaag
     3961 ccaaggagga atacttgcat ttagaacaat gcaaaacttt gtctaaaatg aattaaattg
     4021 acccacctgt aaaatatatc tacattttta attcatgaga tgatatgtgt tcaaccttta
     4081 cagttttacc tgaaattaag gacaatggaa tagaatttgt taagtgaacc attcactaga
     4141 ttgctttctg aatgaatcct ttgaatcaaa taggtgaaac tcttttcaaa aactaagtca
     4201 gtcacaggag cctgtcttag tccaaaagaa gcagggaaat gtatttaagt gtactataaa
     4261 acagggtagg ctttttaaaa actaaaaagt tttaaaggta aatcatattc ccattaggtc
     4321 aacatgagta ataaggttga ctcatgtgaa attgtcaata ttctactatt tctgtaaact
     4381 ctggttctct tatttgcaac cccatgcact ggaagcccaa atcagagaat gactccatat
     4441 atttatggtc acattggaga caaaagtgta tccaagaaaa tgtagtgtgc gttatagaga
     4501 aattccaact ggtcacactc accattatgg tttttcatgc tttagagaaa atgctagatt
     4561 tatactgtct tttgttccat ccttcagctt cccatgcatt ataaaggtgg cacttaagtt
     4621 tttatctttg aaaagtgggc cccaaagttt tttggggtac aaaaagacat gtatgagaac
     4681 catattttct gtttctcttt ttcactctct aaactctttt tgtataaata aggattatcc
     4741 tgggcataat tcatttgaat atgaaaccaa catactttct ttcatttttg tgaaaaaata
     4801 accaaaaaca tgtattaatg tgatacaaag aaagtctcat tcacacaatc aacaatgagg
     4861 ctaagaggta gctaccatgt ggctaatgaa tgtgcctagg taacttcctg tttctattca
     4921 aaactgctgc tttatttgta cattcagaaa tatttttttc aactatgaaa tttcaatatc
     4981 aattttttaa gccagtttct gcaaaaggaa atgacctgtc atttgatgtg ttcatgtgtg
     5041 ttttgtgttt ggatagttta tatcatgcca ttctataaaa tgtatgtttt caaaccaaaa
     5101 agaaaaaaaa tagaaggaaa acaacggcac atactcaaat ttgccctgct ttgtctgttg
     5161 tcttacctaa gacttgtttt gaagagccaa gtctgggaga gaaaaaaaag catcaacagg
     5221 taagcagcat tacattgtgt ggtaataaac caaaataagt tttcaatata tacagacaac
     5281 agaattcaaa tttaatcaac aaaatatatt gtagtgattt gtttgtttgt ttgtttgaga
     5341 cggagtctcg ctctgtcgcc catcctaact aggactataa tctttttttt tttctttaag
     5401 ttgaagttaa ttttctgtgc attctggtcc accagatttt caagcattta tttggatgtt
     5461 tccatttttc cttttgactt taatagccaa gacttagctt aaacatcagg aaacaaacta
     5521 aagccacaat ccaaatgaga gaaacactgt ctcgtctaaa ctctagtttc atggtcagtg
     5581 caacagtgag ttttctttta ataatggtat ggtattgtca agggaggcaa agtgttcatg
     5641 gtaacttgga gctccccaat acatggccat gtcttctaaa gacaacgtaa tgagcccaag
     5701 tgaactgaag gtcatactgg caggtgctga tgacagtttg tccttgaatg ctgacatgtc
     5761 ttgaatattg caaatgtcat aatactcttt taaaacagtc ctctacctga ctctagtttt
     5821 gcgaggatta gtttgtttcc ttggtagatt tcaacatttc agaatgttac ctccaaattt
     5881 cacttgaatt acttcctcct gtgaccttag cagatctgtc acatttgaaa gcatatgact
     5941 cacttccacc cccttctaat gaaaaactgc atggtgttaa aagcactctc attagaaata
     6001 taaggctgag aactgaagaa ggctgtttaa agcaggaatt tcactttatt ttactatgcc
     6061 taaaaataca tctttggacc ccttgcaaag tgctttaaaa gtactttcaa tttatgcatg
     6121 actccaaaaa agtaattttt ttttcccaaa aaaacctctt tatttaaata attgggatat
     6181 ttgctaaata cctatttttt tttacagtgg cctaaaaccc ctattaatga aaagtgaaat
     6241 ttgatttaat taggactctt gcagtcatct tcacgactga ggagaagttt caataggctg
     6301 tctagacatt atgatgttaa taggagatta aaatacattt ggcaattcat tttcattctt
     6361 aatttgagtg catgaaccac tgcagatgag ctgataagca gaaattctca agtgggtttc
     6421 actaataaat gtttttttat atgatttgaa atcaagtaaa gggacaatgt ttatgtacgt
     6481 gtataacaac attcagcaca tttgaggaat cacacactat aataaagctt aaacctgtca
     6541 tagaaccttg atctatatta ctttgtcttc agtaaaaagt gaaggatgag attttgtctt
     6601 tcatgttatt gtagctggca tgcttcaaaa ttttgagctt actgggactg acagcctctc
     6661 acttcaatct gagggattga cagaatttaa acaggctcat tgattctgta cactctaccc
     6721 ttcctgtggc aagtgataat gggatttcat taatgaatca atttgtttta caaatgacat
     6781 ccactgtggc attggaagac agttgggtct gactcaagtt taacatttct taccaaacat
     6841 tcttaagtat gaaattggtc ctttaatcca aatgctcttg gtcatggctg tcctttgcgg
     6901 attacatagc attcaggaaa gtacaaaaac taaacactaa atccccaact ggccccaaag
     6961 accttttatg atgtgagaga caagagttca ccccagatta atttctttta tcattggctt
     7021 tatactctaa catatagata ctctctatag caaaaaaggg atgaatggct ttcaatattc
     7081 atttctgttt atttttgtga gggaaaataa tatatcaaga aaattttctt ccacttagaa
     7141 agctttaaag ctgaagtaga ggtgcagtca agcttggatc tgcaggaaga accactaggc
     7201 cactgagtca tacttgagct tttcttacta ctgccccaat ttctaaattg tgcataaata
     7261 caatcactct caatttttga agggctaatt atctactttg tgggtgtgtt ttgttttttc
     7321 ttttcagcgt gtagggcttg ggctctgttt ccttttatta gcatgtcacc tgagggtgga
     7381 acaaacaatt ggaaataaaa tttgattatt ttatttctta taaagtatta atttcttaag
     7441 ggggtttgaa atcattggta aaattaatat cagtacatta tatgtcataa attttgatta
     7501 tctataatgt cttttcttat ctaccacaaa taattgagag ttggctaaat tcttgcagaa
     7561 tatatgggaa aaaaatcata gcaaagaatt cagcttccct caaaagaaag ctatttttgt
     7621 ttccttcact ccactaaatt tgaaccagta gcacggatca acacgacttc tgcaatgaga
     7681 gtataacggt agctcttggt acagtcatat tcatattttt aaatctttct ttgaccaaaa
     7741 ctattgcatt gttttcatta cattttgact gcgttactta ttaaggccga atgactttga
     7801 cacccccgtg gattattttt atgatcacat caaatttaaa caatgtccaa agtgtaactt
     7861 taatgttata ttttgtttca aaccctctgg tctaagatta ttgagaaaga tgttttttcc
     7921 tcctccctca aatatgttat ctcttcatat ataaaaaaat aagttattcc atgcttttca
     7981 ggaactgtaa aaattatttc aaaaagatat ttgaaaaagt tttctctatt ctggacacaa
     8041 atgcttccat ttatttcaaa agaagaagaa gaaaaatgga atcttaattt aaaaaaatat
     8101 atgtagtagt atctgctatg agatattcag tctctataaa aaaaaaaagg gacacagctt
     8161 cttttaaaac ccttgtttca gtccatattc aacttcatgg aacttctgaa acatcattca
     8221 attttgaact ttatttaaga gcatttttgt actgctgtct ctgactgtca tggaaagttc
     8281 tgtaattcta aggtgtttct ggttttattt ttaatttctt catctgtacc acagtcaaat
     8341 tagcaaccat ctcccccatc ccttgggctt tctgtagatc agtggatgtt aggtttaaac
     8401 ttctgttttc tttgatgaag ctttcaataa aaaatgaaaa taaaatcaa
//
