LOCUS       NP_001003793             437 aa            linear   PRI 23-APR-2024
DEFINITION  RNA-binding motif, single-stranded-interacting protein 3 isoform 1
            [Homo sapiens].
ACCESSION   NP_001003793
VERSION     NP_001003793.1
DBSOURCE    REFSEQ: accession NM_001003793.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 437)
  AUTHORS   Li,Y., Wang,S., Li,G., Gao,C., Cui,Z., Cong,M., Hu,J., Zhang,M.,
            Jin,X., Sun,H. and Kong,D.
  TITLE     The RNA-binding protein RBMS3 inhibits the progression of colon
            cancer by regulating the stability of LIMS1 mRNA
  JOURNAL   Cancer Med 13 (7), e7129 (2024)
   PUBMED   38618967
  REMARK    GeneRIF: The RNA-binding protein RBMS3 inhibits the progression of
            colon cancer by regulating the stability of LIMS1 mRNA.
REFERENCE   2  (residues 1 to 437)
  AUTHORS   Gornicki,T., Lambrinow,J., Mrozowska,M., Romanowicz,H., Smolarz,B.,
            Piotrowska,A., Gomulkiewicz,A., Podhorska-Okolow,M., Dziegiel,P.
            and Grzegrzolka,J.
  TITLE     Expression of RBMS3 in Breast Cancer Progression
  JOURNAL   Int J Mol Sci 24 (3), 2866 (2023)
   PUBMED   36769184
  REMARK    GeneRIF: Expression of RBMS3 in Breast Cancer Progression.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 437)
  AUTHORS   Zhou,Y., Liang,Z., Xia,Y., Li,S., Liang,J., Hu,Z., Tang,C.,
            Zhao,Q., Gong,Q. and Ouyang,Y.
  TITLE     Disruption of RBMS3 suppresses PD-L1 and enhances antitumor immune
            activities and therapeutic effects of auranofin against
            triple-negative breast cancer
  JOURNAL   Chem Biol Interact 369, 110260 (2023)
   PUBMED   36414028
  REMARK    GeneRIF: Disruption of RBMS3 suppresses PD-L1 and enhances
            antitumor immune activities and therapeutic effects of auranofin
            against triple-negative breast cancer.
REFERENCE   4  (residues 1 to 437)
  AUTHORS   Wang,M., Fu,X., Wang,W., Zhang,Y., Jiang,Z., Gu,Y., Chu,M., Shao,Y.
            and Li,S.
  TITLE     Comprehensive bioinformatics analysis confirms RBMS3 as the central
            candidate biological target for ovarian cancer
  JOURNAL   Med Eng Phys 110, 103883 (2022)
   PUBMED   36075788
  REMARK    GeneRIF: Comprehensive bioinformatics analysis confirms RBMS3 as
            the central candidate biological target for ovarian cancer.
REFERENCE   5  (residues 1 to 437)
  AUTHORS   Block,C.J., Mitchell,A.V., Wu,L., Glassbrook,J., Craig,D., Chen,W.,
            Dyson,G., DeGracia,D., Polin,L., Ratnam,M., Gibson,H. and Wu,G.
  TITLE     RNA binding protein RBMS3 is a common EMT effector that modulates
            triple-negative breast cancer progression via stabilizing PRRX1
            mRNA
  JOURNAL   Oncogene 40 (46), 6430-6442 (2021)
   PUBMED   34608266
  REMARK    GeneRIF: RNA binding protein RBMS3 is a common EMT effector that
            modulates triple-negative breast cancer progression via stabilizing
            PRRX1 mRNA.
REFERENCE   6  (residues 1 to 437)
  AUTHORS   Broderick,P., Wang,Y., Vijayakrishnan,J., Matakidou,A., Spitz,M.R.,
            Eisen,T., Amos,C.I. and Houlston,R.S.
  TITLE     Deciphering the impact of common genetic variation on lung cancer
            risk: a genome-wide association study
  JOURNAL   Cancer Res 69 (16), 6633-6641 (2009)
   PUBMED   19654303
REFERENCE   7  (residues 1 to 437)
  AUTHORS   Meigs,J.B., Manning,A.K., Fox,C.S., Florez,J.C., Liu,C.,
            Cupples,L.A. and Dupuis,J.
  TITLE     Genome-wide association with diabetes-related traits in the
            Framingham Heart Study
  JOURNAL   BMC Med Genet 8 Suppl 1 (Suppl 1), S16 (2007)
   PUBMED   17903298
  REMARK    Publication Status: Online-Only
REFERENCE   8  (residues 1 to 437)
  AUTHORS   Kiel,D.P., Demissie,S., Dupuis,J., Lunetta,K.L., Murabito,J.M. and
            Karasik,D.
  TITLE     Genome-wide association with bone mass and geometry in the
            Framingham Heart Study
  JOURNAL   BMC Med Genet 8 Suppl 1 (Suppl 1), S14 (2007)
   PUBMED   17903296
  REMARK    Publication Status: Online-Only
REFERENCE   9  (residues 1 to 437)
  AUTHORS   Fritz,D. and Stefanovic,B.
  TITLE     RNA-binding protein RBMS3 is expressed in activated hepatic
            stellate cells and liver fibrosis and increases expression of
            transcription factor Prx1
  JOURNAL   J Mol Biol 371 (3), 585-595 (2007)
   PUBMED   17586524
  REMARK    GeneRIF: These results suggest that RBMS3, by binding Prx1 mRNA in
            a sequence-specific manner, controls Prx1 expression and indirectly
            collagen synthesis.
REFERENCE   10 (residues 1 to 437)
  AUTHORS   Penkov,D., Ni,R., Else,C., Pinol-Roma,S., Ramirez,F. and Tanaka,S.
  TITLE     Cloning of a human gene closely related to the genes coding for the
            c-myc single-strand binding proteins
  JOURNAL   Gene 243 (1-2), 27-36 (2000)
   PUBMED   10675610
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC012262.15, AY236871.1,
            AK097311.1, AC097633.2 and CA448021.1.
            
            Summary: This gene encodes an RNA-binding protein that belongs to
            the c-myc gene single-strand binding protein family. These proteins
            are characterized by the presence of two sets of ribonucleoprotein
            consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and
            RNP2, originally described in RNA binding proteins, and required
            for DNA binding. These proteins have been implicated in such
            diverse functions as DNA replication, gene transcription, cell
            cycle progression and apoptosis. The encoded protein was isolated
            by virtue of its binding to an upstream element of the alpha2(I)
            collagen promoter. The observation that this protein localizes
            mostly in the cytoplasm suggests that it may be involved in a
            cytoplasmic function such as controlling RNA metabolism, rather
            than transcription. Multiple alternatively spliced transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Apr 2010].
            
            Transcript Variant: This variant (1), also known as DD23-L, encodes
            the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.90682.1,
                                           SRR1803617.233707.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000383767.7/ ENSP00000373277.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..437
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p24.1"
     Protein         1..437
                     /product="RNA-binding motif, single-stranded-interacting
                     protein 3 isoform 1"
                     /note="RNA-binding protein; RNA binding motif, single
                     stranded interacting protein"
                     /calculated_mol_wt=47709
     Region          28..57
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6XE24.1)"
     Region          57..136
                     /region_name="RRM1_RBMS3"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding motif, single-stranded-interacting protein 3
                     (RBMS3); cd12472"
                     /db_xref="CDD:409902"
     Region          139..226
                     /region_name="RRM2_RBMS3"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding motif, single-stranded-interacting protein 3
                     (RBMS3); cd12475"
                     /db_xref="CDD:240919"
     Region          399..437
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6XE24.1)"
     CDS             1..437
                     /gene="RBMS3"
                     /coded_by="NM_001003793.3:612..1925"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS33724.1"
                     /db_xref="GeneID:27303"
                     /db_xref="HGNC:HGNC:13427"
                     /db_xref="MIM:605786"
ORIGIN      
        1 mgkrldqpqm ypqytyyyph ylqtkqsyap aphpmappsp stnsssnnss nnssgeqlsk
       61 tnlyirglpp gttdqdlikl cqpygkivst kaildkntnq ckgygfvdfd spaaaqkava
      121 slkangvqaq makqqeqdpt nlyisnlpis mdeqelenml kpfghvistr ilrdangvsr
      181 gvgfarmest ekcevviqhf ngkylktppg ipapsepllc kfadggqkkr qnqskytqng
      241 rpwpregeag maltydptaa iqngfysspy siatnrmipq tsitpfiaas pvstyqvqst
      301 swmphppyvm qptgavitpt mdhpmsmqpa nmmgpltqqm nhlslgttgt iqsqdrimil
      361 hqllcqymta aapmqgtyip qytpvpptav siegvvadts pqtvapssqd tsgqqqqiav
      421 dtsnehapay syqqskp
//
