LOCUS       NM_001143942            2684 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens RNA binding motif protein 24 (RBM24), transcript
            variant 1, mRNA.
ACCESSION   NM_001143942
VERSION     NM_001143942.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2684)
  AUTHORS   Yao,D., Wang,X., Liu,J. and Xu,X.Q.
  TITLE     Rbm24 modulates neuronal RNA splicing to restrict cognitive
            dysfunction
  JOURNAL   Int J Biol Macromol 276 (Pt 2), 133853 (2024)
   PUBMED   39004256
  REMARK    GeneRIF: Rbm24 modulates neuronal RNA splicing to restrict
            cognitive dysfunction.
REFERENCE   2  (bases 1 to 2684)
  AUTHORS   Chen,X., Lin,X., Xia,X. and Xiang,X.
  TITLE     YAP1-induced RBM24 promotes the tumorigenesis of triple-negative
            breast cancer through the beta-catenin pathway
  JOURNAL   J Investig Med 72 (5), 403-413 (2024)
   PUBMED   38441112
  REMARK    GeneRIF: YAP1-induced RBM24 promotes the tumorigenesis of
            triple-negative breast cancer through the beta-catenin pathway.
REFERENCE   3  (bases 1 to 2684)
  AUTHORS   Xu,L., Mo,C., Lu,M., Wang,P. and Liu,Y.
  TITLE     MiR-20a-5p targets RBM24 and alleviates hypertensive intracerebral
            hemorrhage
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (13), 134-141 (2023)
   PUBMED   38158676
  REMARK    GeneRIF: MiR-20a-5p targets RBM24 and alleviates hypertensive
            intracerebral hemorrhage.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2684)
  AUTHORS   Yao,Y., Sun,H., Chen,Y., Tian,L., Huang,D., Liu,C., Zhou,Y.,
            Wang,Y., Wen,Z., Yang,B., Chen,X. and Pei,R.
  TITLE     RBM24 inhibits the translation of SARS-CoV-2 polyproteins by
            targeting the 5'-untranslated region
  JOURNAL   Antiviral Res 209, 105478 (2023)
   PUBMED   36464077
  REMARK    GeneRIF: RBM24 inhibits the translation of SARS-CoV-2 polyproteins
            by targeting the 5'-untranslated region.
REFERENCE   5  (bases 1 to 2684)
  AUTHORS   Liu,J., Wang,K., Liu,X., Pan,L., Zhou,W., Huang,J., Liu,H., Su,Z.
            and Xu,X.Q.
  TITLE     RBM24 controls cardiac QT interval through CaMKIIdelta splicing
  JOURNAL   Cell Mol Life Sci 79 (12), 613 (2022)
   PUBMED   36454480
  REMARK    GeneRIF: RBM24 controls cardiac QT interval through CaMKIIdelta
            splicing.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2684)
  AUTHORS   Jiang,Y., Zhang,M., Qian,Y., Xu,E., Zhang,J. and Chen,X.
  TITLE     Rbm24, an RNA-binding protein and a target of p53, regulates p21
            expression via mRNA stability
  JOURNAL   J Biol Chem 289 (6), 3164-3175 (2014)
   PUBMED   24356969
  REMARK    GeneRIF: Rbm24 is a novel player in the p53 pathway, which may be
            explored to restore proper cell cycle control in p53-deficient
            tumors via p21.
REFERENCE   7  (bases 1 to 2684)
  AUTHORS   Ovsyannikova,I.G., Kennedy,R.B., O'Byrne,M., Jacobson,R.M.,
            Pankratz,V.S. and Poland,G.A.
  TITLE     Genome-wide association study of antibody response to smallpox
            vaccine
  JOURNAL   Vaccine 30 (28), 4182-4189 (2012)
   PUBMED   22542470
REFERENCE   8  (bases 1 to 2684)
  AUTHORS   Miyamoto,S., Hidaka,K., Jin,D. and Morisaki,T.
  TITLE     RNA-binding proteins Rbm38 and Rbm24 regulate myogenic
            differentiation via p21-dependent and -independent regulatory
            pathways
  JOURNAL   Genes Cells 14 (11), 1241-1252 (2009)
   PUBMED   19817877
  REMARK    GeneRIF: it was found that this protein Rbm24 regulates myogenic
            differentiation via the p21 signal pathway.
REFERENCE   9  (bases 1 to 2684)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   10 (bases 1 to 2684)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL136305.14, AK315856.1 and BC040928.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001143942.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.144858.1,
                                           SRR1660807.195844.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379052.10/ ENSP00000368341.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               AL136305.14        114690-114906
            218-1309            AK315856.1         1-1092
            1310-2684           BC040928.1         880-2254
FEATURES             Location/Qualifiers
     source          1..2684
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.3"
     gene            1..2684
                     /gene="RBM24"
                     /gene_synonym="dJ259A10.1; RNPC6"
                     /note="RNA binding motif protein 24"
                     /db_xref="GeneID:221662"
                     /db_xref="HGNC:HGNC:21539"
                     /db_xref="MIM:617603"
     exon            1..389
                     /gene="RBM24"
                     /gene_synonym="dJ259A10.1; RNPC6"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..932
                     /gene="RBM24"
                     /gene_synonym="dJ259A10.1; RNPC6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RNA-binding region (RNP1, RRM) containing 6; RNA-binding
                     protein 24; RNA-binding region-containing protein 6"
                     /codon_start=1
                     /product="RNA-binding protein 24 isoform 1"
                     /protein_id="NP_001137414.1"
                     /db_xref="CCDS:CCDS47378.1"
                     /db_xref="GeneID:221662"
                     /db_xref="HGNC:HGNC:21539"
                     /db_xref="MIM:617603"
                     /translation="MHTTQKDTTYTKIFVGGLPYHTTDASLRKYFEVFGEIEEAVVIT
                     DRQTGKSRGYGFVTMADRAAAERACKDPNPIIDGRKANVNLAYLGAKPRIMQPGFAFG
                     VQQLHPALIQRPFGIPAHYVYPQAFVQPGVVIPHVQPTAAAASTTPYIDYTGAAYAQY
                     SAAAAAAAAAAAYDQYPYAASPAAAGYVTAGGYGYAVQQPITAAAPGTAAAAAAAAAA
                     AAAFGQYQPQQLQTDRMQ"
     exon            390..513
                     /gene="RBM24"
                     /gene_synonym="dJ259A10.1; RNPC6"
                     /inference="alignment:Splign:2.1.0"
     exon            514..568
                     /gene="RBM24"
                     /gene_synonym="dJ259A10.1; RNPC6"
                     /inference="alignment:Splign:2.1.0"
     exon            569..2684
                     /gene="RBM24"
                     /gene_synonym="dJ259A10.1; RNPC6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2668..2673
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM24"
                     /gene_synonym="dJ259A10.1; RNPC6"
                     /note="hexamer: AATATA"
     polyA_site      2684
                     /gene="RBM24"
                     /gene_synonym="dJ259A10.1; RNPC6"
                     /note="major polyA site"
ORIGIN      
        1 aagtctccag ggccgctggc gacttcggaa gccgcgcgcc cggcgctctc ggccgccccc
       61 ggccgctcgc ccccgccgcg ccgccgccct cgcccccggg ctcgcccttg gcccccggcg
      121 gccgcgaaag ggtgcgggag acgcggagcc ggaggaggag gcgcagccgc tgcccgagcc
      181 gcagccgcag ccggagcccg agccgcgggg cgggtgcgaa gatgcacacg acccagaagg
      241 acacgacgta caccaagatc ttcgtcgggg ggctgcccta ccacaccacc gacgccagcc
      301 tgcgcaagta cttcgaggtc ttcggcgaga tcgaggaggc ggtggtcatc accgaccggc
      361 agacgggcaa gtcccggggc tatggatttg tcaccatggc tgaccgggct gctgccgaaa
      421 gggcctgcaa ggatcccaat cccatcattg atggcagaaa ggccaacgtg aacctggcat
      481 acttaggagc aaaaccaagg atcatgcaac caggttttgc ctttggtgtt caacaacttc
      541 atccagccct tatacaaaga cctttcggga tacctgccca ctatgtctat ccgcaggctt
      601 ttgtgcagcc gggagtggtc attccacacg tccagccgac agcagctgcc gcctccacca
      661 ccccttacat tgattacact ggagctgcat acgcacaata ctcagcagct gctgctgctg
      721 ccgccgccgc tgctgcctat gaccagtacc cctatgcagc ctctccagct gctgcaggat
      781 atgttactgc tgggggctat ggctacgcag tccagcagcc aatcaccgca gcggcacctg
      841 ggacagctgc cgccgccgct gcagcagctg ctgccgctgc agcatttggc cagtaccagc
      901 ctcagcagct gcagacagac cgaatgcaat agaccagcca tctgatcaaa gttgaattgt
      961 tttctctttc cctcccaatt ttccaatttt tagtagctaa taagagagtt aacattgact
     1021 taacagcttt aaaaaaaaaa acagccatgc tattgtgaag cagagttatt atttttttta
     1081 tactccaggt agtgttctag atgagaaaga ggtaagaatg aggggaatgg gcacaatttt
     1141 ggaaatcaat cccaaagagc ctgagtaaat gaaaggccac tacgaaatga cgccaggagt
     1201 aacaacggaa cttcactttt gtaacgggat ttttattttt gctcttttta tagtatcagg
     1261 gaagcaaact gccttttaca agttagaaaa tgctgtttga atctagttga accagggaat
     1321 acagagcgag caatatgtag cttgaattac atttaaaagc agatttttta caaacaaaat
     1381 ggcgaaagca ctgattgtca tttttagcag tcacttaagg cctatagaac ttttttcaag
     1441 tcggaaggtc ctgttcttac tatctcaaaa atgggcatcg aacaatcaat ctaggagcgt
     1501 ggcagtgggt aaaatggtgg acaggcacca aagctatttt ctcatctgtc ctgtggatga
     1561 gtggaactgt ggaacaagtg atgtggaatt aatgggtgca acagctgtac agacaatcaa
     1621 taacacacac agttctggaa agaacacatc acttgtgctt gtttgatgag cttgtcacat
     1681 tctaatccct ctccccatcc tgtttcaatt ttgggaaact tgtatctgct ggtgtcagca
     1741 attctgattc tgaaatagga tcaggctttt actacaacag ccttctcttt ctatttattg
     1801 tgtcgactcg tggcttatga ataaaggcag gcaaagtttg cagaactgtc ttaaggacat
     1861 ttattttttt tcccttttta agtaatttta cactttagta tctatttcag agtcatattt
     1921 aaaactattt attagtgact acagtacatg agacaacaag gttactgaga ttacaattct
     1981 tcaaaggtta atgataatgt ggtttatact gtgccttaat agtaatgcta tttaagatat
     2041 ttatttttaa gttttactat gctgcactct aaagaaagga actttagatg tgacactgta
     2101 aaattatgta ttcatctcat ggcataaatt atttagtaag tctagatgta gcgtattaaa
     2161 tattaaccta ttcaactaaa gatgttgact tggatttatt taaattcata tgtgcactgt
     2221 ataagagagt actcttacat taacacattt tagtttagtt tttagatttt tttttaaacg
     2281 atatattgct agtttcatgc ttcctcctct gattttgcct gtgtagattt catttattgg
     2341 taattcatta gtttaacact attatgtagt ttttaaatgc tgctttacat ttttcttctg
     2401 aaactgcaat acttgcaatt tttattctta aactaaattg aatactattt tacactgtat
     2461 tggattttta tacttgaaca atttcataca agggaagaca ggttagcatt tttatggact
     2521 ttctccatta tcactggatt tactttaagt attcccatac tagacagtgt tatgtaatgt
     2581 agacatgact ctcctgtgca aattatttat tcgttgtgta tattgcttta taacatttca
     2641 gatcttctaa tctattcact tgtattaaat ataattttta aaaa
//
