LOCUS       NM_001324242            7005 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens RNA binding motif protein 41 (RBM41), transcript
            variant 3, mRNA.
ACCESSION   NM_001324242 XM_005262159
VERSION     NM_001324242.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7005)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   2  (bases 1 to 7005)
  AUTHORS   Gordon,D.E., Hiatt,J., Bouhaddou,M., Rezelj,V.V., Ulferts,S.,
            Braberg,H., Jureka,A.S., Obernier,K., Guo,J.Z., Batra,J.,
            Kaake,R.M., Weckstein,A.R., Owens,T.W., Gupta,M., Pourmal,S.,
            Titus,E.W., Cakir,M., Soucheray,M., McGregor,M., Cakir,Z., Jang,G.,
            O'Meara,M.J., Tummino,T.A., Zhang,Z., Foussard,H., Rojc,A.,
            Zhou,Y., Kuchenov,D., Huttenhain,R., Xu,J., Eckhardt,M.,
            Swaney,D.L., Fabius,J.M., Ummadi,M., Tutuncuoglu,B., Rathore,U.,
            Modak,M., Haas,P., Haas,K.M., Naing,Z.Z.C., Pulido,E.H., Shi,Y.,
            Barrio-Hernandez,I., Memon,D., Petsalaki,E., Dunham,A.,
            Marrero,M.C., Burke,D., Koh,C., Vallet,T., Silvas,J.A.,
            Azumaya,C.M., Billesbolle,C., Brilot,A.F., Campbell,M.G.,
            Diallo,A., Dickinson,M.S., Diwanji,D., Herrera,N., Hoppe,N.,
            Kratochvil,H.T., Liu,Y., Merz,G.E., Moritz,M., Nguyen,H.C.,
            Nowotny,C., Puchades,C., Rizo,A.N., Schulze-Gahmen,U., Smith,A.M.,
            Sun,M., Young,I.D., Zhao,J., Asarnow,D., Biel,J., Bowen,A.,
            Braxton,J.R., Chen,J., Chio,C.M., Chio,U.S., Deshpande,I., Doan,L.,
            Faust,B., Flores,S., Jin,M., Kim,K., Lam,V.L., Li,F., Li,J.,
            Li,Y.L., Li,Y., Liu,X., Lo,M., Lopez,K.E., Melo,A.A., Moss,F.R.
            3rd, Nguyen,P., Paulino,J., Pawar,K.I., Peters,J.K., Pospiech,T.H.
            Jr., Safari,M., Sangwan,S., Schaefer,K., Thomas,P.V., Thwin,A.C.,
            Trenker,R., Tse,E., Tsui,T.K.M., Wang,F., Whitis,N., Yu,Z.,
            Zhang,K., Zhang,Y., Zhou,F., Saltzberg,D., Hodder,A.J.,
            Shun-Shion,A.S., Williams,D.M., White,K.M., Rosales,R., Kehrer,T.,
            Miorin,L., Moreno,E., Patel,A.H., Rihn,S., Khalid,M.M.,
            Vallejo-Gracia,A., Fozouni,P., Simoneau,C.R., Roth,T.L., Wu,D.,
            Karim,M.A., Ghoussaini,M., Dunham,I., Berardi,F., Weigang,S.,
            Chazal,M., Park,J., Logue,J., McGrath,M., Weston,S., Haupt,R.,
            Hastie,C.J., Elliott,M., Brown,F., Burness,K.A., Reid,E.,
            Dorward,M., Johnson,C., Wilkinson,S.G., Geyer,A., Giesel,D.M.,
            Baillie,C., Raggett,S., Leech,H., Toth,R., Goodman,N., Keough,K.C.,
            Lind,A.L., Klesh,R.J., Hemphill,K.R., Carlson-Stevermer,J., Oki,J.,
            Holden,K., Maures,T., Pollard,K.S., Sali,A., Agard,D.A., Cheng,Y.,
            Fraser,J.S., Frost,A., Jura,N., Kortemme,T., Manglik,A.,
            Southworth,D.R., Stroud,R.M., Alessi,D.R., Davies,P., Frieman,M.B.,
            Ideker,T., Abate,C., Jouvenet,N., Kochs,G., Shoichet,B., Ott,M.,
            Palmarini,M., Shokat,K.M., Garcia-Sastre,A., Rassen,J.A.,
            Grosse,R., Rosenberg,O.S., Verba,K.A., Basler,C.F., Vignuzzi,M.,
            Peden,A.A., Beltrao,P. and Krogan,N.J.
  CONSRTM   QCRG Structural Biology Consortium; Zoonomia Consortium
  TITLE     Comparative host-coronavirus protein interaction networks reveal
            pan-viral disease mechanisms
  JOURNAL   Science 370 (6521) (2020)
   PUBMED   33060197
REFERENCE   3  (bases 1 to 7005)
  AUTHORS   Gordon,D.E., Jang,G.M., Bouhaddou,M., Xu,J., Obernier,K.,
            White,K.M., O'Meara,M.J., Rezelj,V.V., Guo,J.Z., Swaney,D.L.,
            Tummino,T.A., Huttenhain,R., Kaake,R.M., Richards,A.L.,
            Tutuncuoglu,B., Foussard,H., Batra,J., Haas,K., Modak,M., Kim,M.,
            Haas,P., Polacco,B.J., Braberg,H., Fabius,J.M., Eckhardt,M.,
            Soucheray,M., Bennett,M.J., Cakir,M., McGregor,M.J., Li,Q.,
            Meyer,B., Roesch,F., Vallet,T., Mac Kain,A., Miorin,L., Moreno,E.,
            Naing,Z.Z.C., Zhou,Y., Peng,S., Shi,Y., Zhang,Z., Shen,W.,
            Kirby,I.T., Melnyk,J.E., Chorba,J.S., Lou,K., Dai,S.A.,
            Barrio-Hernandez,I., Memon,D., Hernandez-Armenta,C., Lyu,J.,
            Mathy,C.J.P., Perica,T., Pilla,K.B., Ganesan,S.J., Saltzberg,D.J.,
            Rakesh,R., Liu,X., Rosenthal,S.B., Calviello,L., Venkataramanan,S.,
            Liboy-Lugo,J., Lin,Y., Huang,X.P., Liu,Y., Wankowicz,S.A., Bohn,M.,
            Safari,M., Ugur,F.S., Koh,C., Savar,N.S., Tran,Q.D., Shengjuler,D.,
            Fletcher,S.J., O'Neal,M.C., Cai,Y., Chang,J.C.J., Broadhurst,D.J.,
            Klippsten,S., Sharp,P.P., Wenzell,N.A., Kuzuoglu-Ozturk,D.,
            Wang,H.Y., Trenker,R., Young,J.M., Cavero,D.A., Hiatt,J.,
            Roth,T.L., Rathore,U., Subramanian,A., Noack,J., Hubert,M.,
            Stroud,R.M., Frankel,A.D., Rosenberg,O.S., Verba,K.A., Agard,D.A.,
            Ott,M., Emerman,M., Jura,N., von Zastrow,M., Verdin,E.,
            Ashworth,A., Schwartz,O., d'Enfert,C., Mukherjee,S., Jacobson,M.,
            Malik,H.S., Fujimori,D.G., Ideker,T., Craik,C.S., Floor,S.N.,
            Fraser,J.S., Gross,J.D., Sali,A., Roth,B.L., Ruggero,D.,
            Taunton,J., Kortemme,T., Beltrao,P., Vignuzzi,M., Garcia-Sastre,A.,
            Shokat,K.M., Shoichet,B.K. and Krogan,N.J.
  TITLE     A SARS-CoV-2 protein interaction map reveals targets for drug
            repurposing
  JOURNAL   Nature 583 (7816), 459-468 (2020)
   PUBMED   32353859
REFERENCE   4  (bases 1 to 7005)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 7005)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL390039.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001324242.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.1531.1,
                                           SRR1660809.125494.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000685964.1/ ENSP00000509650.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AL390039.10        86191-86247         c
            58-174              AL390039.10        84075-84191         c
            175-367             AL390039.10        83287-83479         c
            368-572             AL390039.10        82777-82981         c
            573-644             AL390039.10        80822-80893         c
            645-1048            AL390039.10        55861-56264         c
            1049-1196           AL390039.10        36680-36827         c
            1197-7005           AL390039.10        29310-35118         c
FEATURES             Location/Qualifiers
     source          1..7005
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.3"
     gene            1..7005
                     /gene="RBM41"
                     /note="RNA binding motif protein 41"
                     /db_xref="GeneID:55285"
                     /db_xref="HGNC:HGNC:25617"
     exon            1..57
                     /gene="RBM41"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1363
                     /gene="RBM41"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="RNA-binding protein 41 isoform 3"
                     /protein_id="NP_001311171.1"
                     /db_xref="CCDS:CCDS94645.1"
                     /db_xref="GeneID:55285"
                     /db_xref="HGNC:HGNC:25617"
                     /translation="MKRVNSCVKSDEHVLEELETEGERQLKSLLQHQLDTSVSIEECM
                     SKKESFAPGTMYKPFGKEAAGTMTLSQFQTLHEKDQETASLRELGLNETEILIWKSHV
                     SGEKKTKLRATPEAIQNRLQDIEERISERQRILCLPQRFAKSKQLTRREMEIEKSLFQ
                     GADRHSFLKALYYQAYHKKTSADKYMTSMKRKIKLGTKDEPQKKNKGDPMNNLESFYQ
                     EMIMKKRLEEFQLMRGEPFASHSLVSATSVGDSGTAESPSLLQDKGKQAAQGKGPSLH
                     VANVIDFSPEQCWTGPKKLTQPIEFVPEDEIQRNRLSEEEIRKIPMFSSYNPGEPNKV
                     LYLKNLSPRVTERDLVSLFARFQEKKGPPIQFRMMTGRMRGQAFITFPNKEIAWQALH
                     LVNGYKLHGKILVIEFGKNKKQRSNLQATSLISCATGSTTEISGS"
     exon            58..174
                     /gene="RBM41"
                     /inference="alignment:Splign:2.1.0"
     exon            175..367
                     /gene="RBM41"
                     /inference="alignment:Splign:2.1.0"
     exon            368..572
                     /gene="RBM41"
                     /inference="alignment:Splign:2.1.0"
     exon            573..644
                     /gene="RBM41"
                     /inference="alignment:Splign:2.1.0"
     exon            645..1048
                     /gene="RBM41"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1196
                     /gene="RBM41"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..7005
                     /gene="RBM41"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6974..6979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM41"
                     /note="hexamer: AATAAA"
     polyA_site      7005
                     /gene="RBM41"
                     /note="major polyA site"
ORIGIN      
        1 gaggtccgcg gcctatttac ccaagttgga ggtaggggcc tgtggaaaca tgaagagggt
       61 aaacagctgt gtgaagagtg atgagcatgt cctggaggag ctggaaacag aaggggagag
      121 gcagctgaaa agcctccttc agcatcaact tgatacttct gtctccattg aggaatgtat
      181 gtctaagaaa gagagctttg ctcctggtac tatgtacaag ccctttggga aggaagcagc
      241 tgggactatg actttgtccc aattccagac actgcatgag aaggaccagg aaactgcttc
      301 tctcagggaa ttagggctta atgaaacaga aatcttgatc tggaagagcc atgtttctgg
      361 tgaaaagaag acaaaactga gggcaactcc tgaagcaata cagaaccgtc ttcaagatat
      421 tgaagaaagg atctcggagc gtcagcgcat tctttgcctg ccacagagat ttgcaaagag
      481 caaacagctg acccggcgag aaatggaaat agaaaagtct ttatttcagg gagctgatcg
      541 tcactccttc cttaaggctc tttattacca agcataccac aaaaagacaa gtgcagacaa
      601 gtacatgacc tcaatgaaga ggaagataaa attaggcaca aaagatgaac cccaaaagaa
      661 gaacaaaggt gatcccatga acaacctgga aagtttttac caagagatga taatgaaaaa
      721 acgtcttgaa gagtttcaac ttatgagagg tgaacccttt gcttcccact cactggtctc
      781 agctacatca gtgggtgata gtggcacagc tgagagccca tcattactcc aggacaaggg
      841 aaaacaggca gcacagggta aaggccccag tctccatgtg gcaaatgtta ttgatttttc
      901 acctgagcag tgttggactg ggcctaagaa gctgacgcag ccaatagaat ttgtcccaga
      961 agatgaaatc cagagaaatc gtttgtcaga ggaagagatc cgaaaaattc ctatgttttc
     1021 ttcatataat ccaggggaac caaacaaggt attatacctg aagaacctta gccctcgggt
     1081 gactgaaaga gatcttgtgt cattgttcgc tcggttccag gagaaaaaag gacctccaat
     1141 tcaattccga atgatgactg gacgaatgag gggccaggct tttatcacct ttcccaataa
     1201 ggagatagca tggcaagcat tgcatctagt aaatggatac aaactacatg ggaaaatatt
     1261 ggtgatagag tttggaaaga acaaaaagca acggtcaaat ctccaagcga cttctctcat
     1321 atcatgtgct acaggtagca ctacagaaat tagtggtagc tagaatatat ataaattgtg
     1381 ggtcctggat ggtctttctt gaattggaat cttggatcta ggatttatgt atagacacca
     1441 gtttgtttgg agttgaagag gaaaaactaa ctgagggagg ggaaaaaagt aatttcagct
     1501 tttggagaga actggtagaa aacattttct attatataat tgaagactat ataggacaga
     1561 tgatatgctg agtatgaagg gtaaagtgca aagagtatta ttttctcagg atgaattaca
     1621 acggattatt cctaaggatt tttaaaaatc tttataattt ttctggggtc ctcaatattt
     1681 gtctctagag ataacattct ttcttagact gcttcgtata cacagaaata aaaaactaat
     1741 taaatgttga aatatttctt tactagagcc catttgccat atttcatcca cctagtaaat
     1801 aaaagagtag gacccccagg cctaagcatc aacaaatgct attaagtcag aactatcagc
     1861 agtaatagta ggtagtttca taagtcagtt gacttattta atgaatgctt cctccacaag
     1921 ttatcagtct tcaaaaagct atatattttt ctagtgaaat attttagatc aaaatgttgg
     1981 tgttctcaca gccatttaag ctagcaacca ttgagtatca ttgaattcat agcaataaac
     2041 attgattaag tgtctaatat atgttaaata ttaggcatat gaattttaga agaggaacat
     2101 acaagcaaag aatgccaaac ggaaatggaa ataaagcgtt ctctagaaaa gaggatgcca
     2161 gtcacaaatc ccccagttgt ttgtttatgg ttgctggaaa ataaaaaaac aatatacaga
     2221 gaggaagtag tacaaactgg agtcagacct gtacagccac acttaacatt ctatgacctt
     2281 ggcaagtcac ttaatctgag cctcacattt ttcatctata aagtgaggat aataatgcta
     2341 cttacctcac tgggttgtga agatgaactg agatattatc caggctgaag aacagaaagg
     2401 aaaacaatga ataaaattga acaagagtat agaacctgtg tgacaccatt aagcattcct
     2461 acatatttct aatgggagta caggaaaaaa ggaaaagaaa tgaaggagca gaaaaatatt
     2521 ctaagaaata atggctataa atacccccga tttgatgaga gacattaacc tatacatccc
     2581 agaagaaaaa gaaattacag acagatacat cataagaaaa atgctaaaac ccaaaaacga
     2641 aaagaaaatc ttaacagcaa tacgagaaaa atgagccatc acttaccaag gaacccaaat
     2701 aaaattagta gttgacttcc cctcagaaac aatggcagtg gcagtggaat aacacattca
     2761 aagtgttcaa agaaaataac tgtcaaccaa taatcctata tacaataaaa ctatttttca
     2821 aaaatgaacg tgaaataaaa catctcacat aatcaaaaac caagagaatt tgttgctggc
     2881 agacctgact tgctggaaat acaaaaggaa gttcttcagc ctgaaagcaa gtgaccacag
     2941 acagtaatct gaatctacac acatgcagaa aaagagcaca ggcaaaaata attatgtaat
     3001 tatcagaaac aatctatgca tttttctttt ttctcttaac taatgtaaaa cacagttgta
     3061 taaaacaata tgtatatagt tgcatcgttt ggcctataac gtataaaata taatatattt
     3121 gccgataaca ggttgaagaa gctgagtgga agcaaaactg tcttgtacta aagaactgac
     3181 tccagatggt aagacaaatc cacaggaaca aatggagaga acgtgaaata ggaaataagt
     3241 ttaatataaa aaaactataa acatatactt actcttctct cagcttcttt taaagatgta
     3301 aaattatatt aagtaattat aataatgtgt gttgggtttg taatgtatag gaataacata
     3361 tataacaata ataccacaaa gcgggggatg ggtttatata ggaatagggt tgttacattg
     3421 gaattaagtt agtgtttatc tgaagcctat tctgtttagt taagatgtgt atggtaagcc
     3481 ctagagcaac cactgaggaa ataactttta aaaaatcaaa aatattatta aatgtaaata
     3541 tcacattatg aaataatgca aaagaaggaa tggagaagca aaaagcttga ggcatatcaa
     3601 aaacaataaa atggcagtca taagtcttcc tatatcaaaa taacaatgtg catggattaa
     3661 gcaatactat aaaaggcaga gatgtcagaa acaagtctga ttccacttca tgccatctat
     3721 ttgagacaca ctttagaaga tagaaagaga ttaaaggtaa aaggatggaa aacaaatata
     3781 tcacacagac aacagccata agaaagctgg agtggctatt ctaataccag acaaaataga
     3841 cttaaaaaaa tgttactgga gataaagagt aaaatgttac aatgataaaa gggtcaatac
     3901 atcaggaaga tgtaacaact ataaatatat atgcatctaa cagtagagcc caaaatacat
     3961 gaagcaaaaa ctgaaaggaa aggagaaaca gataagtcca taaaaagagt tggaatattc
     4021 aatacccctt tttcaataat agagcaccta gacagaagat aaaccaggaa atagaagact
     4081 tgaacaacat tataaggcaa attgacctaa aagacatcta tagaactttc cacccaacat
     4141 cagaatacat attcttctcg agtgcatatg aaacatctcc aaaataggtc ataagttaaa
     4201 gcataaaaca agccttaata aatataagta gactgaaatc atgcaaagca tgccctctga
     4261 ccacatggga tgaagttaga aaacaatgaa aagttgggaa actcacaaat atgtggaaat
     4321 cagacacact tgtaagtgac tggctgggtg cagtagctca cgcctgaaat ctcagcactt
     4381 tggtaggccg aagtgggagg attccttgga tcccttgaga ccaggaattc aagaccagcc
     4441 tgggcaacac agcaagaccc tgtcattacc aaaaaaaaaa aaaaatgtgt caaagaaaaa
     4501 aatcataagg gaaattacaa aaccctttga gatgagtgat aatgaagaca caacaaacca
     4561 aaacttacaa gatgcagcta aagcagtgtt tacagggaaa tctataggta caaatgcctg
     4621 tacttaagaa gaaaaaagac caggcacagt ggcttacgcc tgtaatccca gcactttggg
     4681 aggccggggc gggtggagat catggggtca ggagatcgag accattctgg gtaacatggt
     4741 gaaaccctgt ctctactaaa aatacaaaaa attagccagg cgtggtcgtg ggcacctgta
     4801 gtcccagcta ctcgggaggc tgaggcagga gaatggcgtg aacctgggag gcagagcttg
     4861 cagtgagcca agattgcacc actgcactcc agcctgggca gcagagcgag actccatctc
     4921 aaaaaaaaaa aaaaaaagaa aagaaagacc atagcactaa cctcacttta caccttaaga
     4981 ccctggaaaa agaagagcaa actaaaccta gagccaggag aaagaaggaa atataaaaga
     5041 ttagatgaga ataaatgaaa tagagtgaag aaaagtagag aaaaatcaat gcaaccaaaa
     5101 gttgattcta taaaaagatc agtaaaactg acacaccttc tgctagactg accaggaaaa
     5161 aaggagaatc aaattactaa aatcagaaat gaaggaggga acatttcaac tgaacttgta
     5221 gaaataaaaa agattatgaa ggcatattat gaataatttt atgtcaataa attatcaatg
     5281 aagtggacaa attcctagga agacacaaac taccaaaacc aactcagaag tagaaaactt
     5341 gaataaacct atatcaagta aataggttaa atgagttttt gaaaagatac ccacaaagaa
     5401 gagcccaggc tgaaatagct tcttaaatga attctacaaa acttttaatg aaaaattaat
     5461 acaaattctt cacaaacttt ttcaaaaagt agaagagtgg tgaacacttc tgacacatac
     5521 tacaacatgg aagaactcag aatatgctca gtgcaagaag ccagtcacaa aagactacat
     5581 attatatgat actatttata tgaagtgtcc agaattggca aatatataga gatagaaagt
     5641 ggattagtgg ttgcttaggg ctagcacaga gttgggggga atgggaaggg ctgggggtaa
     5701 cagttgaagt gtatgaagtt tctttagagg ttgatgaaag tgttctaaaa ttggtcgtgg
     5761 tggtgatttc acaactctga atatactaaa aaccaggaat tgtacacgtt aaatgggtga
     5821 attgtgtggt gtatgaatta tatctcaata aaactcacaa aagtaggggt gtccatcaat
     5881 aggaaaatgg gtaaataact tatggtacat ctatttagta caatactatg cagccattaa
     5941 aatagtgaag tgtatctatg aatatattat gacctatact catgtccaag gttgtgtatt
     6001 aagttaataa acaagatgca gaaatatgta tagtatgaat acatttttat gcaaaagcat
     6061 tcatttatgt atagtatgta tgtatataga tatttctgaa taaatttaag aaaaagctgg
     6121 gaaatagaca tagaaagtta taaacctttg gaagtgggat tgaataggct gaaggaggac
     6181 tttcactttg taaaattttt aaagtggtgt gattttgggg tgatttttac ttttttcatt
     6241 ttttttttta actaaaaaat tttttaaaaa atattctgcc aatggcatgg cttccagaat
     6301 atttgtcagg cctactctgg ggatatcatc tgactatact caggacaaac tcctattcct
     6361 ttgatatact gctcacttag gattaacact ctaatttcag acatagttaa gtgacaagga
     6421 ataaattatc ctgatatagc ctctgataca tgttaccagg ggcatacttc taagctggac
     6481 tttttagaag gaagtgcttc ctgttaggta gaaaatttca cctctgcttt ttactagacc
     6541 tacagaccac tgcaattgag gaacataaaa atgaaggata tccttcaact ggtgcataga
     6601 taaaccgtag tatatccatg caatggaatc ctactcagca ataaactaat gaaatacaca
     6661 tgcaaccact tggatgaatc ttaaatgcat tttactaagt aaaagaagcc aaactcaaaa
     6721 ggctgcttac tgtttgattc cattcatatt attttctcaa aaagcaaaac aatagggatg
     6781 gagaaaaaac ttcagtggat gtcaggggtt aaggttggaa tgctccttga ctacaaagtg
     6841 gtagcatgag gaatttgtct taataattga aattttccgt gtctttattg tagttacata
     6901 agtatatgca tttgtcaaaa cccataggct tgtacactaa aaaggatgaa ttttactgtg
     6961 tgtaattttt ttaaataaat gttattttta tggaggaaag aaaaa
//
