LOCUS       NM_017495               2393 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens RNA binding motif protein 38 (RBM38), transcript
            variant 1, mRNA.
ACCESSION   NM_017495
VERSION     NM_017495.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2393)
  AUTHORS   Zhong,T., Zhang,J., Liu,X. and Li,H.
  TITLE     TRIM17-mediated ubiquitination and degradation of RBM38 promotes
            cisplatin resistance in non-small cell lung cancer
  JOURNAL   Cell Oncol (Dordr) 46 (5), 1493-1507 (2023)
   PUBMED   37219768
  REMARK    GeneRIF: TRIM17-mediated ubiquitination and degradation of RBM38
            promotes cisplatin resistance in non-small cell lung cancer.
REFERENCE   2  (bases 1 to 2393)
  AUTHORS   Zhang,X., Zhang,X., Jia,Q., Li,H., Ma,R., Yang,G., Yin,F., Jiang,N.
            and Yin,D.
  TITLE     LncRNA CALML3-AS1 suppresses papillary thyroid cancer progression
            via sponging miR-20a-5p/RBM38 axis
  JOURNAL   BMC Cancer 22 (1), 344 (2022)
   PUBMED   35351042
  REMARK    GeneRIF: LncRNA CALML3-AS1 suppresses papillary thyroid cancer
            progression via sponging miR-20a-5p/RBM38 axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2393)
  AUTHORS   Zhang,Y.P., Gao,D. and Wu,P.
  TITLE     [RBM38 Mediates the Proliferation of Acute Myeloid Leukemia Cells
            HL-60 by Regulating FZD1 mRNA Stability]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 29 (6), 1775-1779 (2021)
   PUBMED   34893109
  REMARK    GeneRIF: [RBM38 Mediates the Proliferation of Acute Myeloid
            Leukemia Cells HL-60 by Regulating FZD1 mRNA Stability].
REFERENCE   4  (bases 1 to 2393)
  AUTHORS   Li,Y., Shi,Y., He,Y., Li,X. and Yang,J.
  TITLE     RNA binding Motif protein-38 regulates myocardial hypertrophy in
            LXR-alpha-dependent lipogenesis pathway
  JOURNAL   Bioengineered 12 (2), 9655-9667 (2021)
   PUBMED   34854353
  REMARK    GeneRIF: RNA binding Motif protein-38 regulates myocardial
            hypertrophy in LXR-alpha-dependent lipogenesis pathway.
REFERENCE   5  (bases 1 to 2393)
  AUTHORS   Guan,B., Li,G., Wan,B., Guo,X., Huang,D., Ma,J., Gong,P., Guo,J.
            and Bu,Y.
  TITLE     RNA-binding protein RBM38 inhibits colorectal cancer progression by
            partly and competitively binding to PTEN 3'UTR with miR-92a-3p
  JOURNAL   Environ Toxicol 36 (12), 2436-2447 (2021)
   PUBMED   34453780
  REMARK    GeneRIF: RNA-binding protein RBM38 inhibits colorectal cancer
            progression by partly and competitively binding to PTEN 3'UTR with
            miR-92a-3p.
REFERENCE   6  (bases 1 to 2393)
  AUTHORS   Kamatani,Y., Matsuda,K., Okada,Y., Kubo,M., Hosono,N., Daigo,Y.,
            Nakamura,Y. and Kamatani,N.
  TITLE     Genome-wide association study of hematological and biochemical
            traits in a Japanese population
  JOURNAL   Nat Genet 42 (3), 210-215 (2010)
   PUBMED   20139978
REFERENCE   7  (bases 1 to 2393)
  AUTHORS   Miyamoto,S., Hidaka,K., Jin,D. and Morisaki,T.
  TITLE     RNA-binding proteins Rbm38 and Rbm24 regulate myogenic
            differentiation via p21-dependent and -independent regulatory
            pathways
  JOURNAL   Genes Cells 14 (11), 1241-1252 (2009)
   PUBMED   19817877
  REMARK    GeneRIF: it was found that this protein Rbm38 regulates myogenic
            differentiation via the p21 signal pathway.
REFERENCE   8  (bases 1 to 2393)
  AUTHORS   Warzecha,C.C., Sato,T.K., Nabet,B., Hogenesch,J.B. and
            Carstens,R.P.
  TITLE     ESRP1 and ESRP2 are epithelial cell-type-specific regulators of
            FGFR2 splicing
  JOURNAL   Mol Cell 33 (5), 591-601 (2009)
   PUBMED   19285943
REFERENCE   9  (bases 1 to 2393)
  AUTHORS   Shu,L., Yan,W. and Chen,X.
  TITLE     RNPC1, an RNA-binding protein and a target of the p53 family, is
            required for maintaining the stability of the basal and
            stress-induced p21 transcript
  JOURNAL   Genes Dev 20 (21), 2961-2972 (2006)
   PUBMED   17050675
  REMARK    GeneRIF: RNPC1a is required to maintain the stability of p21
            transcript induced by p53.
REFERENCE   10 (bases 1 to 2393)
  AUTHORS   Krackhardt,A.M., Witzens,M., Harig,S., Hodi,F.S., Zauls,A.J.,
            Chessia,M., Barrett,P. and Gribben,J.G.
  TITLE     Identification of tumor-associated antigens in chronic lymphocytic
            leukemia by SEREX
  JOURNAL   Blood 100 (6), 2123-2131 (2002)
   PUBMED   12200376
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL109955.38.
            
            On Nov 23, 2018 this sequence version replaced NM_017495.5.
            
            Transcript Variant: This variant (1) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 3, resulting in
            an isoform (a) that is shorter than isoform c.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.364281.1, AF432218.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356208.10/ ENSP00000348538.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-423               AL109955.38        32409-32831
            424-547             AL109955.38        33667-33790
            548-602             AL109955.38        34292-34346
            603-2393            AL109955.38        48556-50346
FEATURES             Location/Qualifiers
     source          1..2393
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.31"
     gene            1..2393
                     /gene="RBM38"
                     /gene_synonym="dJ800J21.2; HSRNASEB; RNPC1; SEB4B; SEB4D"
                     /note="RNA binding motif protein 38"
                     /db_xref="GeneID:55544"
                     /db_xref="HGNC:HGNC:15818"
                     /db_xref="MIM:612428"
     exon            1..423
                     /gene="RBM38"
                     /gene_synonym="dJ800J21.2; HSRNASEB; RNPC1; SEB4B; SEB4D"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..906
                     /gene="RBM38"
                     /gene_synonym="dJ800J21.2; HSRNASEB; RNPC1; SEB4B; SEB4D"
                     /note="isoform a is encoded by transcript variant 1;
                     RNA-binding region (RNP1, RRM) containing 1;
                     CLL-associated antigen KW-5; RNA-binding protein 38;
                     ssDNA-binding protein SEB4; RNA-binding region-containing
                     protein 1"
                     /codon_start=1
                     /product="RNA-binding protein 38 isoform a"
                     /protein_id="NP_059965.2"
                     /db_xref="CCDS:CCDS46617.1"
                     /db_xref="GeneID:55544"
                     /db_xref="HGNC:HGNC:15818"
                     /db_xref="MIM:612428"
                     /translation="MLLQPAPCAPSAGFPRPLAAPGAMHGSQKDTTFTKIFVGGLPYH
                     TTDASLRKYFEGFGDIEEAVVITDRQTGKSRGYGFVTMADRAAAERACKDPNPIIDGR
                     KANVNLAYLGAKPRSLQTGFAIGVQQLHPTLIQRTYGLTPHYIYPPAIVQPSVVIPAA
                     PVPSLSSPYIEYTPASPAYAQYPPATYDQYPYAASPATAASFVGYSYPAAVPQALSAA
                     APAGTTFVQYQAPQLQPDRMQ"
     exon            424..547
                     /gene="RBM38"
                     /gene_synonym="dJ800J21.2; HSRNASEB; RNPC1; SEB4B; SEB4D"
                     /inference="alignment:Splign:2.1.0"
     exon            548..602
                     /gene="RBM38"
                     /gene_synonym="dJ800J21.2; HSRNASEB; RNPC1; SEB4B; SEB4D"
                     /inference="alignment:Splign:2.1.0"
     exon            603..2393
                     /gene="RBM38"
                     /gene_synonym="dJ800J21.2; HSRNASEB; RNPC1; SEB4B; SEB4D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2366..2371
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM38"
                     /gene_synonym="dJ800J21.2; HSRNASEB; RNPC1; SEB4B; SEB4D"
                     /note="hexamer: AATAAA"
     polyA_site      2393
                     /gene="RBM38"
                     /gene_synonym="dJ800J21.2; HSRNASEB; RNPC1; SEB4B; SEB4D"
                     /note="major polyA site"
ORIGIN      
        1 gcagagtccc cgcagcgccg gtcgggagcg cagcgcggcg cacgtcggcg cgcacggcgg
       61 gacgggcgcc ggagtggtcg ggcctggcgg ctggacgggc gcccctcgct gccccgcgcg
      121 ctccccgccg ccccccatga gcgcagcccc gcgcggcccg ggtccgtagg cggcggggcg
      181 ccccccatgc tgctgcagcc cgcgccgtgc gccccgagcg cgggcttccc gcggcccctg
      241 gccgcccccg gcgccatgca cggctcgcag aaggacacca cgttcaccaa gatcttcgtg
      301 ggcggcctgc cgtaccacac taccgacgcc tcgctcagga agtacttcga gggcttcggc
      361 gacatcgagg aggccgtggt catcaccgac cgccagacgg gcaagtcccg cggctacggc
      421 ttcgtgacca tggccgaccg ggcggcagct gagagggctt gcaaagaccc gaaccccatc
      481 atcgacggcc gcaaggccaa cgtgaacctg gcatatctgg gcgccaagcc gcggagcctc
      541 cagacgggct ttgccattgg ggtgcagcag ctgcacccca ccttgatcca gcggacttac
      601 gggctgaccc cgcactacat ctacccacca gccatcgtgc agcccagcgt ggtgatccca
      661 gccgcccctg tcccgtcgct gtcctcgccc tacattgagt acacgccggc cagcccggcc
      721 tacgcccagt acccaccggc cacctatgac cagtacccat acgccgcctc gcctgccacg
      781 gctgccagct tcgtgggcta cagctaccct gccgccgtgc cccaggccct ctcagccgca
      841 gcacccgcgg gcaccacttt cgtgcagtac caggcgccgc agctgcagcc tgacaggatg
      901 cagtgagggg cgttcctgcc ccgaggactg tggcattgtc accttcacag cagacagagc
      961 tgccaggcca tgatgggctg gcgacagccc ggctgagctt cagtgaggtg ccaccagcac
     1021 ccgtgcctcc gaagaccgct cgggcattcc gcctgcgccc tgggacagcg gagagacggc
     1081 ttctctttaa tctaggtccc attgtgtctt gagggaggac tttaagaatg actgagaact
     1141 atttaaagac gcaatcccag gttccttgca caccatggca gcctctcctt gcaccttctc
     1201 ctgcctctcc acactccagg ttccctcagg cttgtgtccc cactgctgca tcgtggcggg
     1261 gtgtcacaga ccctctgcag cccctggctg ccctggactg tgcagagatg cctgactcca
     1321 gggaaacctg aaagcaagaa gttaatggac tgtttattgt aacttgatcc tcccgagctg
     1381 tgagcgcagt ctgaggtgtg aggacacggc ctcctgttgg agtcccattt tctccatcag
     1441 ggcacgtggg cggcttcctc aagcccggag gagctcccag gcgcacaggg gccgccggta
     1501 acaggggccg ccggccaaag gcccctttcc agtcatagca ctgaagttgc aacttttttc
     1561 ttgtaattgt tttgctacta agataatttc agaagttcag tctatttttt cagcggatac
     1621 tgccgccacc aagaatccaa aacctatttt tgacttggag agacttgctt ttgttggttc
     1681 cgcccgtgga gacgacgata gtgtttctgt ataataaagt gtctgccggc tcgcgggcca
     1741 ggatcctctc ggtgggatgg gcaccacaga caggaggccc ctcaggcccg tgcgggccac
     1801 tgtctgctgc cgcctgccgg ggtggcagag tgagttgtct caggaccccg tcactgcgac
     1861 gttgacactc ctctcccttc ccttcctccc caactcccca aacactgtgg aaggggagaa
     1921 ggaagtgatc cacagcattc aggccacttg gggtctagac catggtggtg ccagcctggg
     1981 gggggcagtg gccctcagct ctgcccgctg gagcggttga gtgcagaagg gtgcgcctct
     2041 tccctctacc cccgcaccac ctgctgtgtg ccagcctgag acggttcctg cctgtcttgg
     2101 gggttggtgg agggtggagg cagttctgcc agccgtggca gggctgctat ggggcatcca
     2161 gggctgtggg ggtctggagg aggggacatg aggtgagagg tatcctggcc gagggcgggg
     2221 ggcagcgggg ggtctccctc cggacctacc tcagggagct gagcgtgcag gcgctccagg
     2281 gcaggcctgg gacagagtca aggctcagag aataaaggta gctaatctca tcataatatt
     2341 tttattagaa tgttctgatg ataaaaataa aacttgtttt ctttaaagaa aaa
//
