LOCUS       NM_021239               6813 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens RNA binding motif protein 25 (RBM25), mRNA.
ACCESSION   NM_021239 XM_027330
VERSION     NM_021239.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6813)
  AUTHORS   Zhi,L., Chen,C., Zhang,G., Huang,T., He,W., Zhang,J., Chen,D.,
            Liu,J., Zhao,J., Qi,Y., Wang,G., Zhang,W. and Wang,Y.
  TITLE     RBM25 depletion suppresses the growth of colon cancer cells through
            regulating alternative splicing of MNK2
  JOURNAL   Sci China Life Sci 67 (10), 2186-2197 (2024)
   PUBMED   39110401
  REMARK    GeneRIF: RBM25 depletion suppresses the growth of colon cancer
            cells through regulating alternative splicing of MNK2.
REFERENCE   2  (bases 1 to 6813)
  AUTHORS   Le Senechal,R., Keruzore,M., Quillevere,A., Loaec,N., Dinh,V.T.,
            Reznichenko,O., Guixens-Gallardo,P., Corcos,L.,
            Teulade-Fichou,M.P., Granzhan,A. and Blondel,M.
  TITLE     Alternative splicing of BCL-x is controlled by RBM25 binding to a
            G-quadruplex in BCL-x pre-mRNA
  JOURNAL   Nucleic Acids Res 51 (20), 11239-11257 (2023)
   PUBMED   37811881
  REMARK    GeneRIF: Alternative splicing of BCL-x is controlled by RBM25
            binding to a G-quadruplex in BCL-x pre-mRNA.
REFERENCE   3  (bases 1 to 6813)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 6813)
  AUTHORS   Zanoni,P., Panteloglou,G., Othman,A., Haas,J.T., Meier,R.,
            Rimbert,A., Futema,M., Abou Khalil,Y., Norrelykke,S.F.,
            Rzepiela,A.J., Stoma,S., Stebler,M., van Dijk,F., Wijers,M.,
            Wolters,J.C., Dalila,N., Huijkman,N.C.A., Smit,M., Gallo,A.,
            Carreau,V., Philippi,A., Rabes,J.P., Boileau,C., Visentin,M.,
            Vonghia,L., Weyler,J., Francque,S., Verrijken,A., Verhaegen,A., Van
            Gaal,L., van der Graaf,A., van Rosmalen,B.V., Robert,J.,
            Velagapudi,S., Yalcinkaya,M., Keel,M., Radosavljevic,S., Geier,A.,
            Tybjaerg-Hansen,A., Varret,M., Rohrer,L., Humphries,S.E.,
            Staels,B., van de Sluis,B., Kuivenhoven,J.A. and von Eckardstein,A.
  TITLE     Posttranscriptional Regulation of the Human LDL Receptor by the
            U2-Spliceosome
  JOURNAL   Circ Res 130 (1), 80-95 (2022)
   PUBMED   34809444
  REMARK    GeneRIF: Posttranscriptional Regulation of the Human LDL Receptor
            by the U2-Spliceosome.
REFERENCE   5  (bases 1 to 6813)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 6813)
  AUTHORS   Gocke,C.B., Yu,H. and Kang,J.
  TITLE     Systematic identification and analysis of mammalian small
            ubiquitin-like modifier substrates
  JOURNAL   J Biol Chem 280 (6), 5004-5012 (2005)
   PUBMED   15561718
REFERENCE   7  (bases 1 to 6813)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   8  (bases 1 to 6813)
  AUTHORS   Heilig,R., Eckenberg,R., Petit,J.L., Fonknechten,N., Da Silva,C.,
            Cattolico,L., Levy,M., Barbe,V., de Berardinis,V., Ureta-Vidal,A.,
            Pelletier,E., Vico,V., Anthouard,V., Rowen,L., Madan,A., Qin,S.,
            Sun,H., Du,H., Pepin,K., Artiguenave,F., Robert,C., Cruaud,C.,
            Bruls,T., Jaillon,O., Friedlander,L., Samson,G., Brottier,P.,
            Cure,S., Segurens,B., Aniere,F., Samain,S., Crespeau,H., Abbasi,N.,
            Aiach,N., Boscus,D., Dickhoff,R., Dors,M., Dubois,I., Friedman,C.,
            Gouyvenoux,M., James,R., Madan,A., Mairey-Estrada,B., Mangenot,S.,
            Martins,N., Menard,M., Oztas,S., Ratcliffe,A., Shaffer,T.,
            Trask,B., Vacherie,B., Bellemere,C., Belser,C., Besnard-Gonnet,M.,
            Bartol-Mavel,D., Boutard,M., Briez-Silla,S., Combette,S.,
            Dufosse-Laurent,V., Ferron,C., Lechaplais,C., Louesse,C.,
            Muselet,D., Magdelenat,G., Pateau,E., Petit,E.,
            Sirvain-Trukniewicz,P., Trybou,A., Vega-Czarny,N., Bataille,E.,
            Bluet,E., Bordelais,I., Dubois,M., Dumont,C., Guerin,T.,
            Haffray,S., Hammadi,R., Muanga,J., Pellouin,V., Robert,D.,
            Wunderle,E., Gauguet,G., Roy,A., Sainte-Marthe,L., Verdier,J.,
            Verdier-Discala,C., Hillier,L., Fulton,L., McPherson,J.,
            Matsuda,F., Wilson,R., Scarpelli,C., Gyapay,G., Wincker,P.,
            Saurin,W., Quetier,F., Waterston,R., Hood,L. and Weissenbach,J.
  TITLE     The DNA sequence and analysis of human chromosome 14
  JOURNAL   Nature 421 (6923), 601-607 (2003)
   PUBMED   12508121
  REMARK    Erratum:[Nature. 2023 Aug;620(7973):E17. doi:
            10.1038/s41586-023-06403-y.. PMID: 37491470]
REFERENCE   9  (bases 1 to 6813)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
REFERENCE   10 (bases 1 to 6813)
  AUTHORS   Elisei,R., Weightman,D., Kendall-Taylor,P., Vassart,G. and
            Ludgate,M.
  TITLE     Muscle autoantigens in thyroid associated ophthalmopathy: the
            limits of molecular genetics
  JOURNAL   J Endocrinol Invest 16 (7), 533-540 (1993)
   PUBMED   8227983
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL442663.3 and AC004858.2.
            
            On Nov 22, 2018 this sequence version replaced NM_021239.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.16205.1,
                                           SRR1803614.103078.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261973.12/ ENSP00000261973.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               AL442663.3         46695-46866         c
            173-293             AL442663.3         33653-33773         c
            294-343             AL442663.3         29032-29081         c
            344-511             AL442663.3         27864-28031         c
            512-569             AC004858.2         118989-119046       c
            570-730             AC004858.2         114379-114539       c
            731-916             AC004858.2         105440-105625       c
            917-970             AC004858.2         103107-103160       c
            971-1054            AC004858.2         102790-102873       c
            1055-1341           AC004858.2         99062-99348         c
            1342-1564           AC004858.2         96459-96681         c
            1565-1654           AC004858.2         96255-96344         c
            1655-1728           AC004858.2         94641-94714         c
            1729-1879           AC004858.2         93048-93198         c
            1880-2204           AC004858.2         91385-91709         c
            2205-2479           AC004858.2         90738-91012         c
            2480-2578           AC004858.2         90290-90388         c
            2579-2626           AC004858.2         88207-88254         c
            2627-6813           AC004858.2         78641-82827         c
FEATURES             Location/Qualifiers
     source          1..6813
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..6813
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
                     /note="RNA binding motif protein 25"
                     /db_xref="GeneID:58517"
                     /db_xref="HGNC:HGNC:23244"
                     /db_xref="MIM:612427"
     exon            1..172
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
                     /inference="alignment:Splign:2.1.0"
     exon            173..293
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..2719
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
                     /note="Arg/Glu/Asp-rich protein, 120 kDa; RNA-binding
                     region (RNP1, RRM) containing 7; functional
                     spliceosome-associated protein 94; U1 small nuclear
                     ribonucleoprotein 1SNRP homolog; arg/Glu/Asp-rich protein
                     of 120 kDa; RNA-binding region-containing protein 7"
                     /codon_start=1
                     /product="RNA-binding protein 25"
                     /protein_id="NP_067062.1"
                     /db_xref="CCDS:CCDS32113.1"
                     /db_xref="GeneID:58517"
                     /db_xref="HGNC:HGNC:23244"
                     /db_xref="MIM:612427"
                     /translation="MSFPPHLNRPPMGIPALPPGIPPPQFPGFPPPVPPGTPMIPVPM
                     SIMAPAPTVLVPTVSMVGKHLGARKDHPGLKAKENDENCGPTTTVFVGNISEKASDML
                     IRQLLAKCGLVLSWKRVQGASGKLQAFGFCEYKEPESTLRALRLLHDLQIGEKKLLVK
                     VDAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREY
                     SSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDL
                     ISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERERERERE
                     REKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRE
                     REREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKL
                     REKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRD
                     DPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRME
                     QEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLRPISSAP
                     SVSSASGNATPNTPGDESPCGIIIPHENSPDQQQPEEHRPKIGLSLKLGASNSPGQPN
                     SVKRKKLPVDSVFNKFEDEDSDDVPRKRKLVPLDYGEDDKNATKGTVNTEEKRKHIKS
                     LIEKIPTAKPELFAYPLDWSIVDSILMERRIRPWINKKIIEYIGEEEATLVDFVCSKV
                     MAHSSPQSILDDVAMVLDEEAEVFIVKMWRLLIYETEAKKIGLVK"
     exon            294..343
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
                     /inference="alignment:Splign:2.1.0"
     exon            344..511
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
                     /inference="alignment:Splign:2.1.0"
     exon            512..569
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
                     /inference="alignment:Splign:2.1.0"
     exon            570..730
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
                     /inference="alignment:Splign:2.1.0"
     exon            731..916
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
                     /inference="alignment:Splign:2.1.0"
     exon            917..970
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1054
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1341
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1564
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1654
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1728
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1879
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2204
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2479
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2578
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
                     /inference="alignment:Splign:2.1.0"
     exon            2579..2626
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
                     /inference="alignment:Splign:2.1.0"
     exon            2627..6813
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3023..3028
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
                     /note="hexamer: ATTAAA"
     polyA_site      3043
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
                     /note="major polyA site"
     regulatory      4207..4212
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
                     /note="hexamer: ATTAAA"
     polyA_site      4227
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
     regulatory      4261..4266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
                     /note="hexamer: AATAAA"
     polyA_site      4282
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
     regulatory      4934..4939
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
                     /note="hexamer: AGTAAA"
     polyA_site      4955
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
     regulatory      5026..5031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
                     /note="hexamer: AATACA"
     polyA_site      5050
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
     regulatory      5153..5158
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
                     /note="hexamer: TATAAA"
     polyA_site      5171
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
     regulatory      6771..6776
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
                     /note="hexamer: AATAAA"
     polyA_site      6813
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
ORIGIN      
        1 agacctccat cagctcgccg cgcagcgcgg ctgtatttgc ggcctgtgcg agtaggcgct
       61 tgggcactca gtctccctgg cgagcgacgg gcagaaatct cgaaccagtg gagcgcactc
      121 gtaacctgga tcccagaagg tcgcgaaggc agtaccgttt cctcagcggc ggactgctgc
      181 agtaagaatg tcttttccac ctcatttgaa tcgccctccc atgggaatcc cagcactccc
      241 accagggatc ccacccccgc agtttccagg atttcctcca cctgtacctc cagggacccc
      301 aatgattcct gtaccaatga gcattatggc tcctgctcca actgtcttag tacccactgt
      361 gtctatggtt ggaaagcatt tgggcgcaag aaaggatcat ccaggcttaa aggctaaaga
      421 aaatgatgaa aattgtggtc ctactaccac tgtttttgtt ggcaacattt ccgagaaagc
      481 ttcagacatg cttataagac aactcttagc taaatgtggt ttggttttga gctggaagag
      541 agtacaaggt gcttccggaa agcttcaagc cttcggattc tgtgagtaca aggagccaga
      601 atctaccctc cgtgcactca gattattaca tgacctgcaa attggagaga aaaagctact
      661 cgttaaagtt gatgcaaaga caaaggcaca gctggatgaa tggaaagcaa agaagaaagc
      721 ttctaatggg aatgcaaggc cagaaactgt cactaatgac gatgaagaag ccttggatga
      781 agaaacaaag aggagagatc agatgattaa aggggctatt gaagttttaa ttcgtgaata
      841 ctccagtgag ctaaatgccc cctcacagga atctgattct caccccagga agaagaagaa
      901 ggaaaagaag gaggacattt tccgcagatt tccagtggcc ccactgatcc cttatccact
      961 catcactaag gaggatataa atgctataga aatggaagaa gacaaaagag acctgatatc
     1021 tcgagagatc agcaaattca gagacacaca taagaaactg gaagaagaga aaggcaaaaa
     1081 ggaaaaagaa agacaggaaa ttgagaaaga acggagagaa agagagaggg agcgtgaaag
     1141 ggaacgagaa aggcgagaac gggaacgaga aagggaaaga gaacgtgaac gagaaaagga
     1201 gaaagaacgg gagcgggaac gagaacggga tagggaccgt gaccggacaa aagagagaga
     1261 ccgagatcgg gatcgagaga gagatcgtga ccgggataga gaaaggagct cagatcgtaa
     1321 taaggatcgc agtcgatcaa gagaaaaaag cagagatcgt gaaagggaac gagagcggga
     1381 aagagagaga gagagagaac gagagcgaga acgagaacgg gagcgagaga gagagcgaga
     1441 gagggaacgg gagcgagaaa gagaaaaaga caaaaaacgg gaccgagaag aagatgaaga
     1501 agatgcatac gaacgaagaa aacttgaaag aaaactccga gagaaagaag ctgcttatca
     1561 agagcgcctt aagaattggg aaatcagaga acgaaagaaa acccgggaat atgagaaaga
     1621 agctgaaaga gaagaagaaa gaagaagaga aatggccaaa gaagctaaac gactaaaaga
     1681 attcttagaa gactatgatg atgatagaga tgaccccaaa tattacagag gaagtgctct
     1741 tcagaaaagg ttgcgtgata gagaaaagga aatggaagca gatgaacgag ataggaagag
     1801 agagaaggag gagcttgagg aaatcaggca gcgccttctg gcagaagggc atccagatcc
     1861 agatgcagag ctccagagga tggaacaaga ggctgagagg cgcaggcagc cacaaataaa
     1921 gcaagagcca gaatcagaag aggaggaaga agaaaagcaa gaaaaagaag aaaaacgaga
     1981 agaacccatg gaagaggaag aggagccaga gcaaaagcct tgtctgaaac ctactctgag
     2041 gcccatcagc tctgctccat ctgtttcctc tgccagtggc aatgcaacac ctaacactcc
     2101 tggggatgag tctccctgtg gtattattat tcctcatgaa aactcaccag atcaacagca
     2161 acctgaggag cataggccaa aaataggact aagtcttaaa ctgggtgctt ccaatagtcc
     2221 tggtcagcct aattctgtga agagaaagaa actacctgta gatagtgtct ttaacaaatt
     2281 tgaggatgaa gacagtgatg acgtaccccg aaaaaggaaa ctggttccct tggattatgg
     2341 tgaagatgat aaaaatgcaa ccaaaggcac tgtaaacact gaagaaaagc gtaaacacat
     2401 taagagtctc attgagaaaa tccctacagc caaacctgag ctcttcgctt atcccctgga
     2461 ttggtctatt gtggattcta tactgatgga acgtcgaatt agaccatgga ttaataagaa
     2521 aatcatagaa tatataggtg aagaagaagc tacattagtt gattttgttt gttctaaggt
     2581 tatggctcat agttcacccc agagcatttt agatgatgtt gccatggtac ttgatgaaga
     2641 agcagaagtt tttatagtca aaatgtggag attattgata tatgaaacag aagccaagaa
     2701 aattggtctt gtgaagtaaa actttttata tttagagttc catttcagat ttcttctttg
     2761 ccaccctttt aaggactttg aatttttctt tgtctttgaa gacattgtga gatctgtaat
     2821 tttttttttt tgtagaaaat gtgaattttt tggtcctcta atttgttgtt gccctgtgta
     2881 ctcccttggt tgtaaagtca tctgaatcct tggttctctt tatactcacc aggtacaaat
     2941 tactggtatg ttttataagc cgcagctact gtacacagcc tatctgatat aatcttgttc
     3001 tgctgatttg tttcttgtaa atattaaaac gactccccaa ttattttgca gaattgcact
     3061 taatattgaa atgtactgta taggaaccaa catgaacaat tttaattgaa aacaccagtc
     3121 ataaactatt accaccccca ctctcttttg atcagaaatg gcaagccctt gtgaaggcat
     3181 ggagtttaaa attggaatgc aaaaattagc agacaatcca ttcctactgt atttctgtat
     3241 gaatgtgttt gtgaatgtat gtgtaaaagt ctttcttttc cctaatttgc tttggtgggg
     3301 tccttaaaac atttcccaac taaagaatag aattgtaaag gaaaagtggt actgttccaa
     3361 cctgaaatgt ctgttataat taggttatta gtttcccaga gcatggtgtt ctcgtgtcgt
     3421 gagcaatgtg gtttgctaac tggatggggt tttcttatta ataagatggc tgcttcagct
     3481 tctcttttaa aggaatgtgg atcatagtga tttttccttt taattttatt gctcagaaat
     3541 gaggcatatc ctaaaaatcc tggagagctg tatttaatgc atttttgcac taattggtcc
     3601 ttagtttaat tctattgtat ctgtttattt aacaaaaaat tcatcatacc aaaaagtgta
     3661 agtgaaaacc ccctttaaaa caaaacaaaa aaatgaaata aaattaggca aattgacaga
     3721 cagtgagagt tttacaaaca tgataggtat tctgctcggc aatttgtaag tttacatgtt
     3781 atttaaggat aaaggtaaat cattcaaggc agttaccaac cactaactat ttgttttcat
     3841 ttttgtcttg tagaaggttt atatcttgtt ttaccttggc tcattagtgt ttaaaaatgt
     3901 actgatgatg tgcttagaga aattcctggg gctttcttcg ttgtagatca gaatttcacc
     3961 agggagtaaa attacctgaa aacgtaagaa gttttaaaca gcttttcaca caaattagat
     4021 gcaactgttc ccatgtctga gtacttattt aaaagaaagg taaagattgg cctgttagaa
     4081 aaagcataat gtgagctttg gattactgga tttttttttt ttttaaacac acctggagag
     4141 gacatttgaa aacactgttc ttaccctcga accctgatgt ggttccatta tgtaaatatt
     4201 tcaaatatta aaaatgtata tatttgatcc tggggactca tattctttca gaatcatgta
     4261 aataaatggc atcatgttgt aattgtgtgg tgcatactag aaaagttaaa aatatgggct
     4321 gaacttttta tggacttgat ttttatgact attggtatct aaaggtcaag gaagccattt
     4381 acattatttt ggatgaatct actatacatc tatggaaatg tctcttttat tttaaattct
     4441 ggtttctcaa cggaaaattt cagaaaagat gccccttgcc attttcgtta atttttcagt
     4501 cttttcttag acacaccccc agcctaagac cttgttcgag gagtttattg tgtctgtctt
     4561 ttcttaacat actgcactgt tcttaagcat catattgtgt tgtttttatt tagccactat
     4621 taacatgaag gtttattcag gtagatttga tttcctttgc ttcgtttctt ctcctgctct
     4681 gtcaactgta cttatcttaa agggccactc taaaaacaag ggagatgtcg taatctgaaa
     4741 cctttgggga gatgtactct gtactgcata acatctccag tgaggtttgt gacaggacct
     4801 caactaaata tatgaatttg tgcaagttca tatattaaag tttctgcagc agagtgaaaa
     4861 ttgttacagt aaatgtggta gaaactgtta atcgcttaat gccagtttaa atcatgtttt
     4921 gtaaccaagc ttcagtaaaa ggctttagat tgtcagagtt ggttgatttt tagaattgta
     4981 tatataaaga attagacatt aaacaggcat attctagtgt ctgaaaatac acataagaaa
     5041 tttctattaa gttgcttgaa ctttgtgggt taattttacc ataatctcat aaattaattt
     5101 tagtttgaaa accttataca gtatgaattc attttgccat ttcaagttgt tatataaaga
     5161 gcatgaaagt ctttttttgt tgtttttttg gggttttttt ttttttgaga ggaagttgtg
     5221 cttttgtcgc ccaggatgga gtgcaatggc gcgagctcag ctcacttcaa cttccgcctc
     5281 ccgggttctg gagatattct gcttcagttt tctgagtagc tgggattaca ggtgcccacc
     5341 acgacacctg gctaattttt tgtattttta gtagagacag gatttcacct tgttggccag
     5401 gctggtctca aactcctgac ctcaggtgat ccacccgcct cagcctccca aagtgctggt
     5461 attacaggcg tgagccacct tgcctggcca aagcgtgaac atcttaagaa ccagtcttga
     5521 tctggcaaaa aagtagtaga atactacttt tctttatttg tccctaaaaa taaagtatgt
     5581 acatctgttc acaaggaaga aaggtaagtt tgaagttgtt tttcttaaac tttaatgtga
     5641 ccccaaatca tctgaggagt gcttgtagaa atagagacac tgaagtagca gcgctggggt
     5701 ggcgccgcag gctttgcatt tctggacagc tcccagctaa tgtcattgcc aactgatcca
     5761 agactacatt ttgattagca ctttaaggtg tctattcagt attattttat cctaacagac
     5821 tacataaatg cagctgaatt ttcctttaag tagattttaa agagaaaaac attttttgag
     5881 gcaaatacac gtaactcatg aacgtaatgt aatcttgcaa aattatgtct gagaaagccc
     5941 taatattcta ggcttttttt ccatccagcc ctgaaaattt tttctgtaga taactttatg
     6001 ttgtaactta ttctgaatct tattatggca tttccctgta aactatgtaa gtgtaagcta
     6061 atgattattt tgtgaagcgt gctgtttcag gtattaatct gccatgaata ctagatatag
     6121 tagaaaaact gagaaaacat ttagcttgag agccaatttg aactagacac tatctttttt
     6181 tctccttttt aatggaataa atttaatgca aataagtgta agcaggtata caatgtttag
     6241 atgaggctta ttttcccaac tctttttaac aggttttatg atatccccaa tttataccca
     6301 aaagactgct gagaggtttt atgtcaaatt gattacaaac ttctctgggt tgtatttcag
     6361 tcttctgtta agtatgaaat tgagaaatag ttttgctcaa caaaagatga tgagggattg
     6421 atttgtgaat gtcactggag ataaaagggt atgagaagga atcccaagca ggcaaagaaa
     6481 cagtctagct gtcaagaaga aaacagggag atacatacca aacccaggag ctactaatat
     6541 aacaatcata ctatagagcg aagtgaactt acactttttg ataaactgat agattttttg
     6601 taatgtgatt atggtaaaat actgaaatat ttatgttaat ttatttgcat ttgaatgctt
     6661 acatttttaa ttgacagaat ctttgcattt cattacttga gtcatgaagg cgaaattaaa
     6721 gaatggcagt ctaaaatacc caggtaaaga agataatttc tagaaacaaa aataaaaatt
     6781 cttttcaagc catgttgttt gaattaaatg aca
//
