LOCUS       NM_144979               2524 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens RNA binding motif protein 46 (RBM46), transcript
            variant 1, mRNA.
ACCESSION   NM_144979
VERSION     NM_144979.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2524)
  AUTHORS   Wang,S., Kim,K., Gelvez,N., Chung,C., Gout,J.F., Fixman,B.,
            Vermulst,M. and Chen,X.S.
  TITLE     Identification of RBM46 as a novel APOBEC1 cofactor for C-to-U
            RNA-editing activity
  JOURNAL   J Mol Biol 435 (24) (2023)
   PUBMED   38708190
  REMARK    GeneRIF: Identification of RBM46 as a novel APOBEC1 cofactor for
            C-to-U RNA-editing activity.
REFERENCE   2  (bases 1 to 2524)
  AUTHORS   Qian,B., Li,Y., Yan,R., Han,S., Bu,Z., Gong,J., Zheng,B., Yuan,Z.,
            Ren,S., He,Q., Zhang,J., Xu,C., Wang,R., Sun,Z., Lin,M., Zhou,J.
            and Ye,L.
  TITLE     RNA binding protein RBM46 regulates mitotic-to-meiotic transition
            in spermatogenesis
  JOURNAL   Sci Adv 8 (34), eabq2945 (2022)
   PUBMED   36001654
  REMARK    GeneRIF: RNA binding protein RBM46 regulates mitotic-to-meiotic
            transition in spermatogenesis.
REFERENCE   3  (bases 1 to 2524)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2524)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 2524)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB449155.1, BC028588.2 and DB527978.1.
            
            On Nov 22, 2018 this sequence version replaced NM_144979.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028588.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000281722.8/ ENSP00000281722.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                DB449155.1         1-76
            77-2064             BC028588.2         1-1988
            2065-2096           DB527978.1         1-32
            2097-2524           BC028588.2         2020-2447
FEATURES             Location/Qualifiers
     source          1..2524
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.1"
     gene            1..2524
                     /gene="RBM46"
                     /gene_synonym="CT68"
                     /note="RNA binding motif protein 46"
                     /db_xref="GeneID:166863"
                     /db_xref="HGNC:HGNC:28401"
                     /db_xref="MIM:620147"
     exon            1..165
                     /gene="RBM46"
                     /gene_synonym="CT68"
                     /inference="alignment:Splign:2.1.0"
     exon            166..327
                     /gene="RBM46"
                     /gene_synonym="CT68"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..1778
                     /gene="RBM46"
                     /gene_synonym="CT68"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cancer/testis antigen 68; probable RNA-binding protein 46"
                     /codon_start=1
                     /product="probable RNA-binding protein 46 isoform 1"
                     /protein_id="NP_659416.1"
                     /db_xref="CCDS:CCDS3790.1"
                     /db_xref="GeneID:166863"
                     /db_xref="HGNC:HGNC:28401"
                     /db_xref="MIM:620147"
                     /translation="MNEENIDGTNGCSKVRTGIQNEAALLALMEKTGYNMVQENGQRK
                     FGGPPPGWEGPPPPRGCEVFVGKIPRDMYEDELVPVFERAGKIYEFRLMMEFSGENRG
                     YAFVMYTTKEEAQLAIRILNNYEIRPGKFIGVCVSLDNCRLFIGAIPKEKKKEEILDE
                     MKKVTEGVVDVIVYPSATDKTKNRGFAFVEYESHRAAAMARRKLIPGTFQLWGHTIQV
                     DWADPEKEVDEETMQRVKVLYVRNLMISTTEETIKAEFNKFKPGAVERVKKLRDYAFV
                     HFFNREDAVAAMSVMNGKCIDGASIEVTLAKPVNKENTWRQHLNGQISPNSENLIVFA
                     NKEESHPKTLGKLPTLPARLNGQHSPSPPEVERCTYPFYPGTKLTPISMYSLKSNHFN
                     SAVMHLDYYCNKNNWAPPEYYLYSTTSQDGKVLLVYKIVIPAIANGSQSYFMPDKLCT
                     TLEDAKELAAQFTLLHLDYNFHRSSINSLSPVSATLSSGTPSVLPYTSRPYSYPGYPL
                     SPTISLANGSHVGQRLCISNQASFF"
     exon            328..795
                     /gene="RBM46"
                     /gene_synonym="CT68"
                     /inference="alignment:Splign:2.1.0"
     exon            796..1578
                     /gene="RBM46"
                     /gene_synonym="CT68"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..2524
                     /gene="RBM46"
                     /gene_synonym="CT68"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2504..2509
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM46"
                     /gene_synonym="CT68"
                     /note="hexamer: ATTAAA"
     polyA_site      2524
                     /gene="RBM46"
                     /gene_synonym="CT68"
                     /note="major polyA site"
ORIGIN      
        1 gggaaacgag tggagacacg aggaccagcg cgagcggtcc cggtgggcta ccctccccct
       61 gcgacgaccc cccctcgctc tgaccgactg gtcccctaaa cggtggcggc ggtttttggt
      121 cgttgggccc cgggatttag gaccaacatt tgaagacccg aaggggaact gcaaccatga
      181 atgaagaaaa tatagatgga acaaatggat gcagtaaagt tcgaactggt attcagaatg
      241 aagcagcatt acttgctttg atggaaaaga ctggttacaa catggttcag gaaaatggac
      301 aaaggaaatt tggcggtcct cctccaggtt gggaaggtcc acctccacct agaggctgtg
      361 aagtttttgt aggaaaaata cctcgtgata tgtatgaaga tgagttagtt cctgtatttg
      421 aaagagctgg gaagatatat gaatttcgac ttatgatgga atttagtggt gaaaatcgag
      481 gttatgcttt tgtgatgtac actacaaaag aagaagccca attagccatc agaattctta
      541 ataattatga aattcgacca gggaagttta ttggtgtgtg tgtaagcctg gataattgta
      601 gattatttat tggagctatt cccaaggaaa agaagaaaga agaaatttta gatgaaatga
      661 agaaagttac agaaggagtt gtagatgtca ttgtttatcc aagtgcaact gataagacca
      721 aaaatcgtgg ttttgcattt gtggaatatg aatctcacag agctgctgct atggcaagga
      781 ggaaactaat tccaggaaca ttccaactat ggggccacac cattcaggta gattgggctg
      841 acccagagaa agaggtggat gaggaaacca tgcagagagt taaagttctt tatgtaagaa
      901 atttaatgat ctcaactaca gaggaaacaa ttaaagcaga attcaataaa tttaagcctg
      961 gtgcagttga acgggtaaag aaacttagag attatgcttt tgttcacttt ttcaaccgag
     1021 aagatgcagt ggctgccatg tctgttatga atggaaaatg cattgatgga gcaagtattg
     1081 aggtaacact agctaaacca gtaaataaag aaaacacttg gagacagcat cttaatggtc
     1141 agattagtcc aaattctgaa aatctgattg tgtttgctaa caaagaagag agccacccaa
     1201 aaactctagg caagctgcca actcttcctg ctcgtctcaa tggtcagcat agcccaagtc
     1261 cgcctgaagt tgaaagatgc acttaccctt tttatcctgg aacaaagctt actccaatta
     1321 gtatgtattc tttaaaatcc aatcatttta attctgcagt aatgcatttg gattattact
     1381 gcaacaaaaa taactgggca ccaccagaat attatttata ttcaacaaca agtcaagatg
     1441 ggaaagtact cttggtgtat aagatagtta ttcctgctat tgcaaatgga tcccagagtt
     1501 acttcatgcc agacaaactc tgtactacgt tagaagatgc aaaggaactg gcagcccagt
     1561 ttacattact tcatttggac tacaatttcc atcgcagctc aataaatagt ctttcccctg
     1621 ttagtgctac cctctcttct gggactccca gcgtgcttcc ttatacttca aggccttatt
     1681 cttatccagg ctatcctttg tcaccaacaa tatcacttgc taatggcagc catgttggac
     1741 agcggctatg tatctccaat caggcctcct tcttctgaag aaaatactaa cattagtatg
     1801 aaaatttgtg taaatttgta gtatgaaaac ttgcaaatta aaatattgtt ttattttaga
     1861 atcgggtttg catatttggt tttaaaaagg tatttattcc aaagtactaa acatcagcta
     1921 taattcagaa taacatggag ttgtagaatt tataaaaatg caaagtttaa aaagttattc
     1981 agtggtttct cttgataaag gtacagcaaa ctactattct ttttaaactt ctaggatttt
     2041 cttctacttt ctgagtgggc aatagaacct agtcatttat gttttttttt ttttttgcat
     2101 aattttacta aatagtattt cacaaatatt aaagcacttg aagacaatgg ttatagtaga
     2161 tttgattacc aaggatcact atctgtactg gagattagaa caattatatg accagaagca
     2221 tctaaccatt atgtaaaaag aaatgatgag acaaaaagat taagatacaa attttgtgca
     2281 gtactaaaga aaaagcagtc taccattgtg gtccttgaaa ataactatag atatttttgt
     2341 tatttgttag acacaaatta taattttgtt gttaatgtat ttaagcattt tatagttatg
     2401 ctttgtgttt ttgatattct ttgtattgtt aataacaagt gttatgggtt tttaatgttg
     2461 aaatcatgtg ttaatttttg tacttgaatt caaatttttt gacattaaat atgtgatgct
     2521 tcta
//
