LOCUS       NM_005105               4909 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens RNA binding motif protein 8A (RBM8A), mRNA.
ACCESSION   NM_005105 NM_021618
VERSION     NM_005105.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4909)
  AUTHORS   Li,F., Wang,X., Zhang,J., Zhang,J., Jing,X., Jiang,Q., Zhou,J.,
            Cao,L., Peng,H., Tong,D. and Huang,C.
  TITLE     RBM8A, a new target of TEAD4, promotes breast cancer progression by
            regulating IGF1R and IRS-2
  JOURNAL   J Transl Med 22 (1), 823 (2024)
   PUBMED   39232805
  REMARK    GeneRIF: RBM8A, a new target of TEAD4, promotes breast cancer
            progression by regulating IGF1R and IRS-2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4909)
  AUTHORS   Song,T. and Zhang,H.
  TITLE     RBM8A Depletion Decreases the Cisplatin Resistance and Represses
            the Proliferation and Metastasis of Breast Cancer Cells via
            AKT/mTOR Pathway
  JOURNAL   Breast J 2022, 4576789 (2022)
   PUBMED   36105365
  REMARK    GeneRIF: RBM8A Depletion Decreases the Cisplatin Resistance and
            Represses the Proliferation and Metastasis of Breast Cancer Cells
            via AKT/mTOR Pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4909)
  AUTHORS   Monteiro,C., Goncalves,A., Oliveira,J., Salvado,R., Tomaz,J.,
            Morais,S., Lima,M. and Santos,R.
  TITLE     Thrombocytopenia-Absent Radius Syndrome: Descriptions of Three New
            Cases and a Novel Splicing Variant in RBM8A That Expands the
            Spectrum of Null Alleles
  JOURNAL   Int J Mol Sci 23 (17), 9621 (2022)
   PUBMED   36077017
  REMARK    GeneRIF: Thrombocytopenia-Absent Radius Syndrome: Descriptions of
            Three New Cases and a Novel Splicing Variant in RBM8A That Expands
            the Spectrum of Null Alleles.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4909)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 4909)
  AUTHORS   Abukar,A., Wipplinger,M., Hariharan,A., Sun,S., Ronner,M.,
            Sculco,M., Okonska,A., Kresoja-Rakic,J., Rehrauer,H., Qi,W.,
            Beusechem,V.W.V. and Felley-Bosco,E.
  TITLE     Double-Stranded RNA Structural Elements Holding the Key to
            Translational Regulation in Cancer: The Case of Editing in
            RNA-Binding Motif Protein 8A
  JOURNAL   Cells 10 (12), 3543 (2021)
   PUBMED   34944051
  REMARK    GeneRIF: Double-Stranded RNA Structural Elements Holding the Key to
            Translational Regulation in Cancer: The Case of Editing in
            RNA-Binding Motif Protein 8A.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4909)
  AUTHORS   Salicioni,A.M., Xi,M., Vanderveer,L.A., Balsara,B., Testa,J.R.,
            Dunbrack,R.L. Jr. and Godwin,A.K.
  TITLE     Identification and structural analysis of human RBM8A and RBM8B:
            two highly conserved RNA-binding motif proteins that interact with
            OVCA1, a candidate tumor suppressor
  JOURNAL   Genomics 69 (1), 54-62 (2000)
   PUBMED   11013075
REFERENCE   7  (bases 1 to 4909)
  AUTHORS   Conklin,D.C., Rixon,M.W., Kuestner,R.E., Maurer,M.F., Whitmore,T.E.
            and Millar,R.P.
  TITLE     Cloning and gene expression of a novel human ribonucleoprotein
  JOURNAL   Biochim Biophys Acta 1492 (2-3), 465-469 (2000)
   PUBMED   11004516
REFERENCE   8  (bases 1 to 4909)
  AUTHORS   Zhao,X.F., Nowak,N.J., Shows,T.B. and Aplan,P.D.
  TITLE     MAGOH interacts with a novel RNA-binding protein
  JOURNAL   Genomics 63 (1), 145-148 (2000)
   PUBMED   10662555
REFERENCE   9  (bases 1 to 4909)
  AUTHORS   Wilson,K.F., Fortes,P., Singh,U.S., Ohno,M., Mattaj,I.W. and
            Cerione,R.A.
  TITLE     The nuclear cap-binding complex is a novel target of growth factor
            receptor-coupled signal transduction
  JOURNAL   J Biol Chem 274 (7), 4166-4173 (1999)
   PUBMED   9933612
REFERENCE   10 (bases 1 to 4909)
  AUTHORS   Petit,F. and Boussion,S.
  TITLE     Thrombocytopenia Absent Radius Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301781
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB286556.1, AF127761.1,
            AC243547.1 and AI424454.1.
            
            On Dec 4, 2019 this sequence version replaced NM_005105.4.
            
            Summary: This gene encodes a protein with a conserved RNA-binding
            motif. The protein is found predominantly in the nucleus, although
            it is also present in the cytoplasm. It is preferentially
            associated with mRNAs produced by splicing, including both nuclear
            mRNAs and newly exported cytoplasmic mRNAs. It is thought that the
            protein remains associated with spliced mRNAs as a tag to indicate
            where introns had been present, thus coupling pre- and post-mRNA
            splicing events. Previously, it was thought that two genes encode
            this protein, RBM8A and RBM8B; it is now thought that the RBM8B
            locus is a pseudogene. There are two alternate translation start
            codons with this gene, which result in two forms of the protein. An
            allele mutation and a low-frequency noncoding single-nucleotide
            polymorphism (SNP) in this gene cause thrombocytopenia-absent
            radius (TAR) syndrome. [provided by RefSeq, Jul 2013].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC071577.1, SRR1803615.81506.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000583313.7/ ENSP00000463058.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                DB286556.1         53-98
            47-2816             AF127761.1         1-2770
            2817-4583           AC243547.1         111572-113338
            4584-4909           AI424454.1         14-339              c
FEATURES             Location/Qualifiers
     source          1..4909
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.1"
     gene            1..4909
                     /gene="RBM8A"
                     /gene_synonym="BOV-1A; BOV-1B; BOV-1C; C1DELq21.1;
                     DEL1q21.1; MDS014; RBM8; RBM8B; TAR; Y14; ZNRP; ZRNP1"
                     /note="RNA binding motif protein 8A"
                     /db_xref="GeneID:9939"
                     /db_xref="HGNC:HGNC:9905"
                     /db_xref="MIM:605313"
     exon            1..125
                     /gene="RBM8A"
                     /gene_synonym="BOV-1A; BOV-1B; BOV-1C; C1DELq21.1;
                     DEL1q21.1; MDS014; RBM8; RBM8B; TAR; Y14; ZNRP; ZRNP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..583
                     /gene="RBM8A"
                     /gene_synonym="BOV-1A; BOV-1B; BOV-1C; C1DELq21.1;
                     DEL1q21.1; MDS014; RBM8; RBM8B; TAR; Y14; ZNRP; ZRNP1"
                     /note="binder of OVCA1-1; ribonucleoprotein RBM8; RNA
                     binding motif protein 8B; BOV-1; RNA-binding protein Y14;
                     ribonucleoprotein RBM8A; exon junction complex core
                     component Y14"
                     /codon_start=1
                     /product="RNA-binding protein 8A"
                     /protein_id="NP_005096.1"
                     /db_xref="CCDS:CCDS72872.1"
                     /db_xref="GeneID:9939"
                     /db_xref="HGNC:HGNC:9905"
                     /db_xref="MIM:605313"
                     /translation="MADVLDLHEAGGEDFAMDEDGDESIHKLKEKAKKRKGRGFGSEE
                     GSRARMREDYDSVEQDGDEPGPQRSVEGWILFVTGVHEEATEEDIHDKFAEYGEIKNI
                     HLNLDRRTGYLKGYTLVEYETYKEAQAAMEGLNGQDLMGQPISVDWCFVRGPPKGKRR
                     GGRRRSRSPDRRRR"
     exon            126..185
                     /gene="RBM8A"
                     /gene_synonym="BOV-1A; BOV-1B; BOV-1C; C1DELq21.1;
                     DEL1q21.1; MDS014; RBM8; RBM8B; TAR; Y14; ZNRP; ZRNP1"
                     /inference="alignment:Splign:2.1.0"
     exon            186..263
                     /gene="RBM8A"
                     /gene_synonym="BOV-1A; BOV-1B; BOV-1C; C1DELq21.1;
                     DEL1q21.1; MDS014; RBM8; RBM8B; TAR; Y14; ZNRP; ZRNP1"
                     /inference="alignment:Splign:2.1.0"
     exon            264..400
                     /gene="RBM8A"
                     /gene_synonym="BOV-1A; BOV-1B; BOV-1C; C1DELq21.1;
                     DEL1q21.1; MDS014; RBM8; RBM8B; TAR; Y14; ZNRP; ZRNP1"
                     /inference="alignment:Splign:2.1.0"
     exon            401..537
                     /gene="RBM8A"
                     /gene_synonym="BOV-1A; BOV-1B; BOV-1C; C1DELq21.1;
                     DEL1q21.1; MDS014; RBM8; RBM8B; TAR; Y14; ZNRP; ZRNP1"
                     /inference="alignment:Splign:2.1.0"
     exon            538..4909
                     /gene="RBM8A"
                     /gene_synonym="BOV-1A; BOV-1B; BOV-1C; C1DELq21.1;
                     DEL1q21.1; MDS014; RBM8; RBM8B; TAR; Y14; ZNRP; ZRNP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      717..722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM8A"
                     /gene_synonym="BOV-1A; BOV-1B; BOV-1C; C1DELq21.1;
                     DEL1q21.1; MDS014; RBM8; RBM8B; TAR; Y14; ZNRP; ZRNP1"
                     /note="hexamer: AATAAA"
     polyA_site      744
                     /gene="RBM8A"
                     /gene_synonym="BOV-1A; BOV-1B; BOV-1C; C1DELq21.1;
                     DEL1q21.1; MDS014; RBM8; RBM8B; TAR; Y14; ZNRP; ZRNP1"
                     /note="major polyA site"
     regulatory      4886..4891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM8A"
                     /gene_synonym="BOV-1A; BOV-1B; BOV-1C; C1DELq21.1;
                     DEL1q21.1; MDS014; RBM8; RBM8B; TAR; Y14; ZNRP; ZRNP1"
                     /note="hexamer: AATAAA"
     polyA_site      4909
                     /gene="RBM8A"
                     /gene_synonym="BOV-1A; BOV-1B; BOV-1C; C1DELq21.1;
                     DEL1q21.1; MDS014; RBM8; RBM8B; TAR; Y14; ZNRP; ZRNP1"
                     /note="major polyA site"
ORIGIN      
        1 agtttcccga ggtacctagt gtctgagcgg cacagacgag atctcgatcg aaggcgagat
       61 ggcggacgtg ctagatcttc acgaggctgg gggcgaagat ttcgccatgg atgaggatgg
      121 ggacgagagc attcacaaac tgaaagaaaa agcgaagaaa cggaagggtc gcggctttgg
      181 ctccgaagag gggtcccgag cgcggatgcg tgaggattat gacagcgtgg agcaggatgg
      241 cgatgaaccc ggaccacaac gctctgttga aggctggatt ctctttgtaa ctggagtcca
      301 tgaggaagcc accgaagaag acatacacga caaattcgca gaatatgggg aaattaaaaa
      361 cattcatctc aacctcgaca ggcgaacagg atatctgaag gggtatactc tagttgaata
      421 tgaaacatac aaggaagccc aggctgctat ggagggactc aatggccagg atttgatggg
      481 acagcccatc agcgttgact ggtgttttgt tcggggtcca ccaaaaggca agaggagagg
      541 tggccgaaga cgcagcagaa gtccagaccg gagacgtcgc tgacaggtcc tctgttgtcc
      601 aggtgttctc ttcaagattc catttgacca tgcagccttg gacaaatagg actggggtgg
      661 aacttgctgt gtttatattt aatctcttac cgtatatgcg tagtatttga gttgcgaata
      721 aatgttccat ttttgttttc tacatttaat gttactttcc tgtcctaaaa ttgaaagttc
      781 taaagcatag caaggctgta tggatcattg tgaagatact tctagggact gaactctatg
      841 tatttctttt ttttcttttt tttgagatag agtcttgctg tgttacccag ggtggattgc
      901 agctgatcat agctcactgc agcttcaaac tcttgggctc aagccatcct tctgcctcac
      961 tgtccctagt agttgggatt acaggcacat gccaccatgc ccagctaaat ttttaatatt
     1021 tttgtagaga tggggtcttg ctgtgttacc tgggctagtt atgtgagttt ctatattaga
     1081 catagtctca agtttcaggt agggtttaaa gtagagacac tggtcagtat ttcttttttg
     1141 gggggaacta ggagagcagg agtagaagtg agatgttaag atcttatggc actaaagact
     1201 tactattctg ttcctacata ctctgttagg atcagataga tgttatagaa atgccttttg
     1261 tttctcctgc ccttcttgat gtcacagttt tttgtacttc cagctgtcta aaggcatgaa
     1321 tctcctcttg gagcattctc ccagaccctt ctttagaaga gtctatacta agttcttggt
     1381 gccctcttcg gcagccaagg gtgaaggccc catagaggag aggatccaaa ggagcattga
     1441 ggaggcccaa gaggaaaagg atgtggctca ggctgggagg gacttcagtt agcatggtgg
     1501 gggagaacca gtaccacata cccagtaggt aataaggtgt ccagcagagg atgaaggtca
     1561 gcaagataag cagggccagt ctcagggccc ggagacgaac acggggacaa ttgtcaaagg
     1621 agcgggggag ggcaaattca ccagcagggg ctaggaattt agaaaatata ctgtaattca
     1681 gacactcagc ttctgatctg agtatagggt gaattgatgg aggggcatag ctagtgagac
     1741 agagctcgcc tcctacaagg aggagaatgt tgcaaaccgt tttccccttc ccaacctggg
     1801 actatatgat ttcttacccc cagggattat gatagaaata tgaagccacc aagtctagac
     1861 ttgatggtgt tcaagaataa ataatactga ttgcctccct agtccttgtc cagctaactc
     1921 agctgtttat aattgaaggg attcaacaaa attatctcta gcatcaggtg ctagacatgg
     1981 ttagaatctc accatggttt agtgactggt agatagctat taggtaggta gataaataaa
     2041 tgatgctaga ggcaacaggt ctagggttaa ggattaaggc ctgggaattg gagtctcacc
     2101 atggctcccc ttccttgtct ggggcctgga cacactgagg acaatgcggc tatagcagat
     2161 ggccatggca gtcagtggca gcagaaagag gcagcagaag gtgaagaggt tataggtggt
     2221 ctcttgccat tgagccttga agctgccttt ggtgacacac tgagtgaaag ggactgggcc
     2281 agctcagtgg accgtgtgga acaggaacag ctggagtgga gttgaggact attagaactg
     2341 gttcccctca ccacccaacc tacccaccta tgtcatactg tctcctccca attcatcctt
     2401 aattccaagt gaagcagcac agtgctgaga aacagttcat ccatggtgcc atgttaaaga
     2461 agttggaaat atatcttgaa aatcctatct tccttttagg cttgaatatg atgctgaaca
     2521 gtaagtttgt taaatcttgg aacttaaaac aatcctgctt tctcaagtac tattctaaca
     2581 ttgcgcttta taagggatga tatttctacc acctcactca tatttttagc tgaaatgatt
     2641 ttcctggtat gtctgttatt ttgtggaaaa agaaatattg tgtaaaatgg gtgctgccaa
     2701 aattccaggc cattttgcag ggactctgaa gtgaccttta gtagtaatag tcttatgtgc
     2761 agtaactata atggtaaaga atgttaaata ataaaattta acattttcca aatgctattg
     2821 ggctgcccct cccccttttt gttaaattgc tgggttttcc aactgaatca gtaaaaacta
     2881 tttctgttta gagctacaag gttaaagtgc ctgctttcca gtaatggaga ttgagtcact
     2941 attaatttga taaaaggtaa gctcagtagg catcagattc ctagatacaa ggcatttggg
     3001 aaagtgattt tagcagacat gagggacatt taggaaagat gaatagtttc agcctaagag
     3061 aattttgtga actgtttgga gttacgatca ggctactctg agctagttgg gaaatggtct
     3121 ttcctcttcc catctcttgc attcatatat ttctaagttt ttttttttgt ttttgttttt
     3181 gtgctctgcc taagaagtgc ttgagaattg tgaggagtat aaaaatagtc aaagctggct
     3241 gggcgcggtg gctcacgcct gtaatcccag cactttggga ggctgaggcg ggcggatcac
     3301 gaggttagga gatggagacc atcctggcta acacagtgaa accctgtctg tactaaagat
     3361 acaaaaaact agccgggcgt ggtggtaggt gcctgtagtc ccagctactt gggaactcgg
     3421 gaggctgagg caggagaatg acctgaaccc aggaggcgga gcttgcagtg agcagagatt
     3481 gcgccattgc actccagcct gggcgacaga gtaagactgt ctccaaaaaa aaaaaaaata
     3541 ataatcaaag ctcttggatt tatagtttgg tccacagcct tgttttgatc tttcctttat
     3601 cctgttttat tgccatttac cacgtactgt agaaacatcc ctttcaactg ctgataactt
     3661 ggaaacaagc ctacaaaaat aagtaatttc taactactcc taatactacc tataactacc
     3721 cctaagccct taccactcta acgtgacatt attaaatttt ttattttatt aacactaata
     3781 ttttaactac aattacagca tatgggcaat acagaattta cctaaaagga tactaatttg
     3841 gaacaaaaaa aatcaccttt cgcacatgta tcatgtcaca accagtttgc cattgaaaca
     3901 aatagaggtt gcaaatattg tcagattgtc aggctgtaag aaaggatgaa attcatttcc
     3961 cattgcatca tcttgtggcc catggatttc aagtgcctta gccaaaatca tatagctagt
     4021 tagcagtaga gccgagactc agaaaaaaac aaagtaaaac aggcagactg aaacaaaaag
     4081 tcttctaatt cccagtccac atgtaaaatt tgcttcatat aaacaaacct aattgtaaat
     4141 ggcactgtag caacaggctt ctttttaaca cttggattgg taaaggtctt gtttgcaaca
     4201 tattagaagt attatttttc tctttccccc ccaccccacc cccaacagag tctggctctg
     4261 ccgcccacgc cggagtgcag tggtgcagtc ttggctcact gcagcctcca cttcccaggt
     4321 tcaagcaatt ctcgtgcctc agcctcctga gtagttggga ttacaggtgc tcaccactat
     4381 acccggctaa tttttgtatt tttagtagag atggggtttc gtcatgttgg ccaggttggt
     4441 cttaaactcc tgacctcaag tgatccaccc accttggcct tccaaaatgc tgggattaca
     4501 ggcttgagcc accaggcctt tctttgttct taggagtata gtcagactaa cttctagtag
     4561 ttatatttct aataattgag gatgtaagta aggatcaaat cttaaatcag tataatgcat
     4621 tgtcattcca gagataaatc ctagaccctt cttggcctcc ttctgacata attctaatcc
     4681 tacagtctca gagatgctgt tgtatcctgc cccccaaccc catgatagtg atagtggttt
     4741 ttgccttgaa ggaattgctt tgtatttagc ttttccccct ctagatttct agttcctttt
     4801 cagtattgga ttggatttga gatttgatta acctagtact caggttcaga tgctcgcctc
     4861 tttgcaattt taacactcat tcgacaataa agtcagtaaa aaacacaaa
//
