LOCUS       NM_005778               3177 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens RNA binding motif protein 5 (RBM5), transcript variant
            1, mRNA.
ACCESSION   NM_005778
VERSION     NM_005778.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3177)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3177)
  AUTHORS   Li,L., Qu,D., Wang,B., Yuan,S., Zhao,Y., Liu,N., Huo,F., Zhang,D.
            and Zhang,L.
  TITLE     FTO blocks RNA translational activity via the loss of
            N6-methyladenosine methylation at 5' UTR regulated by RBM5 in
            cisplatin-resistant NSCLC
  JOURNAL   J Cell Physiol 239 (8), e31296 (2024)
   PUBMED   38742685
  REMARK    GeneRIF: FTO blocks RNA translational activity via the loss of
            N6-methyladenosine methylation at 5' UTR regulated by RBM5 in
            cisplatin-resistant NSCLC.
REFERENCE   3  (bases 1 to 3177)
  AUTHORS   Zhu,C.C., Sun,H.L., Long,T.F., Lyu,Y.Y., Liu,J.L. and Ni,G.T.
  TITLE     ZNF554 Inhibits Endometrial Cancer Progression via Regulating RBM5
            and Inactivating WNT/beta-Catenin Signaling Pathway
  JOURNAL   Curr Med Sci 44 (2), 406-418 (2024)
   PUBMED   38619681
  REMARK    GeneRIF: ZNF554 Inhibits Endometrial Cancer Progression via
            Regulating RBM5 and Inactivating WNT/beta-Catenin Signaling
            Pathway.
REFERENCE   4  (bases 1 to 3177)
  AUTHORS   Jin,B., Wang,M., Sun,Y., Lee,P.A.H., Zhang,X., Lu,Y. and Zhao,B.
  TITLE     CHIP suppresses the proliferation and migration of A549 cells by
            mediating the ubiquitination of eIF2alpha and upregulation of tumor
            suppressor RBM5
  JOURNAL   J Biol Chem 300 (3), 105673 (2024)
   PUBMED   38272235
  REMARK    GeneRIF: CHIP suppresses the proliferation and migration of A549
            cells by mediating the ubiquitination of eIF2alpha and upregulation
            of tumor suppressor RBM5.
REFERENCE   5  (bases 1 to 3177)
  AUTHORS   Oh,J.J., Koegel,A.K., Phan,D.T., Razfar,A. and Slamon,D.J.
  TITLE     The two single nucleotide polymorphisms in the H37/RBM5 tumour
            suppressor gene at 3p21.3 correlated with different subtypes of
            non-small cell lung cancers
  JOURNAL   Lung Cancer 58 (1), 7-14 (2007)
   PUBMED   17606309
  REMARK    GeneRIF: specific allele types at C1138T and C2185T single
            nucleotide polymorphisms positions are correlated with different
            histological subtypes of non-small cell lung cancer
REFERENCE   6  (bases 1 to 3177)
  AUTHORS   Sutherland,L.C., Edwards,S.E., Cable,H.C., Poirier,G.G.,
            Miller,B.A., Cooper,C.S. and Williams,G.T.
  TITLE     LUCA-15-encoded sequence variants regulate CD95-mediated apoptosis
  JOURNAL   Oncogene 19 (33), 3774-3781 (2000)
   PUBMED   10949932
REFERENCE   7  (bases 1 to 3177)
  AUTHORS   Scanlan,M.J., Gordan,J.D., Williamson,B., Stockert,E., Bander,N.H.,
            Jongeneel,V., Gure,A.O., Jager,D., Jager,E., Knuth,A., Chen,Y.T.
            and Old,L.J.
  TITLE     Antigens recognized by autologous antibody in patients with
            renal-cell carcinoma
  JOURNAL   Int J Cancer 83 (4), 456-464 (1999)
   PUBMED   10508479
REFERENCE   8  (bases 1 to 3177)
  AUTHORS   Oh,J.J., Grosshans,D.R., Wong,S.G. and Slamon,D.J.
  TITLE     Identification of differentially expressed genes associated with
            HER-2/neu overexpression in human breast cancer cells
  JOURNAL   Nucleic Acids Res 27 (20), 4008-4017 (1999)
   PUBMED   10497265
REFERENCE   9  (bases 1 to 3177)
  AUTHORS   Timmer,T., Terpstra,P., van den Berg,A., Veldhuis,P.M., Ter
            Elst,A., van der Veen,A.Y., Kok,K., Naylor,S.L. and Buys,C.H.
  TITLE     An evolutionary rearrangement of the Xp11.3-11.23 region in 3p21.3,
            a region frequently deleted in a variety of cancers
  JOURNAL   Genomics 60 (2), 238-240 (1999)
   PUBMED   10486216
REFERENCE   10 (bases 1 to 3177)
  AUTHORS   Timmer,T., Terpstra,P., van den Berg,A., Veldhuis,P.M., Ter
            Elst,A., Voutsinas,G., Hulsbeek,M.M., Draaijers,T.G., Looman,M.W.,
            Kok,K., Naylor,S.L. and Buys,C.H.
  TITLE     A comparison of genomic structures and expression patterns of two
            closely related flanking genes in a critical lung cancer region at
            3p21.3
  JOURNAL   Eur J Hum Genet 7 (4), 478-486 (1999)
   PUBMED   10352938
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB080737.1, AF091263.1,
            DA776815.1, CN293007.1, BM985111.1 and AC104450.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_005778.3.
            
            Summary: This gene is a candidate tumor suppressor gene which
            encodes a nuclear RNA binding protein that is a component of the
            spliceosome A complex. The encoded protein plays a role in the
            induction of cell cycle arrest and apoptosis through pre-mRNA
            splicing of multiple target genes including the tumor suppressor
            protein p53. This gene is located within the tumor suppressor
            region 3p21.3, and may play a role in the inhibition of tumor
            transformation and progression of several malignancies including
            lung cancer. [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and is protein coding.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.73267.1,
                                           SRR1803617.129474.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000347869.8/ ENSP00000343054.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DB080737.1         12-27
            17-1153             AF091263.1         1-1137
            1154-1154           DA776815.1         386-386
            1155-2200           AF091263.1         1139-2184
            2201-2636           CN293007.1         137-572
            2637-3120           BM985111.1         19-502              c
            3121-3177           AC104450.2         57103-57159         c
FEATURES             Location/Qualifiers
     source          1..3177
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..3177
                     /gene="RBM5"
                     /gene_synonym="G15; H37; LUCA-15; LUCA15; RMB5"
                     /note="RNA binding motif protein 5"
                     /db_xref="GeneID:10181"
                     /db_xref="HGNC:HGNC:9902"
                     /db_xref="MIM:606884"
     exon            1..111
                     /gene="RBM5"
                     /gene_synonym="G15; H37; LUCA-15; LUCA15; RMB5"
                     /inference="alignment:Splign:2.1.0"
     exon            112..181
                     /gene="RBM5"
                     /gene_synonym="G15; H37; LUCA-15; LUCA15; RMB5"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..2612
                     /gene="RBM5"
                     /gene_synonym="G15; H37; LUCA-15; LUCA15; RMB5"
                     /note="putative tumor suppressor LUCA15; renal carcinoma
                     antigen NY-REN-9"
                     /codon_start=1
                     /product="RNA-binding protein 5"
                     /protein_id="NP_005769.1"
                     /db_xref="CCDS:CCDS2810.1"
                     /db_xref="GeneID:10181"
                     /db_xref="HGNC:HGNC:9902"
                     /db_xref="MIM:606884"
                     /translation="MGSDKRVSRTERSGRYGSIIDRDDRDERESRSRRRDSDYKRSSD
                     DRRGDRYDDYRDYDSPERERERRNSDRSEDGYHSDGDYGEHDYRHDISDERESKTIML
                     RGLPITITESDIREMMESFEGPQPADVRLMKRKTGVSRGFAFVEFYHLQDATSWMEAN
                     QKKLVIQGKHIAMHYSNPRPKFEDWLCNKCCLNNFRKRLKCFRCGADKFDSEQEVPPG
                     TTESVQSVDYYCDTIILRNIAPHTVVDSIMTALSPYASLAVNNIRLIKDKQTQQNRGF
                     AFVQLSSAMDASQLLQILQSLHPPLKIDGKTIGVDFAKSARKDLVLSDGNRVSAFSVA
                     STAIAAAQWSSTQSQSGEGGSVDYSYLQPGQDGYAQYAQYSQDYQQFYQQQAGGLESD
                     ASSASGTAVTTTSAAVVSQSPQLYNQTSNPPGSPTEEAQPSTSTSTQAPAASPTGVVP
                     GTKYAVPDTSTYQYDESSGYYYDPTTGLYYDPNSQYYYNSLTQQYLYWDGEKETYVPA
                     AESSSHQQSGLPPAKEGKEKKEKPKSKTAQQIAKDMERWAKSLNKQKENFKNSFQPVN
                     SLREEERRESAAADAGFALFEKKGALAERQQLIPELVRNGDEENPLKRGLVAAYSGDS
                     DNEEELVERLESEEEKLADWKKMACLLCRRQFPNKDALVRHQQLSDLHKQNMDIYRRS
                     RLSEQELEALELREREMKYRDRAAERREKYGIPEPPEPKRKKQFDAGTVNYEQPTKDG
                     IDHSNIGNKMLQAMGWREGSGLGRKCQGITAPIEAQVRLKGAGLGAKGSAYGLSGADS
                     YKDAVRKAMFARFTEME"
     exon            182..347
                     /gene="RBM5"
                     /gene_synonym="G15; H37; LUCA-15; LUCA15; RMB5"
                     /inference="alignment:Splign:2.1.0"
     exon            348..503
                     /gene="RBM5"
                     /gene_synonym="G15; H37; LUCA-15; LUCA15; RMB5"
                     /inference="alignment:Splign:2.1.0"
     exon            504..573
                     /gene="RBM5"
                     /gene_synonym="G15; H37; LUCA-15; LUCA15; RMB5"
                     /inference="alignment:Splign:2.1.0"
     exon            574..647
                     /gene="RBM5"
                     /gene_synonym="G15; H37; LUCA-15; LUCA15; RMB5"
                     /inference="alignment:Splign:2.1.0"
     exon            648..731
                     /gene="RBM5"
                     /gene_synonym="G15; H37; LUCA-15; LUCA15; RMB5"
                     /inference="alignment:Splign:2.1.0"
     exon            732..792
                     /gene="RBM5"
                     /gene_synonym="G15; H37; LUCA-15; LUCA15; RMB5"
                     /inference="alignment:Splign:2.1.0"
     exon            793..858
                     /gene="RBM5"
                     /gene_synonym="G15; H37; LUCA-15; LUCA15; RMB5"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1019
                     /gene="RBM5"
                     /gene_synonym="G15; H37; LUCA-15; LUCA15; RMB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1117
                     /gene="RBM5"
                     /gene_synonym="G15; H37; LUCA-15; LUCA15; RMB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1205
                     /gene="RBM5"
                     /gene_synonym="G15; H37; LUCA-15; LUCA15; RMB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1283
                     /gene="RBM5"
                     /gene_synonym="G15; H37; LUCA-15; LUCA15; RMB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1356
                     /gene="RBM5"
                     /gene_synonym="G15; H37; LUCA-15; LUCA15; RMB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1442
                     /gene="RBM5"
                     /gene_synonym="G15; H37; LUCA-15; LUCA15; RMB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1527
                     /gene="RBM5"
                     /gene_synonym="G15; H37; LUCA-15; LUCA15; RMB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1619
                     /gene="RBM5"
                     /gene_synonym="G15; H37; LUCA-15; LUCA15; RMB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1781
                     /gene="RBM5"
                     /gene_synonym="G15; H37; LUCA-15; LUCA15; RMB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1931
                     /gene="RBM5"
                     /gene_synonym="G15; H37; LUCA-15; LUCA15; RMB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2003
                     /gene="RBM5"
                     /gene_synonym="G15; H37; LUCA-15; LUCA15; RMB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2183
                     /gene="RBM5"
                     /gene_synonym="G15; H37; LUCA-15; LUCA15; RMB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2258
                     /gene="RBM5"
                     /gene_synonym="G15; H37; LUCA-15; LUCA15; RMB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2356
                     /gene="RBM5"
                     /gene_synonym="G15; H37; LUCA-15; LUCA15; RMB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2486
                     /gene="RBM5"
                     /gene_synonym="G15; H37; LUCA-15; LUCA15; RMB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..3177
                     /gene="RBM5"
                     /gene_synonym="G15; H37; LUCA-15; LUCA15; RMB5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3099..3104
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM5"
                     /gene_synonym="G15; H37; LUCA-15; LUCA15; RMB5"
                     /note="hexamer: AAGAAA"
     polyA_site      3116
                     /gene="RBM5"
                     /gene_synonym="G15; H37; LUCA-15; LUCA15; RMB5"
                     /note="major polyA site"
ORIGIN      
        1 actgtgggta ggagacggcc gtcggcggag gcgccatttt gtgtagccgc cgaaccttgt
       61 tggaggttct ggggcgcaga accgctactg ctgcttcggt ctctccttgg gaaaaaataa
      121 aatttgaacc ttttggagct gtgtgctaaa tcttcagtgg gacaatgggt tcagacaaaa
      181 gagtgagtag aacagagcgt agtggaagat acggttccat catagacagg gatgaccgtg
      241 atgagcgtga atcccgaagc aggcggaggg actcagatta caaaagatct agtgatgatc
      301 ggaggggtga tagatatgat gactaccgag actatgacag tccagagaga gagcgtgaaa
      361 gaaggaacag tgaccgatcc gaagatggct accattcaga tggtgactat ggtgagcacg
      421 actataggca tgacatcagt gacgagaggg agagcaagac catcatgctg cgcggccttc
      481 ccatcaccat cacagagagc gatattcgag aaatgatgga gtccttcgaa ggccctcagc
      541 ctgcggatgt gaggctgatg aagaggaaaa caggtgtaag ccgtggtttc gccttcgtgg
      601 agttttatca cttgcaagat gctaccagct ggatggaagc caatcagaaa aagttggtga
      661 ttcaaggaaa gcacattgca atgcattata gcaatcccag acctaagttt gaagattggc
      721 tttgtaacaa gtgctgcctt aacaatttca ggaaaagact aaaatgcttc cgatgtggag
      781 cagacaagtt tgactctgaa caggaagtgc ctcctggaac cacagagtcg gttcagtctg
      841 tggattacta ctgtgatacg atcattcttc ggaacatagc tccgcacact gtggtggatt
      901 ccatcatgac agcactgtct ccttacgcgt ctttagctgt caataacatc cgcctcataa
      961 aagacaaaca gacccagcag aacagaggct tcgcatttgt gcagctgtcc tctgcaatgg
     1021 atgcttctca gctgcttcag atattacaga gtctccatcc tcctttgaaa attgatggca
     1081 aaactattgg ggttgatttt gcaaaaagtg ccagaaaaga cttggtcctc tcagatggta
     1141 accgcgtcag cgctttctct gtagctagta cggctattgc tgctgctcag tggtcatcca
     1201 cccagtctca aagtggtgaa ggaggcagtg ttgactacag ttatctgcaa ccaggtcaag
     1261 atggctatgc ccaatatgct cagtattcac aggattatca gcagttttat caacaacaag
     1321 ctggaggatt ggaatctgat gcatcatctg catcaggcac agcagtgacc accacctcag
     1381 cggctgtagt gtcccagagt cctcagctgt ataatcaaac ctccaatcca cctggctctc
     1441 cgactgagga agcacagcct agcactagca caagtacaca ggccccagcc gcttccccta
     1501 ctggtgtagt tcctggtacc aaatatgcag tacctgacac gtccacttac cagtatgatg
     1561 aatcttcagg atattactat gatccgacaa cagggctcta ttatgacccc aactcgcaat
     1621 actactataa ttccttgacc cagcagtacc tttactggga tggggaaaaa gagacctacg
     1681 tgccagctgc agagtctagc tcccaccagc agtcgggcct gcctcctgca aaagagggga
     1741 aagagaagaa ggagaaaccc aagagcaaaa cagcccagca gattgccaaa gacatggaac
     1801 gctgggctaa gagtttgaat aagcagaaag aaaactttaa aaatagcttt cagcctgtca
     1861 attccttgag ggaagaagaa aggagagaat ctgctgcagc agacgctggc tttgctctct
     1921 ttgagaagaa gggagcctta gctgaaaggc agcagctcat cccagaattg gtgcgaaatg
     1981 gagatgagga gaatcccctc aaaaggggtc tggttgctgc ttacagtggt gacagtgaca
     2041 atgaggagga gctggtggag agacttgaga gtgaggaaga gaagctagct gactggaaga
     2101 agatggcctg tctgctctgc cggcgccagt tcccgaacaa agatgcccta gtcaggcacc
     2161 agcaactctc agaccttcac aagcaaaaca tggacatcta tcgacgatcc aggctgagcg
     2221 agcaggagct ggaagccttg gagctaaggg agagagagat gaaataccga gaccgagctg
     2281 cagaaagacg ggagaagtac ggcattccag aacctccaga gcccaagcgc aagaagcagt
     2341 ttgatgccgg cactgtgaat tacgagcaac ccaccaaaga tggcattgac cacagtaaca
     2401 ttggcaacaa gatgctgcag gccatgggct ggcgggaagg ctctggcttg ggacgaaagt
     2461 gtcaaggcat tacggctccc attgaggctc aagttcggct aaagggagct ggcctaggag
     2521 ccaaaggcag cgcatatggt ttgtcgggcg ccgattccta caaagatgct gtccggaaag
     2581 ccatgtttgc ccggttcact gagatggagt gagagagaga gagagagaga gatgacaagg
     2641 agcacaagaa gtggtccatc tcccgaattc gctgttaccg cctgtctctt taagggcatg
     2701 ccttgtgctg ttaatagatc ttagggtgaa ccacttcatt ctgcagggtt ctccctccca
     2761 ccttaaagaa gttcccctta tgtgggttgc ctggtgaatg gccttccttc ccgccagagg
     2821 gcttgtgaac agaccggaga ggacagtgga ttgtttatac tccagtgtac atagtgtaat
     2881 gtagcgtgtt tacatgtgta gcctatgttg tggtccatca gcccctcaca ttcctagggg
     2941 tttgagatgc tgtaggtggt atgtgacacc aaagccacct ctgtcatttg ttgtgatgtc
     3001 ttttcttggc aaaagccttg tgtatatttg tatattacac atttgtacag aattttggaa
     3061 gattttcagt ctagttgcca aatctggctc ctttacaaaa gaaatacctt gagaaatggg
     3121 tgtcctgtgt ctctttattc ttgggtgggt aggtgggtca agcatgtctg agccagt
//
