LOCUS       NM_006743               4298 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens RNA binding motif protein 3 (RBM3), mRNA.
ACCESSION   NM_006743 XR_110616 XR_115510
VERSION     NM_006743.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4298)
  AUTHORS   Feng,J., Long,M., Zhao,X., Yan,P., Lin,Y., Wang,M. and Huang,W.
  TITLE     RBM3 Accelerates Wound Healing of Skin in Diabetes through ERK1/2
            Signaling
  JOURNAL   Curr Mol Pharmacol 17 (1), e18761429260980 (2024)
   PUBMED   37982286
  REMARK    GeneRIF: RBM3 Accelerates Wound Healing of Skin in Diabetes through
            ERK1/2 Signaling.
REFERENCE   2  (bases 1 to 4298)
  AUTHORS   Long,F., Hu,L., Chen,Y., Duan,X., Xie,K., Feng,J. and Wang,M.
  TITLE     RBM3 is associated with acute lung injury in septic mice and
            patients via the NF-kappaB/NLRP3 pathway
  JOURNAL   Inflamm Res 72 (4), 731-744 (2023)
   PUBMED   36781430
  REMARK    GeneRIF: RBM3 is associated with acute lung injury in septic mice
            and patients via the NF-kappaB/NLRP3 pathway.
REFERENCE   3  (bases 1 to 4298)
  AUTHORS   Wang,L., Shao,T.C., Wang,C.Y., Li,J.J., Jian,S.Q., Wang,D. and
            Cheng,B.F.
  TITLE     Influence of RRM, RGG and Potential Phosphorylated Sites in
            Cold-Inducible Protein RBM3 on its Subcellular Localization and
            Neuroprotective Effects
  JOURNAL   Front Biosci (Landmark Ed) 28 (2), 24 (2023)
   PUBMED   36866549
  REMARK    GeneRIF: Influence of RRM, RGG and Potential Phosphorylated Sites
            in Cold-Inducible Protein RBM3 on its Subcellular Localization and
            Neuroprotective Effects.
REFERENCE   4  (bases 1 to 4298)
  AUTHORS   Wang,N., Wang,L., Li,C., Rao,P., Wang,X., Xu,Y., Yang,L., Sun,L.
            and Lu,D.
  TITLE     RBM3 interacts with Raptor to regulate autophagy and protect
            cardiomyocytes from ischemia-reperfusion-induced injury
  JOURNAL   J Physiol Biochem 79 (1), 47-57 (2023)
   PUBMED   36192581
  REMARK    GeneRIF: RBM3 interacts with Raptor to regulate autophagy and
            protect cardiomyocytes from ischemia-reperfusion-induced injury.
REFERENCE   5  (bases 1 to 4298)
  AUTHORS   Xiao,Q., Liu,Y., Zhang,X., Liu,Z., Xiao,J., Ye,Q. and Fu,B.
  TITLE     Mild hypothermia ameliorates hepatic ischemia reperfusion injury by
            inducing RBM3 expression
  JOURNAL   Apoptosis 27 (11-12), 899-912 (2022)
   PUBMED   35930183
  REMARK    GeneRIF: Mild hypothermia ameliorates hepatic ischemia reperfusion
            injury by inducing RBM3 expression.
REFERENCE   6  (bases 1 to 4298)
  AUTHORS   Dellis,S., Strickland,K.C., McCrary,W.J., Patel,A., Stocum,E. and
            Wright,C.F.
  TITLE     Protein interactions among the vaccinia virus late transcription
            factors
  JOURNAL   Virology 329 (2), 328-336 (2004)
   PUBMED   15518812
REFERENCE   7  (bases 1 to 4298)
  AUTHORS   Brill,L.M., Salomon,A.R., Ficarro,S.B., Mukherji,M.,
            Stettler-Gill,M. and Peters,E.C.
  TITLE     Robust phosphoproteomic profiling of tyrosine phosphorylation sites
            from human T cells using immobilized metal affinity chromatography
            and tandem mass spectrometry
  JOURNAL   Anal Chem 76 (10), 2763-2772 (2004)
   PUBMED   15144186
REFERENCE   8  (bases 1 to 4298)
  AUTHORS   Wellmann,S., Buhrer,C., Moderegger,E., Zelmer,A., Kirschner,R.,
            Koehne,P., Fujita,J. and Seeger,K.
  TITLE     Oxygen-regulated expression of the RNA-binding proteins RBM3 and
            CIRP by a HIF-1-independent mechanism
  JOURNAL   J Cell Sci 117 (Pt 9), 1785-1794 (2004)
   PUBMED   15075239
  REMARK    GeneRIF: RBM3 and CIRP are adaptatively expressed in response to
            hypoxia by a mechanism that involves neither HIF-1 nor mitochondria
REFERENCE   9  (bases 1 to 4298)
  AUTHORS   Danno,S., Nishiyama,H., Higashitsuji,H., Yokoi,H., Xue,J.H.,
            Itoh,K., Matsuda,T. and Fujita,J.
  TITLE     Increased transcript level of RBM3, a member of the glycine-rich
            RNA-binding protein family, in human cells in response to cold
            stress
  JOURNAL   Biochem Biophys Res Commun 236 (3), 804-807 (1997)
   PUBMED   9245737
REFERENCE   10 (bases 1 to 4298)
  AUTHORS   Derry,J.M., Kerns,J.A. and Francke,U.
  TITLE     RBM3, a novel human gene in Xp11.23 with a putative RNA-binding
            domain
  JOURNAL   Hum Mol Genet 4 (12), 2307-2311 (1995)
   PUBMED   8634703
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC115618.3 and BC006825.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006743.4.
            
            Summary: This gene is a member of the glycine-rich RNA-binding
            protein family and encodes a protein with one RNA recognition motif
            (RRM) domain. Expression of this gene is induced by cold shock and
            low oxygen tension. A pseudogene exists on chromosome 1. Multiple
            alternatively spliced transcript variants that are predicted to
            encode different isoforms have been characterized although some of
            these variants fit nonsense-mediated decay (NMD) criteria.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000859.1, SRR1660807.9289.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376759.8/ ENSP00000365950.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AC115618.3         12486-12525
            41-675              BC006825.1         1-635
            676-4298            AC115618.3         15542-19164
FEATURES             Location/Qualifiers
     source          1..4298
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.23"
     gene            1..4298
                     /gene="RBM3"
                     /gene_synonym="IS1-RNPL; RNPL"
                     /note="RNA binding motif protein 3"
                     /db_xref="GeneID:5935"
                     /db_xref="HGNC:HGNC:9900"
                     /db_xref="MIM:300027"
     exon            1..90
                     /gene="RBM3"
                     /gene_synonym="IS1-RNPL; RNPL"
                     /inference="alignment:Splign:2.1.0"
     exon            91..206
                     /gene="RBM3"
                     /gene_synonym="IS1-RNPL; RNPL"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..577
                     /gene="RBM3"
                     /gene_synonym="IS1-RNPL; RNPL"
                     /note="RNA binding motif (RNP1, RRM) protein 3"
                     /codon_start=1
                     /product="RNA-binding protein 3"
                     /protein_id="NP_006734.1"
                     /db_xref="CCDS:CCDS14301.1"
                     /db_xref="GeneID:5935"
                     /db_xref="HGNC:HGNC:9900"
                     /db_xref="MIM:300027"
                     /translation="MSSEEGKLFVGGLNFNTDEQALEDHFSSFGPISEVVVVKDRETQ
                     RSRGFGFITFTNPEHASVAMRAMNGESLDGRQIRVDHAGKSARGTRGGGFGAHGRGRS
                     YSRGGGDQGYGSGRYYDSRPGGYGYGYGRSRDYNGRNQGGYDRYSGGNYRDNYDN"
     exon            207..313
                     /gene="RBM3"
                     /gene_synonym="IS1-RNPL; RNPL"
                     /inference="alignment:Splign:2.1.0"
     exon            314..419
                     /gene="RBM3"
                     /gene_synonym="IS1-RNPL; RNPL"
                     /inference="alignment:Splign:2.1.0"
     exon            420..516
                     /gene="RBM3"
                     /gene_synonym="IS1-RNPL; RNPL"
                     /inference="alignment:Splign:2.1.0"
     exon            517..600
                     /gene="RBM3"
                     /gene_synonym="IS1-RNPL; RNPL"
                     /inference="alignment:Splign:2.1.0"
     exon            601..4298
                     /gene="RBM3"
                     /gene_synonym="IS1-RNPL; RNPL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1401..1406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM3"
                     /gene_synonym="IS1-RNPL; RNPL"
                     /note="hexamer: ATTAAA"
     polyA_site      1420
                     /gene="RBM3"
                     /gene_synonym="IS1-RNPL; RNPL"
                     /note="major polyA site"
     regulatory      4272..4277
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM3"
                     /gene_synonym="IS1-RNPL; RNPL"
                     /note="hexamer: AATAAA"
     polyA_site      4298
                     /gene="RBM3"
                     /gene_synonym="IS1-RNPL; RNPL"
ORIGIN      
        1 atcaatcgtc ttccggcgca gccccgtccc tgttttttgt gctcctccga gctcgctgtt
       61 cgtccgggtt ttttacgttt taatttccag gacttgaact gccatgtcct ctgaagaagg
      121 aaagctcttc gtgggagggc tcaactttaa caccgacgag caggcactgg aagaccactt
      181 cagcagtttc ggacctatct ctgaggtggt cgttgtcaag gaccgggaga ctcagcggtc
      241 caggggtttt ggtttcatca ccttcaccaa cccagagcat gcttcagttg ccatgagagc
      301 catgaacgga gagtctctgg atggtcgtca gatccgtgtg gatcatgcag gcaagtctgc
      361 tcggggaacc agaggaggtg gctttggggc ccatgggcgt ggtcgcagct actctagagg
      421 tggtggggac cagggctatg ggagtggcag gtattatgac agtcgacctg gagggtatgg
      481 atatggatat ggacgttcca gagactataa tggcagaaac cagggtggtt atgaccgcta
      541 ctcaggagga aattacagag acaattatga caactgaaat gagacatgca cataatatag
      601 atacacaagg aataatttct gatccaggat cgtccttcca aatggctgta tttataaagg
      661 tttttggagc tgcaccgaag catcttattt tatagtatat caaccttttg tttttaaatt
      721 gacctgccaa ggtagctgaa gaccttttag acagttccat cttttttttt aaattttttc
      781 tgcctattta aagacaaatt atgggacgtt tgtagaacct gagtattttt ctttttacca
      841 gttttttagt ttgagctctt aggtttattg gagctagcaa taattggttc tggcaagttt
      901 ggccagactg acttcaaaaa attaatgtgt atccagggac attttaaaaa cctgtacaca
      961 gtgtttattg tggttaggaa gcaatttccc aatgtaccta taagaaatgt gcatcaagcc
     1021 agcctgacca acatggtgaa accccatctg tactaaacat aaaaaaatta gcctggcatg
     1081 gtggtgtacg cctgtaatcc cagtgacttg ggaggctgag gcaggagaat cgcttgaacc
     1141 cgggaggcgg aggttgcagt gagctaagat cgcgccactg tactccagcc tgggcaacag
     1201 cgagactcca tctcaaaaaa aaaggaaatg tgtatcaaga acatgattat ccagcggtat
     1261 tttctaattc agatcatcaa actgattata tagaagagtt ggctttaaaa tgtttgcaaa
     1321 tgtctttttt tttttaatac tggaagaaaa aatattctgt tgtgtctcat acagtgctta
     1381 ggatgtcttt cacagagctt attaaaaaga tgaaacctga gaacaaactg ctttattctt
     1441 actcagccca ttttgcaaat taaaagtggg ggcagaggtg ggcggatcac ctgaggtcag
     1501 gagttcgaga ccagcctggc caacagggca aaaccccatc tctactaaaa atacaaaagt
     1561 tagcggggcg tggtggcggg tgcatgtaat cccagctact cgggaggctg aggcaggaga
     1621 attgcttgaa cccaggaggc ggaagttgca gtgagctgag attgtgccac tgcactccag
     1681 cctaggtgac agcaagactc tgtctcaaaa aaaaaaaaat ggcacatcaa cgagagggag
     1741 gcttggagaa tatttggttg gtgggtgggc agggactgcc agagggttag gtgtacattg
     1801 aggcctgagg cctgctggaa ttgggtttcc ttaactggtc tcttatctta gtcccattgt
     1861 tctgagaaca taagcaccta atctcatggc gtgagctaat ccctatcata aatagtggta
     1921 ccagttcatt ccttcccctg aaatgatggg ggttgggcag agatgcactg aactcatctt
     1981 tgtgtatgag ggccatgaga gaggcctggt ttgaaaacaa tgctaagagc tcagattcca
     2041 ggatttatgt aggggctctt ctacttccca ggtatttgac ctcaggtgag tcatttaatt
     2101 tcagccttat gccattttac attttctgtg gagggttagg ttaattggca tataaagcca
     2161 ctgagaagag ttggcaaagc tctcagtcac ggggatttga tcttttttgg tgtgtgtgtg
     2221 tcttgggtgg taaagtggta attttgtaat tctagctggt cttagttcct cagttctgct
     2281 ccctttagtc atggttcttt ctagtggctg tattgaggcc ccatgggtgt tatccctcca
     2341 ttggttctag tttggaacag aaaaatctgt tgtattcatg gctttcacct ggctaatact
     2401 gagctaagtt accaccaggt tgcaaactcc aggacattat tgtcctgagc tgcctattcc
     2461 cttgctggtg cgttgtggaa ccctgtatta ttagttccag tcctggaggc ctgcctcctg
     2521 agtttcccag ctagttggga caggccccaa tatcccttct tcctgtaacc caaacagtca
     2581 tgaatttgct ttggcaggtg gatggagact tgggaacttc cacctcaccc actaagccag
     2641 gcccaggcta tggggcattg tggctaaccc caccaggtgg atacttggtc tgaggacgca
     2701 tcttattctg ggcctttagg gagctaaggc agtgagaatt ggcaggagga ctgctgtgaa
     2761 tgccttgtag gtcgggggat tggagggggt cctctgctcc ctgtctctca ggatggcaat
     2821 gtacctctca cccccagtgt cagctgaggt aggatccata atcagtaata ttcctgcaac
     2881 aaaatgttcc taagtggaat caatgaagac caaaatttat ttgtataaca actctaaacc
     2941 tgctctgctc tgctgtgttt acaatgtgct ttgtgatcat ccagcccagg gagtcccagt
     3001 ctctggctgt ctatctgctc taaggaagag agcccacagt tctctatagt gccatagtct
     3061 gtgatgaata aagttccaga tttgaggtca acccccgacc acccttaaag tgcttgttgg
     3121 tctcctactt tggtttgtct tcagcatcca actgatgcac atttgtcaag aacccactga
     3181 ggctagaaac cccccaaaca ctcaaggtac cttgagaaca tgtatcccaa gacctgcaaa
     3241 gaccaaacac atggcctgta actacttttc actttcaagc cctggaactt gtctgtacca
     3301 aaaatctttc tgaaccattc accaaatctc ttgtcaaggg ccagaataaa ttaagagatt
     3361 ggcttttggt tttcaattag gctttcaagt cctaagccca acccctccta tcccacctag
     3421 gcagaaatca cttcagatcc ttgcttccta gtttaatttc ttctctgcct cagttataac
     3481 atccataaaa tggaaataat aatacccacc tcacacaggg gttaggagtg tttttttgtt
     3541 ggtttttttc cagacagggt ctcactctgt ctcccaggct ggagtgcagt ggcacaatct
     3601 cggctcactg taccctccgc ctcccaggtt caagcagttc tcatgcctca gcctcccaag
     3661 tagctgggat tacaggtgcc tgccaccacg cccggctaat ttttgtatta atagagacag
     3721 ggtttcaccg tgttgggcag gctggtcctg aactcctgac ctcaagtgat ccacccgcct
     3781 cggcctccca aagtgctggg attacaggcg tgagccacca cacctggcct aggagttaag
     3841 agtattaaat gttaagaaca gaccaagtcc atcaaacagc tccacaccct tgttccatgt
     3901 tctggattgg ggagttgtgg gggtggaggt gtagaacttt taaaaagctt cttaaaataa
     3961 gttgctgtga atacttcagg tatataaaaa aacattggtt gacaataagc cagtgttctg
     4021 ccattcttac ctgcttatca agacaaaacc tgctcaagtc cctgcccagc tgcattccaa
     4081 gtgttttcaa gtttggtggt aagacctgac ctgaggcttc ttataacctt tactcagtgg
     4141 gaatatgcat acagttcact acagaaatat ttgtatttac ttagaggaag tgccctggat
     4201 ctgggggcgg gggggggcgg ggggaatggg tcttttctaa attgttaaaa gcagttcatg
     4261 ccattattct taataaacat ttctaatatg ctgtgaaa
//
