LOCUS       NM_015014               1847 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens RNA binding motif protein 34 (RBM34), transcript
            variant 1, mRNA.
ACCESSION   NM_015014 XM_351352
VERSION     NM_015014.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1847)
  AUTHORS   Li,H.D., Menon,R., Govindarajoo,B., Panwar,B., Zhang,Y., Omenn,G.S.
            and Guan,Y.
  TITLE     Functional Networks of Highest-Connected Splice Isoforms: From The
            Chromosome 17 Human Proteome Project
  JOURNAL   J Proteome Res 14 (9), 3484-3491 (2015)
   PUBMED   26216192
REFERENCE   2  (bases 1 to 1847)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 1847)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 1847)
  AUTHORS   Clery,A., Blatter,M. and Allain,F.H.
  TITLE     RNA recognition motifs: boring? Not quite
  JOURNAL   Curr Opin Struct Biol 18 (3), 290-298 (2008)
   PUBMED   18515081
  REMARK    Review article
REFERENCE   5  (bases 1 to 1847)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC029451.1 and BM995796.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015014.3.
            
            Summary: This gene encodes a member of the RNA-binding motif family
            of RNA recognition motif proteins. The encoded protein contains an
            RNA-binding domain made up of two RNA recognition motif subdomains
            referred to as RNA recognition motif-1 and RNA recognition motif-2.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Oct 2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.528669.1,
                                           SRR3476690.1078554.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000408888.8/ ENSP00000386226.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1396              BC029451.1         7-1402
            1397-1847           BM995796.1         18-468              c
FEATURES             Location/Qualifiers
     source          1..1847
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.3"
     gene            1..1847
                     /gene="RBM34"
                     /note="RNA binding motif protein 34"
                     /db_xref="GeneID:23029"
                     /db_xref="HGNC:HGNC:28965"
                     /db_xref="MIM:619915"
     exon            1..77
                     /gene="RBM34"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1317
                     /gene="RBM34"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RNA-binding protein 34; epididymis secretory sperm binding
                     protein"
                     /codon_start=1
                     /product="RNA-binding protein 34 isoform 1"
                     /protein_id="NP_055829.2"
                     /db_xref="CCDS:CCDS41477.2"
                     /db_xref="GeneID:23029"
                     /db_xref="HGNC:HGNC:28965"
                     /db_xref="MIM:619915"
                     /translation="MALEGMSKRKRKRSVQEGENPDDGVRGSPPEDYRLGQVASSLFR
                     GEHHSRGGTGRLASLFSSLEPQIQPVYVPVPKQTIKKTKRNEEEESTSQIERPLSQEP
                     AKKVKAKKKHTNAEKKLADRESALASADLEEEIHQKQGQKRKNSQPGVKVADRKILDD
                     TEDTVVSQRKKIQINQEEERLKNERTVFVGNLPVTCNKKKLKSFFKEYGQIESVRFRS
                     LIPAEGTLSKKLAAIKRKIHPDQKNINAYVVFKEESAATQALKRNGAQIADGFRIRVD
                     LASETSSRDKRSVFVGNLPYKVEESAIEKHFLDCGSIMAVRIVRDKMTGIGKGFGYVL
                     FENTDSVHLALKLNNSELMGRKLRVMRSVNKEKFKQQNSNPRLKNVSKPKQGLNFTSK
                     TAEGHPKSLFIGEKAVLLKTKKKGQKKSGRPKKQRKQK"
     exon            78..252
                     /gene="RBM34"
                     /inference="alignment:Splign:2.1.0"
     exon            253..389
                     /gene="RBM34"
                     /inference="alignment:Splign:2.1.0"
     exon            390..621
                     /gene="RBM34"
                     /inference="alignment:Splign:2.1.0"
     exon            622..681
                     /gene="RBM34"
                     /inference="alignment:Splign:2.1.0"
     exon            682..725
                     /gene="RBM34"
                     /inference="alignment:Splign:2.1.0"
     exon            726..809
                     /gene="RBM34"
                     /inference="alignment:Splign:2.1.0"
     exon            810..873
                     /gene="RBM34"
                     /inference="alignment:Splign:2.1.0"
     exon            874..913
                     /gene="RBM34"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1032
                     /gene="RBM34"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1847
                     /gene="RBM34"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1358..1363
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM34"
                     /note="hexamer: AATAAA"
     polyA_site      1396
                     /gene="RBM34"
                     /note="major polyA site"
     regulatory      1824..1829
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM34"
                     /note="hexamer: ATTAAA"
     polyA_site      1847
                     /gene="RBM34"
ORIGIN      
        1 agtctgggag tctttggagt aagaatggcc ttggaaggga tgagcaaacg gaagagaaag
       61 agaagtgtcc aggagggaga gaatcctgac gacggcgttc gcgggagtcc gccggaagac
      121 tacaggcttg gacaggtcgc cagtagctta tttcgcggcg aacaccattc cagaggtggc
      181 accggtcggc tggcgtccct cttcagttct ctggagcccc agattcaacc cgtgtacgtg
      241 cctgtgccta aacaaaccat caaaaaaacg aaacggaatg aggaggaaga aagtacatcc
      301 cagattgaaa gaccactttc gcaagaacct gccaaaaaag tgaaagcgaa gaagaaacac
      361 actaacgcag aaaaaaagtt ggcagacagg gaaagcgctc tagcgagtgc tgatttagaa
      421 gaagaaattc accagaaaca agggcagaaa aggaaaaatt ctcaacctgg tgttaaagta
      481 gcagatagaa aaatacttga tgacacagaa gacacagttg tcagtcaaag aaagaaaatt
      541 caaatcaacc aagaagaaga gagattaaag aatgagagaa ctgtgtttgt tgggaatttg
      601 cctgttacat gtaataagaa gaagctgaag tcgtttttta aagagtatgg acaaatagaa
      661 tctgtacgat ttcgttctct gattccagca gagggaacgc tatccaaaaa gttggcagca
      721 ataaaacgta aaattcatcc tgatcagaaa aatattaatg cctatgttgt gtttaaggag
      781 gagagtgctg ccacgcaagc attgaaaaga aatggggccc agattgcaga tggatttcgt
      841 attagagttg atctcgcatc tgagacctca tctagagaca agagatcggt ttttgtgggg
      901 aatctccctt ataaagttga agaatctgcc attgagaagc actttctgga ctgtggaagt
      961 atcatggccg tgaggattgt gagagacaaa atgacaggca tcggcaaagg gtttggctat
     1021 gtgctctttg agaatacaga ttctgttcat cttgctctga aattaaataa ttctgaactc
     1081 atggggagaa aactcagagt catgcgttct gttaataaag aaaaatttaa acaacaaaat
     1141 tcaaatccac gattgaagaa tgtcagtaaa cctaagcagg gacttaattt tacttccaaa
     1201 actgcagaag gacatcctaa aagcttattt attggagaaa aagctgttct ccttaaaacg
     1261 aagaagaaag gacagaagaa aagtggacgc cctaagaaac agagaaaaca gaaataacaa
     1321 ccaggaactg ctttttcttt tcctgctgag tactgctaat aaaagtgcta ttatctgctg
     1381 atagcatcgt ctgctattca tgtgttgagt tttatacttc tttatggatg gtgtatgtga
     1441 aatgtggaga cttccacatt ctcagtttat tcacattgtg atactacctt tgaaggtttt
     1501 tttgtttttg ttttgttttt tgagatggag tttggctgtt gtctcccagg ctggagtgca
     1561 gtggcgtgat cttggctcac tgcaacctct gccttctggg ttcaagcgct tctcctgcct
     1621 cagcctccca agtagctggg attacaggcg cctgccacca cgcctggcta attttttgta
     1681 tttttagtag agacggggtt tcaccatgtt ggccaggctg gtctcgaact cctgacctca
     1741 ggtgatccac ctgccttggc ctctcaaagt gctgggatta caggcgtgag tcactgcacc
     1801 caagcctcct ttctcttttg cctattaaac ctctgctctt aacctta
//
