LOCUS       NM_001098634            5114 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens RNA binding motif protein 47 (RBM47), transcript
            variant 1, mRNA.
ACCESSION   NM_001098634
VERSION     NM_001098634.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5114)
  AUTHORS   Li,Z., Tian,Y., Zong,H., Wang,X., Li,D., Keranmu,A., Xin,S., Ye,B.,
            Bai,R., Chen,W., Yang,G., Ye,L. and Wang,S.
  TITLE     Deubiquitinating enzyme OTUD4 stabilizes RBM47 to induce ATF3
            transcription: a novel mechanism underlying the restrained
            malignant properties of ccRCC cells
  JOURNAL   Apoptosis 29 (7-8), 1051-1069 (2024)
   PUBMED   38553613
  REMARK    GeneRIF: Deubiquitinating enzyme OTUD4 stabilizes RBM47 to induce
            ATF3 transcription: a novel mechanism underlying the restrained
            malignant properties of ccRCC cells.
REFERENCE   2  (bases 1 to 5114)
  AUTHORS   Xing,Y.Q. and Zhu,T.Z.
  TITLE     RNA-Binding Motif Protein RBM47 Promotes Invasiveness of
            Glioblastoma Through Activation of Epithelial-to-Mesenchymal
            Transition Program
  JOURNAL   Genet Test Mol Biomarkers 27 (12), 384-392 (2023)
   PUBMED   38156907
  REMARK    GeneRIF: RNA-Binding Motif Protein RBM47 Promotes Invasiveness of
            Glioblastoma Through Activation of Epithelial-to-Mesenchymal
            Transition Program.
REFERENCE   3  (bases 1 to 5114)
  AUTHORS   Yang,Y., Lee,G.C., Nakagaki-Silva,E., Huang,Y., Peacey,M.,
            Partridge,R., Gooding,C. and Smith,C.W.J.
  TITLE     Cell-type specific regulator RBPMS switches alternative splicing
            via higher-order oligomerization and heterotypic interactions with
            other splicing regulators
  JOURNAL   Nucleic Acids Res 51 (18), 9961-9982 (2023)
   PUBMED   37548402
REFERENCE   4  (bases 1 to 5114)
  AUTHORS   Soleymanjahi,S., Blanc,V., Molitor,E.A., Alvarado,D.M., Xie,Y.,
            Gazit,V., Brown,J.W., Byrnes,K., Liu,T.C., Mills,J.C., Ciorba,M.A.,
            Rubin,D.C. and Davidson,N.O.
  TITLE     RBM47 regulates intestinal injury and tumorigenesis by modifying
            proliferation, oxidative response, and inflammatory pathways
  JOURNAL   JCI Insight 8 (9), e161118 (2023)
   PUBMED   37014710
  REMARK    GeneRIF: RBM47 regulates intestinal injury and tumorigenesis by
            modifying proliferation, oxidative response, and inflammatory
            pathways.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5114)
  AUTHORS   Shivalingappa,P.K.M., Sharma,V., Shiras,A. and Bapat,S.A.
  TITLE     RNA binding motif 47 (RBM47): emerging roles in vertebrate
            development, RNA editing and cancer
  JOURNAL   Mol Cell Biochem 476 (12), 4493-4505 (2021)
   PUBMED   34499322
  REMARK    GeneRIF: RNA binding motif 47 (RBM47): emerging roles in vertebrate
            development, RNA editing and cancer.
            Review article
REFERENCE   6  (bases 1 to 5114)
  AUTHORS   Guan,R., El-Rass,S., Spillane,D., Lam,S., Wang,Y., Wu,J., Chen,Z.,
            Wang,A., Jia,Z., Keating,A., Hu,J. and Wen,X.Y.
  TITLE     rbm47, a novel RNA binding protein, regulates zebrafish head
            development
  JOURNAL   Dev Dyn 242 (12), 1395-1404 (2013)
   PUBMED   24038582
REFERENCE   7  (bases 1 to 5114)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   8  (bases 1 to 5114)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   9  (bases 1 to 5114)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   10 (bases 1 to 5114)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC112717.5 and AC098869.3.
            
            On Nov 22, 2018 this sequence version replaced NM_001098634.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC126261.1, AF262323.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295971.12/ ENSP00000295971.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-469               AC112717.5         73351-73819         c
            470-554             AC098869.3         13540-13624
            555-677             AC098869.3         91347-91469
            678-1831            AC098869.3         119122-120275
            1832-2038           AC098869.3         121399-121605
            2039-2250           AC098869.3         125184-125395
            2251-5114           AC098869.3         131903-134766
FEATURES             Location/Qualifiers
     source          1..5114
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p14"
     gene            1..5114
                     /gene="RBM47"
                     /gene_synonym="NET18"
                     /note="RNA binding motif protein 47"
                     /db_xref="GeneID:54502"
                     /db_xref="HGNC:HGNC:30358"
                     /db_xref="MIM:619104"
     exon            1..469
                     /gene="RBM47"
                     /gene_synonym="NET18"
                     /inference="alignment:Splign:2.1.0"
     exon            470..554
                     /gene="RBM47"
                     /gene_synonym="NET18"
                     /inference="alignment:Splign:2.1.0"
     exon            555..677
                     /gene="RBM47"
                     /gene_synonym="NET18"
                     /inference="alignment:Splign:2.1.0"
     exon            678..1831
                     /gene="RBM47"
                     /gene_synonym="NET18"
                     /inference="alignment:Splign:2.1.0"
     CDS             709..2490
                     /gene="RBM47"
                     /gene_synonym="NET18"
                     /note="isoform a is encoded by transcript variant 1;
                     RNA-binding protein 47"
                     /codon_start=1
                     /product="RNA-binding protein 47 isoform a"
                     /protein_id="NP_001092104.1"
                     /db_xref="CCDS:CCDS43223.1"
                     /db_xref="GeneID:54502"
                     /db_xref="HGNC:HGNC:30358"
                     /db_xref="MIM:619104"
                     /translation="MTAEDSTAAMSSDSAAGSSAKVPEGVAGAPNEAALLALMERTGY
                     SMVQENGQRKYGGPPPGWEGPHPQRGCEVFVGKIPRDVYEDELVPVFEAVGRIYELRL
                     MMDFDGKNRGYAFVMYCHKHEAKRAVRELNNYEIRPGRLLGVCCSVDNCRLFIGGIPK
                     MKKREEILEEIAKVTEGVLDVIVYASAADKMKNRGFAFVEYESHRAAAMARRKLMPGR
                     IQLWGHQIAVDWAEPEIDVDEDVMETVKILYVRNLMIETTEDTIKKSFGQFNPGCVER
                     VKKIRDYAFVHFTSREDAVHAMNNLNGTELEGSCLEVTLAKPVDKEQYSRYQKAARGG
                     GAAEAAQQPSYVYSCDPYTLAYYGYPYNALIGPNRDYFVKAGSIRGRGRGAAGNRAPG
                     PRGSYLGGYSAGRGIYSRYHEGKGKQQEKGYELVPNLEIPTVNPVAIKPGTVAIPAIG
                     AQYSMFPAAPAPKMIEDGKIHTVEHMISPIAVQPDPASAAAAAAAAAAAAAAVIPTVS
                     TPPPFQGRPITPVYTVAPNVQRIPTAGIYGASYVPFAAPATATIATLQKNAAAAAAMY
                     GGYAGYIPQAFPAAAIQVPIPDVYQTY"
     exon            1832..2038
                     /gene="RBM47"
                     /gene_synonym="NET18"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2250
                     /gene="RBM47"
                     /gene_synonym="NET18"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..5114
                     /gene="RBM47"
                     /gene_synonym="NET18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5093..5098
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM47"
                     /gene_synonym="NET18"
                     /note="hexamer: AATAAA"
     polyA_site      5114
                     /gene="RBM47"
                     /gene_synonym="NET18"
                     /note="major polyA site"
ORIGIN      
        1 agactagacg ctgagcgctc ccgtgcgcag cgccccacgc agccgggacg cggcgccgct
       61 ctgcgggtgg aaccgccgcg cgctcccggc ctcgggagct gagcccgaga gaacttcgct
      121 gccttcgggt cgccgctccc gctttccact gtggaatgtg cagcttggga tagagagaaa
      181 ccagggtttg gggagcggtc ctcctggaga ctttctctct gcaagtctcc aaggttaagc
      241 aattctgacc cactggaatt cccagagcct gggagttaag cctaaaacgc tctgttgctt
      301 taagcggcgc ggtggggagt cgctggacac tccttatttt ggttttacat taaaaagaag
      361 gcggacgaga agatgttgta ggtgacttcc tagctgtgtt aagttgctcc tgggctgtga
      421 atggtgttaa tttctgaagt gggcggctcc aaaaacttaa caaggaaagc tcaggtaacg
      481 gaggccttgg aaagagactc tgcgtcaggt cacccagcag agatcagcaa tccttggctc
      541 actgaggagg tttggatttg cctcaaaggg cactgcaaaa attgaacaga ggaatcccaa
      601 ggaagctgcc tgaatttgcc tgtatactct cgttctgcga cttataaagg accagacaaa
      661 tcaaattagt ggttttggtt tccgccagct gtggatgcct ttgacattat gaccgcagag
      721 gattccaccg cagccatgag cagtgactcg gccgccgggt cctccgccaa ggtgcccgag
      781 ggcgtggcgg gcgcgcccaa cgaggcagca ctgctggcgc tgatggagcg cacgggctac
      841 agcatggtgc aagagaacgg gcagcgcaag tacggcggcc caccgcccgg ctgggagggc
      901 ccgcacccgc agcgtggctg cgaggtcttc gtgggcaaga tcccgcgcga cgtgtacgag
      961 gacgagctgg tgcccgtgtt cgaggccgtg ggccgcatct acgagctgcg cctcatgatg
     1021 gactttgacg gcaagaaccg cggctacgcc ttcgtcatgt actgccacaa gcacgaggcc
     1081 aagcgcgcag tgcgtgagct caacaactac gagatccgcc cgggccgcct gctcggcgtg
     1141 tgctgcagcg tggacaactg ccgcctcttc atcggcggga tccccaagat gaagaagcgc
     1201 gaggaaatcc tggaggagat tgccaaggtc accgagggcg tgctggacgt gatcgtctac
     1261 gccagcgcgg ccgacaagat gaagaaccgc ggcttcgcct tcgtggagta cgagagccac
     1321 cgcgcggctg ccatggctcg ccgcaagctc atgcctggcc gcatccagct gtggggccac
     1381 cagatcgccg tggactgggc cgaacctgag atcgacgtgg acgaggacgt gatggagacc
     1441 gtgaagatcc tctacgtgcg caacctcatg atcgagacca ccgaggacac catcaagaag
     1501 agcttcggcc agttcaaccc cggctgcgtg gagcgcgtca agaagatccg cgactacgcc
     1561 ttcgtgcact tcaccagccg cgaggatgcc gtgcatgcca tgaacaacct caacggcact
     1621 gagctggagg gctcgtgcct ggaggtcacg ctggccaagc ccgtggacaa ggagcagtac
     1681 tcgcgctacc agaaggcagc caggggcggc ggcgcggctg aggcagcgca gcagcccagc
     1741 tacgtgtact cctgcgaccc ctacacactg gcctactacg gctaccccta caacgcgctc
     1801 attgggccca acagggacta ctttgtgaaa gcaggcagca taagaggccg agggcgaggt
     1861 gcagctggca acagagcccc agggcctagg ggttcctacc tcgggggata ttctgctggt
     1921 cgtggtatat atagccgata tcatgaaggg aaaggaaagc agcaagaaaa aggatatgaa
     1981 ctggtgccga atttggaaat ccctaccgtc aacccagttg ccattaaacc tggtacagta
     2041 gccatccctg ccattggggc tcagtattcc atgtttccag cagctccagc ccctaaaatg
     2101 attgaagatg gcaaaatcca cacagtggag cacatgatca gccccattgc tgtgcagcca
     2161 gacccagcca gtgctgctgc cgccgcagcc gcggccgcag ccgccgcagc cgctgtcatt
     2221 cccactgtgt cgacgccacc acctttccag ggccgcccaa taactccagt atacacggtg
     2281 gctccaaacg ttcagagaat tcctactgcc gggatctacg gggccagtta cgtgccattt
     2341 gctgctccag ctacagccac gatcgccaca ctacagaaga acgcggcagc cgcggccgcc
     2401 atgtatggag gatacgcagg ctacatacct caggccttcc ctgctgctgc cattcaggtc
     2461 cccatccccg acgtctacca gacatactga ggctggtgac cagcacgaag acagaccaca
     2521 caaacaccac tgaaggaacg cttgactatt tatgaagaag gaacatgttg gattcacaca
     2581 tgcaacctga aagtgaagaa tgttagcaga tttatttctg aattatttta tatacatgaa
     2641 gttttcacta gttttttaag actattttca acttagcatg cctacgttca tacatttcca
     2701 aaagacttgc aatggttcgt gccttcattc catcttttaa aaatttgtat gctgtactac
     2761 atttgtatag aggtttttgt tgttgttttt ttaaggatat attttcagta tgaaggttat
     2821 tttcttaact tctgcactcc agagatttct attttgtagt accttcaata atatatcaac
     2881 tatatattaa aaaagcacac ttgaggagct agggaactat tttgaaaaat atatacaata
     2941 tttaaagata caaacagtag tgcttaaaaa tactacataa agcattattt taaaggttat
     3001 actggaaagt gcaattttaa aatgagtaaa acctctgtat ttctgctggc attaagggtt
     3061 gatggtgtta ccatgtatca tcatggcggt actatttttt aaaagaaatt aaacactgga
     3121 tctctcctta agccaacatt gaaaagactt gccgcacttc tgagtccaaa cactggaaag
     3181 ctctcctttg ccaccgttag ccggggctca ttctccatgt gccttagcct taaacatgcc
     3241 cccactccca catctctcac cctgtcccct cctccccaga ttcccaatcc caccgcaatg
     3301 tttggcaagc ctaggactga taagtagctc tgatagagga gctggtggct tttatacttc
     3361 ttcctgggtt tttgttgggg tttgttgttt cgttgttttt tgtttttttt tttgtttggt
     3421 tggggaagta ttgtcttcta cgtgtgctat tttcagtagc agagtaagca caaggtttta
     3481 atcgagttgc ataagacacc tttgcatagc tatttaattg cccaatgtaa aactttaatg
     3541 ccatttctaa tgcttttatt catttttgaa gtatgagttt gtagggacaa agaatgtatg
     3601 ttatcgtaga caagaccccc agagactctt ttcagcagaa agttatgctt ctagttgcct
     3661 taccatgttt cttgcaaaac tgtccatggt cctcaagggt gttggaaaca ttatgtttat
     3721 taaatgggcc tctcttcctt tgctgtgcac ttgatgggtg aactggattg gggtgtgcac
     3781 atccaggagg aggaggagag acctgtagaa gtttaaagat agtttgtaaa tatcttctaa
     3841 tgcttgtttt tagtcctttt atgttggaga agttcatggt atgtagttta atgcaaaatg
     3901 aaaccatttt atttcaatgt tattaaaaag gtttgtttta ttaggaagtt aatgtattgt
     3961 tgcagtgttt tgtgcctgtt taaaggcttt tgtttagcag agtgaatgta aaatacagta
     4021 aaatgttaag attgtcatct actttttaaa aaaaaatatc aacttggaat tgttttttaa
     4081 aggctcaatc aaggaagtga ggtgtgcaat aaggtagcaa gtaaaacgca gttgcgtttt
     4141 tatgtcatgt tagagatcca tacaattttc cactcacggg atttttgttg atggctgaat
     4201 tcttgtggat tcataagagg atcatgccct tagcaagtac ttttgttttg ttttaaatta
     4261 agagattccc aaatgccttt ttccccctca tcttgaaatg agatgagttt ttatgtgtaa
     4321 gcaatattta tttaactatt ctataaaatt attgagtgcc tactgaggcc tttaagcacc
     4381 gctaacattc ctttccatca ttcttttaaa tgacataaaa taattgtgca atgttcctga
     4441 tgatgtaccc cacaagctgc attcaaactc aaatctgtgg gaatgagtga ctcgacaaaa
     4501 tgtaattcgg atcagatcct catcccctga ctgtgtgaaa aaagtactct ccttctagtg
     4561 aaggattgtc acagagtttc actggatgaa actatgaccc agtattctta ctgtatttta
     4621 catatgcctg taaattattt gcaaaaaaga agaagaagag gaagaaagaa aagaaagaaa
     4681 agaaagaaag aaagaaagaa agaaagaaag aaagaaagaa agaaagaaag aaagaaagaa
     4741 aaagaaagaa agaataaaaa aaaatgataa catggcaacc accaaactcc cttaaaaaca
     4801 aacattggtg acatggccaa ttaagtatca gtgagcctcc tatctgggac ttatctgttc
     4861 ctattgtttc aaaaccattt catgtacact actgaggtaa gtttataact tgaaatgtga
     4921 actttttttt tttttagtgt taagaacaaa ctatataaat gtaaaaaaaa agttttagag
     4981 ttctgttttc aaacattgct agtggtttag ttaactttag ctgctttata tttgaaaagc
     5041 ttttatttag atcttgctcc atttacagta cattcttagg atgtatgtag taaataaagc
     5101 tttctttaaa gcaa
//
