LOCUS       NM_001286045            3610 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens RNA binding motif protein 7 (RBM7), transcript variant
            1, mRNA.
ACCESSION   NM_001286045 XM_005271377
VERSION     NM_001286045.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3610)
  AUTHORS   Fukushima,K. and Akira,S.
  TITLE     Novel insights into the pathogenesis of lung fibrosis: the
            RBM7-NEAT1-CXCL12-SatM axis at fibrosis onset
  JOURNAL   Int Immunol 33 (12), 659-663 (2021)
   PUBMED   34165514
  REMARK    GeneRIF: Novel insights into the pathogenesis of lung fibrosis: the
            RBM7-NEAT1-CXCL12-SatM axis at fibrosis onset.
            Review article
REFERENCE   2  (bases 1 to 3610)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3610)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3610)
  AUTHORS   Bugai,A., Quaresma,A.J.C., Friedel,C.C., Lenasi,T., Duster,R.,
            Sibley,C.R., Fujinaga,K., Kukanja,P., Hennig,T., Blasius,M.,
            Geyer,M., Ule,J., Dolken,L. and Barboric,M.
  TITLE     P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional
            Response to Genotoxic Stress
  JOURNAL   Mol Cell 74 (2), 254-267 (2019)
   PUBMED   30824372
  REMARK    GeneRIF: interfering with the axis of RBM7 and P-TEFb provokes
            cellular hypersensitivity to DNA-damage-inducing agents due to
            activation of apoptosis. Our work uncovers the importance of
            stress-dependent stimulation of Pol II pause release, which enables
            a pro-survival transcriptional response that is crucial for cell
            fate upon genotoxic insult.
REFERENCE   5  (bases 1 to 3610)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 3610)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 3610)
  AUTHORS   Hegele,A., Kamburov,A., Grossmann,A., Sourlis,C., Wowro,S.,
            Weimann,M., Will,C.L., Pena,V., Luhrmann,R. and Stelzl,U.
  TITLE     Dynamic protein-protein interaction wiring of the human spliceosome
  JOURNAL   Mol Cell 45 (4), 567-580 (2012)
   PUBMED   22365833
REFERENCE   8  (bases 1 to 3610)
  AUTHORS   Lubas,M., Christensen,M.S., Kristiansen,M.S., Domanski,M.,
            Falkenby,L.G., Lykke-Andersen,S., Andersen,J.S., Dziembowski,A. and
            Jensen,T.H.
  TITLE     Interaction profiling identifies the human nuclear exosome
            targeting complex
  JOURNAL   Mol Cell 43 (4), 624-637 (2011)
   PUBMED   21855801
REFERENCE   9  (bases 1 to 3610)
  AUTHORS   Gustafson,M.P., Welcker,M., Hwang,H.C. and Clurman,B.E.
  TITLE     Zcchc8 is a glycogen synthase kinase-3 substrate that interacts
            with RNA-binding proteins
  JOURNAL   Biochem Biophys Res Commun 338 (3), 1359-1367 (2005)
   PUBMED   16263084
REFERENCE   10 (bases 1 to 3610)
  AUTHORS   Guo,T.B., Boros,L.G., Chan,K.C., Hikim,A.P., Hudson,A.P.,
            Swerdloff,R.S., Mitchell,A.P. and Salameh,W.A.
  TITLE     Spermatogenetic expression of RNA-binding motif protein 7, a
            protein that interacts with splicing factors
  JOURNAL   J Androl 24 (2), 204-214 (2003)
   PUBMED   12634307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK002015.1, AK225615.1 and AP002373.3.
            
            On May 21, 2020 this sequence version replaced NM_001286045.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.272500.1, AK002015.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375490.10/ ENSP00000364639.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-309               AK002015.1         51-359
            310-924             AK225615.1         313-927
            925-1927            AK002015.1         975-1977
            1928-3610           AP002373.3         44426-46108
FEATURES             Location/Qualifiers
     source          1..3610
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.2"
     gene            1..3610
                     /gene="RBM7"
                     /note="RNA binding motif protein 7"
                     /db_xref="GeneID:10179"
                     /db_xref="HGNC:HGNC:9904"
                     /db_xref="MIM:612413"
     exon            1..102
                     /gene="RBM7"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..810
                     /gene="RBM7"
                     /note="isoform a is encoded by transcript variant 1;
                     RNA-binding protein 7"
                     /codon_start=1
                     /product="RNA-binding protein 7 isoform a"
                     /protein_id="NP_001272974.1"
                     /db_xref="CCDS:CCDS66233.1"
                     /db_xref="GeneID:10179"
                     /db_xref="HGNC:HGNC:9904"
                     /db_xref="MIM:612413"
                     /translation="MGAAAAEADRTLFVGNLETKVTEELLFELFHQAGPVIKVKIPKD
                     KDGKPKQFAFVNFKHEVSVPYAMNLLNGIKLYGRPIKIQFRSGSSHAPQDVSLSYPQH
                     HVGNSSPTSTSPSSRYERTMDNMTSSAQIIQRSFSSPENFQRQAVMNSALRQMSYGGK
                     FGSSPLDQSGFSPSVQSHSHSFNQSSSSQWRQGTPSSQRKVRMNSYPYLADRHYSREQ
                     RYTDHGSDHHYRGKRDDFFYEDRNHDDWSHDYDNRRDSSRDGKWRSSRH"
     exon            103..265
                     /gene="RBM7"
                     /inference="alignment:Splign:2.1.0"
     exon            266..353
                     /gene="RBM7"
                     /inference="alignment:Splign:2.1.0"
     exon            354..447
                     /gene="RBM7"
                     /inference="alignment:Splign:2.1.0"
     exon            448..3610
                     /gene="RBM7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1893..1898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM7"
                     /note="hexamer: AATATA"
     polyA_site      1916
                     /gene="RBM7"
                     /note="major polyA site"
     regulatory      3238..3243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM7"
                     /note="hexamer: AAGAAA"
     polyA_site      3268
                     /gene="RBM7"
     regulatory      3390..3395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM7"
                     /note="hexamer: AATAAA"
     polyA_site      3415
                     /gene="RBM7"
     regulatory      3588..3593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM7"
                     /note="hexamer: AATAAA"
     polyA_site      3610
                     /gene="RBM7"
ORIGIN      
        1 gctgagatgg gggcggcggc ggcggaagcg gatcgcactc tctttgtggg caaccttgaa
       61 acgaaagtga ccgaggagct ccttttcgag cttttccacc aggctgggcc agtaataaag
      121 gtgaaaattc caaaagataa ggatggtaaa ccaaagcagt ttgcgtttgt gaatttcaaa
      181 catgaagtgt ctgttcctta tgcaatgaat ctacttaatg gaatcaaact ttatggaagg
      241 cctatcaaaa ttcaatttag atcaggaagt agtcatgccc cacaagatgt cagtttgtca
      301 tatccccaac atcatgttgg aaattcaagc cctacctcca catctcctag cagcaggtac
      361 gaaaggacta tggataacat gacttcatca gcacagataa ttcagagatc tttctcttct
      421 ccagaaaatt ttcagagaca agcagtgatg aacagtgctt tgagacaaat gtcatatggt
      481 ggaaaatttg gttcttcacc tctggatcaa tcaggatttt caccatcagt tcaatcacac
      541 agtcatagtt tcaatcagtc ttcaagctcc cagtggcgcc aaggtacacc atcatcacag
      601 cgtaaagtca gaatgaattc ttatccctac ctagcagata gacattatag ccgggaacag
      661 cgttacactg atcatgggtc tgaccatcat tacagaggaa agagagatga tttcttctat
      721 gaagacagga atcatgatga ctggagccat gactatgata acagaagaga cagtagtaga
      781 gatggaaaat ggcgctcatc tcgacactaa cacatgttaa aaggacattg tttttatagg
      841 gtcattttag gccctttgac taagttgata tggaaatatt ttgttgaaaa actgtacaga
      901 gcagctttac aagttgtcac atttctttat aaattttttt aaagctacag tttaatacaa
      961 aatgaattgc ggttttatta cattaataac ctttcacctc agggttttat gaagaggaaa
     1021 gggttttatg caaaagaaag tgctacaatt cctaatcatt ttagacactt taggaggggg
     1081 tgaagttgta tgataaagca gatattttaa ttatttgtta tctttttgta ttgcaagaaa
     1141 tttcttgcta gtgaatcaag aaaacatcca ggttgacagt ctaaaatggc tactggtatt
     1201 ttagttaatt caaaaatgaa acttttcagt gattcacttt actaacattc tatttgagaa
     1261 ggcttattgg taaagtttgg ggataaaggc attgcttaac ttcttatata atttaggtat
     1321 aaattctgtg acatgctctt gagctttacc ctagttgaac atacatgtgt agatttacac
     1381 atactgtttc attctaaaat ttagaaattg ttcattaaat cccatttgag gtataagtca
     1441 ctcaggaagt taaaatatct ctacacgtat atttttacat taaaaataca gtgttagcat
     1501 aaatcccctt ttcaggaaga acaaaaatgt cagtgcatag ttagataaaa tggtaaaatg
     1561 ttttactgaa agcatacttt tttggaaaat agattcatga agcctttaag tgctgcttct
     1621 gtcagtcaaa cgttaaaaac tttaacattt tcaaagtgcc cagactgtgt acaaagacac
     1681 atgtaatgga gattgtacag gttgtttttt tgtttgaacc tttgaaagag tttaatctta
     1741 acgttttcta attttaaaat tttaaaatct tgtttaacaa aagcttgtat taagatactg
     1801 ttttcatttc attacagaat tgtttataaa agttcatttg ttgaaaaata aggatccttt
     1861 ttaataccac agcatttgta ctgttccttt ttaatatact gaaaatataa aaggaagggt
     1921 gtgtgttatt tttttttttt tatgtcactg acttcagaga cattgtacac aaagaattaa
     1981 catactttta ttcactgatt gcctgctgtt tagaatatca gttctttaat tttgagcatc
     2041 ctgaaataca tcttttgtac atatagagca tgatgtttca caatcagatt ttcagtgacc
     2101 cctcgattat agcttggagt actttagtta ccctcagtgg tctctaggag ttaaagtaca
     2161 cttagatttc ctgtttataa atgaattcag tttttctgtt tctaagtaaa tgtagctatt
     2221 caactactca ctatagaatt aagataaaca atttgtttgc ttaagcattt tcacagaatt
     2281 tgtttccaat gagattatta tttttgggta tcttatccat atgaaaactt agtaggtttg
     2341 tagatgttaa cgaagattaa tactgcatgt ttgtttttgt tttttttttg agacagagtc
     2401 ttgctacgac acccaggcta gagtgcaatg gcgggatctc aggtcactgc aacctccata
     2461 tcccgggttc aagtgattct cctgccttag cctcccgagt agctgggatt acaggcaccc
     2521 accaccacgc ctggctagtt tttgtatttt tagtagagat ggggtttcac cacattggcc
     2581 aggctggtct caaactcctg acctcaagtg atccacctac cttggcctac cgaggtgctg
     2641 gaattacagg tgtgagccac cgcgcctggc ctaatactgc tttattacaa cgttatctgt
     2701 gggtcggatc cttttatatt ggttaacaga tgaccctgac tcagaataat ctttttcaat
     2761 ggctttttga gggaagcttg tgaagttctg gtgaatcttc tttttcactt cactttcagt
     2821 gagctgaaag taaccaaact aaatacatgt attgtgtaaa gggacaggac aagacagcct
     2881 taaaaaattg aatatagttg gtgagacaac tcagaagtac aggtttgagc atcccttatt
     2941 caaaatgctt gagaagtgtt ttgggttctg gaatatttgc attaatgctt gccagttgag
     3001 catcccaggt ccggaaatcc acagtgctcc aatgagcctt tcccctgagt gtcacatctg
     3061 tattggcact caaaaagttt catattttgg agcatttcag atttcagatt tgggatgctt
     3121 catctatatt gacagctgca agaacagaaa ggaagaagag attatttttg tgggagaaca
     3181 gtttctccca tagtgtttcc tgtggaatgc tagtgtctca taaagtcttc taaaaaaaag
     3241 aaaaaaaaaa tcaaatgttt ggaagccatt ttgtgttact gtgtgacttt cttttactca
     3301 aaaacagcac cataaaattt ctgacaagta ctataggtaa agaaatccct ttatacttaa
     3361 cctagtattt tctacctttc cccatctaaa ataaaatttt tataccactt tctaattatg
     3421 ttgtgtgtgc ccactttccc catacctact gctaccatct tagagtaggc aattttctca
     3481 agaggattat tccaagaaca ccctaatgtt ttcctgcttc cagtcttctt tcctcaaatt
     3541 tattccacac tcttaagaat tgaagatgta aatctgtcac tcgcctgaat aaagcttcag
     3601 tggcctctga
//
