LOCUS       NM_016836               4286 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens RNA binding motif single stranded interacting protein
            1 (RBMS1), transcript variant 1, mRNA.
ACCESSION   NM_016836 NM_016838
VERSION     NM_016836.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4286)
  AUTHORS   Sun,Y., Chen,D., Sun,S., Ren,M., Zhou,L., Chen,C., Zhao,J., Wei,H.,
            Zhao,Q., Qi,Y., Zhang,J., Zhang,G., Liu,H., Yang,Q., Liu,Q.,
            Wang,Y. and Zhang,W.
  TITLE     RBMS1 Coordinates with the m6A Reader YTHDF1 to Promote NSCLC
            Metastasis through Stimulating S100P Translation
  JOURNAL   Adv Sci (Weinh) 11 (15), e2307122 (2024)
   PUBMED   38342601
  REMARK    GeneRIF: RBMS1 Coordinates with the m[6]A Reader YTHDF1 to Promote
            NSCLC Metastasis through Stimulating S100P Translation.
REFERENCE   2  (bases 1 to 4286)
  AUTHORS   Silva,A.N.A., Nicchio,I.G., da Silva,B.R., Martelli,M.G.G.,
            Hidalgo,M.A.R., Nepomuceno,R., Theodoro,L.H., Cirelli,J.A.,
            Orrico,S.R.P., Cirelli,T., Barros,S.P. and Scarel-Caminaga,R.M.
  TITLE     Polymorphisms in risk genes of type 2 diabetes mellitus could be
            also markers of susceptibility to periodontitis
  JOURNAL   Arch Oral Biol 143, 105529 (2022)
   PUBMED   36058090
  REMARK    GeneRIF: Polymorphisms in risk genes of type 2 diabetes mellitus
            could be also markers of susceptibility to periodontitis.
REFERENCE   3  (bases 1 to 4286)
  AUTHORS   Jin,L., Zhang,Y., Jiang,Y., Tan,M. and Liu,C.
  TITLE     Circular RNA Rbms1 inhibited the development of myocardial ischemia
            reperfusion injury by regulating miR-92a/BCL2L11 signaling pathway
  JOURNAL   Bioengineered 13 (2), 3082-3092 (2022)
   PUBMED   35068339
  REMARK    GeneRIF: Circular RNA Rbms1 inhibited the development of myocardial
            ischemia reperfusion injury by regulating miR-92a/BCL2L11 signaling
            pathway.
REFERENCE   4  (bases 1 to 4286)
  AUTHORS   Zhang,W., Sun,Y., Bai,L., Zhi,L., Yang,Y., Zhao,Q., Chen,C., Qi,Y.,
            Gao,W., He,W., Wang,L., Chen,D., Fan,S., Chen,H., Piao,H.L.,
            Qiao,Q., Xu,Z., Zhang,J., Zhao,J., Zhang,S., Yin,Y., Peng,C.,
            Li,X., Liu,Q., Liu,H. and Wang,Y.
  TITLE     RBMS1 regulates lung cancer ferroptosis through translational
            control of SLC7A11
  JOURNAL   J Clin Invest 131 (22) (2021)
   PUBMED   34609966
  REMARK    GeneRIF: RBMS1 regulates lung cancer ferroptosis through
            translational control of SLC7A11.
REFERENCE   5  (bases 1 to 4286)
  AUTHORS   Aggarwal,P. and Bhavesh,N.S.
  TITLE     Hinge like domain motion facilitates human RBMS1 protein binding to
            proto-oncogene c-myc promoter
  JOURNAL   Nucleic Acids Res 49 (10), 5943-5955 (2021)
   PUBMED   33999211
  REMARK    GeneRIF: Hinge like domain motion facilitates human RBMS1 protein
            binding to proto-oncogene c-myc promoter.
REFERENCE   6  (bases 1 to 4286)
  AUTHORS   Niki,T., Galli,I., Ariga,H. and Iguchi-Ariga,S.M.
  TITLE     MSSP, a protein binding to an origin of replication in the c-myc
            gene, interacts with a catalytic subunit of DNA polymerase alpha
            and stimulates its polymerase activity
  JOURNAL   FEBS Lett 475 (3), 209-212 (2000)
   PUBMED   10869558
REFERENCE   7  (bases 1 to 4286)
  AUTHORS   Haigermoser,C., Fujimoto,M., Iguchi-Ariga,S.M. and Ariga,H.
  TITLE     Cloning and characterization of the genomic DNA of the human MSSP
            genes
  JOURNAL   Nucleic Acids Res 24 (19), 3846-3857 (1996)
   PUBMED   8871567
REFERENCE   8  (bases 1 to 4286)
  AUTHORS   Takai,T., Nishita,Y., Iguchi-Ariga,S.M. and Ariga,H.
  TITLE     Molecular cloning of MSSP-2, a c-myc gene single-strand binding
            protein: characterization of binding specificity and DNA
            replication activity
  JOURNAL   Nucleic Acids Res 22 (25), 5576-5581 (1994)
   PUBMED   7838710
REFERENCE   9  (bases 1 to 4286)
  AUTHORS   Kanaoka,Y. and Nojima,H.
  TITLE     SCR: novel human suppressors of cdc2/cdc13 mutants of
            Schizosaccharomyces pombe harbour motifs for RNA binding proteins
  JOURNAL   Nucleic Acids Res 22 (13), 2687-2693 (1994)
   PUBMED   8041632
REFERENCE   10 (bases 1 to 4286)
  AUTHORS   Negishi,Y., Nishita,Y., Saegusa,Y., Kakizaki,I., Galli,I.,
            Kihara,F., Tamai,K., Miyajima,N., Iguchi-Ariga,S.M. and Ariga,H.
  TITLE     Identification and cDNA cloning of single-stranded DNA binding
            proteins that interact with the region upstream of the human c-myc
            gene
  JOURNAL   Oncogene 9 (4), 1133-1143 (1994)
   PUBMED   8134115
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN296957.1, BC018951.2,
            CN399839.1, AI675628.1 and BC065192.1.
            
            On Nov 23, 2018 this sequence version replaced NM_016836.3.
            
            Summary: This gene encodes a member of a small family of proteins
            which bind single stranded DNA/RNA. These proteins are
            characterized by the presence of two sets of ribonucleoprotein
            consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and
            RNP2, originally described in RNA binding proteins, and required
            for DNA binding. These proteins have been implicated in such
            diverse functions as DNA replication, gene transcription, cell
            cycle progression and apoptosis. Several transcript variants,
            resulting from alternative splicing and encoding different
            isoforms, have been described. A pseudogene for this locus is found
            on chromosome 12. [provided by RefSeq, Feb 2009].
            
            Transcript Variant: This variant (1), also known as YC1 and MSSP-1,
            encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018951.2, ERR4352444.188017.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000348849.8/ ENSP00000294904.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-550               CN296957.1         19-568
            551-2436            BC018951.2         538-2423
            2437-2707           CN399839.1         275-545
            2708-2946           AI675628.1         1-239               c
            2947-4286           BC065192.1         208-1547
FEATURES             Location/Qualifiers
     source          1..4286
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q24.2"
     gene            1..4286
                     /gene="RBMS1"
                     /gene_synonym="C2orf12; HCC-4; MSSP; MSSP-1; MSSP-2;
                     MSSP-3; SCR2; YC1"
                     /note="RNA binding motif single stranded interacting
                     protein 1"
                     /db_xref="GeneID:5937"
                     /db_xref="HGNC:HGNC:9907"
                     /db_xref="MIM:602310"
     exon            1..519
                     /gene="RBMS1"
                     /gene_synonym="C2orf12; HCC-4; MSSP; MSSP-1; MSSP-2;
                     MSSP-3; SCR2; YC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             445..1665
                     /gene="RBMS1"
                     /gene_synonym="C2orf12; HCC-4; MSSP; MSSP-1; MSSP-2;
                     MSSP-3; SCR2; YC1"
                     /note="isoform a is encoded by transcript variant 1; c-myc
                     gene single strand binding protein 2; cervical cancer
                     oncogene 4; suppressor of cdc 2 (cdc13) with RNA binding
                     motif 2; single-stranded DNA-binding protein MSSP-1;
                     suppressor of CDC2 with RNA-binding motif 2"
                     /codon_start=1
                     /product="RNA-binding motif, single-stranded-interacting
                     protein 1 isoform a"
                     /protein_id="NP_058520.1"
                     /db_xref="CCDS:CCDS2213.1"
                     /db_xref="GeneID:5937"
                     /db_xref="HGNC:HGNC:9907"
                     /db_xref="MIM:602310"
                     /translation="MGKVWKQQMYPQYATYYYPQYLQAKQSLVPAHPMAPPSPSTTSS
                     NNNSSSSSNSGWDQLSKTNLYIRGLPPHTTDQDLVKLCQPYGKIVSTKAILDKTTNKC
                     KGYGFVDFDSPAAAQKAVSALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELENM
                     LKPFGQVISTRILRDSSGTSRGVGFARMESTEKCEAVIGHFNGKFIKTPPGVSAPTEP
                     LLCKFADGGQKKRQNPNKYIPNGRPWHREGEVRLAGMTLTYDPTTAAIQNGFYPSPYS
                     IATNRMITQTSITPYIASPVSAYQVQSPSWMQPQPYILQHPGAVLTPSMEHTMSLQPA
                     SMISPLAQQMSHLSLGSTGTYMPATSAMQGAYLPQYAHMQTTAVPVEEASGQQQVAVE
                     TSNDHSPYTFQPNK"
     exon            520..695
                     /gene="RBMS1"
                     /gene_synonym="C2orf12; HCC-4; MSSP; MSSP-1; MSSP-2;
                     MSSP-3; SCR2; YC1"
                     /inference="alignment:Splign:2.1.0"
     exon            696..754
                     /gene="RBMS1"
                     /gene_synonym="C2orf12; HCC-4; MSSP; MSSP-1; MSSP-2;
                     MSSP-3; SCR2; YC1"
                     /inference="alignment:Splign:2.1.0"
     exon            755..846
                     /gene="RBMS1"
                     /gene_synonym="C2orf12; HCC-4; MSSP; MSSP-1; MSSP-2;
                     MSSP-3; SCR2; YC1"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1004
                     /gene="RBMS1"
                     /gene_synonym="C2orf12; HCC-4; MSSP; MSSP-1; MSSP-2;
                     MSSP-3; SCR2; YC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1084
                     /gene="RBMS1"
                     /gene_synonym="C2orf12; HCC-4; MSSP; MSSP-1; MSSP-2;
                     MSSP-3; SCR2; YC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1200
                     /gene="RBMS1"
                     /gene_synonym="C2orf12; HCC-4; MSSP; MSSP-1; MSSP-2;
                     MSSP-3; SCR2; YC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1250
                     /gene="RBMS1"
                     /gene_synonym="C2orf12; HCC-4; MSSP; MSSP-1; MSSP-2;
                     MSSP-3; SCR2; YC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1344
                     /gene="RBMS1"
                     /gene_synonym="C2orf12; HCC-4; MSSP; MSSP-1; MSSP-2;
                     MSSP-3; SCR2; YC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1395
                     /gene="RBMS1"
                     /gene_synonym="C2orf12; HCC-4; MSSP; MSSP-1; MSSP-2;
                     MSSP-3; SCR2; YC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1506
                     /gene="RBMS1"
                     /gene_synonym="C2orf12; HCC-4; MSSP; MSSP-1; MSSP-2;
                     MSSP-3; SCR2; YC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1587
                     /gene="RBMS1"
                     /gene_synonym="C2orf12; HCC-4; MSSP; MSSP-1; MSSP-2;
                     MSSP-3; SCR2; YC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1672
                     /gene="RBMS1"
                     /gene_synonym="C2orf12; HCC-4; MSSP; MSSP-1; MSSP-2;
                     MSSP-3; SCR2; YC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..4286
                     /gene="RBMS1"
                     /gene_synonym="C2orf12; HCC-4; MSSP; MSSP-1; MSSP-2;
                     MSSP-3; SCR2; YC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4264..4269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBMS1"
                     /gene_synonym="C2orf12; HCC-4; MSSP; MSSP-1; MSSP-2;
                     MSSP-3; SCR2; YC1"
                     /note="hexamer: AATAAA"
     polyA_site      4286
                     /gene="RBMS1"
                     /gene_synonym="C2orf12; HCC-4; MSSP; MSSP-1; MSSP-2;
                     MSSP-3; SCR2; YC1"
                     /note="major polyA site"
ORIGIN      
        1 agatgccgcc tggcaccaag cgcagccgcc gctgccgcac tttccacttg tattgatcac
       61 ctctcagccc cgcgcagccg gctcgcccga gcggaccgcg gccagcgcgc cagcccttgg
      121 cagccccgga gcagtcgggc tccgggagga aactccttgg gagcgccctg tccggggtgc
      181 cctctgcgct ctgcagtgtc tttctttctg cctgggagga ggaggaggag gaggaagagg
      241 aggaggagga ggaggaggag gaggaagagg aggaggagga ggaggacgtc tggtcccggc
      301 tgggaggtgg agcagcggca gcagcagcag ccgccgccgc cgccgccgct gccgccgccg
      361 ccggaaaggg agaggcagga gagcccgaga cttggaaacc ccaaagtgtc cgcgaccctg
      421 cacggcaggc tcccttccag cttcatgggc aaagtgtgga aacagcagat gtaccctcag
      481 tacgccacct actattaccc ccagtatctg caagccaagc agtctctggt cccagcccac
      541 cccatggccc ctcccagtcc cagcaccacc agcagtaata acaacagtag cagcagtagc
      601 aactcaggat gggatcagct cagcaaaacg aacctctata tccgaggact gcctccccac
      661 accaccgacc aggacctggt gaagctctgt caaccatatg ggaaaatagt ctccacaaag
      721 gcaattttgg ataagacaac gaacaaatgc aaaggttatg gttttgtcga ctttgacagc
      781 cctgcagcag ctcaaaaagc tgtgtctgcc ctgaaggcca gtggggttca agctcaaatg
      841 gcaaagcaac aggaacaaga tcctaccaac ctctacattt ctaatttgcc actctccatg
      901 gatgagcaag aactagaaaa tatgctcaaa ccatttggac aagttatttc tacaaggata
      961 ctacgtgatt ccagtggtac aagtcgtggt gttggctttg ctaggatgga atcaacagaa
     1021 aaatgtgaag ctgttattgg tcattttaat ggaaaattta ttaagacacc accaggagtt
     1081 tctgccccca cagaaccttt attgtgtaag tttgctgatg gaggacagaa aaagagacag
     1141 aacccaaaca aatacatccc taatggaaga ccatggcata gagaaggaga ggtgagactt
     1201 gctggaatga cacttactta cgacccaact acagctgcta tacagaacgg attttatcct
     1261 tcaccataca gtattgctac aaaccgaatg atcactcaaa cttctattac accctatatt
     1321 gcatctcctg tatctgccta ccaggtgcaa agtccttcgt ggatgcaacc tcaaccatat
     1381 attctacagc accctggtgc cgtgttaact ccctcaatgg agcacaccat gtcactacag
     1441 cccgcatcaa tgatcagccc tctggcccag cagatgagtc atctgtcact aggcagcacc
     1501 ggaacataca tgcctgcaac gtcagctatg caaggagcct acttgccaca gtatgcacat
     1561 atgcagacga cagcggttcc tgttgaggag gcaagtggtc aacagcaggt ggctgtcgag
     1621 acgtctaatg accattctcc atataccttt caacctaata agtaactgtg agatgtacag
     1681 aaaggtgttc ttacatgaag aagggtgtga aggctgaaca atcatggatt tttctgatca
     1741 attgtgcttt aggaaattat tgacagtttt gcacaggttc ttgaaaacgt tatttataat
     1801 gaaatcaact aaaactattt ttgctataag ttctataagg tgcataaaac ccttaaattc
     1861 atctagtagc tgttcccccg aacaggttta ttttagtaaa aaaaaaaaaa caaaaaacaa
     1921 aaacaaaaga tttttatcaa atgttatgat gcaaaaaaag aaaaagaaaa aaaaaaagaa
     1981 aagaaaactt caattttctg ggtatgcaca aagaccatga agacttatcc aagtgcatga
     2041 ccggattttt gtggttttgt tcattttgtg tttaatttgt gttttttttt tccagctgta
     2101 tgaaatgggc tttctgaagt ttaaatagtc cgacttcacc catggtgttc tgtgcttgca
     2161 gtgcgagtgt tgctgtaatt cagtgttgcc gtcagtgtct cttttcttag ctttctgtct
     2221 ttctttcaac gtagtgtgaa gtgtcttatc cttttctatg aattccaatt tgccttaact
     2281 cttttgatgc tgtagctgtt tcagtaaaag ttagttcaaa ctaatgatgt agaatgcttt
     2341 gaccaaatga gctggtctat tatgccttgt aaaacagcag catagggctt ttaaaaggta
     2401 gtcaataaaa gttgctgaaa ttttggcttt tttaaatatg tagtaggtgt ttttaatgat
     2461 ttttcacata atgtgtaagg tagtgaaatg caagaaggga aaaatgtttt gtgtgaaaca
     2521 cattttctga ctggggaact tttattaggg taaattgttt gtaaggctgt acgccaacag
     2581 tttcctctga tagtttgact gatttaggat atctgctgta tgatgcaatg taaagtcttt
     2641 tttgcctttt ttcaggaaaa aaaaaaagct aacttgatgt actagattta gtgtaggtag
     2701 tgttggggtt ggggatgggg gtgggggagg ggagtcactg aatgttttgt ccttccttta
     2761 tactaatgat agtgctttag aatgagaatt atgcctgaaa tctggcaaac cgaaaaatgt
     2821 tgctattgca acaaagtggc aaaagctaaa agtaaggatt tatcttcaaa cataagctga
     2881 gataacgaat agaagcaaaa cgattggcta ctagctctct ctctctctct ctattaggta
     2941 aatttgaaaa ataaaaatga cttggcactt ttaaaggtaa cttcaccaaa gaccgaagag
     3001 ccagtaacca gtagctccaa cttgtctcag catcacatct tctgtgctct ttatttttgc
     3061 cggaccagtt tgcggttagg agaatgtgcc ttttttgtac ctttgcattt aggttttata
     3121 attttaattg atgtatggac acacacaaac aaaaaagcat gaaggaagat ttggatccaa
     3181 gcagtgccac actttacatc atcactacaa gtgttcaagt gtaaagaaaa ccaattttga
     3241 aactatgaaa ttcctgattc ataaatacac agttatttct actttagtac atataagata
     3301 attcactgtt attaaagctc ttttattaag gcaattgcat atgttttaaa agcaatggta
     3361 aattaagttg tcttccaaaa ctgtgtactt gtctggtcag ctgtgtatga tcagttatct
     3421 acctcagagt ctattttctt ttgtgctggg acaggttgct ggccctccct gtttccacag
     3481 accaaatcct cctagctcag gagctagggc taagcagtta tttctttcaa gtatttttta
     3541 gttcttaaat tttatgcttg tatttgatga tagatgtcag tgacatttca tagtttcaaa
     3601 agtccttgct gctctgagaa gtgtagattc tagtgaaaat tacatagtca taagagaaat
     3661 gtgtttttgt ttttgttttt gtttcatttt tttaaagttg tggtattatt ggttctatgc
     3721 tccctggaat attactgctt tgtgaaagtc cagactgaac gcagcaccct ctgtgtacct
     3781 agtacagtta taaacctggg tctctcacta cttgatattt ttgcattagt taagacagaa
     3841 atttgatagc tcggttagag gggaggggaa atctgctgct agaaatgtct gaactaagtg
     3901 ccatactcgt ctgggtaaga tttgggaaac ataacctctg tacataaaaa aaaaaaaatc
     3961 agttaaacat cacatagtag acagccatta aattataaaa aaattaattt atgaagaaag
     4021 accttttgta cagattgaaa aaaaaagatt ttcatagaga tatctatatg atcaagagag
     4081 ttaatttttt atttttgttt tactagtgcc acagacttgc cagtggtaac ttatttgtcc
     4141 ggttcaagat aactctgtag ttttctttcc taggacttgt tgttaaacgc caaaagacat
     4201 ttttgaactg tacatttgat cagattgtta gcttttctgt tttatttctt ttgagaacct
     4261 ttgaataaaa aacatctgaa atttta
//
