LOCUS       NM_018989               6537 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens RNA binding motif protein 27 (RBM27), mRNA.
ACCESSION   NM_018989 XM_001720239 XM_001723796 XM_001723897
VERSION     NM_018989.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6537)
  AUTHORS   Contreras,X., Depierre,D., Akkawi,C., Srbic,M., Helsmoortel,M.,
            Nogaret,M., LeHars,M., Salifou,K., Heurteau,A., Cuvier,O. and
            Kiernan,R.
  TITLE     PAPgamma associates with PAXT nuclear exosome to control the
            abundance of PROMPT ncRNAs
  JOURNAL   Nat Commun 14 (1), 6745 (2023)
   PUBMED   37875486
  REMARK    GeneRIF: PAPgamma associates with PAXT nuclear exosome to control
            the abundance of PROMPT ncRNAs.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6537)
  AUTHORS   Zouboulis,C.C., Nogueira da Costa,A., Fimmel,S. and Zouboulis,K.C.
  TITLE     Apocrine glands are bystanders in hidradenitis suppurativa and
            their involvement is gender specific
  JOURNAL   J Eur Acad Dermatol Venereol 34 (7), 1555-1563 (2020)
   PUBMED   32031713
REFERENCE   3  (bases 1 to 6537)
  AUTHORS   Silla,T., Schmid,M., Dou,Y., Garland,W., Milek,M., Imami,K.,
            Johnsen,D., Polak,P., Andersen,J.S., Selbach,M., Landthaler,M. and
            Jensen,T.H.
  TITLE     The human ZC3H3 and RBM26/27 proteins are critical for
            PAXT-mediated nuclear RNA decay
  JOURNAL   Nucleic Acids Res 48 (5), 2518-2530 (2020)
   PUBMED   31950173
  REMARK    GeneRIF: three additional proteins required for Poly(A) Tail
            eXosome Targeting (PAXT) function: ZC3H3, RBM26 and RBM27 along
            with the known PAXT-associated protein, PABPN1, were identified.
REFERENCE   4  (bases 1 to 6537)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 6537)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 6537)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   7  (bases 1 to 6537)
  AUTHORS   Kavanagh,S.J., Schulz,T.C., Davey,P., Claudianos,C., Russell,C. and
            Rathjen,P.D.
  TITLE     A family of RS domain proteins with novel subcellular localization
            and trafficking
  JOURNAL   Nucleic Acids Res 33 (4), 1309-1322 (2005)
   PUBMED   15741184
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 6537)
  AUTHORS   Schmutz,J., Martin,J., Terry,A., Couronne,O., Grimwood,J.,
            Lowry,S., Gordon,L.A., Scott,D., Xie,G., Huang,W., Hellsten,U.,
            Tran-Gyamfi,M., She,X., Prabhakar,S., Aerts,A., Altherr,M.,
            Bajorek,E., Black,S., Branscomb,E., Caoile,C., Challacombe,J.F.,
            Chan,Y.M., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Glavina,T., Gomez,M., Gonzales,E., Goodstein,D.,
            Grigoriev,I., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Israni,S.,
            Jett,J., Kadner,K., Kimball,H., Kobayashi,A., Lopez,F., Lou,Y.,
            Martinez,D., Medina,C., Morgan,J., Nandkeshwar,R., Noonan,J.P.,
            Pitluck,S., Pollard,M., Predki,P., Priest,J., Ramirez,L.,
            Retterer,J., Rodriguez,A., Rogers,S., Salamov,A., Salazar,A.,
            Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N., Wheeler,J.,
            Wu,K., Yang,J., Dickson,M., Cheng,J.F., Eichler,E.E., Olsen,A.,
            Pennacchio,L.A., Rokhsar,D.S., Richardson,P., Lucas,S.M.,
            Myers,R.M. and Rubin,E.M.
  TITLE     The DNA sequence and comparative analysis of human chromosome 5
  JOURNAL   Nature 431 (7006), 268-274 (2004)
   PUBMED   15372022
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX647384.1, AB037732.1 and AL833706.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018989.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.98509.1, BX647384.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265271.7/ ENSP00000265271.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-672               BX647384.1         6-677
            673-6446            AB037732.1         1-5774
            6447-6537           AL833706.1         4100-4190
FEATURES             Location/Qualifiers
     source          1..6537
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q32"
     gene            1..6537
                     /gene="RBM27"
                     /gene_synonym="ARRS1; Psc1; ZC3H18; ZC3H20"
                     /note="RNA binding motif protein 27"
                     /db_xref="GeneID:54439"
                     /db_xref="HGNC:HGNC:29243"
                     /db_xref="MIM:620082"
     exon            1..220
                     /gene="RBM27"
                     /gene_synonym="ARRS1; Psc1; ZC3H18; ZC3H20"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..3344
                     /gene="RBM27"
                     /gene_synonym="ARRS1; Psc1; ZC3H18; ZC3H20"
                     /note="acidic rich RS domain containing 1"
                     /codon_start=1
                     /product="RNA-binding protein 27"
                     /protein_id="NP_061862.1"
                     /db_xref="CCDS:CCDS43378.1"
                     /db_xref="GeneID:54439"
                     /db_xref="HGNC:HGNC:29243"
                     /db_xref="MIM:620082"
                     /translation="MLIEDVDALKSWLAKLLEPICDADPSALANYVVALVKKDKPEKE
                     LKAFCADQLDVFLQKETSGFVDKLFESLYTKNYLPLLEPVKPEPKPLVQEKEEIKEEV
                     FQEPAEEERDGRKKKYPSPQKTRSESSERRTREKKREDGKWRDYDRYYERNELYREKY
                     DWRRGRSKSRSKSRGLSRSRSRSRGRSKDRDPNRNVEHRERSKFKSERNDLESSYVPV
                     SAPPPNSSEQYSSGAQSIPSTVTVIAPAHHSENTTESWSNYYNNHSSSNSFGRNLPPK
                     RRCRDYDERGFCVLGDLCQFDHGNDPLVVDEVALPSMIPFPPPPPGLPPPPPPGMLMP
                     PMPGPGPGPGPGPGPGPGPGPGPGHSMRLPVPQGHGQPPPSVVLPIPRPPITQSSLIN
                     SRDQPGTSAVPNLASVGTRLPPPLPQNLLYTVSERQPMYSREHGAAASERLQLGTPPP
                     LLAARLVPPRNLMGSSIGYHTSVSSPTPLVPDTYEPDGYNPEAPSITSSGRSQYRQFF
                     SRTQTQRPNLIGLTSGDMDVNPRAANIVIQTEPPVPVSINSNITRVVLEPDSRKRAMS
                     GLEGPLTKKPWLGKQGNNNQNKPGFLRKNQYTNTKLEVKKIPQELNNITKLNEHFSKF
                     GTIVNIQVAFKGDPEAALIQYLTNEEARKAISSTEAVLNNRFIRVLWHRENNEQPTLQ
                     SSAQLLLQQQQTLSHLSQQHHHLPQHLHQQQVLVAQSAPSTVHGGIQKMMSKPQTSGA
                     YVLNKVPVKHRLGHAGGNQSDASHLLNQSGGAGEDCQIFSTPGHPKMIYSSSNLKTPS
                     KLCSGSKSHDVQEVLKKKQEAMKLQQDMRKKRQEVLEKQIECQKMLISKLEKNKNMKP
                     EERANIMKTLKELGEKISQLKDELKTSSAVSTPSKVKTKTEAQKELLDTELDLHKRLS
                     SGEDTTELRKKLSQLQVEAARLGILPVGRGKTMSSQGRGRGRGRGGRGRGSLNHMVVD
                     HRPKALTVGGFIEEEKEDLLQHFSTANQGPKFKDRRLQISWHKPKVPSISTETEEEEV
                     KEEETETSDLFLPDDDDEDEDEYESRSWRR"
     exon            221..339
                     /gene="RBM27"
                     /gene_synonym="ARRS1; Psc1; ZC3H18; ZC3H20"
                     /inference="alignment:Splign:2.1.0"
     exon            340..464
                     /gene="RBM27"
                     /gene_synonym="ARRS1; Psc1; ZC3H18; ZC3H20"
                     /inference="alignment:Splign:2.1.0"
     exon            465..556
                     /gene="RBM27"
                     /gene_synonym="ARRS1; Psc1; ZC3H18; ZC3H20"
                     /inference="alignment:Splign:2.1.0"
     exon            557..750
                     /gene="RBM27"
                     /gene_synonym="ARRS1; Psc1; ZC3H18; ZC3H20"
                     /inference="alignment:Splign:2.1.0"
     exon            751..1011
                     /gene="RBM27"
                     /gene_synonym="ARRS1; Psc1; ZC3H18; ZC3H20"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1305
                     /gene="RBM27"
                     /gene_synonym="ARRS1; Psc1; ZC3H18; ZC3H20"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1440
                     /gene="RBM27"
                     /gene_synonym="ARRS1; Psc1; ZC3H18; ZC3H20"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1605
                     /gene="RBM27"
                     /gene_synonym="ARRS1; Psc1; ZC3H18; ZC3H20"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1755
                     /gene="RBM27"
                     /gene_synonym="ARRS1; Psc1; ZC3H18; ZC3H20"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1900
                     /gene="RBM27"
                     /gene_synonym="ARRS1; Psc1; ZC3H18; ZC3H20"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2054
                     /gene="RBM27"
                     /gene_synonym="ARRS1; Psc1; ZC3H18; ZC3H20"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2351
                     /gene="RBM27"
                     /gene_synonym="ARRS1; Psc1; ZC3H18; ZC3H20"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2492
                     /gene="RBM27"
                     /gene_synonym="ARRS1; Psc1; ZC3H18; ZC3H20"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..2612
                     /gene="RBM27"
                     /gene_synonym="ARRS1; Psc1; ZC3H18; ZC3H20"
                     /inference="alignment:Splign:2.1.0"
     exon            2613..2687
                     /gene="RBM27"
                     /gene_synonym="ARRS1; Psc1; ZC3H18; ZC3H20"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2852
                     /gene="RBM27"
                     /gene_synonym="ARRS1; Psc1; ZC3H18; ZC3H20"
                     /inference="alignment:Splign:2.1.0"
     exon            2853..2957
                     /gene="RBM27"
                     /gene_synonym="ARRS1; Psc1; ZC3H18; ZC3H20"
                     /inference="alignment:Splign:2.1.0"
     exon            2958..3149
                     /gene="RBM27"
                     /gene_synonym="ARRS1; Psc1; ZC3H18; ZC3H20"
                     /inference="alignment:Splign:2.1.0"
     exon            3150..3260
                     /gene="RBM27"
                     /gene_synonym="ARRS1; Psc1; ZC3H18; ZC3H20"
                     /inference="alignment:Splign:2.1.0"
     exon            3261..6537
                     /gene="RBM27"
                     /gene_synonym="ARRS1; Psc1; ZC3H18; ZC3H20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6519..6524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM27"
                     /gene_synonym="ARRS1; Psc1; ZC3H18; ZC3H20"
                     /note="hexamer: ATTATA"
     polyA_site      6537
                     /gene="RBM27"
                     /gene_synonym="ARRS1; Psc1; ZC3H18; ZC3H20"
                     /note="major polyA site"
ORIGIN      
        1 agttcctgtt aggccccggc cgggggagta ggttgaagtc tcctaagatg cccggtgggc
       61 tggggcaccg ggagctgtga agggaacgtg agggggcggc gtagtggaga cccacggcag
      121 gcctgaagaa gagcggcggc cgagcccgcc ttccctgcac catgctcata gaggatgtgg
      181 atgccctcaa gtcctggctg gccaagttac tggagccgat atgtgatgct gatccttcag
      241 ccttagccaa ctatgttgta gcactggtca agaaggacaa acctgagaaa gaattaaaag
      301 ccttttgtgc tgatcaactt gatgtctttt tacaaaaaga aacttcaggt tttgtggaca
      361 aactatttga aagtctctat actaagaact accttccact tttggaacca gtaaagcctg
      421 agccaaaacc actagtccaa gaaaaagaag aaattaaaga agaggtattt caggagccag
      481 cagaggaaga acgagatggc agaaaaaaga aatatcctag tccccagaag actcgttcag
      541 aatctagtga acgaaggaca cgtgagaaaa aaagagaaga cgggaaatgg agagactatg
      601 accggtacta tgagcggaat gaattgtacc gtgagaagta tgactggaga agaggcagga
      661 gtaagagtcg gagtaagagt cgaggcctga gtcgcagtag aagccgaagt agggggcgca
      721 gcaaagaccg ggatccaaat aggaatgttg agcacaggga aagatcgaag tttaagagtg
      781 aaaggaatga cctggagagt tcctatgtgc ctgtgtctgc accacctcca aactcttctg
      841 agcagtattc ctctggggca cagtctattc ccagcactgt tactgtgatc gcacctgctc
      901 accactctga aaacacaact gagagttggt ctaattacta taacaatcat agctcttcca
      961 attcttttgg tcgaaaccta ccaccaaaga ggcgatgcag agattatgat gaaagaggat
     1021 tttgtgtact tggtgacctt tgtcagtttg atcatggaaa tgatccccta gttgttgatg
     1081 aagttgctct gccaagtatg attcctttcc caccccctcc tcctgggctt cctcctccac
     1141 cacctcctgg aatgttaatg cctccaatgc caggtccagg cccaggcccg ggcccaggtc
     1201 caggcccagg cccgggccca ggtccaggtc ctggccatag tatgagactt cctgttcccc
     1261 aaggacatgg tcagcctcca ccatccgttg tgcttcccat accaagacca cctataacac
     1321 aatcaagctt gataaacagc cgtgaccagc ctgggacaag tgcagtgccc aatcttgcat
     1381 cagtgggaac aagactacct cctcctttac cccagaacct cctttacaca gtatcagaac
     1441 gacagcccat gtactctcgt gaacatggtg ctgctgcatc tgagcgactt cagttgggga
     1501 caccgcctcc tctgttggca gctcgtttgg tgccacctcg aaacctcatg ggatcctcca
     1561 ttggatacca tacctcagtc tccagcccta cccctctggt tccagataca tatgaaccag
     1621 atggttacaa cccagaagct cctagtatta ctagttctgg tagatctcag tacagacagt
     1681 tcttttcaag aactcagaca cagcgtccca atctgattgg cctaacatct ggagatatgg
     1741 atgtaaatcc aagagctgct aacattgtga tccagactga accaccagtt cctgtttcga
     1801 ttaatagcaa cataaccaga gtagttcttg aaccagatag tcgaaaaaga gctatgagtg
     1861 gtttggaagg gccactcaca aagaaacctt ggctgggaaa gcaaggaaat aacaatcaaa
     1921 ataaaccagg gttcttacga aagaatcagt atacaaacac caaattagaa gtcaagaaaa
     1981 tccctcagga attgaacaac attaccaagc tcaatgaaca cttcagcaaa tttggaacta
     2041 ttgttaatat ccaggttgct tttaagggtg acccagaagc agccctaatc caatatctta
     2101 ccaatgagga ggccaggaaa gccatttcta gcacagaagc agttctaaac aaccgattca
     2161 ttcgagtctt gtggcatagg gaaaataatg agcaaccgac actacagtcc tcagcacagc
     2221 tgctcctgca acaacagcaa acacttagtc acctctcaca gcagcaccat cacctgccac
     2281 agcatctaca tcagcagcag gtgctagtgg cccagtctgc tccttcaaca gtgcacggag
     2341 gtatccagaa gatgatgagc aaaccacaga catcaggtgc atatgttctt aacaaagttc
     2401 ctgttaaaca tcgtcttgga catgcaggtg gtaaccagag tgatgcatca catttgttga
     2461 atcagtctgg tggtgctgga gaagattgcc agatattttc aactccaggc catccaaaaa
     2521 tgatttacag ctcctcaaac ttaaagacac cttcaaagct ctgttcaggg tctaaatctc
     2581 atgatgttca agaagtgctt aaaaaaaaac aggaagcaat gaagttacaa caagatatga
     2641 ggaaaaaaag acaggaagtg ttagaaaagc aaatagaatg ccaaaagatg ttaatatcca
     2701 agttagaaaa aaacaaaaac atgaaaccag aagaaagagc aaatataatg aagactttga
     2761 aagagcttgg agagaagatc tcacaattaa aagatgaatt aaaaacatct tctgcagtct
     2821 ccacaccatc taaagtgaag acaaaaacgg aggcccagaa ggagttatta gatactgaac
     2881 tggacctcca caagaggctg tcctcaggag aagacaccac agaattacgg aaaaaactca
     2941 gtcagttaca ggttgaggct gcacggttag gtattttacc tgtgggtcga ggaaagacca
     3001 tgtcctctca aggtcgagga agaggccgag ggcgtggagg aagaggaagg ggctcactaa
     3061 atcacatggt ggtggaccat cgtcccaaag cactaacagt tggaggattc attgaggaag
     3121 aaaaagaaga cttgcttcag catttctcaa ccgcaaacca agggccaaaa tttaaagacc
     3181 gtcggctaca gatatcatgg cacaagccca aggtaccatc tatatccact gagactgaag
     3241 aagaagaagt caaggaggag gaaacagaaa cctcagattt gtttttgcct gatgatgacg
     3301 atgaagatga agatgaatat gagtctcgct catggcgaag atgaaatctg atgctagctg
     3361 tataattttt aggaatattg tttagaagaa caacttttaa aaattattta aaagaagtca
     3421 atgagccaaa aaaaattttt ttatttttct tttcaacaca gtaggttcaa gaacagcaag
     3481 tttgctattt aaacacatct cataactgta catgatatta aagcaccaaa ggcctagtga
     3541 cttttacaca gttgtgaaga tccacagcaa tgacatggat aatctctaga gccttatttt
     3601 ccacaccacc ttttttttgt tgctgttggt gttggattat gatgtaaatg acagggtgtt
     3661 cagaaatttt attttggatt ataatctact gataaaattt aattaaatgt caaaatcacc
     3721 tgtaatcttt taactctcag ttgttatgga tgggtcatca gacagtagga aatatttgta
     3781 attaaaatac ccttttgctt tcaagagtgg tcttggaaga aaaatatgtt tattttaatt
     3841 ttaatttttt ttttttttta ctttggagga gcccaatttg tattcagtct aaatttgttt
     3901 ttcatggttt ttatgtgtgg tagtactagt tcagtgaaaa tcacaacaaa ctgtgtgttc
     3961 ttaaatgcta cagcaatggt agctagctct atagtatttc cattctcttg tcatatgaac
     4021 tcctggactt ttcctgctac tgattcttag tttgctttga tatttagtga gcgctggttc
     4081 ggctggtctt tttaaaaatt tttataactc agaatgtaaa aggctttcac ctattgcccc
     4141 tttctcgtcc cccttttctt cctcttgcct ttctattaat aggcctgact tagtcatcat
     4201 tgatataagt ggttcatttg ggcaaccgca ggcagtctcc aataaaaggt tcaaaccagc
     4261 acctggataa ataagtgatg ttttgatgag aatgatggaa ggattttggg gagaagagaa
     4321 tcaccagctt tattttttcc ctcttttgaa gcttcagttc agtatagtta cacagaaggg
     4381 tttaaaaatg tctgaaattc ttttcctaaa tttaaaccat gatggtgagg tgactggggg
     4441 gtggggggtg gaggtgggag ggggttgagg gctgagtatg ctagtaataa atgggagtca
     4501 tatatgactt tgttcagatg accttatttt ttcataattt tgtagcttgt tgctatccat
     4561 gaacatacgc atccctcagt agacagtttc ctttactgtg tgcattttta ctgtacactg
     4621 tatagagtag agtatctgtt aagtaaaata tatatgtaaa tttatgtctt cgtgttctga
     4681 atgttagatg gaaaagcaga ggagcaacac tacactgtac tgacccctgg gaaaataaaa
     4741 tgattaatgt acctaggctg tcactttttc aaggatatac acatctgtgt ttttatatat
     4801 gtgtggtatg aaaatttgaa acctcctgtt gtctccaaaa gggtcttggt gaccactata
     4861 tcaaggattt tgtttgctga ggtaaagaca atttctcaat atagaaacta ttcactaaga
     4921 acttaaaacc atcaggattc tagatttact tagctataag aagttaaatc ccacgttctg
     4981 ataatcttta ttcttctaca tgttttcctg gaatgatgtg tcaaaccagg gtcattttta
     5041 agttcatata attttctttc ataataatga ggacttcctt tttctaggtt attgttatat
     5101 ttctagtaac actgaaggta aaataagctt ataaaagaag gaaaacatca gaatggtgta
     5161 tctagaatac acaatcttgc tccttactcc tccatcatct ctaatgaaat ttttcttgat
     5221 gtctgtggct cagtcagtat atattttgaa agattcattg tggtgaatat tttgagtcct
     5281 gacagtttaa acgtgataga gggaacaaag gatttatata ttttttgtac aaagtttttt
     5341 cttaaactgt ataattttgt aaataatttg tttgggtttt ttttttgtgt actaaaacta
     5401 ccagcgtata gatttcaata agaattgttg tatttttgta tttggaaact gaaaattaca
     5461 gtaaataaat ggaactctaa gaaaaatttc agtagacagt tcaacagaat gagattcctt
     5521 ttcatatgat ttttttgacc tcaaaatgga catcttattt cactctcagt aaaaagttga
     5581 aaatttgact ttttagtatt gggggcagaa gatagaagtg tgttaaagtg aaaaacagtt
     5641 ttttcagtaa ggtttgaggc cctttctata agttttcagt acaccttaaa caggactaaa
     5701 aatactttaa aagtgtgctt tcaaagaatt ttaaaacatg tttgactcaa agatgaattt
     5761 gaagtgagtt aattataata ctggaaaact tcaggttagc ataaaatagt ttatatatat
     5821 cccctgcccc ctttgggatt tacttccacc atcaaatctt caactgttag aatttcactt
     5881 aaaagtgaat aactgccata catgttttct tggcatcttc atttacagaa ataacataca
     5941 gcatctaaag caagttctgt ccctcttaat gtgtatgaca tctttttaag tagctgatca
     6001 gcaataatag ccaccagttg actaggtcag cctgatatac tagtggatca ctgtccaaga
     6061 taaaaaggta accccaagta ttgcaaaatt tccctcaatt tctttatgta acattgaaga
     6121 aatgttgtta ccagctaaga tgataaattg gaaaacagtc ttgttaaggt gaaaggggtc
     6181 cttggtgatg gatcattatt tcaaaaaaga aaaaaatcat gtgaaaagga atagtggttc
     6241 ctcttgatgt atagtatgcc tgtattatag tttttacaaa attgtgaact tgtgtaatag
     6301 tataatagga gatattgttg aatttctaac tgtttataca tttaaattca tatatgtaat
     6361 gtttgtttta tcaattacaa tctgaatttc taagaagcat gttgactttt gcaataaaga
     6421 tgcaatatgg aatggttcac aattggaaaa aaaaaagaaa aaagatgaaa gtattacaaa
     6481 tttaaaagaa tttggaaaat ttatgaacca ttccaaaaat tataacaatc accaaaa
//
