LOCUS       NM_031492               1806 bp    mRNA    linear   PRI 18-DEC-2024
DEFINITION  Homo sapiens RNA binding motif protein 4B (RBM4B), transcript
            variant 1, mRNA.
ACCESSION   NM_031492
VERSION     NM_031492.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1806)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1806)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   3  (bases 1 to 1806)
  AUTHORS   Weimann,M., Grossmann,A., Woodsmith,J., Ozkan,Z., Birth,P.,
            Meierhofer,D., Benlasfer,N., Valovka,T., Timmermann,B.,
            Wanker,E.E., Sauer,S. and Stelzl,U.
  TITLE     A Y2H-seq approach defines the human protein methyltransferase
            interactome
  JOURNAL   Nat Methods 10 (4), 339-342 (2013)
   PUBMED   23455924
REFERENCE   4  (bases 1 to 1806)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 1806)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 1806)
  AUTHORS   Pfuhl,T., Mamiani,A., Durr,M., Welter,S., Stieber,J., Ankara,J.,
            Liss,M., Dobner,T., Schmitt,A., Falkai,P., Kremmer,E., Jung,V.,
            Barth,S. and Grasser,F.A.
  TITLE     The LARK/RBM4a protein is highly expressed in cerebellum as
            compared to cerebrum
  JOURNAL   Neurosci Lett 444 (1), 11-15 (2008)
   PUBMED   18708123
REFERENCE   7  (bases 1 to 1806)
  AUTHORS   Guo,D., Ling,J., Wang,M.H., She,J.X., Gu,J. and Wang,C.Y.
  TITLE     Physical interaction and functional coupling between ACDP4 and the
            intracellular ion chaperone COX11, an implication of the role of
            ACDP4 in essential metal ion transport and homeostasis
  JOURNAL   Mol Pain 1, 15 (2005)
   PUBMED   15840172
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1806)
  AUTHORS   Lai,M.C., Kuo,H.W., Chang,W.C. and Tarn,W.Y.
  TITLE     A novel splicing regulator shares a nuclear import pathway with SR
            proteins
  JOURNAL   EMBO J 22 (6), 1359-1369 (2003)
   PUBMED   12628928
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ428264.1 and BC004951.1.
            
            On Nov 22, 2018 this sequence version replaced NM_031492.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.250994.1,
                                           SRR1803616.20599.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310046.9/ ENSP00000310471.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                BQ428264.1         26-108
            84-1806             BC004951.1         1-1723
FEATURES             Location/Qualifiers
     source          1..1806
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..1806
                     /gene="RBM4B"
                     /gene_synonym="RBM30; RBM4L; ZCCHC15; ZCCHC21B; ZCRB3B"
                     /note="RNA binding motif protein 4B"
                     /db_xref="GeneID:83759"
                     /db_xref="HGNC:HGNC:28842"
                     /db_xref="MIM:621045"
     exon            1..124
                     /gene="RBM4B"
                     /gene_synonym="RBM30; RBM4L; ZCCHC15; ZCCHC21B; ZCRB3B"
                     /inference="alignment:Splign:2.1.0"
     exon            125..548
                     /gene="RBM4B"
                     /gene_synonym="RBM30; RBM4L; ZCCHC15; ZCCHC21B; ZCRB3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1216
                     /gene="RBM4B"
                     /gene_synonym="RBM30; RBM4L; ZCCHC15; ZCCHC21B; ZCRB3B"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger CCHC-type and RNA binding motif 3B; RNA-binding
                     protein 4B; RNA-binding motif protein 30"
                     /codon_start=1
                     /product="RNA-binding protein 4B isoform 1"
                     /protein_id="NP_113680.1"
                     /db_xref="CCDS:CCDS8149.1"
                     /db_xref="GeneID:83759"
                     /db_xref="HGNC:HGNC:28842"
                     /db_xref="MIM:621045"
                     /translation="MVKLFIGNLPREATEQEIRSLFEQYGKVLECDIIKNYGFVHIED
                     KTAAEDAIRNLHHYKLHGVNINVEASKNKSKASTKLHVGNISPTCTNQELRAKFEEYG
                     PVIECDIVKDYAFVHMERAEDAVEAIRGLDNTEFQGKRMHVQLSTSRLRTAPGMGDQS
                     GCYRCGKEGHWSKECPVDRTGRVADFTEQYNEQYGAVRTPYTMGYGESMYYNDAYGAL
                     DYYKRYRVRSYEAVAAAAAASAYNYAEQTMSHLPQVQSTTVTSHLNSTSVDPYDRHLL
                     PNSGAAATSAAMAAAAATTSSYYGRDRSPLRRAAAMLPTVGEGYGYGPESELSQASAA
                     TRNSLYDMARYEREQYVDRARYSAF"
     exon            549..1225
                     /gene="RBM4B"
                     /gene_synonym="RBM30; RBM4L; ZCCHC15; ZCCHC21B; ZCRB3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1806
                     /gene="RBM4B"
                     /gene_synonym="RBM30; RBM4L; ZCCHC15; ZCCHC21B; ZCRB3B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1784..1789
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM4B"
                     /gene_synonym="RBM30; RBM4L; ZCCHC15; ZCCHC21B; ZCRB3B"
                     /note="hexamer: AATAAA"
     polyA_site      1806
                     /gene="RBM4B"
                     /gene_synonym="RBM30; RBM4L; ZCCHC15; ZCCHC21B; ZCRB3B"
                     /note="major polyA site"
ORIGIN      
        1 gcactcgcgc gtgcgtgagc tggcgcgcga gaaagggccc ggtcgcgtcc aggctcgagc
       61 ggccgtcgcc attttgtaag gttctctctg acgtgggagc cgccgtcgct gccgccaccc
      121 ggaggctctt gtcaggatgg tgaagctgtt catcggaaac cttccccggg aggctacaga
      181 gcaggagatt cgctcactct tcgagcagta tgggaaggtg ctggaatgtg acatcattaa
      241 gaattacggc tttgtgcaca tagaagacaa gacggcagct gaggatgcca tacgcaacct
      301 gcaccattac aagcttcatg gggtgaacat caacgtggaa gccagcaaga ataagagcaa
      361 agcttcaacc aagttacacg tgggtaacat cagccccact tgtaccaacc aagagcttcg
      421 agccaagttt gaggagtatg gtccggtcat cgaatgtgac atcgtgaaag attatgcctt
      481 cgtacacatg gagcgggcag aggatgcagt ggaggccatc aggggccttg acaacacaga
      541 gtttcaaggc aaaagaatgc atgtgcagtt gtccacaagc cggcttcgga ctgcccctgg
      601 tatgggagac cagagtggct gctatcggtg tgggaaagaa gggcactggt ccaaagagtg
      661 cccagtagat cgtacgggtc gtgtggcaga ctttactgag cagtataatg aacaatatgg
      721 agcagttcga acaccttaca ccatgggcta cggggaatcc atgtattaca acgatgcata
      781 tggagcactc gactactata agcgataccg ggtccgctct tatgaggcag tagcagcggc
      841 ggcagcggct tctgcataca actacgcaga gcagaccatg tcccatctgc ctcaagtcca
      901 aagcacaact gtgaccagcc acctcaactc tacttctgtt gatccctatg acagacacct
      961 attgccaaac tctggcgctg ctgccacttc agctgctatg gctgctgctg cagccaccac
     1021 ttcctcctac tatggaaggg acaggagccc actgcgtcgt gctgcagcca tgctccccac
     1081 agttggagag ggctacggtt atgggccaga gagtgaatta tctcaggctt ccgcagctac
     1141 acggaattct ctgtatgaca tggcccggta tgaacgggag cagtatgtgg accgagcccg
     1201 gtactcagcc ttttaaaaac tggaggtagg ataattgcgg actgaaccct cgggctgcgg
     1261 tcatatatga gaacttgctc cgcgcggtcc cctttgccgg gatgtttcca ttgcttcatg
     1321 tttcagtaaa caaaaggagt ttgtgaccaa ctatgttttc tttcttaatt cttctaagtt
     1381 gacttttctt tcctcctgaa actagtctct gtagcctttc actctgttcc ttatattctc
     1441 agcctctgag cagccctagg taaggattat gctggcatcc cctttttcct gtgcagtgga
     1501 acccctctta tcttgctttc cctaggagtt gaatccttct ccctgcctac ctgcagcatc
     1561 tcctttccct ttaaaatgac catgtagtgg caagcagcct tttactcttc tgttagctct
     1621 ggactcttaa cacttaagtt actcttctga aattgctagg accattgggg gttttgttgt
     1681 tttgtttgtt ttttatgtcc gacctgtgat cgtggtacag cattagctga aatttaccct
     1741 tgttttactc cactcctccc ttttttaaaa aaattttttg acaaataaat gtttctaaca
     1801 cttaaa
//
