LOCUS       NM_152945               1803 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens RNA binding motif protein 45 (RBM45), transcript
            variant 1, mRNA.
ACCESSION   NM_152945
VERSION     NM_152945.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1803)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1803)
  AUTHORS   Wang,C., Chen,Z., Yi,Y., Ding,Y., Xu,F., Kang,H., Lin,K., Shu,X.,
            Zhong,Z., Zhang,Z., Liu,J., Xu,Z., Liu,L., He,X., Chang,Y. and
            Zhao,Q.
  TITLE     RBM45 reprograms lipid metabolism promoting hepatocellular
            carcinoma via Rictor and ACSL1/ACSL4
  JOURNAL   Oncogene 43 (5), 328-340 (2024)
   PUBMED   38040804
  REMARK    GeneRIF: RBM45 reprograms lipid metabolism promoting hepatocellular
            carcinoma via Rictor and ACSL1/ACSL4.
REFERENCE   3  (bases 1 to 1803)
  AUTHORS   Wang,R., Sun,H., Chen,W., Zhao,B. and Chen,L.
  TITLE     Molecular basis of ssDNA recognition by RBM45 protein of
            neurodegenerative disease from multiple molecular dynamics
            simulations and energy predictions
  JOURNAL   J Mol Graph Model 118, 108377 (2023)
   PUBMED   36435031
  REMARK    GeneRIF: Molecular basis of ssDNA recognition by RBM45 protein of
            neurodegenerative disease from multiple molecular dynamics
            simulations and energy predictions.
REFERENCE   4  (bases 1 to 1803)
  AUTHORS   van der Zee,J., Dillen,L., Baradaran-Heravi,Y., Gossye,H.,
            Kocoglu,C., Cuyt,I., Dermaut,B., Sieben,A., Baets,J., De Jonghe,P.,
            Vandenberghe,R., De Deyn,P., Cras,P., Engelborghs,S. and Van
            Broeckhoven,C.
  CONSRTM   BELNEU Consortium
  TITLE     Family-based exome sequencing identifies RBM45 as a possible
            candidate gene for frontotemporal dementia and amyotrophic lateral
            sclerosis
  JOURNAL   Neurobiol Dis 156, 105421 (2021)
   PUBMED   34118419
  REMARK    GeneRIF: Family-based exome sequencing identifies RBM45 as a
            possible candidate gene for frontotemporal dementia and amyotrophic
            lateral sclerosis.
REFERENCE   5  (bases 1 to 1803)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1803)
  AUTHORS   Collins,M., Riascos,D., Kovalik,T., An,J., Krupa,K., Krupa,K.,
            Hood,B.L., Conrads,T.P., Renton,A.E., Traynor,B.J. and Bowser,R.
  TITLE     The RNA-binding motif 45 (RBM45) protein accumulates in inclusion
            bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal
            lobar degeneration with TDP-43 inclusions (FTLD-TDP) patients
  JOURNAL   Acta Neuropathol 124 (5), 717-732 (2012)
   PUBMED   22993125
  REMARK    GeneRIF: This study demonistrated that RBM45 protein accumulates in
            inclusion bodies in amyotrophic lateral sclerosis (ALS) and
            frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP)
            patients.
REFERENCE   7  (bases 1 to 1803)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   8  (bases 1 to 1803)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   9  (bases 1 to 1803)
  AUTHORS   Chu,X., Pan,C.M., Zhao,S.X., Liang,J., Gao,G.Q., Zhang,X.M.,
            Yuan,G.Y., Li,C.G., Xue,L.Q., Shen,M., Liu,W., Xie,F., Yang,S.Y.,
            Wang,H.F., Shi,J.Y., Sun,W.W., Du,W.H., Zuo,C.L., Shi,J.X.,
            Liu,B.L., Guo,C.C., Zhan,M., Gu,Z.H., Zhang,X.N., Sun,F.,
            Wang,Z.Q., Song,Z.Y., Zou,C.Y., Sun,W.H., Guo,T., Cao,H.M.,
            Ma,J.H., Han,B., Li,P., Jiang,H., Huang,Q.H., Liang,L., Liu,L.B.,
            Chen,G., Su,Q., Peng,Y.D., Zhao,J.J., Ning,G., Chen,Z., Chen,J.L.,
            Chen,S.J., Huang,W. and Song,H.D.
  CONSRTM   China Consortium for Genetics of Autoimmune Thyroid Disease
  TITLE     A genome-wide association study identifies two new risk loci for
            Graves' disease
  JOURNAL   Nat Genet 43 (9), 897-901 (2011)
   PUBMED   21841780
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1803)
  AUTHORS   Tamada,H., Sakashita,E., Shimazaki,K., Ueno,E., Hamamoto,T.,
            Kagawa,Y. and Endo,H.
  TITLE     cDNA cloning and characterization of Drb1, a new member of RRM-type
            neural RNA-binding protein
  JOURNAL   Biochem Biophys Res Commun 297 (1), 96-104 (2002)
   PUBMED   12220514
  REMARK    GeneRIF: a new member of RRM-type neural RNA-binding protein
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI763677.1 and BC066549.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152945.3.
            
            Summary: This gene encodes a member of the RNA recognition motif
            (RRM)-type RNA-binding family of proteins. This protein exhibits
            preferential binding to poly(C) RNA. Initial cloning of this gene
            found that the rat ortholog was dynamically expressed in the
            developing rat brain. This protein has been localized to inclusion
            bodies in the brain and spinal cord of amyotrophic lateral
            sclerosis and Alzheimer's patients. A pseudogene has been
            identified on chromosome 8. [provided by RefSeq, Feb 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.818402.1,
                                           SRR3476690.1116965.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000286070.10/ ENSP00000286070.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BI763677.1         14-31
            19-1803             BC066549.1         1-1785
FEATURES             Location/Qualifiers
     source          1..1803
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.2"
     gene            1..1803
                     /gene="RBM45"
                     /gene_synonym="DRB1; RB-1"
                     /note="RNA binding motif protein 45"
                     /db_xref="GeneID:129831"
                     /db_xref="HGNC:HGNC:24468"
                     /db_xref="MIM:608888"
     exon            1..410
                     /gene="RBM45"
                     /gene_synonym="DRB1; RB-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1535
                     /gene="RBM45"
                     /gene_synonym="DRB1; RB-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RNA-binding protein 45; putative RNA binding protein RB-1;
                     developmentally regulated RNA-binding protein 1"
                     /codon_start=1
                     /product="RNA-binding protein 45 isoform 1"
                     /protein_id="NP_694453.2"
                     /db_xref="CCDS:CCDS33335.1"
                     /db_xref="GeneID:129831"
                     /db_xref="HGNC:HGNC:24468"
                     /db_xref="MIM:608888"
                     /translation="MDEAGSSASGGGFRPGVDSLDEPPNSRIFLVISKYTPESVLRER
                     FSPFGDIQDIWVVRDKHTKESKGIAFVKFARSSQACRAMEEMHGQCLGPNDTKPIKVF
                     IAQSRSSGSHRDVEDEELTRIFVMIPKSYTEEDLREKFKVYGDIEYCSIIKNKVTGES
                     KGLGYVRYLKPSQAAQAIENCDRSFRAILAEPKNKASESSEQDYYSNMRQEALGHEPR
                     VNMFPFEQQSEFSSFDKNDSRGQEAISKRLSVVSRVPFTEEQLFSIFDIVPGLEYCEV
                     QRDPYSNYGHGVVQYFNVASAIYAKYKLHGFQYPPGNRIGVSFIDDGSNATDLLRKMA
                     TQMVAAQLASMVWNNPSQQQFMQFGGSSGSQLPQIQTDVVLPSCKKKAPAETPVKERL
                     FIVFNPHPLPLDVLEDIFCRFGNLIEVYLVSGKNVGYAKYADRISANDAIATLHGKIL
                     NGVRLKVMLADSPREESNKRQRTY"
     exon            411..533
                     /gene="RBM45"
                     /gene_synonym="DRB1; RB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            534..660
                     /gene="RBM45"
                     /gene_synonym="DRB1; RB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            661..783
                     /gene="RBM45"
                     /gene_synonym="DRB1; RB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            784..963
                     /gene="RBM45"
                     /gene_synonym="DRB1; RB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1093
                     /gene="RBM45"
                     /gene_synonym="DRB1; RB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1178
                     /gene="RBM45"
                     /gene_synonym="DRB1; RB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1342
                     /gene="RBM45"
                     /gene_synonym="DRB1; RB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1543
                     /gene="RBM45"
                     /gene_synonym="DRB1; RB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1803
                     /gene="RBM45"
                     /gene_synonym="DRB1; RB-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1778..1783
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM45"
                     /gene_synonym="DRB1; RB-1"
                     /note="hexamer: AATAAA"
     polyA_site      1803
                     /gene="RBM45"
                     /gene_synonym="DRB1; RB-1"
                     /note="major polyA site"
ORIGIN      
        1 ctcccggaag cggagcaccg agccggcaaa ggcttgggtg tgagacagca gcggtggcag
       61 acaccgcaga agcaaagagc agtgaggctc ctgcattcgg gtggagcacc atggacgaag
      121 ctggcagctc tgcgagcggc gggggcttcc gcccgggcgt ggacagcctg gacgaaccgc
      181 ccaacagccg catcttcctt gtgatcagca agtacacacc tgagtcggtg ctgagggagc
      241 gcttctcgcc ttttggcgac atccaggaca tctgggtggt gcgggacaag cacaccaagg
      301 agtccaaggg cattgctttc gtcaagttcg cccgcagctc acaggcctgc agggccatgg
      361 aggagatgca tggccagtgc ctcggcccca acgacaccaa gcccatcaag gttttcattg
      421 ctcagtcccg atcatctgga agtcaccgag atgttgaaga tgaagaactt acaagaatct
      481 ttgttatgat accaaagtcc tacacagaag aagatctgcg ggaaaaattt aaggtgtatg
      541 gagatatcga gtattgcagc attattaaga ataaagtgac tggagaaagt aaaggtttgg
      601 gctacgtacg atacttaaaa ccatcacaag ctgcccaagc aatagaaaac tgtgatcgaa
      661 gttttagagc aatcttggct gaacctaaaa ataaagcatc tgaatcctct gaacaagatt
      721 attatagtaa tatgaggcaa gaagctttgg gacatgaacc tagagtaaat atgtttccat
      781 ttgaacaaca atctgaattt tcaagttttg acaagaatga tagccgaggc caggaagcaa
      841 tctccaaacg cttgtcagtt gtatcaagag ttcctttcac tgaagaacag cttttcagca
      901 tttttgatat agtaccagga ttggaatatt gtgaagttca acgagatcct tattcaaatt
      961 atggtcatgg agtggttcag tattttaatg tagcatcagc tatttatgca aaatacaaat
     1021 tacatggatt tcagtaccct cctgggaacc gaataggtgt ttccttcatt gatgatggaa
     1081 gtaatgcaac agatctcctt agaaaaatgg caacacagat ggtagctgca cagcttgcat
     1141 caatggtgtg gaataaccca agtcagcaac aatttatgca atttggagga agctctggat
     1201 cacagttgcc tcaaatccag acagatgttg tacttccatc atgcaaaaaa aaagctcctg
     1261 ctgaaactcc tgtgaaagaa agacttttta ttgtgtttaa tcctcatcct ttacctttag
     1321 acgtattaga agatatattc tgtcgttttg gtaacctgat cgaagtttac cttgtgtcag
     1381 gaaaaaatgt ggggtatgcc aagtatgccg atagaataag tgctaatgat gccattgcca
     1441 ctctacatgg aaagattctg aatggggtga gacttaaagt tatgctggca gattcgccaa
     1501 gagaagaatc taacaaacgg caaagaactt actgattctt gagaacaaag actaaataat
     1561 gacataatcc tcagctgact gactgaaaat gtgactggac gcattccctg tggacagttg
     1621 acagcttttt ttttttccat atacctgata gtctgtgtac agcattgttt tgtctgggaa
     1681 gcagggattg ctgacatgta tttttgaatc catacattaa tgctaaaacg aatatagtag
     1741 ttgttcctta gagcaatatg ttgttacgtg tagcagaaat aaagttttct ttgcttaact
     1801 aaa
//
