LOCUS       NM_053043              10168 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens RNA binding motif protein 33 (RBM33), mRNA.
ACCESSION   NM_053043 XM_001125870 XM_001132137
VERSION     NM_053043.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10168)
  AUTHORS   Xu,Y., Weng,X., Qiu,J. and Wang,S.
  TITLE     Biogenesis of circRBM33 mediated by N6-methyladenosine and its
            function in abdominal aortic aneurysm
  JOURNAL   Epigenetics 19 (1), 2392401 (2024)
   PUBMED   39246182
  REMARK    GeneRIF: Biogenesis of circRBM33 mediated by N6-methyladenosine and
            its function in abdominal aortic aneurysm.
REFERENCE   2  (bases 1 to 10168)
  AUTHORS   Yu,F., Zhu,A.C., Liu,S., Gao,B., Wang,Y., Khudaverdyan,N., Yu,C.,
            Wu,Q., Jiang,Y., Song,J., Jin,L., He,C. and Qian,Z.
  TITLE     RBM33 is a unique m6A RNA-binding protein that regulates ALKBH5
            demethylase activity and substrate selectivity
  JOURNAL   Mol Cell 83 (12), 2003-2019 (2023)
   PUBMED   37257451
  REMARK    GeneRIF: RBM33 is a unique m[6]A RNA-binding protein that regulates
            ALKBH5 demethylase activity and substrate selectivity.
REFERENCE   3  (bases 1 to 10168)
  AUTHORS   Thomas,A., Rehfeld,F., Zhang,H., Chang,T.C., Goodarzi,M., Gillet,F.
            and Mendell,J.T.
  TITLE     RBM33 directs the nuclear export of transcripts containing GC-rich
            elements
  JOURNAL   Genes Dev 36 (9-10), 550-565 (2022)
   PUBMED   35589130
REFERENCE   4  (bases 1 to 10168)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 10168)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 10168)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC011923.2, DA504982.1, BP373239.1, DA947894.1, AL137724.1,
            DA459140.1, CN402759.1, AL832196.1 and AC078834.5.
            
            On Nov 23, 2018 this sequence version replaced NM_053043.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000401878.8/ ENSP00000384160.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               BC011923.2         211-330
            121-121             DA504982.1         103-103
            122-924             BC011923.2         332-1134
            925-1039            BP373239.1         1-115
            1040-1468           DA947894.1         141-569
            1469-1953           AL137724.1         1205-1689
            1954-2339           DA459140.1         174-559
            2340-3102           AL137724.1         3387-4149
            3103-3676           CN402759.1         117-690
            3677-5748           AL832196.1         563-2634
            5749-10168          AC078834.5         68870-73289
FEATURES             Location/Qualifiers
     source          1..10168
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.3"
     gene            1..10168
                     /gene="RBM33"
                     /gene_synonym="PRR8"
                     /note="RNA binding motif protein 33"
                     /db_xref="GeneID:155435"
                     /db_xref="HGNC:HGNC:27223"
                     /db_xref="MIM:620833"
     exon            1..259
                     /gene="RBM33"
                     /gene_synonym="PRR8"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..3729
                     /gene="RBM33"
                     /gene_synonym="PRR8"
                     /note="proline rich 8; proline-rich protein 8;
                     hypothetical protein MGC20460"
                     /codon_start=1
                     /product="RNA-binding protein 33"
                     /protein_id="NP_444271.2"
                     /db_xref="CCDS:CCDS5941.2"
                     /db_xref="GeneID:155435"
                     /db_xref="HGNC:HGNC:27223"
                     /db_xref="MIM:620833"
                     /translation="MAAALGASGGAGAGDDDFDQFDKPGAERSWRRRAADEDWDSELE
                     DDLLGEDLLSGKKNQSDLSDEELNDDLLQSDNEDEENFSSQGVTISLNATSGMVTSFE
                     LSDNTNDQSGEQESEYEQEQGEDELVYHKSDGSELYTQEYPEEGQYEGHEAELTEDQI
                     EYVEEPEEEQLYTDEVLDIEINEPLDEFTGGMETLELQKDIKEESDEEEEDDEESGRL
                     RFKTERKEGTIIRLSDVTRERRNIPETLELSAEAKAALLEFEERERQHKQGRYSSRRG
                     GRRGGPLMCRGVGDQRRESTERGRMKDHRPALLPTQPPVVPQAPPPPPPPPQQQPIRS
                     LFQPQPLQPLLPVQHPHHPSPPQGMHMPPQLETPRMMMTPPPVTPQQPKNIHINPHFK
                     GTVVTPVQVPLLPVPSQPRPAVGPQRFPGPPEFPQHTPGPVPNSFSQPPRLPLQDQWR
                     APPPPQDRDPFFLGVSGEPRFPSHLFLEQRSPPPPPPPPTLLNSSHPVPTQSPLPFTQ
                     PGPAFNQQGQQPVFPRERPVRPALQPPGPVGILHFSQPGSATTRPFIPPRQPFLPGPG
                     QPFLPTHTQPNLQGPLHPPLPPPHQPQPQQPQQQPPPQHQPPHQPPHQPPPQHQPPPQ
                     HPPQHPPQHQHHHHHHHLSVPPPPLMPMSQPQFRPHVQTAQPQASSSRMQCPQRQGLR
                     HNTTSQNVSKRPMQQMQPTAPRNSNLRELPIAPSHVIEMSSSRCSATPSAQVKPIVSA
                     SPPSRAVAGSRSSQGKTEVKVKPASPVAQPKEEAKTETEFPDEDEETRLYRLKIEEQK
                     RLREEILKQKELRRQQQAGARKKELLERLAQQQQQLYAPPPPAEQEEQALSPSPTNGN
                     PLLPFPGAQVRQNVKNRLLVKNQDVSISNVQPKTSNFVPSSANMQYQGQQMKALKHLR
                     QTRTVPQSQTQPLHKVLPIKPADVEEPAVPQTPRVASIQGRPQDTKPGVKRTVTHRTN
                     SGGGDGPHISSKVRVIKLSGGGGESDGFFHPEGQPQRLPQPPEVGPQPARKVTLTRGG
                     LQQPPHLPAGPHAHSPVPPGIKSIQGIHPAKKAIMHGRGRGVAGPMGRGRLMPNKQNL
                     RVVECKPQPCVVSVEGLSSSTTDAQLKSLLMSVGPIQSLQMLPQQRKAIAKFKEPAHA
                     LAFQQKFHRHMIDLSHINVALIVE"
     exon            260..338
                     /gene="RBM33"
                     /gene_synonym="PRR8"
                     /inference="alignment:Splign:2.1.0"
     exon            339..387
                     /gene="RBM33"
                     /gene_synonym="PRR8"
                     /inference="alignment:Splign:2.1.0"
     exon            388..464
                     /gene="RBM33"
                     /gene_synonym="PRR8"
                     /inference="alignment:Splign:2.1.0"
     exon            465..783
                     /gene="RBM33"
                     /gene_synonym="PRR8"
                     /inference="alignment:Splign:2.1.0"
     exon            784..955
                     /gene="RBM33"
                     /gene_synonym="PRR8"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1164
                     /gene="RBM33"
                     /gene_synonym="PRR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1417
                     /gene="RBM33"
                     /gene_synonym="PRR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1476
                     /gene="RBM33"
                     /gene_synonym="PRR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1609
                     /gene="RBM33"
                     /gene_synonym="PRR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1953
                     /gene="RBM33"
                     /gene_synonym="PRR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2265
                     /gene="RBM33"
                     /gene_synonym="PRR8"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2553
                     /gene="RBM33"
                     /gene_synonym="PRR8"
                     /inference="alignment:Splign:2.1.0"
     exon            2554..3195
                     /gene="RBM33"
                     /gene_synonym="PRR8"
                     /inference="alignment:Splign:2.1.0"
     exon            3196..3402
                     /gene="RBM33"
                     /gene_synonym="PRR8"
                     /inference="alignment:Splign:2.1.0"
     exon            3403..3591
                     /gene="RBM33"
                     /gene_synonym="PRR8"
                     /inference="alignment:Splign:2.1.0"
     exon            3592..3680
                     /gene="RBM33"
                     /gene_synonym="PRR8"
                     /inference="alignment:Splign:2.1.0"
     exon            3681..10168
                     /gene="RBM33"
                     /gene_synonym="PRR8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6493..6498
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM33"
                     /gene_synonym="PRR8"
                     /note="hexamer: TATAAA"
     polyA_site      6518
                     /gene="RBM33"
                     /gene_synonym="PRR8"
     regulatory      10148..10153
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM33"
                     /gene_synonym="PRR8"
                     /note="hexamer: AATAAA"
     polyA_site      10168
                     /gene="RBM33"
                     /gene_synonym="PRR8"
                     /note="major polyA site"
ORIGIN      
        1 gggcgcgggc gcgcggccat gttgcggtag tttgttgttt tcttcctgcg gaggcgaagg
       61 gccagctgtg gaccgcgaag cgcccggctt cgcctctgcc tcctgcagcc ccctcccttc
      121 tctgtcctcc gtcacccgta cccgggcccg gaccaggcac gtcggcccac cagctggctt
      181 ggtgggggag gctgaaggcc gggccccgcg agtgccatgg cggccgccct gggagcgagc
      241 ggaggagcag gcgccggaga tgatgacttt gaccagtttg ataagcctgg cgcggaacgg
      301 tcgtggagaa gaagagctgc tgatgaggac tgggacagtg aacttgaaga tgatttactt
      361 ggagaagatt tgctatctgg caaaaagaat cagtcggatt tgtcagatga agagctaaat
      421 gatgatcttt tgcagagtga taatgaagat gaagaaaatt tcagttctca gggtgttaca
      481 attagtctga atgctacatc tggcatggtt acatcatttg aactctctga caacactaac
      541 gaccaatctg gagaacagga atctgagtat gaacaagaac aaggagagga tgaactggtt
      601 tatcacaaat ctgatggatc agaattgtat actcaagagt acccagaaga aggacagtat
      661 gaaggccacg aagctgagtt gacagaagac caaatagaat atgtggaaga gccagaggag
      721 gagcagcttt acactgatga agtgttagac atcgagatca atgaaccttt agatgaattt
      781 acaggaggta tggaaacatt ggaacttcaa aaggacatca aagaagaatc agatgaagaa
      841 gaagaagatg atgaagaatc tggacgatta cgtttcaaaa ctgaaaggaa agaaggaaca
      901 attattaggc tctcagatgt aactagagag agaaggaaca ttccagaaac tttggagctt
      961 tcagcagagg ccaaggcagc attgcttgaa tttgaagaaa gggagcgaca gcataaacaa
     1021 ggacgctaca gctccaggcg gggaggacgg cgaggaggtc cgctgatgtg tcgtggtgtg
     1081 ggggaccaga ggagagagag caccgagagg ggcaggatga aggaccacag acctgcgctg
     1141 cttcctacac agcctcctgt cgtgccccag gctccccctc caccgccacc gccgcctcag
     1201 cagcagccga tcagaagcct gttccagccg cagccgctgc agccgctgct tccggtgcag
     1261 cacccgcacc acccatcccc gcctcaggga atgcacatgc ctccccagct agagacccca
     1321 aggatgatga tgaccccgcc acccgtgact ccacagcagc ccaagaacat acacatcaac
     1381 ccgcacttca aagggacggt ggtcacgcct gttcaagtgc ccttgctacc agttccgagc
     1441 cagccgagac ctgccgtggg accccagaga ttcccaggcc ctccagaatt tccacagcat
     1501 acacctggac ctgttcccaa cagtttcagc cagcccccac gactccctct ccaggaccag
     1561 tggagagccc cacccccgcc tcaggatcga gaccctttct tcttaggagt ttcaggtgaa
     1621 ccaagattcc cgagccatct ttttctggaa cagcgaagtc cccctccacc accaccgcct
     1681 cctacccttc ttaacagtag ccatcctgtt cctactcaga gtcctctacc attcactcag
     1741 ccaggaccag catttaatca gcaaggacag cagccagtgt tcccaagaga gcggcccgta
     1801 cgaccagcct tgcagcctcc aggtccggtg gggattctgc actttagcca gcctgggtcg
     1861 gcaaccacac ggcccttcat tcctcctaga cagccgttcc tgccaggccc aggacagccg
     1921 tttctgccca cacacacaca gcccaacctg caggggccgt tgcatcctcc attgccccct
     1981 ccgcatcagc ctcagcctca gcaacctcag caacagcccc cgccacagca ccagcctccg
     2041 caccagcccc cgcaccagcc cccgccccag caccagcccc caccccagca cccaccacag
     2101 cacccgccgc agcaccagca ccaccaccac caccaccacc tgtccgtccc gccccctcct
     2161 ttgatgccga tgtctcagcc acagttccgg cctcacgtac agaccgctca gcctcaggcc
     2221 agcagcagcc ggatgcagtg cccccagcgc caggggctcc ggcataatac aacttctcag
     2281 aatgtaagca agcggcccat gcagcaaatg cagcccactg cgccaaggaa cagcaatttg
     2341 cgtgaattac ccatagcgcc gtcacacgtg atagaaatga gcagcagccg ctgctctgcc
     2401 acgccctcag cacaagtgaa acctatcgtc agcgcgtcac caccctcgcg ggccgtggcg
     2461 ggttccagaa gctcacaggg aaagacggaa gtgaaagtca agccagctag ccctgtggct
     2521 caacctaaag aagaggcaaa aacagaaaca gagtttcctg atgaagatga ggaaacaagg
     2581 ttatatcgct taaagataga agaacagaaa cgcctaagag aagaaatcct gaaacagaag
     2641 gagttacggc ggcagcagca ggctggtgcc aggaagaagg agctgctgga gagactcgcg
     2701 cagcaacagc agcagctgta cgctccccca cccccagcag agcaggaaga gcaggcactg
     2761 tcaccatcac ccaccaacgg taacccactg ttgccctttc caggtgcaca ggtcagacaa
     2821 aatgtgaaga acagacttct tgttaaaaac caggatgtca gtatttcaaa cgttcagccc
     2881 aaaacatcca attttgtacc atccagtgcc aacatgcagt atcaaggaca acagatgaaa
     2941 gcactgaaac atttgagaca gaccagaaca gttcctcaaa gtcagactca gccgctgcat
     3001 aaagtgctcc cgatcaaacc tgcagatgtg gaggagccag ctgtccccca gactcctcga
     3061 gtggcgtcca tccagggccg gccccaggac acaaagcctg gcgtgaaaag gactgtcacg
     3121 cacaggacaa acagtggtgg tggagacggg ccccacatca gctccaaggt cagggtgatt
     3181 aagctgtcag gtgggggagg agagagcgat ggcttttttc acccagaagg ccagccccag
     3241 cggcttcccc agcctccgga agtgggacca cagcctgccc gcaaggtgac gctgaccagg
     3301 gggggcctcc agcagccccc acatctgcca gcggggcccc acgcacactc gcctgtccct
     3361 ccagggatca aaagcatcca aggaattcac ccggcgaaga aggccatcat gcacggacga
     3421 ggcagaggag tggccggtcc catgggccgg gggcgcctga tgccaaacaa gcagaacctg
     3481 cgggtggtgg agtgcaagcc ccagccctgc gtggtgtctg tggaggggct gtcctcgtcc
     3541 accacggatg cccagctgaa gagcctgctg atgtcagtgg gacccattca gagtttacag
     3601 atgcttcctc agcaacggaa agccatagct aagttcaagg agccagccca cgcattagca
     3661 tttcagcaga aattccacag gcatatgata gatttgtccc acataaatgt ggccctgatc
     3721 gtggagtgag tcctaacaag agagcctgac cttaggctgt acacacactg tggaatttct
     3781 tcaagggagc tgccggccgg cgcagaaccc ccaggagcac aggtctctcc gggccgctgt
     3841 cctgcgtaac tgttctccag agcgccagcc agccacgggc ctgattccag aggagccgaa
     3901 ctgacaggac acagcaggct ggagttggtg ttagattgct tcacattctc ttgtcaccac
     3961 caagaactcc aagtttttcg ttttgttttg ttttcaaagt gcttacaatg catgtagaca
     4021 ttgttctttg tggtctgact ctatgatcga tcacagtgac ttagattcag gaaagaacat
     4081 taacgtcaca agttctaagt agttttcaca gcaaagaata tttgataatg gttgcactta
     4141 tcttcagtgc aggttagaag agtcttctca accaagctta actcgagttg tcttctcagc
     4201 cctcaaaagg ctcttgtaca aaatgtagat taaaatttgg gtgattgttg attgaccttt
     4261 gcataccctg gaaagccagg gtgtgagtgg ggtggttggg agtggtgcca gttgaacagc
     4321 agattctgct tcttgtcact gtttcaaaag cgtcaactct gtgttcctag tttcgatgaa
     4381 ctccccattc atttttaaca cacttcccag ataaggcaat gtgctggaca ggcacacggc
     4441 atggccctcg gctagagcag ggtctgtgat ggcctcacct ggcagccctc tggcctagtt
     4501 cccaccacac atgaggtggt ggaatggcct gaaggtggaa cagacctgtt tttttccttt
     4561 ttaaatgcag taaggtggcc tgtttatcac tggctctgtg atacatgaca ttctttggga
     4621 atttggtggc cactgcttca gtcacctctg tttttctgaa ggctgttcca gcagggctgc
     4681 cctgttcatc agcggatgtt cactctggcc tgccgttccc cgtggcatgc ggggtgaggg
     4741 tggctttctt ccagccccaa atgagacgag tctgtgtcat cattgaaact gcttttcgta
     4801 attgcgggta ggttcctgta ggtgagacat attctccata aagctactgt agtagaattc
     4861 attctgggca aacactgaaa aaagtgcctt acagtatttc tgctcatgaa agagtttcac
     4921 tattttggat atattctaaa gtggacctga gctatttgag caaataatga tagggcatac
     4981 tcagacattt tagctacctt ttatacctac gatttcatgt cacatttact aatagaatta
     5041 agggaaatag aagcccgttc tttcttactg cccctggagg gagcatggcg ctagggctct
     5101 cagcctccta gaaggaaggg actaaggaga cgggcacaga cttgcgtcat ctcgtttcca
     5161 cagttgacgt tttatattac tttctcaaat taagttacca aaacaaactg aagagctgaa
     5221 gcaggtcttc cagaccctgc gatcctttct gtagcagtga ttctaaagtg gcgtttgctg
     5281 tgtgcttgag agtaacactg cacgctgcag gggctgttgc agcagtcagt cccaggaagc
     5341 cacagcgctt gtaggatctg ctaggaccct gcagctgtgc tgccgccacc tctgctccag
     5401 agtgtcccag ccaaccctcg gaagatggga ttgccagtca gccctgcctc accatgcctg
     5461 caggaggctg tccagggagc aggtctgtgt gcccatcagc aggttcccat ggctgtcact
     5521 gcccactcat ttccacagtt agatacggat gtgttgatgt atttcgtcta gtttatttgg
     5581 ctcagtccac agctgcgttg gagtggtgac tttggtagcc cttgagctct aattaagaga
     5641 gatccaaacc actcagtacc cactgggcag tgggaaggcc taccgactta ctttatcatt
     5701 gagggcttac tgatacaatg aaatgagttt catgactttt ttttttttta aacacttttt
     5761 gaaatagagt gtgctgtgtt taaaaccaaa aatatgcatg ttgtctctga aaagtaggca
     5821 ttgaaacaga cttttttgta gtcagtgtta ataaaacgga tcctgtttgg gccttcattg
     5881 ttaaggtgga cttcatggcc actggaaggt ctgttttggt gttacctgag tgtgacacag
     5941 gccctggggt gtgcgtgttt ctctaactgt ctacacgtgc acataggcag actttctcat
     6001 agaatgttct tgaaaggtga ttggcaaagt catgcaggcc cgccttaaag cgctgattag
     6061 aacagtccaa cacagtccga cctcactcaa tacccacaac catcgaaaat ggattcttag
     6121 taccagacaa tcccagtaat gaaggtttag tttccttgaa ggaaactaca gaaaaggaaa
     6181 gaagcagaat gagaaaggaa tggtacttag gtgtttggta tgctgctcac gtgaagtcag
     6241 cccacaccag ccaaaccctc gtggaagatc tgctgcaacc attatctttg ttcttgagtt
     6301 catcatgcat ttaaaatgag atgcaagagc atttagcata ccatgtaaat atggaccttt
     6361 taaaattaaa atactattgg aagtgctttc aactcagcca catcttagct attagttctt
     6421 tgtgttgtct tatcaaagtt taatggatac agttccacag ttgttgatgt gtttgtgtgt
     6481 atattcgatt tttataaaga tggtagtaag tcaatacatt tatcctgatc tgtgtattat
     6541 ttgttcacaa attcaagaag cttaaaggtc gtaaatatca gtatctcata aggtaaacca
     6601 atagctgatt atgtggagcc aagttacttc ttttcttttt gcattatctt gttttggttt
     6661 tgtgctgtaa tagaagttca cttagctact ttagataacc ttgcattacc actggtctgg
     6721 ccacgtttgt taaatcctta tactgatatt cttctaaaga gtaaatctca tcatttttcc
     6781 agacaaattt tgaggggttt ctctgttttg tggacaggca gcagcctccg taggcacccg
     6841 caccctgcct tgctggagga gatgggatgg ggcgggaggt ggcttcacca taactatttt
     6901 taatatgggt cattcttagc atgatttgta aaggtctcag gcaaacagtt gttgaagctt
     6961 gcttctgtgg catttctgaa ttgtggcaga gcttagatcc tgcacccagg ggtctttttt
     7021 tcaaacagca tcttgctcag ttctgtgaac agaaggcttt gttactgaag gaggtggaag
     7081 aggagtttag ggtgaaaagg aggaagggat ggacagaccc aggtgaggag aggcctgggg
     7141 attggggaag ctgtcatctc agtgttaata atcaacttgc ttctaacaca ctggcttatc
     7201 aggggaggtc atccagtccg gtcggtggag ttgagagccc ttgggccagg gtgtttggcg
     7261 gcacaggggc atccgctgga tggcctggag gagtggggga ggggaacgtc ttcactgggt
     7321 ggtgatcagc tgggacagtt caggtagggc aggtgaggga cccccgaggc cctggagcct
     7381 tgtcctggga tgggtttgaa gaactcatca ctcatcactt gttttctttt ggcttttgtt
     7441 gtttttgttt tgttctgttt gttttgtttt gtatttcttt gttattttat tgggaaggta
     7501 agcggaatgt gctcatagac catcagacgc ttgtcgaagg caggtcctag tcatgtaatt
     7561 gcacaggaca aggaggtcag cgtgtgtgat ggcagcatgc tgtgccggca catcgtggag
     7621 tcctagaaac tctctagtcc ctgcggctgt tcccctcctc tgctctctcc ctggagagga
     7681 ctgccagctc ttaagaaaca ttcctggtgc ggtgtctgca gtgccctttg tgggtgactt
     7741 caggcttccc gctttcgtgg tgctcttcct gggattcgtt tttttattac cctccctccc
     7801 tacttgtagg cctcagctat ggcttgacgt aatcgctttt agacccaggt tggcttccct
     7861 tcattaagct atgatcctcc accccatttt tttttttttt aatttggagt gggagggagg
     7921 ggggtgggcg agagaaagct cgaaaggtat tattggtttt tcaaaaaatt agaggtgacg
     7981 attctaccag ggagttgact gataggagtg tgtgcagggc aggaaaggtt cggaggcacc
     8041 cgactaccac cactcggaaa gccgctagtc cagatcgact agggagaggc ttagatactt
     8101 tagtgtattt aaagagcatt tcagttaact ttttcagcta tttttaaagt ttgtgaatgg
     8161 agtgttattt tggacattct taaatatgaa ttctccaaag gcatttagcc ttgacttaat
     8221 attaaatcct aaggatttta tgtaaggttt ttttgcaacc tatttaattt tttttaaatg
     8281 cctaacttct gaggtgcata agcccgtggt ttgtgtactg gaactaaagc ggaactcact
     8341 gattcatatt ggatccccag gtataccttc tgctggtagc atatggctgg aaaaggccgt
     8401 ttgcctcaca cattgtaacc tgccttggct agaaaatgct tttaatgtct caactctctc
     8461 ttttctgtgt catgttttgg taggaaatct ttaagattgg cggacggaac aggtatttta
     8521 gtgagacact tctgagtact tgctttttcc tttgacttct aaccaactaa aagagaagga
     8581 ggtcttcatg ttgatatttt gcttggtttt attttactga ttttaaaagg tatatagaaa
     8641 aatgtaggcc tttaaaaaga aacagcatgt agttttttat tttaatatgt tccatagagt
     8701 ggataggcag acaggtacta ttgtaatgta ttctgtattt aataatttaa tatactctag
     8761 aaagtagacc tcatgcattc ttttagcatg attttctttt aaactgcttt tcattttaag
     8821 ggcacccgtg gcggaagctg gttttgcaag gactgtgtaa gctgtatgcg ttctagctgt
     8881 atgcgttctg tagtcttttc ttaggtgggt aacattttca ataacgcgcg cacagcacac
     8941 aggggtgccc tgagccgaag gagcaaaaaa agccaccgct cgtttctata atccagcttt
     9001 gcttttcaca ggcgtgggat ccaggatggt gtcctctgtg aggacttgaa ctctggggct
     9061 ttaattccac tgtttaattt tcaggtacca cagcagcaaa gcacagagtg tgaccttttt
     9121 catgtctgag ctgattctgt ttgctccacg tgcctgcttc ttgctactgt tcatttagta
     9181 atgggatcac ctcaccatgc catgctctgg gctctccctc tctgtccatt tctgttttgc
     9241 tttcctggct aaacccatct accattctta acactggtag ctcctgtccc attccaagac
     9301 tcactctctc agaccttccc atctccctgg ctttccatgc tcctctccct ccacctcctg
     9361 gcttcaactg ggtgagggcc gtattcctgc cactctgctc cgcctcagcc ttgagaactc
     9421 cacgtgggct gggtgggaag gtgctgacga ttttcacact gtgtttacca ctccatcacc
     9481 tctcaacctt tgcttcgaca ggtcttcact cacgatttat tcctccaggt ctttgattgg
     9541 agagagtaac tttttaattc tgttgttttg cagtttggct ctgtaggagt gagtggcgat
     9601 tcaaagatgc cggcgtcccg cagtgtgcgg ttcgtgccct taaccacccg cttctttgtt
     9661 tcccgcccct ctgctttcgc aggagctctt gtgcttgagt tcagtgttag tggtagcgtg
     9721 gctcactcca cttggaggtg gcggccgtct gaccgtgtgt tactgctttg ccgacggggc
     9781 ctcccggccc tgatgcgtgt acactctgcg ggctgcaccg ggtggctctg gttgggggcg
     9841 aagctgtgtt gactgggaga gcgttggaaa ttgagacatg gagagatgac gggagtgcgt
     9901 ttctctgggt ttgatctcca tcctgttttc tcccagacac accacaccta ccttggggga
     9961 atgccgttgc ctgttccacc cctttgttca cttcgcgtta actgctgtgg taactttttc
    10021 aggatctgtg tgaagaatgg taatgacgta gttgaaagga aaatgtactg ttgtgtgttt
    10081 catttgtgtg atttcgtacc aaaaaaatgt gtttgaacta tattgtatgt aatttggaag
    10141 tcgtgttaat aaaaccctgc agtttcca
//
