LOCUS       NM_002898               8488 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens RNA binding motif single stranded interacting protein
            2 (RBMS2), transcript variant 1, mRNA.
ACCESSION   NM_002898
VERSION     NM_002898.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8488)
  AUTHORS   Sun,X., Hu,Y., Wu,J., Shi,L., Zhu,L., Xi,P.W., Wei,J.F. and Ding,Q.
  TITLE     RBMS2 inhibits the proliferation by stabilizing P21 mRNA in breast
            cancer
  JOURNAL   J Exp Clin Cancer Res 37 (1), 298 (2018)
   PUBMED   30514345
  REMARK    GeneRIF: RBMS2 acts as a tumor suppressor in breast cancer and
            positively regulated the expression of P21 by stabilizing its mRNA.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8488)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 8488)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 8488)
  AUTHORS   Dastani,Z., Hivert,M.F., Timpson,N., Perry,J.R., Yuan,X.,
            Scott,R.A., Henneman,P., Heid,I.M., Kizer,J.R., Lyytikainen,L.P.,
            Fuchsberger,C., Tanaka,T., Morris,A.P., Small,K., Isaacs,A.,
            Beekman,M., Coassin,S., Lohman,K., Qi,L., Kanoni,S., Pankow,J.S.,
            Uh,H.W., Wu,Y., Bidulescu,A., Rasmussen-Torvik,L.J.,
            Greenwood,C.M., Ladouceur,M., Grimsby,J., Manning,A.K., Liu,C.T.,
            Kooner,J., Mooser,V.E., Vollenweider,P., Kapur,K.A., Chambers,J.,
            Wareham,N.J., Langenberg,C., Frants,R., Willems-Vandijk,K.,
            Oostra,B.A., Willems,S.M., Lamina,C., Winkler,T.W., Psaty,B.M.,
            Tracy,R.P., Brody,J., Chen,I., Viikari,J., Kahonen,M.,
            Pramstaller,P.P., Evans,D.M., St Pourcain,B., Sattar,N., Wood,A.R.,
            Bandinelli,S., Carlson,O.D., Egan,J.M., Bohringer,S., van
            Heemst,D., Kedenko,L., Kristiansson,K., Nuotio,M.L., Loo,B.M.,
            Harris,T., Garcia,M., Kanaya,A., Haun,M., Klopp,N., Wichmann,H.E.,
            Deloukas,P., Katsareli,E., Couper,D.J., Duncan,B.B.,
            Kloppenburg,M., Adair,L.S., Borja,J.B., Wilson,J.G., Musani,S.,
            Guo,X., Johnson,T., Semple,R., Teslovich,T.M., Allison,M.A.,
            Redline,S., Buxbaum,S.G., Mohlke,K.L., Meulenbelt,I.,
            Ballantyne,C.M., Dedoussis,G.V., Hu,F.B., Liu,Y., Paulweber,B.,
            Spector,T.D., Slagboom,P.E., Ferrucci,L., Jula,A., Perola,M.,
            Raitakari,O., Florez,J.C., Salomaa,V., Eriksson,J.G.,
            Frayling,T.M., Hicks,A.A., Lehtimaki,T., Smith,G.D.,
            Siscovick,D.S., Kronenberg,F., van Duijn,C., Loos,R.J.,
            Waterworth,D.M., Meigs,J.B., Dupuis,J., Richards,J.B., Voight,B.F.,
            Scott,L.J., Steinthorsdottir,V., Dina,C., Welch,R.P., Zeggini,E.,
            Huth,C., Aulchenko,Y.S., Thorleifsson,G., McCulloch,L.J.,
            Ferreira,T., Grallert,H., Amin,N., Wu,G., Willer,C.J.,
            Raychaudhuri,S., McCarroll,S.A., Hofmann,O.M., Segre,A.V., van
            Hoek,M., Navarro,P., Ardlie,K., Balkau,B., Benediktsson,R.,
            Bennett,A.J., Blagieva,R., Boerwinkle,E., Bonnycastle,L.L.,
            Bostrom,K.B., Bravenboer,B., Bumpstead,S., Burtt,N.P.,
            Charpentier,G., Chines,P.S., Cornelis,M., Crawford,G., Doney,A.S.,
            Elliott,K.S., Elliott,A.L., Erdos,M.R., Fox,C.S., Franklin,C.S.,
            Ganser,M., Gieger,C., Grarup,N., Green,T., Griffin,S., Groves,C.J.,
            Guiducci,C., Hadjadj,S., Hassanali,N., Herder,C., Isomaa,B.,
            Jackson,A.U., Johnson,P.R., Jorgensen,T., Kao,W.H., Kong,A.,
            Kraft,P., Kuusisto,J., Lauritzen,T., Li,M., Lieverse,A.,
            Lindgren,C.M., Lyssenko,V., Marre,M., Meitinger,T., Midthjell,K.,
            Morken,M.A., Narisu,N., Nilsson,P., Owen,K.R., Payne,F.,
            Petersen,A.K., Platou,C., Proenca,C., Prokopenko,I., Rathmann,W.,
            Rayner,N.W., Robertson,N.R., Rocheleau,G., Roden,M., Sampson,M.J.,
            Saxena,R., Shields,B.M., Shrader,P., Sigurdsson,G., Sparso,T.,
            Strassburger,K., Stringham,H.M., Sun,Q., Swift,A.J., Thorand,B.,
            Tichet,J., Tuomi,T., van Dam,R.M., van Haeften,T.W., van Herpt,T.,
            van Vliet-Ostaptchouk,J.V., Walters,G.B., Weedon,M.N., Wijmenga,C.,
            Witteman,J., Bergman,R.N., Cauchi,S., Collins,F.S., Gloyn,A.L.,
            Gyllensten,U., Hansen,T., Hide,W.A., Hitman,G.A., Hofman,A.,
            Hunter,D.J., Hveem,K., Laakso,M., Morris,A.D., Palmer,C.N.,
            Rudan,I., Sijbrands,E., Stein,L.D., Tuomilehto,J., Uitterlinden,A.,
            Walker,M., Watanabe,R.M., Abecasis,G.R., Boehm,B.O., Campbell,H.,
            Daly,M.J., Hattersley,A.T., Pedersen,O., Barroso,I., Groop,L.,
            Sladek,R., Thorsteinsdottir,U., Wilson,J.F., Illig,T., Froguel,P.,
            van Duijn,C.M., Stefansson,K., Altshuler,D., Boehnke,M.,
            McCarthy,M.I., Soranzo,N., Wheeler,E., Glazer,N.L.,
            Bouatia-Naji,N., Magi,R., Randall,J., Elliott,P., Rybin,D.,
            Dehghan,A., Hottenga,J.J., Song,K., Goel,A., Lajunen,T., Doney,A.,
            Cavalcanti-Proenca,C., Kumari,M., Timpson,N.J., Zabena,C.,
            Ingelsson,E., An,P., O'Connell,J., Luan,J., Elliott,A.,
            McCarroll,S.A., Roccasecca,R.M., Pattou,F., Sethupathy,P.,
            Ariyurek,Y., Barter,P., Beilby,J.P., Ben-Shlomo,Y., Bergmann,S.,
            Bochud,M., Bonnefond,A., Borch-Johnsen,K., Bottcher,Y., Brunner,E.,
            Bumpstead,S.J., Chen,Y.D., Chines,P., Clarke,R., Coin,L.J.,
            Cooper,M.N., Crisponi,L., Day,I.N., de Geus,E.J., Delplanque,J.,
            Fedson,A.C., Fischer-Rosinsky,A., Forouhi,N.G., Franzosi,M.G.,
            Galan,P., Goodarzi,M.O., Graessler,J., Grundy,S., Gwilliam,R.,
            Hallmans,G., Hammond,N., Han,X., Hartikainen,A.L., Hayward,C.,
            Heath,S.C., Hercberg,S., Hillman,D.R., Hingorani,A.D., Hui,J.,
            Hung,J., Kaakinen,M., Kaprio,J., Kesaniemi,Y.A., Kivimaki,M.,
            Knight,B., Koskinen,S., Kovacs,P., Kyvik,K.O., Lathrop,G.M.,
            Lawlor,D.A., Le Bacquer,O., Lecoeur,C., Li,Y., Mahley,R.,
            Mangino,M., Martinez-Larrad,M.T., McAteer,J.B., McPherson,R.,
            Meisinger,C., Melzer,D., Meyre,D., Mitchell,B.D., Mukherjee,S.,
            Naitza,S., Neville,M.J., Orru,M., Pakyz,R., Paolisso,G.,
            Pattaro,C., Pearson,D., Peden,J.F., Pedersen,N.L., Pfeiffer,A.F.,
            Pichler,I., Polasek,O., Posthuma,D., Potter,S.C., Pouta,A.,
            Province,M.A., Rayner,N.W., Rice,K., Ripatti,S., Rivadeneira,F.,
            Rolandsson,O., Sandbaek,A., Sandhu,M., Sanna,S., Sayer,A.A.,
            Scheet,P., Seedorf,U., Sharp,S.J., Shields,B., Sigurethsson,G.,
            Sijbrands,E.J., Silveira,A., Simpson,L., Singleton,A., Smith,N.L.,
            Sovio,U., Swift,A., Syddall,H., Syvanen,A.C., Tonjes,A.,
            Uitterlinden,A.G., van Dijk,K.W., Varma,D., Visvikis-Siest,S.,
            Vitart,V., Vogelzangs,N., Waeber,G., Wagner,P.J., Walley,A.,
            Ward,K.L., Watkins,H., Wild,S.H., Willemsen,G., Witteman,J.C.,
            Yarnell,J.W., Zelenika,D., Zethelius,B., Zhai,G., Zhao,J.H.,
            Zillikens,M.C., Borecki,I.B., Meneton,P., Magnusson,P.K.,
            Nathan,D.M., Williams,G.H., Silander,K., Bornstein,S.R.,
            Schwarz,P., Spranger,J., Karpe,F., Shuldiner,A.R., Cooper,C.,
            Serrano-Rios,M., Lind,L., Palmer,L.J., Hu,F.B. 1st, Franks,P.W.,
            Ebrahim,S., Marmot,M., Kao,W.H., Pramstaller,P.P., Wright,A.F.,
            Stumvoll,M., Hamsten,A., Buchanan,T.A., Valle,T.T., Rotter,J.I.,
            Penninx,B.W., Boomsma,D.I., Cao,A., Scuteri,A., Schlessinger,D.,
            Uda,M., Ruokonen,A., Jarvelin,M.R., Peltonen,L., Mooser,V.,
            Sladek,R., Musunuru,K., Smith,A.V., Edmondson,A.C., Stylianou,I.M.,
            Koseki,M., Pirruccello,J.P., Chasman,D.I., Johansen,C.T.,
            Fouchier,S.W., Peloso,G.M., Barbalic,M., Ricketts,S.L., Bis,J.C.,
            Feitosa,M.F., Orho-Melander,M., Melander,O., Li,X., Li,M.,
            Cho,Y.S., Go,M.J., Kim,Y.J., Lee,J.Y., Park,T., Kim,K., Sim,X.,
            Ong,R.T., Croteau-Chonka,D.C., Lange,L.A., Smith,J.D., Ziegler,A.,
            Zhang,W., Zee,R.Y., Whitfield,J.B., Thompson,J.R., Surakka,I.,
            Spector,T.D., Smit,J.H., Sinisalo,J., Scott,J., Saharinen,J.,
            Sabatti,C., Rose,L.M., Roberts,R., Rieder,M., Parker,A.N., Pare,G.,
            O'Donnell,C.J., Nieminen,M.S., Nickerson,D.A., Montgomery,G.W.,
            McArdle,W., Masson,D., Martin,N.G., Marroni,F., Lucas,G., Luben,R.,
            Lokki,M.L., Lettre,G., Launer,L.J., Lakatta,E.G., Laaksonen,R.,
            Kyvik,K.O., Konig,I.R., Khaw,K.T., Kaplan,L.M., Johansson,A.,
            Janssens,A.C., Igl,W., Hovingh,G.K., Hengstenberg,C.,
            Havulinna,A.S., Hastie,N.D., Harris,T.B., Haritunians,T.,
            Hall,A.S., Groop,L.C., Gonzalez,E., Freimer,N.B., Erdmann,J.,
            Ejebe,K.G., Doring,A., Dominiczak,A.F., Demissie,S., Deloukas,P.,
            de Faire,U., Crawford,G., Chen,Y.D., Caulfield,M.J.,
            Boekholdt,S.M., Assimes,T.L., Quertermous,T., Seielstad,M.,
            Wong,T.Y., Tai,E.S., Feranil,A.B., Kuzawa,C.W., Taylor,H.A. Jr.,
            Gabriel,S.B., Holm,H., Gudnason,V., Krauss,R.M., Ordovas,J.M.,
            Munroe,P.B., Kooner,J.S., Tall,A.R., Hegele,R.A., Kastelein,J.J.,
            Schadt,E.E., Strachan,D.P., Reilly,M.P., Samani,N.J., Schunkert,H.,
            Cupples,L.A., Sandhu,M.S., Ridker,P.M., Rader,D.J. and
            Kathiresan,S.
  CONSRTM   DIAGRAM+ Consortium; MAGIC Consortium; GLGC Investigators; MuTHER
            Consortium; DIAGRAM Consortium; GIANT Consortium; Global B Pgen
            Consortium; Procardis Consortium; MAGIC investigators; GLGC
            Consortium
  TITLE     Novel loci for adiponectin levels and their influence on type 2
            diabetes and metabolic traits: a multi-ethnic meta-analysis of
            45,891 individuals
  JOURNAL   PLoS Genet 8 (3), e1002607 (2012)
   PUBMED   22479202
REFERENCE   5  (bases 1 to 8488)
  AUTHORS   Silva,J.M., Perez,D.S., Pritchett,J.R., Halling,M.L., Tang,H. and
            Smith,D.I.
  TITLE     Identification of long stress-induced non-coding transcripts that
            have altered expression in cancer
  JOURNAL   Genomics 95 (6), 355-362 (2010)
   PUBMED   20214974
REFERENCE   6  (bases 1 to 8488)
  AUTHORS   Kanaoka,Y. and Nojima,H.
  TITLE     SCR: novel human suppressors of cdc2/cdc13 mutants of
            Schizosaccharomyces pombe harbour motifs for RNA binding proteins
  JOURNAL   Nucleic Acids Res 22 (13), 2687-2693 (1994)
   PUBMED   8041632
REFERENCE   7  (bases 1 to 8488)
  AUTHORS   Skerka,C., Timmann,C., Horstmann,R.D. and Zipfel,P.F.
  TITLE     Two additional human serum proteins structurally related to
            complement factor H. Evidence for a family of factor H-related
            genes
  JOURNAL   J Immunol 148 (10), 3313-3318 (1992)
   PUBMED   1533657
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC097104.18, DC382164.1,
            BC027863.1, AC090681.13 and CF890834.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002898.3.
            
            Summary: The protein encoded by this gene is a member of a small
            family of proteins which bind single stranded DNA/RNA. These
            proteins are characterized by the presence of two sets of
            ribonucleoprotein consensus sequence (RNP-CS) that contain
            conserved motifs, RNP1 and RNP2, originally described in RNA
            binding proteins, and required for DNA binding. The RBMS proteins
            have been implicated in such diverse functions as DNA replication,
            gene transcription, cell cycle progression and apoptosis. This
            protein was isolated by phenotypic complementation of cdc2 and
            cdc13 mutants of yeast and is thought to suppress cdc2 and cdc13
            mutants through the induction of translation of cdc2. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027863.1, SRR1803611.80591.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262031.10/ ENSP00000262031.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC097104.18        56572-56576
            6-178               DC382164.1         1-173
            179-196             AC097104.18        56750-56767
            197-282             BC027863.1         1-86
            283-283             AC097104.18        97181-97181
            284-1901            BC027863.1         88-1705
            1902-8248           AC090681.13        20023-26369
            8249-8488           CF890834.1         22-261              c
FEATURES             Location/Qualifiers
     source          1..8488
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.3"
     gene            1..8488
                     /gene="RBMS2"
                     /gene_synonym="SCR3"
                     /note="RNA binding motif single stranded interacting
                     protein 2"
                     /db_xref="GeneID:5939"
                     /db_xref="HGNC:HGNC:9909"
                     /db_xref="MIM:602387"
     exon            1..270
                     /gene="RBMS2"
                     /gene_synonym="SCR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..1428
                     /gene="RBMS2"
                     /gene_synonym="SCR3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     suppressor of CDC2 with RNA-binding motif 3"
                     /codon_start=1
                     /product="RNA-binding motif, single-stranded-interacting
                     protein 2 isoform 1"
                     /protein_id="NP_002889.1"
                     /db_xref="CCDS:CCDS8923.1"
                     /db_xref="GeneID:5939"
                     /db_xref="HGNC:HGNC:9909"
                     /db_xref="MIM:602387"
                     /translation="MLLSVTSRPGISTFGYNRNNKKPYVSLAQQMAPPSPSNSTPNSS
                     SGSNGNDQLSKTNLYIRGLQPGTTDQDLVKLCQPYGKIVSTKAILDKTTNKCKGYGFV
                     DFDSPSAAQKAVTALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELEGMLKPFGQ
                     VISTRILRDTSGTSRGVGFARMESTEKCEAIITHFNGKYIKTPPGVPAPSDPLLCKFA
                     DGGPKKRQNQGKFVQNGRAWPRNADMGVMALTYDPTTALQNGFYPAPYNITPNRMLAQ
                     SALSPYLSSPVSSYQRVTQTSPLQVPNPSWMHHHSYLMQPSGSVLTPGMDHPISLQPA
                     SMMGPLTQQLGHLSLSSTGTYMPTAAAMQGAYISQYTPVPSSSVSVEESSGQQNQVAV
                     DAPSEHGVYSFQFNK"
     exon            271..437
                     /gene="RBMS2"
                     /gene_synonym="SCR3"
                     /inference="alignment:Splign:2.1.0"
     exon            438..496
                     /gene="RBMS2"
                     /gene_synonym="SCR3"
                     /inference="alignment:Splign:2.1.0"
     exon            497..588
                     /gene="RBMS2"
                     /gene_synonym="SCR3"
                     /inference="alignment:Splign:2.1.0"
     exon            589..746
                     /gene="RBMS2"
                     /gene_synonym="SCR3"
                     /inference="alignment:Splign:2.1.0"
     exon            747..826
                     /gene="RBMS2"
                     /gene_synonym="SCR3"
                     /inference="alignment:Splign:2.1.0"
     exon            827..936
                     /gene="RBMS2"
                     /gene_synonym="SCR3"
                     /inference="alignment:Splign:2.1.0"
     exon            937..983
                     /gene="RBMS2"
                     /gene_synonym="SCR3"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1077
                     /gene="RBMS2"
                     /gene_synonym="SCR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1155
                     /gene="RBMS2"
                     /gene_synonym="SCR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1266
                     /gene="RBMS2"
                     /gene_synonym="SCR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1347
                     /gene="RBMS2"
                     /gene_synonym="SCR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1434
                     /gene="RBMS2"
                     /gene_synonym="SCR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..8488
                     /gene="RBMS2"
                     /gene_synonym="SCR3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3230..3235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBMS2"
                     /gene_synonym="SCR3"
                     /note="hexamer: AATAAA"
     polyA_site      3272
                     /gene="RBMS2"
                     /gene_synonym="SCR3"
                     /note="major polyA site"
     regulatory      7063..7068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBMS2"
                     /gene_synonym="SCR3"
                     /note="hexamer: AATAAA"
     polyA_site      7087
                     /gene="RBMS2"
                     /gene_synonym="SCR3"
                     /note="major polyA site"
     regulatory      7877..7882
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBMS2"
                     /gene_synonym="SCR3"
                     /note="hexamer: AATAAA"
     polyA_site      7895
                     /gene="RBMS2"
                     /gene_synonym="SCR3"
                     /note="major polyA site"
     regulatory      8386..8391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBMS2"
                     /gene_synonym="SCR3"
                     /note="hexamer: AATAAA"
     polyA_site      8408
                     /gene="RBMS2"
                     /gene_synonym="SCR3"
     regulatory      8451..8456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBMS2"
                     /gene_synonym="SCR3"
                     /note="hexamer: TATAAA"
     polyA_site      8488
                     /gene="RBMS2"
                     /gene_synonym="SCR3"
ORIGIN      
        1 agcccgagct cattctctgc ccgcagcccc ccttcatctc tctcctcctg ctccttttct
       61 cctcctttct cctccccctc ccttttttcc tccctccctc tccccctttc cctcgctccc
      121 ctcctccctc cctccccgtc tttcttaccc cctccctttc tctctctctc tctctctcgc
      181 tcgttcccta acattaaaga gaaaatgctg ctatccgtga cttccaggcc cgggatttcg
      241 acttttggct acaatagaaa caacaagaag ccatatgtgt cattggctca gcagatggca
      301 ccacctagcc caagcaacag tacacctaac agcagtagtg gaagcaatgg aaatgaccag
      361 ctgagcaaaa ccaacctata catccgagga ttgcaaccag gcactactga ccaagatctt
      421 gtcaagctgt gtcagccata tggcaagatt gtttccacta aggccatact ggacaagacc
      481 acaaacaaat gtaaaggcta tggctttgta gattttgaca gcccttcagc agcacagaaa
      541 gctgtaacag cactgaaggc cagcggtgta caggcacaga tggcaaagca acaggaacag
      601 gaccccacaa atttatacat ctcaaacctc ccactgtcaa tggatgagca ggaactggag
      661 gggatgctga agccctttgg ccaggttatc tccacccgta tccttcgaga taccagtggg
      721 accagcagag gtgttggctt tgcaaggatg gagtccacag agaagtgtga agccatcatc
      781 acccacttta atggaaaata tattaagaca ccccctggag taccagcccc atccgatccc
      841 ttgctttgca aatttgctga tggcgggcca aagaaacgac agaaccaagg aaaatttgtg
      901 caaaatggac gggcttggcc aaggaatgca gacatgggcg tcatggcctt gacctatgac
      961 cccaccacag ctcttcagaa tgggttttac ccagccccct ataacatcac ccccaacagg
     1021 atgcttgctc agtctgcact ctccccatac ctttcctctc ctgtgtcttc gtatcagaga
     1081 gtgactcaga catctcctct acaagtacct aacccatcct ggatgcacca ccattcatac
     1141 ctcatgcagc cttcaggttc agttctgaca ccagggatgg accatcccat ttctctccag
     1201 cctgcctcca tgatgggacc ccttacccag caactgggcc atctctccct cagcagcaca
     1261 ggcacgtata tgccgacggc tgcagctatg caaggagctt acatctccca gtacacccct
     1321 gtgccttctt ccagtgtttc agtcgaggag agcagcggcc aacagaacca agtggcagtg
     1381 gacgcaccct cagagcatgg ggtctattct ttccagttca acaagtaaca gtgggattcc
     1441 cctccccatc tttactgaat agaaatgaat tcttggagat actcatgctc ccagattcca
     1501 gagggttaac caggaatgga gaccatccgt cggccctgct aaggactaac acttagccat
     1561 cgtttttcac aggcctgggc ctggaaaaag aaatctctac gttcctgccc tttactattg
     1621 ctgatggagc ctgggggaac catcactttt tttgtgtgct acattcaagg agatcaaaaa
     1681 aacttttctt cttttgcaaa gaaagctttt tgtttttaac tgcaacgtac ttttccccta
     1741 ccttgaagag acatggtggt cgcagcttct catctatatg aaaaagtttt cgatgtattg
     1801 gaattatttg ggaatgcttt taaaacaatt tgtaattatt tctttacaaa ccaaaacaga
     1861 acagaaaggt gtggtgctgg aacatcgatg aaggagccct acttactgag cttagttatg
     1921 gacttttttg atgcatgtgt gtatgtgttt taaaaagtat gcaggctcta aaaatgttat
     1981 tttgtaaagc tctcagctca tgcaccccat ctcctcttca cccatattat gccttctttc
     2041 tcttgtccag attcttcttt ttctcttttc taaacagctg agcctgccta ctttgccctt
     2101 ttacagcttt taattttatg gatttttaaa aatgaaattt catgtggaat ttggggttgg
     2161 ggggcaggct gggcaaggaa caaggcagaa cactaagtag gccatggaag tggctgttct
     2221 ttcccccacc ctgccacacc ctgggagaaa aaactagact ttggcttcag aaagcacaga
     2281 tgtgacccag gcttactaaa gagacaactc cacagccctg ggaacacacc cttgagccaa
     2341 acttggttga agactaggtc ttccctggca agttccggaa gaatggactt actgactttt
     2401 atcaactctt ctcactgcca aggccaacag catctgaggt atagcttttt gggagtacct
     2461 gctttcttgc ctcctggagg atattttctg tcctgggctt catggcccct ctcttccctg
     2521 ttacacattg ctgtgctcag agcctttgca gctgcgacct agttgaatcc acataggctc
     2581 cttccacacg gtggaagatc tgctgcttca ctcacagacc aggagttctc aatcagaggt
     2641 ggttttgtcc ctcaggcctt tggcaacatc tagagacagt tttgattgcc acgcctggag
     2701 gtgggatgtg tgtgctactg gcatctagtg gctgctaaac atcctacact gcataggata
     2761 gtccccacta cccccagcca agaattatct gactccaggg gtcaatattg ccaagactgg
     2821 gaaacactga tatagacagt gttgtccctg cctcctgggt tagggtaaat tttcacccca
     2881 accctggaca aacagtgcct tttgacactc atgcaactgt tggggaagga ctggactggg
     2941 atccttgaat tctccccaga ctttgacttt tgataactct gcatatagca agagtgattc
     3001 ttgaaagagc tgtggctcca tgctgaatgc acacatgtac tcagagggat tcaggtgggc
     3061 attgttctgg tgtgtgctgt gcaatggtgg gaaaggacaa agctctctaa actgtccaga
     3121 gcaacctgcc ctgccccggt gtgcttggac cctttgccca gggaaccagg acatcagaaa
     3181 taatgttcct tctgtggaag gacaacgggg agctagggta gcaaagagca ataaattcca
     3241 actctttatg aggtcaggag tcctttaaaa aagcctatgt cttggtcttt aactgtcccc
     3301 ttctgcaaga tgtgactcta tacacatgga gacagattga agaaagactt cacccatctt
     3361 ctaggaaata aaatcctgct cttgtcttct cccagtcact cccttatgca ctgaaaggag
     3421 aatttgactc ccttgcactt caaggccagg tgcctctcca ctagacagtc agacaaaggc
     3481 aaataatgga ggatagagag acaggtgttc attaggctgg ccatagggag aggaaggggg
     3541 tgacagcagg ggaaaagaaa ctgtagtatc agttgtcaca agtagagctc ggcccagctt
     3601 tccctccctt cccagccacc ctagaattga gagtcccagt gcccctagtg tcgactttct
     3661 atgtacatcc taggggtgag ggagtgcggg gcaatgggta ggatataaag cgtaaaggac
     3721 aaattgccgc agtcttctaa ttgatgcttc caaactcagg aagggcttat ccagtgtaaa
     3781 atagccccaa gcccagcaac cttctagagg gctctggctg ggcagatagc ttttgttttt
     3841 gagtctccag ccctcagtca aggaaaatat accatagctg ctttcttgtc agtggccttt
     3901 gagagaaaga gaaaacaaat ctagaattct gttcatctga tagaccgggg gagctttgct
     3961 atggtaggag gtttaggaag ggcctttcac gcatagaaac cattgttgat attgccactc
     4021 ccctctcctc tgcctcacag aactcctgat tctgtcttct ttctctctct atatatatat
     4081 tttaaaatgt ttaaatggct ctaatttttt gttttgaatt ttgaatttac cttttggagt
     4141 tcttctcatg tgaatctact tgttagattg tattaatgag tgtttctggt ttgggcatgg
     4201 gaagtgatgg gggcctgaag ttattttgca gtggctaatg gcactgagga atttcttttt
     4261 tggtgcattt ggtttacact catttcctct cctaattgtt agttcatttg taacagtggg
     4321 tgagtgtttg gaggaaagga gggagaagaa aggagggata ctgtttctcc catgaaatag
     4381 tctaattggt tgggttgatg gcagaaggaa acatagggga gccttccagc tcacagccaa
     4441 gggttgggct cttaaacact atgcctagtg ttttctgaat gctgtcttca tggagcccag
     4501 ctcttactct ctttgtactt tacatctcac ccccactcat tacagatgct cataacattc
     4561 ttaaaatatt ttagtacttg gcatttttct gttttcagtc agctagaaca cactagagtc
     4621 ctttcctcag atggcataat cctttatagg ctctgagcct gcctagccat ctcctatcgg
     4681 tgttattact cctcatctca ggctctgaga tgatactcag accctaaact gattggactt
     4741 tttggaggag ggtgccagta gagaggtcag gaagatgtgg agatgatgat ggagagagat
     4801 gtttttattt tattttattt tttcagacag agtcttgctc tgtcgcccag gctggagtgc
     4861 aatggcacga tctcggctca ctgcaacctc cgcctcccag gttcaagcaa ttctcctgcc
     4921 tcagcctccc atgtagctgg gattacaggc acccaccacc atgcccggct aattttttta
     4981 tttttagtag agatggggtt tcaccatgtt ggccaggctg gtctcgaact cctgacctca
     5041 ggtgatctgc ccgccttagc ctcccaaagt gctgggatta caggcgtgag ccaccgcgcc
     5101 cggcctttat tttatttttt agagatggtc ttgctgtgtc acccaggctg gagtgcagtg
     5161 atgcagtcgt agtctactac agtcttgaat tcctgggccc aagggttctt cccacctaag
     5221 cctcccaagt agctggaagt acaggcacat actaccaagc ccagttcgtt attttaagtt
     5281 tttgtagaga caggggtctt actatgttgc ccagactggt cttgaactcc tgtcaagtga
     5341 gcctcccacc tcagcctccc aaagtgctat gattacaggt gtgagcctcc atgcttggat
     5401 gagatgttgt ttttaatgtt tttggttttt tggttttgtt gttttgtttt tttgagacag
     5461 ggtctcactc tgtggcccag gctggagtgc agtggcacca taatggctca ctgcagcctc
     5521 gacctcccaa ggctcaggtg atcctcttgc ctcagccacc ccttccccgg ccaccaagta
     5581 gctgggacta tgggcttgtg ccaccatgcc tggctaattt ttttattttt agtagagatg
     5641 gggttttacc acgttggcca ggctagtgtc caactcctga cctccaaaca gctaattttt
     5701 gtatttttaa tagagacagg ttttcgccat gttgcccagc ctcgtctcga actcctgggc
     5761 tcaaatgatc cacccacctc ggcctcccaa agtgctggga ttataggcat gagccaccac
     5821 acctggcctt ttcagttttt ttatttttat tttttctttg agacggagtc tcgctctgtc
     5881 gcccaggctg gagtgcagtg gcgtgatctt ggctcactga aacctccatc tcctgggttc
     5941 aagcagttct cctgcctcag cctcctgagt agctgggatt acaggtgcct gccaccatgc
     6001 ctggctaatt tttgtatttt tagtagagac agggttttgc cacattgccc aggctggtgt
     6061 tgaactcctg ggctcaaatg atccacctgc cttggcctcc caaagtgctg ggattacagg
     6121 cgtgagccac tgcacccggc cctttgtagt gtttttaact aaagaatttg tagagttgcc
     6181 caggccagga agcctggtgg ctctaaaggg taatagacct tgtcagtaac agataaggag
     6241 tggtaagagg acattactca tattgaagat gaagaccaga ctttgctgct tcacaggcca
     6301 tgcgctgggt tgggccactt cagctccact ccattcgttt tcctttccta acttgacaat
     6361 cagctcactc accctccctt agtgcctcca gtgcctactc ctgtcactcc aatgtcaacc
     6421 cattgggagt tgaggcctgt cactccaatg tcaacccgtg ggctgttact ttgcgtcata
     6481 tgatgctgtg agaggccttg ctggaatgtc ctaggaatcc ctagtagcag tggctattag
     6541 tcttctagaa aagaactatt gctgctgcct tgtgcacatg ccccaccttc tgggcaagtg
     6601 gcagcattgc gctcatgagg ggctttgcat tcttagccaa gggcaataaa ctgggtgggt
     6661 gatctggccc aaacttgccc ctaggctctg ctagccctga atcagcaggc ttcagagacg
     6721 agggtgggtg ttataaaagc cagtctgtaa agggtaaatt ccaaatcttg tgccttgtta
     6781 taccaatcct tcctgattcc cgtttaaacc aactactcta tttctgtgct gcctacattt
     6841 tcaatcctcc cacgcattag caaattcctg aaatttcctc atttggtagg ccttccatag
     6901 gagtcagcta tggacttcca taggagttgg cagctaaaac cagactgtga gcttctgtct
     6961 ccgttctgat ttttgctgca cctcccaggg gacagtcccc acatgattac aaaagccagg
     7021 tgccctcatc acccgttacc cctgacctgt ccacttgttt tgaataaacc ttcattctcc
     7081 aagcagatcc ccaaacttcc ttgtccttgt tacacgtcta cctcacaacc tcacaattca
     7141 acaacaggta aatacctgga ttcactgatt tctttactgt ccttctctga gggttgggaa
     7201 ggtgggggct agaaaaggct cataattttt aaactcttgg gaattaaact tgggaatttc
     7261 tattcctaca gtgttttctc tgggattttt agctcactga tcgccctaga atagtgtgaa
     7321 ctctccagat aggtcctgct gtgataggcc aggggagtag gctgtgcagt gacggcttag
     7381 ggtaataagt aatggttgga ggacaccagc ataggagcag agtttagaac ttaagaggac
     7441 aagaaagctg ctcagtggct ggcgtatagc tgtgaaggta accaaacacc aaagagggag
     7501 tctgtcattt ttataaggct ggaagcgaat gttccttttc taccttaaca tacagtttag
     7561 ggggttgcac caagacaaag tttccaggct ggagggtaat acatatccag cgcgagtgaa
     7621 gtccccactc caacatatac cctttttggg tgggtaaaca cctctttgca tgtggacaga
     7681 aaatgtttat acttaaacag acatattttg catattttta tctggagact tcttctagtt
     7741 ttatactctt cccacatcta tgccaatgcc accattctaa aacttacact ccttttctac
     7801 ccctggtctt ttccttgtcc ttccctacaa cttggtagag gtccattttg tcttacttca
     7861 cacttttttt tttttaaata aaacacaaaa gtctacgtct tggtgtctta tccgtgagtg
     7921 ggaagtggta agctggtgat ggtcccatat ttgctatgac aggaacacag aggtggcagc
     7981 ttaggaagct ggggccacat ctcacaaggc aggacctgga tgcactgaat ccccctttgc
     8041 tccagcaact cagccagaca tttaggcagg agcactaatg accctttcca tccacacaga
     8101 gggtatggaa caggagcccc tgttgttccc ttgcctgtgg tctcttaagc cagtcatacc
     8161 tatcccaacg ccgtctcccc ctcaggtgtg tagaagggaa gatgaataca cagagtcttt
     8221 tgaatctcta tcaaatgtgg ttttttttat tcaacaactg acaagcactt ttctacagct
     8281 gcacttgtgg aacatcacat ggcaaaaaca ggagtttttt cgctagactt tttttttctt
     8341 tttaacctta ttaaaaatga gattggtcct aaaaatatag aaagaaataa atttaaattc
     8401 acaaaaaact gtacattatc aaaaagtcac taaaacacca catttggtta tataaaaagt
     8461 cccttttgct gtaaaaggaa cacagaaa
//
