LOCUS       NM_198557               4176 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens RNA binding motif protein 43 (RBM43), mRNA.
ACCESSION   NM_198557 XM_351503
VERSION     NM_198557.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4176)
  AUTHORS   Feng,H., Liu,J., Qiu,Y., Liu,Y., Saiyin,H., Liang,X., Zheng,F.,
            Wang,Y., Jiang,D., Wang,Y., Yu,L., Su,W., Shen,S. and Wu,J.
  TITLE     RNA-binding motif protein 43 (RBM43) suppresses hepatocellular
            carcinoma progression through modulation of cyclin B1 expression
  JOURNAL   Oncogene 39 (33), 5495-5506 (2020)
   PUBMED   32632220
  REMARK    GeneRIF: RNA-binding motif protein 43 (RBM43) suppresses
            hepatocellular carcinoma progression through modulation of cyclin
            B1 expression.
REFERENCE   2  (bases 1 to 4176)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4176)
  AUTHORS   Albertsen,H.M., Chettier,R., Farrington,P. and Ward,K.
  TITLE     Genome-wide association study link novel loci to endometriosis
  JOURNAL   PLoS One 8 (3), e58257 (2013)
   PUBMED   23472165
REFERENCE   4  (bases 1 to 4176)
  AUTHORS   Palmer,N.D., McDonough,C.W., Hicks,P.J., Roh,B.H., Wing,M.R.,
            An,S.S., Hester,J.M., Cooke,J.N., Bostrom,M.A., Rudock,M.E.,
            Talbert,M.E., Lewis,J.P., Ferrara,A., Lu,L., Ziegler,J.T.,
            Sale,M.M., Divers,J., Shriner,D., Adeyemo,A., Rotimi,C.N., Ng,M.C.,
            Langefeld,C.D., Freedman,B.I., Bowden,D.W., Voight,B.F.,
            Scott,L.J., Steinthorsdottir,V., Morris,A.P., Dina,C., Welch,R.P.,
            Zeggini,E., Huth,C., Aulchenko,Y.S., Thorleifsson,G.,
            McCulloch,L.J., Ferreira,T., Grallert,H., Amin,N., Wu,G.,
            Willer,C.J., Raychaudhuri,S., McCarroll,S.A., Langenberg,C.,
            Hofmann,O.M., Dupuis,J., Qi,L., Segre,A.V., van Hoek,M.,
            Navarro,P., Ardlie,K., Balkau,B., Benediktsson,R., Bennett,A.J.,
            Blagieva,R., Boerwinkle,E., Bonnycastle,L.L., Bostrom,K.B.,
            Bravenboer,B., Bumpstead,S., Burtt,N.P., Charpentier,G.,
            Chines,P.S., Cornelis,M., Couper,D.J., Crawford,G., Doney,A.S.,
            Elliott,K.S., Elliott,A.L., Erdos,M.R., Fox,C.S., Franklin,C.S.,
            Ganser,M., Gieger,C., Grarup,N., Green,T., Griffin,S., Groves,C.J.,
            Guiducci,C., Hadjadj,S., Hassanali,N., Herder,C., Isomaa,B.,
            Jackson,A.U., Johnson,P.R., Jorgensen,T., Kao,W.H., Klopp,N.,
            Kong,A., Kraft,P., Kuusisto,J., Lauritzen,T., Li,M., Lieverse,A.,
            Lindgren,C.M., Lyssenko,V., Marre,M., Meitinger,T., Midthjell,K.,
            Morken,M.A., Narisu,N., Nilsson,P., Owen,K.R., Payne,F.,
            Perry,J.R., Petersen,A.K., Platou,C., Proenca,C., Prokopenko,I.,
            Rathmann,W., Rayner,N.W., Robertson,N.R., Rocheleau,G., Roden,M.,
            Sampson,M.J., Saxena,R., Shields,B.M., Shrader,P., Sigurdsson,G.,
            Sparso,T., Strassburger,K., Stringham,H.M., Sun,Q., Swift,A.J.,
            Thorand,B., Tichet,J., Tuomi,T., van Dam,R.M., van Haeften,T.W.,
            van Herpt,T., van Vliet-Ostaptchouk,J.V., Walters,G.B.,
            Weedon,M.N., Wijmenga,C., Witteman,J., Bergman,R.N., Cauchi,S.,
            Collins,F.S., Gloyn,A.L., Gyllensten,U., Hansen,T., Hide,W.A.,
            Hitman,G.A., Hofman,A., Hunter,D.J., Hveem,K., Laakso,M.,
            Mohlke,K.L., Morris,A.D., Palmer,C.N., Pramstaller,P.P., Rudan,I.,
            Sijbrands,E., Stein,L.D., Tuomilehto,J., Uitterlinden,A.,
            Walker,M., Wareham,N.J., Watanabe,R.M., Abecasis,G.R., Boehm,B.O.,
            Campbell,H., Daly,M.J., Hattersley,A.T., Hu,F.B., Meigs,J.B.,
            Pankow,J.S., Pedersen,O., Wichmann,H.E., Barroso,I., Florez,J.C.,
            Frayling,T.M., Groop,L., Sladek,R., Thorsteinsdottir,U.,
            Wilson,J.F., Illig,T., Froguel,P., van Duijn,C.M., Stefansson,K.,
            Altshuler,D., Boehnke,M., McCarthy,M.I., Soranzo,N., Wheeler,E.,
            Glazer,N.L., Bouatia-Naji,N., Magi,R., Randall,J., Johnson,T.,
            Elliott,P., Rybin,D., Henneman,P., Dehghan,A., Hottenga,J.J.,
            Song,K., Goel,A., Egan,J.M., Lajunen,T., Doney,A., Kanoni,S.,
            Cavalcanti-Proenca,C., Kumari,M., Timpson,N.J., Zabena,C.,
            Ingelsson,E., An,P., O'Connell,J., Luan,J., Elliott,A.,
            McCarroll,S.A., Roccasecca,R.M., Pattou,F., Sethupathy,P.,
            Ariyurek,Y., Barter,P., Beilby,J.P., Ben-Shlomo,Y., Bergmann,S.,
            Bochud,M., Bonnefond,A., Borch-Johnsen,K., Bottcher,Y., Brunner,E.,
            Bumpstead,S.J., Chen,Y.D., Chines,P., Clarke,R., Coin,L.J.,
            Cooper,M.N., Crisponi,L., Day,I.N., de Geus,E.J., Delplanque,J.,
            Fedson,A.C., Fischer-Rosinsky,A., Forouhi,N.G., Frants,R.,
            Franzosi,M.G., Galan,P., Goodarzi,M.O., Graessler,J., Grundy,S.,
            Gwilliam,R., Hallmans,G., Hammond,N., Han,X., Hartikainen,A.L.,
            Hayward,C., Heath,S.C., Hercberg,S., Hicks,A.A., Hillman,D.R.,
            Hingorani,A.D., Hui,J., Hung,J., Jula,A., Kaakinen,M., Kaprio,J.,
            Kesaniemi,Y.A., Kivimaki,M., Knight,B., Koskinen,S., Kovacs,P.,
            Kyvik,K.O., Lathrop,G.M., Lawlor,D.A., Le Bacquer,O., Lecoeur,C.,
            Li,Y., Mahley,R., Mangino,M., Manning,A.K., Martinez-Larrad,M.T.,
            McAteer,J.B., McPherson,R., Meisinger,C., Melzer,D., Meyre,D.,
            Mitchell,B.D., Mukherjee,S., Naitza,S., Neville,M.J., Oostra,B.A.,
            Orru,M., Pakyz,R., Paolisso,G., Pattaro,C., Pearson,D., Peden,J.F.,
            Pedersen,N.L., Perola,M., Pfeiffer,A.F., Pichler,I., Polasek,O.,
            Posthuma,D., Potter,S.C., Pouta,A., Province,M.A., Psaty,B.M.,
            Rayner,N.W., Rice,K., Ripatti,S., Rivadeneira,F., Rolandsson,O.,
            Sandbaek,A., Sandhu,M., Sanna,S., Sayer,A.A., Scheet,P.,
            Seedorf,U., Sharp,S.J., Shields,B., Sijbrands,E.J., Silveira,A.,
            Simpson,L., Singleton,A., Smith,N.L., Sovio,U., Swift,A.,
            Syddall,H., Syvanen,A.C., Tanaka,T., Tonjes,A., Uitterlinden,A.G.,
            van Dijk,K.W., Varma,D., Visvikis-Siest,S., Vitart,V.,
            Vogelzangs,N., Waeber,G., Wagner,P.J., Walley,A., Ward,K.L.,
            Watkins,H., Wild,S.H., Willemsen,G., Witteman,J.C., Yarnell,J.W.,
            Zelenika,D., Zethelius,B., Zhai,G., Zhao,J.H., Zillikens,M.C.,
            Borecki,I.B., Loos,R.J., Meneton,P., Magnusson,P.K., Nathan,D.M.,
            Williams,G.H., Silander,K., Salomaa,V., Smith,G.D., Bornstein,S.R.,
            Schwarz,P., Spranger,J., Karpe,F., Shuldiner,A.R., Cooper,C.,
            Dedoussis,G.V., Serrano-Rios,M., Lind,L., Palmer,L.J., Franks,P.W.,
            Ebrahim,S., Marmot,M., Kao,W.H., Pramstaller,P.P., Wright,A.F.,
            Stumvoll,M., Hamsten,A., Buchanan,T.A., Valle,T.T., Rotter,J.I.,
            Siscovick,D.S., Penninx,B.W., Boomsma,D.I., Deloukas,P.,
            Spector,T.D., Ferrucci,L., Cao,A., Scuteri,A., Schlessinger,D.,
            Uda,M., Ruokonen,A., Jarvelin,M.R., Waterworth,D.M.,
            Vollenweider,P., Peltonen,L., Mooser,V. and Sladek,R.
  CONSRTM   DIAGRAM Consortium; MAGIC Investigators
  TITLE     A genome-wide association search for type 2 diabetes genes in
            African Americans
  JOURNAL   PLoS One 7 (1), e29202 (2012)
   PUBMED   22238593
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX337439.2, DA658209.1, BC136411.1 and AC018731.5.
            
            On Nov 23, 2018 this sequence version replaced NM_198557.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK127552.1, BC136410.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331426.6/ ENSP00000331211.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BX337439.2         18-27
            11-107              DA658209.1         1-97
            108-1415            BC136411.1         20-1327
            1416-3902           AC018731.5         126996-129482       c
            3903-4176           AC018731.5         126722-126995       c
FEATURES             Location/Qualifiers
     source          1..4176
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q23.3"
     gene            1..4176
                     /gene="RBM43"
                     /gene_synonym="C2orf38"
                     /note="RNA binding motif protein 43"
                     /db_xref="GeneID:375287"
                     /db_xref="HGNC:HGNC:24790"
     exon            1..139
                     /gene="RBM43"
                     /gene_synonym="C2orf38"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1210
                     /gene="RBM43"
                     /gene_synonym="C2orf38"
                     /codon_start=1
                     /product="RNA-binding protein 43"
                     /protein_id="NP_940959.1"
                     /db_xref="CCDS:CCDS2191.1"
                     /db_xref="GeneID:375287"
                     /db_xref="HGNC:HGNC:24790"
                     /translation="MASVLNVKESKAPERTVVVAGLPVDLFSDQLLAVLVKSHFQDIK
                     NEGGDVEDVIYPTRTKGVAYVIFKEKKVAENVIRQKKHWLARKTRHAELTVSLRVSHF
                     GDKIFSSVNAILDLSVFGKEVTLETLVKDLKKKIPSLSFSPLKPNGRISVEGSFLAVK
                     RLRESLLARACSLLEKDRNFTSEERKWNRQNPQRNLQRSNNSLASVRTLVPETARSGE
                     MLVLDTDVFLYLKHKCGSYESTLKKFHILSQEKVDGEITTICLKSIQVGSQPNNAKHV
                     KELIEEWSHALYLKLRKETFILEGKENREKRMIKRACEQLSSRYLEVLINLYRTHIDI
                     IGSSSDTYLFKKGVMKLIGQKVS"
     exon            140..350
                     /gene="RBM43"
                     /gene_synonym="C2orf38"
                     /inference="alignment:Splign:2.1.0"
     exon            351..451
                     /gene="RBM43"
                     /gene_synonym="C2orf38"
                     /inference="alignment:Splign:2.1.0"
     exon            452..4176
                     /gene="RBM43"
                     /gene_synonym="C2orf38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4155..4160
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM43"
                     /gene_synonym="C2orf38"
                     /note="hexamer: AATAAA"
     polyA_site      4176
                     /gene="RBM43"
                     /gene_synonym="C2orf38"
                     /note="major polyA site"
ORIGIN      
        1 ccttttcttc gtagcctcca agggagctgg aacaaaaaac gaaaccaaaa cctgcctgct
       61 cgctcctctc cccatcgcct gcgttccgct ggttgtgggc tttctgcggc cgctgagggc
      121 gcgtctcccc tccgccatgg catcagtttt gaatgtcaag gaatccaaag ctcctgaaag
      181 aacggttgta gttgctggtc ttccagttga cctttttagt gatcaattat tggccgtatt
      241 agtgaagagc cacttccaag acattaagaa tgagggcgga gatgttgaag atgtgatata
      301 tccgacaaga accaagggag ttgcatatgt aatattcaaa gaaaaaaaag ttgcagagaa
      361 tgtcatcaga caaaagaaac actggctagc aaggaagact agacatgctg aactcacagt
      421 ctctctcaga gtctctcatt ttggtgacaa gatcttcagc tctgtaaatg ccatccttga
      481 tctttctgtt tttggaaaag aagttactct agaaactctg gtaaaagacc tgaaaaaaaa
      541 aatcccgagt ttaagcttca gtcctttgaa acccaatgga agaatctccg tggaaggatc
      601 atttctggct gtcaagaggc tcagagaatc tttgctagca agagcatgtt ctctcttaga
      661 aaaagacaga aattttacca gtgaggagag aaagtggaat agacaaaatc cccagaggaa
      721 tctacagaga agtaataact ctttggcatc agtcaggacc ttagtacctg agactgctag
      781 aagtggagaa atgcttgtgc ttgacacaga tgtttttctt tacctgaaac acaagtgtgg
      841 atcttatgaa agcacactga aaaaattcca cattctgagt caggagaaag tggatggtga
      901 aatcaccaca atttgtctaa aaagcattca agttggttct cagccaaaca atgcaaaaca
      961 tgtaaaagag ctcattgagg aatggtcaca tgctctttac ttaaagctta gaaaagagac
     1021 atttattttg gaaggaaagg aaaatagaga gaaaagaatg atcaaaaggg catgtgaaca
     1081 attaagttcg agataccttg aagtcctgat taacctttat aggacacaca ttgacattat
     1141 aggatcttct tctgacactt acctgtttaa aaaaggggtc atgaaattaa tagggcaaaa
     1201 ggttagttaa taaaatctca gcaatatagt cataagggct gctttctctt gctgagcagt
     1261 gaccattgcc atgaatgagg ctagctttac acaccgtatc tcatgaatcc ttatagtcat
     1321 ccttctttgt cagtgttgac tatcctcatg ttacagcgga agaaactagg atttggagaa
     1381 gttaaaacac ttttctgaag ttatccagtt gacaaagaat gaggctgtgg cttagcccag
     1441 tctatctgat tacacagata atatctaagg aataaaactt tgaaaaaaac tcaccaaact
     1501 tttttttttt tttttttgag atggagtctc gctctgttgt ccaggctgga gtgcagtggc
     1561 gtgatctcgg ctcactgcaa cgtccacctc ctgggttcac accattctcc tgcctcaacc
     1621 tctggagtag ctgggactac aggtgcccac caccacgccc ggctaatctt tttgtatttt
     1681 tttagtagag atggggtttc accgtgttag tcaggatggt ctccatctcc tgaccttgtg
     1741 atccacccgc ctcggcctcc caaagtgctg ggattacagg cgtgagccac tgcgcccagc
     1801 aaactcacca aactttgaag gaatcttact ttctctgtaa ctccaaatta ttagagaata
     1861 ataattatta agaagtagcc ttaacatatg agaaatttga aaggtgatta ttatgccatg
     1921 ggcaatttct taacatttac agtttgtgtt tactccgtgt agaattagaa tactggcaaa
     1981 aatcactggg gaaactactt agatggaaag catatcttat gcaggtaatc attatttgac
     2041 taaattctat tgtttcaagg ctgctggcca cataggatgt ttttactatt tttttagcct
     2101 aagtgcttac ataaaatggt gattctttta taattgtgca agttgataat attaattgag
     2161 tcattcttgt cacatccaac taaaacagac tcaagaagct agggggaaaa agtacttggg
     2221 acacataata ttgctccaag aatgtaattc tctgtgagcc tggctactga aactgcttgc
     2281 tgtaacctga gaccagtttt gtctatagct gctgagataa cttgctgtaa ctctaggact
     2341 aattttacct atggccattg cccaccagtt ggagcttgcc agctccccag ggctttacta
     2401 ataccaatga actttctctt aagatcacaa gttggccggg cgtggtgact catacctgta
     2461 atcccagcac tttgggaggc cgaggcgggt ggatcacaag gtcaggagat tgagaccatc
     2521 ctggctaaca tggtaaaacc ccatctctac taaaaataca aaaattagcc gggcatggtg
     2581 gtgggcgcct gtagtcccac ctactcggga ggctagaggc tgaggcagga gaatggcgtg
     2641 aacccgggag gtggagcttg cagtgagcca agactgcact actgcactcc agcctgggtg
     2701 acagagcgag actccgtctc aaaaaaaaaa aaaaaaaaaa aagaaagacc acaagtaaca
     2761 ttcttagttt taaataaaac cctcaacctt ctctttgttt gttggacata ctaaagatca
     2821 cctagaattg aaattctttc ttctcaaaac attaaattta gttttgtgtc tacattttca
     2881 ttttgacttt gacatgcatg gtgtcagaag tgggatacaa agctgactca cctcatggag
     2941 aatcattggc ctttggagtt atggcatgag gtacccatgt tggggccctt tgaaccccct
     3001 acacccccac cactttcaca ggtaatcctt tctccctcca gtaagtatct cttggacaga
     3061 actctcagat atggttcgag ttctgtttta tttgggatat gattagggag aggtctttcc
     3121 ccctcttgtt tggtagatct gttgggtaga attattttcc ccctgttgac ctcagctgcg
     3181 aggtttggac cttgaggctt ggatgaggga atttttccct ttctttggag aaggcttatc
     3241 attcttactg gtaagcatgt attttatttt ctgtcctgtc ttgtatttat ttggcctttg
     3301 tgtattcagt gcttgcattt acttggcttt tgcatagttg acattaaatc agagcaccca
     3361 cgaaatgagc tctcaaagtt caaaggcatg ccagaatatt ttctggaact ccagctagta
     3421 acatattcaa acattacagg gatcatttag tctgtttttc ttaaaactga actaaaagat
     3481 ggaggctata aaatcataca ctccaaataa gatatgcata tttcattgat atcttgaggc
     3541 taaaaaaaaa taaaaacaaa aacaaaacac attcaggata caaatattgc cttgttaaaa
     3601 aatactgtct caaaggtggc tgaaactttc ttttctagac ctttcccctc cccttcttac
     3661 agtatcccct ctttatcctt ctctaaacag ctattctaac atactactta aataaaaaca
     3721 cttgaaaacc agcagatata aaacaaagtc attttgacct tcctactgtt ttttttttaa
     3781 agcaaagatt aaattcccat gtaaaacctt cctccctata caaaaaagaa tagcagcatt
     3841 tttatcttca atgacaaaga attgagtcca agaaaatact gtataaacct tgttaaaaat
     3901 cactcttgtc ttttggtcct actcacataa ttcagcacac tttcacagtt aactattttt
     3961 tgttcaattt agtgcactgg tgagtgactc aaactgcttt atcccaaatt tgatttacag
     4021 cctttataag attgcctatt aaaaaagctt aaagcttatc cttagcccat tttgtcagaa
     4081 aaataatttg catctaatca tttttataaa ctggtgaatt tacgtgtttt actatatcat
     4141 gactaaaatt ctaaaataaa agttttaata tcttta
//
