LOCUS       NM_005777               3630 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens RNA binding motif protein 6 (RBM6), transcript variant
            1, mRNA.
ACCESSION   NM_005777
VERSION     NM_005777.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3630)
  AUTHORS   Machour,F.E., Abu-Zhayia,E.R., Awwad,S.W., Bidany-Mizrahi,T.,
            Meinke,S., Bishara,L.A., Heyd,F., Aqeilan,R.I. and Ayoub,N.
  TITLE     RBM6 splicing factor promotes homologous recombination repair of
            double-strand breaks and modulates sensitivity to chemotherapeutic
            drugs
  JOURNAL   Nucleic Acids Res 49 (20), 11708-11727 (2021)
   PUBMED   34718714
  REMARK    GeneRIF: RBM6 splicing factor promotes homologous recombination
            repair of double-strand breaks and modulates sensitivity to
            chemotherapeutic drugs.
REFERENCE   2  (bases 1 to 3630)
  AUTHORS   Ye,Z., Zhang,J., Yang,Y., Wei,Y., Li,L. and Wang,X.
  TITLE     RNA-binding protein RBM6 acts as a tumor suppressor gene to inhibit
            the progression of hepatocellular carcinoma
  JOURNAL   J BUON 26 (2), 402-408 (2021)
   PUBMED   34076986
  REMARK    GeneRIF: RNA-binding protein RBM6 acts as a tumor suppressor gene
            to inhibit the progression of hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 3630)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3630)
  AUTHORS   Duan,B., Hu,X., Fan,M., Xiong,X., Han,L., Wang,Z., Tong,D., Liu,L.,
            Wang,X., Li,W., Yang,J. and Huang,C.
  TITLE     RNA-Binding Motif Protein 6 is a Candidate Serum Biomarker for
            Pancreatic Cancer
  JOURNAL   Proteomics Clin Appl 13 (5), e1900048 (2019)
   PUBMED   31207145
  REMARK    GeneRIF: RNA-Binding Motif Protein 6 is a Candidate Serum Biomarker
            for Pancreatic Cancer
REFERENCE   5  (bases 1 to 3630)
  AUTHORS   Wang,Q., Wang,F., Zhong,W., Ling,H., Wang,J., Cui,J., Xie,T.,
            Wen,S. and Chen,J.
  TITLE     RNA-binding protein RBM6 as a tumor suppressor gene represses the
            growth and progression in laryngocarcinoma
  JOURNAL   Gene 697, 26-34 (2019)
   PUBMED   30772516
  REMARK    GeneRIF: Upregulation of RBM6 reduced the expression of EGFR, ERK
            and p-ERK in vitro and in vivo. Data suggest that RBM6 as a tumor
            suppressor represses the growth and progression in
            laryngocarcinoma.
REFERENCE   6  (bases 1 to 3630)
  AUTHORS   Lerman,M.I. and Minna,J.D.
  TITLE     The 630-kb lung cancer homozygous deletion region on human
            chromosome 3p21.3: identification and evaluation of the resident
            candidate tumor suppressor genes. The International Lung Cancer
            Chromosome 3p21.3 Tumor Suppressor Gene Consortium
  JOURNAL   Cancer Res 60 (21), 6116-6133 (2000)
   PUBMED   11085536
REFERENCE   7  (bases 1 to 3630)
  AUTHORS   Timmer,T., Terpstra,P., van den Berg,A., Veldhuis,P.M., Ter
            Elst,A., van der Veen,A.Y., Kok,K., Naylor,S.L. and Buys,C.H.
  TITLE     An evolutionary rearrangement of the Xp11.3-11.23 region in 3p21.3,
            a region frequently deleted in a variety of cancers
  JOURNAL   Genomics 60 (2), 238-240 (1999)
   PUBMED   10486216
REFERENCE   8  (bases 1 to 3630)
  AUTHORS   Timmer,T., Terpstra,P., van den Berg,A., Veldhuis,P.M., Ter
            Elst,A., Voutsinas,G., Hulsbeek,M.M., Draaijers,T.G., Looman,M.W.,
            Kok,K., Naylor,S.L. and Buys,C.H.
  TITLE     A comparison of genomic structures and expression patterns of two
            closely related flanking genes in a critical lung cancer region at
            3p21.3
  JOURNAL   Eur J Hum Genet 7 (4), 478-486 (1999)
   PUBMED   10352938
REFERENCE   9  (bases 1 to 3630)
  AUTHORS   Drabkin,H.A., West,J.D., Hotfilder,M., Heng,Y.M., Erickson,P.,
            Calvo,R., Dalmau,J., Gemmill,R.M. and Sablitzky,F.
  TITLE     DEF-3(g16/NY-LU-12), an RNA binding protein from the 3p21.3
            homozygous deletion region in SCLC
  JOURNAL   Oncogene 18 (16), 2589-2597 (1999)
   PUBMED   10353602
REFERENCE   10 (bases 1 to 3630)
  AUTHORS   Gure,A.O., Altorki,N.K., Stockert,E., Scanlan,M.J., Old,L.J. and
            Chen,Y.T.
  TITLE     Human lung cancer antigens recognized by autologous antibodies:
            definition of a novel cDNA derived from the tumor suppressor gene
            locus on chromosome 3p21.3
  JOURNAL   Cancer Res 58 (5), 1034-1041 (1998)
   PUBMED   9500467
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK291719.1, AF091264.1 and BC012112.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005777.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF069517.1, AK291719.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266022.9/ ENSP00000266022.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AK291719.1         107-115
            10-3462             AF091264.1         1-3453
            3463-3630           BC012112.1         3350-3517
FEATURES             Location/Qualifiers
     source          1..3630
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..3630
                     /gene="RBM6"
                     /gene_synonym="3G2; DEF-3; DEF3; g16; HLC-11; NY-LU-12"
                     /note="RNA binding motif protein 6"
                     /db_xref="GeneID:10180"
                     /db_xref="HGNC:HGNC:9903"
                     /db_xref="MIM:606886"
     exon            1..76
                     /gene="RBM6"
                     /gene_synonym="3G2; DEF-3; DEF3; g16; HLC-11; NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            77..186
                     /gene="RBM6"
                     /gene_synonym="3G2; DEF-3; DEF3; g16; HLC-11; NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..3514
                     /gene="RBM6"
                     /gene_synonym="3G2; DEF-3; DEF3; g16; HLC-11; NY-LU-12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RNA-binding protein 6; lung cancer protooncogene 11;
                     RNA-binding protein DEF-3; lung cancer antigen NY-LU-12"
                     /codon_start=1
                     /product="RNA-binding protein 6 isoform 1"
                     /protein_id="NP_005768.1"
                     /db_xref="CCDS:CCDS2809.1"
                     /db_xref="GeneID:10180"
                     /db_xref="HGNC:HGNC:9903"
                     /db_xref="MIM:606886"
                     /translation="MWGDSRPANRTGPFRGSQEERFAPGWNRDYPPPPLKSHAQERHS
                     GNFPGRDSLPFDFQGHSGPPFANVEEHSFSYGARDGPHGDYRGGEGPGHDFRGGDFSS
                     SDFQSRDSSQLDFRGRDIHSGDFRDREGPPMDYRGGDGTSMDYRGREAPHMNYRDRDA
                     HAVDFRGRDAPPSDFRGRGTYDLDFRGRDGSHADFRGRDLSDLDFRAREQSRSDFRNR
                     DVSDLDFRDKDGTQVDFRGRGSGTTDLDFRDRDTPHSDFRGRHRSRTDQDFRGREMGS
                     CMEFKDREMPPVDPNILDYIQPSTQDREHSGMNVNRREESTHDHTIERPAFGIQKGEF
                     EHSETREGETQGVAFEHESPADFQNSQSPVQDQDKSQLSGREEQSSDAGLFKEEGGLD
                     FLGRQDTDYRSMEYRDVDHRLPGSQMFGYGQSKSFPEGKTARDAQRDLQDQDYRTGPS
                     EEKPSRLIRLSGVPEDATKEEILNAFRTPDGMPVKNLQLKEYNTGYDYGYVCVEFSLL
                     EDAIGCMEANQGTLMIQDKEVTLEYVSSLDFWYCKRCKANIGGHRSSCSFCKNPREVT
                     EAKQELITYPQPQKTSIPAPLEKQPNQPLRPADKEPEPRKREEGQESRLGHQKREAER
                     YLPPSRREGPTFRRDRERESWSGETRQDGESKTIMLKRIYRSTPPEVIVEVLEPYVRL
                     TTANVRIIKNRTGPMGHTYGFIDLDSHAEALRVVKILQNLDPPFSIDGKMVAVNLATG
                     KRRNDSGDHSDHMHYYQGKKYFRDRRGGGRNSDWSSDTNRQGQQSSSDCYIYDSATGY
                     YYDPLAGTYYDPNTQQEVYVPQDPGLPEEEEIKEKKPTSQGKSSSKKEMSKRDGKEKK
                     DRGVTRFQENASEGKAPAEDVFKKPLPPTVKKEESPPPPKVVNPLIGLLGEYGGDSDY
                     EEEEEEEQTPPPQPRTAQPQKREEQTKKENEEDKLTDWNKLACLLCRRQFPNKEVLIK
                     HQQLSDLHKQNLEIHRKIKQSEQELAYLERREREGKFKGRGNDRREKLQSFDSPERKR
                     IKYSRETDSDRKLVDKEDIDTSSKGGCVQQATGWRKGTGLGYGHPGLASSEEAEGRMR
                     GPSVGASGRTSKRQSNETYRDAVRRVMFARYKELD"
     exon            187..1465
                     /gene="RBM6"
                     /gene_synonym="3G2; DEF-3; DEF3; g16; HLC-11; NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1555
                     /gene="RBM6"
                     /gene_synonym="3G2; DEF-3; DEF3; g16; HLC-11; NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1625
                     /gene="RBM6"
                     /gene_synonym="3G2; DEF-3; DEF3; g16; HLC-11; NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1699
                     /gene="RBM6"
                     /gene_synonym="3G2; DEF-3; DEF3; g16; HLC-11; NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1774
                     /gene="RBM6"
                     /gene_synonym="3G2; DEF-3; DEF3; g16; HLC-11; NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1835
                     /gene="RBM6"
                     /gene_synonym="3G2; DEF-3; DEF3; g16; HLC-11; NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..2111
                     /gene="RBM6"
                     /gene_synonym="3G2; DEF-3; DEF3; g16; HLC-11; NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2272
                     /gene="RBM6"
                     /gene_synonym="3G2; DEF-3; DEF3; g16; HLC-11; NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2370
                     /gene="RBM6"
                     /gene_synonym="3G2; DEF-3; DEF3; g16; HLC-11; NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2413
                     /gene="RBM6"
                     /gene_synonym="3G2; DEF-3; DEF3; g16; HLC-11; NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..2495
                     /gene="RBM6"
                     /gene_synonym="3G2; DEF-3; DEF3; g16; HLC-11; NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2581
                     /gene="RBM6"
                     /gene_synonym="3G2; DEF-3; DEF3; g16; HLC-11; NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2582..2728
                     /gene="RBM6"
                     /gene_synonym="3G2; DEF-3; DEF3; g16; HLC-11; NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2729..2824
                     /gene="RBM6"
                     /gene_synonym="3G2; DEF-3; DEF3; g16; HLC-11; NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2825..3085
                     /gene="RBM6"
                     /gene_synonym="3G2; DEF-3; DEF3; g16; HLC-11; NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            3086..3160
                     /gene="RBM6"
                     /gene_synonym="3G2; DEF-3; DEF3; g16; HLC-11; NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            3161..3258
                     /gene="RBM6"
                     /gene_synonym="3G2; DEF-3; DEF3; g16; HLC-11; NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            3259..3388
                     /gene="RBM6"
                     /gene_synonym="3G2; DEF-3; DEF3; g16; HLC-11; NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            3389..3630
                     /gene="RBM6"
                     /gene_synonym="3G2; DEF-3; DEF3; g16; HLC-11; NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3609..3614
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM6"
                     /gene_synonym="3G2; DEF-3; DEF3; g16; HLC-11; NY-LU-12"
                     /note="hexamer: AATAAA"
     polyA_site      3630
                     /gene="RBM6"
                     /gene_synonym="3G2; DEF-3; DEF3; g16; HLC-11; NY-LU-12"
                     /note="major polyA site"
ORIGIN      
        1 ccggtgtccg cggcgctggg tcggtggcgg aggctgagga gaaggaggag cgggccgtgg
       61 aggcttcgcc gcctaggtac tgctataacc agaatttggt agaaaaagga tttacttgtt
      121 ggggccctct tgataaaaag agatgtgggg ggattctcga cctgctaaca gaactggacc
      181 ttttcgtggg agccaagaag aaaggtttgc tcccgggtgg aacagggatt atcctcctcc
      241 tccccttaag agtcatgctc aagagagaca ctctggcaac tttcctggca gagattcact
      301 tccctttgat ttccaggggc attcggggcc tccttttgca aatgtagagg agcattcttt
      361 cagctatgga gctagagacg gaccgcatgg tgactatcga ggaggggagg gacctggaca
      421 tgatttcagg gggggagatt tttcgtcttc tgatttccag agcagagatt catcacagtt
      481 ggacttcagg ggtagggaca tacattctgg ggattttcgg gatagagaag gaccacctat
      541 ggactatagg ggtggagatg gtacttctat ggattataga ggtagggagg cacctcatat
      601 gaactacaga gacagggatg ctcacgctgt tgacttcaga ggtagggatg ctcctccatc
      661 tgacttcagg ggccggggca cttatgattt agattttaga ggccgggatg gatcccatgc
      721 agattttagg ggaagggatt tatcagattt ggattttagg gccagagaac agtcccgttc
      781 tgattttagg aatagagatg tatctgattt ggactttaga gacaaagacg gaacacaagt
      841 agactttaga ggccgaggtt caggtactac tgatctagac tttagggaca gggatacgcc
      901 acattcagat ttcagaggta gacaccgatc taggactgat caggatttta ggggcagaga
      961 gatgggatct tgtatggaat ttaaagatag ggagatgccc cctgtggatc caaatatttt
     1021 ggattacatt cagccctcta cacaagatag agaacattct ggtatgaatg tgaacaggag
     1081 agaagaatcc acacatgacc atacgataga aaggcctgct tttggcattc agaagggaga
     1141 atttgagcat tcagaaacaa gagaaggaga aacacaaggt gtagcctttg aacatgagtc
     1201 tccagcagac tttcagaaca gccaaagtcc agttcaagac caagataagt cacagctttc
     1261 tggacgtgaa gagcagagtt cagatgctgg tctgtttaaa gaagaaggcg gtctggactt
     1321 tcttgggcgg caagacaccg attacagaag catggagtac cgtgatgtgg atcataggct
     1381 gccaggaagc cagatgtttg gctatggcca gagcaagtct tttccagagg gcaaaactgc
     1441 ccgagatgcc caacgggacc ttcaggatca agattatagg accggcccaa gtgaggagaa
     1501 acccagcagg cttattcgat taagtggggt acctgaagat gccacaaaag aagagattct
     1561 taatgctttt cggactcctg atggcatgcc tgtaaagaac ttgcagttga aggagtataa
     1621 cacaggttac gactatggct atgtctgcgt ggagttttca ctcttggaag atgccatcgg
     1681 atgcatggag gccaaccagg gaactctaat gatccaggac aaagaagtta ccctggagta
     1741 tgtatcaagc ctggattttt ggtactgcaa acgatgtaag gcaaacattg gtgggcaccg
     1801 atcttcctgt tcattctgca agaacccaag agaagtgaca gaggccaagc aagaattaat
     1861 aacctaccct cagcctcaga aaacatccat accagcacca ttggaaaaac agcccaacca
     1921 gcccctaaga ccagctgata aggaacctga acccaggaag agggaagaag gccaagagtc
     1981 acgcttagga catcaaaaga gagaagcaga aaggtatctg cctccttctc gaagggaagg
     2041 gccaactttc cgaagagacc gagagaggga gtcatggtct ggagagacac gccaggatgg
     2101 agagagcaaa actatcatgc taaagcgtat ctatcgttcc acaccacctg aggtgatagt
     2161 ggaagtgctg gagccctatg tccgccttac tactgccaac gtccgtatca tcaagaacag
     2221 aacaggccct atggggcata cctatggctt tattgacctc gactcccatg cggaagctct
     2281 tcgtgtggtg aagatcttac agaaccttga tccgccattt agcattgatg ggaagatggt
     2341 agctgtaaac ctggccactg gaaaacgaag aaatgattct ggggaccatt ctgaccacat
     2401 gcattactat cagggtaaaa aatatttccg agataggagg ggaggtggca gaaattcaga
     2461 ctggtcttca gatacaaatc gacaaggaca acagtcatca tctgactgct acatatatga
     2521 ttctgctact ggctactatt atgacccctt ggcaggaact tattatgacc ccaataccca
     2581 gcaagaagtc tatgtgcccc aggatcctgg attacctgag gaagaagaga tcaaggaaaa
     2641 aaaacccacc agtcaaggaa agtcaagtag caagaaggaa atgtctaaaa gagatggcaa
     2701 ggagaaaaaa gacagaggag tgacgaggtt tcaggaaaat gccagtgaag ggaaggcccc
     2761 tgcagaagac gtctttaaga agcccctgcc tcctactgtg aagaaggaag agagtccccc
     2821 tccacctaaa gtggtaaacc cactgatcgg cctcttgggt gaatatggag gagacagtga
     2881 ctatgaggag gaagaagagg aggaacagac ccctccccca cagccccgca cagcacagcc
     2941 ccagaagcga gaggagcaaa ccaagaagga gaatgaagaa gacaaactca ctgactggaa
     3001 taaactggct tgtctgcttt gcagaaggca gtttcccaat aaagaagttc tgatcaaaca
     3061 ccagcagctg tcagacctgc acaagcaaaa cctggaaatc caccggaaga taaaacagtc
     3121 tgagcaggag ctagcctatc tggaaaggag agaacgagag ggaaagttta aaggaagagg
     3181 aaatgatcgc agggaaaagc tccagtcttt tgactctcca gaaaggaaac ggattaagta
     3241 ctccagggaa actgacagtg atcgtaaact tgttgataaa gaagatatcg acactagcag
     3301 caaaggaggc tgtgtccaac aggctactgg ctggaggaaa gggacaggcc tgggatatgg
     3361 ccatcctgga ttggcttcat cagaggaggc tgaaggccgg atgaggggcc ccagtgttgg
     3421 agcctcagga agaaccagca aaagacagtc caacgagact taccgagatg ctgttcgaag
     3481 agtcatgttt gctcgatata aagaactcga ttaagaaagg agacaagttc catgggatac
     3541 aacctccctc ttgttttgtt tgtctctcct tttcttttgt tactgttctt gctgctagaa
     3601 cttttttaaa taaacttttt ttcaatgtga
//
