LOCUS       NM_001286048            3359 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens RNA binding motif protein 7 (RBM7), transcript variant
            5, mRNA.
ACCESSION   NM_001286048
VERSION     NM_001286048.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3359)
  AUTHORS   Fukushima,K. and Akira,S.
  TITLE     Novel insights into the pathogenesis of lung fibrosis: the
            RBM7-NEAT1-CXCL12-SatM axis at fibrosis onset
  JOURNAL   Int Immunol 33 (12), 659-663 (2021)
   PUBMED   34165514
  REMARK    GeneRIF: Novel insights into the pathogenesis of lung fibrosis: the
            RBM7-NEAT1-CXCL12-SatM axis at fibrosis onset.
            Review article
REFERENCE   2  (bases 1 to 3359)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3359)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3359)
  AUTHORS   Bugai,A., Quaresma,A.J.C., Friedel,C.C., Lenasi,T., Duster,R.,
            Sibley,C.R., Fujinaga,K., Kukanja,P., Hennig,T., Blasius,M.,
            Geyer,M., Ule,J., Dolken,L. and Barboric,M.
  TITLE     P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional
            Response to Genotoxic Stress
  JOURNAL   Mol Cell 74 (2), 254-267 (2019)
   PUBMED   30824372
  REMARK    GeneRIF: interfering with the axis of RBM7 and P-TEFb provokes
            cellular hypersensitivity to DNA-damage-inducing agents due to
            activation of apoptosis. Our work uncovers the importance of
            stress-dependent stimulation of Pol II pause release, which enables
            a pro-survival transcriptional response that is crucial for cell
            fate upon genotoxic insult.
REFERENCE   5  (bases 1 to 3359)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 3359)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 3359)
  AUTHORS   Hegele,A., Kamburov,A., Grossmann,A., Sourlis,C., Wowro,S.,
            Weimann,M., Will,C.L., Pena,V., Luhrmann,R. and Stelzl,U.
  TITLE     Dynamic protein-protein interaction wiring of the human spliceosome
  JOURNAL   Mol Cell 45 (4), 567-580 (2012)
   PUBMED   22365833
REFERENCE   8  (bases 1 to 3359)
  AUTHORS   Lubas,M., Christensen,M.S., Kristiansen,M.S., Domanski,M.,
            Falkenby,L.G., Lykke-Andersen,S., Andersen,J.S., Dziembowski,A. and
            Jensen,T.H.
  TITLE     Interaction profiling identifies the human nuclear exosome
            targeting complex
  JOURNAL   Mol Cell 43 (4), 624-637 (2011)
   PUBMED   21855801
REFERENCE   9  (bases 1 to 3359)
  AUTHORS   Gustafson,M.P., Welcker,M., Hwang,H.C. and Clurman,B.E.
  TITLE     Zcchc8 is a glycogen synthase kinase-3 substrate that interacts
            with RNA-binding proteins
  JOURNAL   Biochem Biophys Res Commun 338 (3), 1359-1367 (2005)
   PUBMED   16263084
REFERENCE   10 (bases 1 to 3359)
  AUTHORS   Guo,T.B., Boros,L.G., Chan,K.C., Hikim,A.P., Hudson,A.P.,
            Swerdloff,R.S., Mitchell,A.P. and Salameh,W.A.
  TITLE     Spermatogenetic expression of RNA-binding motif protein 7, a
            protein that interacts with splicing factors
  JOURNAL   J Androl 24 (2), 204-214 (2003)
   PUBMED   12634307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA027521.1, BQ067937.1, BC034381.1 and AP002373.3.
            
            On Jun 2, 2019 this sequence version replaced NM_001286048.1.
            
            Transcript Variant: This variant (5) lacks two alternate exons in
            the 5' region and initiates translation at a downstream in-frame
            start codon, compared to variant 1. The encoded isoform (c) has a
            shorter N-terminus than isoform a. Variants 3, 4, and 5 encode the
            same isoform (c).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.26535.1,
                                           SRR1163655.239917.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DA027521.1         138-150
            14-632              BQ067937.1         20-638
            633-1665            BC034381.1         885-1917
            1666-3359           AP002373.3         44415-46108
FEATURES             Location/Qualifiers
     source          1..3359
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.2"
     gene            1..3359
                     /gene="RBM7"
                     /note="RNA binding motif protein 7"
                     /db_xref="GeneID:10179"
                     /db_xref="HGNC:HGNC:9904"
                     /db_xref="MIM:612413"
     exon            1..102
                     /gene="RBM7"
                     /inference="alignment:Splign:2.1.0"
     exon            103..196
                     /gene="RBM7"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..559
                     /gene="RBM7"
                     /note="isoform c is encoded by transcript variant 5;
                     RNA-binding protein 7"
                     /codon_start=1
                     /product="RNA-binding protein 7 isoform c"
                     /protein_id="NP_001272977.1"
                     /db_xref="CCDS:CCDS73395.1"
                     /db_xref="GeneID:10179"
                     /db_xref="HGNC:HGNC:9904"
                     /db_xref="MIM:612413"
                     /translation="MDNMTSSAQIIQRSFSSPENFQRQAVMNSALRQMSYGGKFGSSP
                     LDQSGFSPSVQSHSHSFNQSSSSQWRQGTPSSQRKVRMNSYPYLADRHYSREQRYTDH
                     GSDHHYRGKRDDFFYEDRNHDDWSHDYDNRRDSSRDGKWRSSRH"
     exon            197..3359
                     /gene="RBM7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1642..1647
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM7"
                     /note="hexamer: AATATA"
     polyA_site      1665
                     /gene="RBM7"
                     /note="major polyA site"
     regulatory      2987..2992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM7"
                     /note="hexamer: AAGAAA"
     polyA_site      3017
                     /gene="RBM7"
     regulatory      3139..3144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM7"
                     /note="hexamer: AATAAA"
     polyA_site      3164
                     /gene="RBM7"
     regulatory      3337..3342
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM7"
                     /note="hexamer: AATAAA"
     polyA_site      3359
                     /gene="RBM7"
ORIGIN      
        1 gctgagatgg gggcggcggc ggcggaagcg gatcgcactc tctttgtggg caaccttgaa
       61 acgaaagtga ccgaggagct ccttttcgag cttttccacc agcaggtacg aaaggactat
      121 ggataacatg acttcatcag cacagataat tcagagatct ttctcttctc cagaaaattt
      181 tcagagacaa gcagtgatga acagtgcttt gagacaaatg tcatatggtg gaaaatttgg
      241 ttcttcacct ctggatcaat caggattttc accatcagtt caatcacaca gtcatagttt
      301 caatcagtct tcaagctccc agtggcgcca aggtacacca tcatcacagc gtaaagtcag
      361 aatgaattct tatccctacc tagcagatag acattatagc cgggaacagc gttacactga
      421 tcatgggtct gaccatcatt acagaggaaa gagagatgat ttcttctatg aagacaggaa
      481 tcatgatgac tggagccatg actatgataa cagaagagac agtagtagag atggaaaatg
      541 gcgctcatct cgacactaac acatgttaaa aggacattgt ttttataggg tcattttagg
      601 ccctttgact aagttgatat ggaaatattt tgttgaaaaa ctgtacagag cagctttaca
      661 agttgtcaca tttctttata aattttttta aagctacagt ttaatacaaa atgaattgcg
      721 gttttattac attaataacc tttcacctca gggttttatg aagaggaaag ggttttatgc
      781 aaaagaaagt gctacaattc ctaatcattt tagacacttt aggagggggt gaagttgtat
      841 gataaagcag atattttaat tatttgttat ctttttgtat tgcaagaaat ttcttgctag
      901 tgaatcaaga aaacatccag gttgacagtc taaaatggct actggtattt tagttaattc
      961 aaaaatgaaa cttttcagtg attcacttta ctaacattct atttgagaag gcttattggt
     1021 aaagtttggg gataaaggca ttgcttaact tcttatataa tttaggtata aattctgtga
     1081 catgctcttg agctttaccc tagttgaaca tacatgtgta gatttacaca tactgtttca
     1141 ttctaaaatt tagaaattgt tcattaaatc ccatttgagg tataagtcac tcaggaagtt
     1201 aaaatatctc tacacgtata tttttacatt aaaaatacag tgttagcata aatccccttt
     1261 tcaggaagaa caaaaatgtc agtgcatagt tagataaaat ggtaaaatgt tttactgaaa
     1321 gcatactttt ttggaaaata gattcatgaa gcctttaagt gctgcttctg tcagtcaaac
     1381 gttaaaaact ttaacatttt caaagtgccc agactgtgta caaagacaca tgtaatggag
     1441 attgtacagg ttgttttttt gtttgaacct ttgaaagagt ttaatcttaa cgttttctaa
     1501 ttttaaaatt ttaaaatctt gtttaacaaa agcttgtatt aagatactgt tttcatttca
     1561 ttacagaatt gtttataaaa gttcatttgt tgaaaaataa ggatcctttt taataccaca
     1621 gcatttgtac tgttcctttt taatatactg aaaatataaa aggaagggtg tgtgttattt
     1681 tttttttttt atgtcactga cttcagagac attgtacaca aagaattaac atacttttat
     1741 tcactgattg cctgctgttt agaatatcag ttctttaatt ttgagcatcc tgaaatacat
     1801 cttttgtaca tatagagcat gatgtttcac aatcagattt tcagtgaccc ctcgattata
     1861 gcttggagta ctttagttac cctcagtggt ctctaggagt taaagtacac ttagatttcc
     1921 tgtttataaa tgaattcagt ttttctgttt ctaagtaaat gtagctattc aactactcac
     1981 tatagaatta agataaacaa tttgtttgct taagcatttt cacagaattt gtttccaatg
     2041 agattattat ttttgggtat cttatccata tgaaaactta gtaggtttgt agatgttaac
     2101 gaagattaat actgcatgtt tgtttttgtt ttttttttga gacagagtct tgctacgaca
     2161 cccaggctag agtgcaatgg cgggatctca ggtcactgca acctccatat cccgggttca
     2221 agtgattctc ctgccttagc ctcccgagta gctgggatta caggcaccca ccaccacgcc
     2281 tggctagttt ttgtattttt agtagagatg gggtttcacc acattggcca ggctggtctc
     2341 aaactcctga cctcaagtga tccacctacc ttggcctacc gaggtgctgg aattacaggt
     2401 gtgagccacc gcgcctggcc taatactgct ttattacaac gttatctgtg ggtcggatcc
     2461 ttttatattg gttaacagat gaccctgact cagaataatc tttttcaatg gctttttgag
     2521 ggaagcttgt gaagttctgg tgaatcttct ttttcacttc actttcagtg agctgaaagt
     2581 aaccaaacta aatacatgta ttgtgtaaag ggacaggaca agacagcctt aaaaaattga
     2641 atatagttgg tgagacaact cagaagtaca ggtttgagca tcccttattc aaaatgcttg
     2701 agaagtgttt tgggttctgg aatatttgca ttaatgcttg ccagttgagc atcccaggtc
     2761 cggaaatcca cagtgctcca atgagccttt cccctgagtg tcacatctgt attggcactc
     2821 aaaaagtttc atattttgga gcatttcaga tttcagattt gggatgcttc atctatattg
     2881 acagctgcaa gaacagaaag gaagaagaga ttatttttgt gggagaacag tttctcccat
     2941 agtgtttcct gtggaatgct agtgtctcat aaagtcttct aaaaaaaaga aaaaaaaaat
     3001 caaatgtttg gaagccattt tgtgttactg tgtgactttc ttttactcaa aaacagcacc
     3061 ataaaatttc tgacaagtac tataggtaaa gaaatccctt tatacttaac ctagtatttt
     3121 ctacctttcc ccatctaaaa taaaattttt ataccacttt ctaattatgt tgtgtgtgcc
     3181 cactttcccc atacctactg ctaccatctt agagtaggca attttctcaa gaggattatt
     3241 ccaagaacac cctaatgttt tcctgcttcc agtcttcttt cctcaaattt attccacact
     3301 cttaagaatt gaagatgtaa atctgtcact cgcctgaata aagcttcagt ggcctctga
//
