LOCUS       NM_001077351           10007 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens RNA binding motif protein 23 (RBM23), transcript
            variant 1, mRNA.
ACCESSION   NM_001077351
VERSION     NM_001077351.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10007)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 10007)
  AUTHORS   Han,H., Lin,T., Fang,Z. and Zhou,G.
  TITLE     RBM23 Drives Hepatocellular Carcinoma by Activating NF-kappaB
            Signaling Pathway
  JOURNAL   Biomed Res Int 2021, 6697476 (2021)
   PUBMED   33791378
  REMARK    GeneRIF: RBM23 Drives Hepatocellular Carcinoma by Activating
            NF-kappaB Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10007)
  AUTHORS   Faust,T.B., Yoon,H., Nowak,R.P., Donovan,K.A., Li,Z., Cai,Q.,
            Eleuteri,N.A., Zhang,T., Gray,N.S. and Fischer,E.S.
  TITLE     Structural complementarity facilitates E7820-mediated degradation
            of RBM39 by DCAF15
  JOURNAL   Nat Chem Biol 16 (1), 7-14 (2020)
   PUBMED   31686031
  REMARK    GeneRIF: aryl-sulfonamides neo-functionalize a shallow,
            non-conserved pocket on DCAF15 to selectively bind and degrade
            RBM39 and the closely related splicing factor RBM23 without the
            requirement for a high-affinity ligand
REFERENCE   4  (bases 1 to 10007)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   5  (bases 1 to 10007)
  AUTHORS   Varjosalo,M., Keskitalo,S., Van Drogen,A., Nurkkala,H.,
            Vichalkovski,A., Aebersold,R. and Gstaiger,M.
  TITLE     The protein interaction landscape of the human CMGC kinase group
  JOURNAL   Cell Rep 3 (4), 1306-1320 (2013)
   PUBMED   23602568
REFERENCE   6  (bases 1 to 10007)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 10007)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
REFERENCE   8  (bases 1 to 10007)
  AUTHORS   Dowhan,D.H., Hong,E.P., Auboeuf,D., Dennis,A.P., Wilson,M.M.,
            Berget,S.M. and O'Malley,B.W.
  TITLE     Steroid hormone receptor coactivation and alternative RNA splicing
            by U2AF65-related proteins CAPERalpha and CAPERbeta
  JOURNAL   Mol Cell 17 (3), 429-439 (2005)
   PUBMED   15694343
REFERENCE   9  (bases 1 to 10007)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   10 (bases 1 to 10007)
  AUTHORS   Heilig,R., Eckenberg,R., Petit,J.L., Fonknechten,N., Da Silva,C.,
            Cattolico,L., Levy,M., Barbe,V., de Berardinis,V., Ureta-Vidal,A.,
            Pelletier,E., Vico,V., Anthouard,V., Rowen,L., Madan,A., Qin,S.,
            Sun,H., Du,H., Pepin,K., Artiguenave,F., Robert,C., Cruaud,C.,
            Bruls,T., Jaillon,O., Friedlander,L., Samson,G., Brottier,P.,
            Cure,S., Segurens,B., Aniere,F., Samain,S., Crespeau,H., Abbasi,N.,
            Aiach,N., Boscus,D., Dickhoff,R., Dors,M., Dubois,I., Friedman,C.,
            Gouyvenoux,M., James,R., Madan,A., Mairey-Estrada,B., Mangenot,S.,
            Martins,N., Menard,M., Oztas,S., Ratcliffe,A., Shaffer,T.,
            Trask,B., Vacherie,B., Bellemere,C., Belser,C., Besnard-Gonnet,M.,
            Bartol-Mavel,D., Boutard,M., Briez-Silla,S., Combette,S.,
            Dufosse-Laurent,V., Ferron,C., Lechaplais,C., Louesse,C.,
            Muselet,D., Magdelenat,G., Pateau,E., Petit,E.,
            Sirvain-Trukniewicz,P., Trybou,A., Vega-Czarny,N., Bataille,E.,
            Bluet,E., Bordelais,I., Dubois,M., Dumont,C., Guerin,T.,
            Haffray,S., Hammadi,R., Muanga,J., Pellouin,V., Robert,D.,
            Wunderle,E., Gauguet,G., Roy,A., Sainte-Marthe,L., Verdier,J.,
            Verdier-Discala,C., Hillier,L., Fulton,L., McPherson,J.,
            Matsuda,F., Wilson,R., Scarpelli,C., Gyapay,G., Wincker,P.,
            Saurin,W., Quetier,F., Waterston,R., Hood,L. and Weissenbach,J.
  TITLE     The DNA sequence and analysis of human chromosome 14
  JOURNAL   Nature 421 (6923), 601-607 (2003)
   PUBMED   12508121
  REMARK    Erratum:[Nature. 2023 Aug;620(7973):E17. doi:
            10.1038/s41586-023-06403-y.. PMID: 37491470]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CK003276.1, BX161440.1,
            BC106012.1 and AL135998.6.
            
            On Nov 22, 2018 this sequence version replaced NM_001077351.1.
            
            Summary: This gene encodes a member of the U2AF-like family of RNA
            binding proteins. This protein interacts with some steroid nuclear
            receptors, localizes to the promoter of a steroid- responsive gene,
            and increases transcription of steroid-responsive transcriptional
            reporters in a hormone-dependent manner. It is also implicated in
            the steroid receptor-dependent regulation of alternative splicing.
            Multiple transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK225792.1, SRR1660805.183650.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359890.8/ ENSP00000352956.3
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                CK003276.1         31-59
            30-2514             BX161440.1         1-2485
            2515-2566           BC106012.1         2232-2283
            2567-10007          AL135998.6         4540-11980
FEATURES             Location/Qualifiers
     source          1..10007
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..10007
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
                     /note="RNA binding motif protein 23"
                     /db_xref="GeneID:55147"
                     /db_xref="HGNC:HGNC:20155"
                     /db_xref="MIM:621023"
     exon            1..151
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            152..227
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..1481
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RNA-binding region (RNP1, RRM) containing 4; splicing
                     factor SF2; probable RNA-binding protein 23; RNA-binding
                     region-containing protein 4; coactivator of activating
                     protein-1 and estrogen recep- tors beta; CAPER beta"
                     /codon_start=1
                     /product="probable RNA-binding protein 23 isoform 1"
                     /protein_id="NP_001070819.1"
                     /db_xref="CCDS:CCDS41921.1"
                     /db_xref="GeneID:55147"
                     /db_xref="HGNC:HGNC:20155"
                     /db_xref="MIM:621023"
                     /translation="MASDDFDIVIEAMLEAPYKKEEDEQQRKEVKKDYPSNTTSSTSN
                     SGNETSGSSTIGETSKKKRSRSHNKSRDRKRSRSRDRDRYRRRNSRSRSPGRQCRHRS
                     RSWDRRHGSESRSRDHRREDRVHYRSPPLATGYRYGHSKSPHFREKSPVREPVDNLSP
                     EERDARTVFCMQLAARIRPRDLEDFFSAVGKVRDVRIISDRNSRRSKGIAYVEFCEIQ
                     SVPLAIGLTGQRLLGVPIIVQASQAEKNRLAAMANNLQKGNGGPMRLYVGSLHFNITE
                     DMLRGIFEPFGKIDNIVLMKDSDTGRSKGYGFITFSDSECARRALEQLNGFELAGRPM
                     RVGHVTERLDGGTDITFPDGDQELDLGSAGGRFQLMAKLAEGAGIQLPSTAAAAAAAA
                     AQAAALQLNGAVPLGALNPAALTALSPALNLASQCFQLSSLFTPQTM"
     exon            228..340
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            341..388
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            389..562
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            563..616
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            617..734
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            735..887
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1025
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1091
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1287
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1407
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1477
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..10007
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2426..2431
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
                     /note="hexamer: CATAAA"
     polyA_site      2445
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
                     /note="major polyA site"
     regulatory      2546..2551
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
                     /note="hexamer: TATAAA"
     polyA_site      2566
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
     regulatory      9927..9932
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
                     /note="hexamer: ATTAAA"
     polyA_site      9949
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
     regulatory      9984..9989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
                     /note="hexamer: AATAAA"
     polyA_site      10007
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
ORIGIN      
        1 agagctgccg ccattttgcg ggaagaggag gctctgtacc tgcagtgctg cttttcttgc
       61 ctagactcta ggaactatcc gagctccact ccccacaaca tactcaaagg aacggagaga
      121 accgggaccc ccctgcgggg acccggaact gatctgacag gatggcatct gatgactttg
      181 acatagtgat tgaggccatg ctggaagctc cctataaaaa agaagaggat gagcaacaaa
      241 ggaaagaagt taaaaaggat tatcctagca ataccaccag cagcaccagc aacagtggca
      301 atgagaccag tggaagcagc accatcgggg agacaagcaa gaagaagagg agtcggagcc
      361 ataataaaag cagggataga aagcgcagtc gtagtcgaga tcgggatcgg tatagacgga
      421 gaaatagtcg gagccgaagt ccaggtcggc agtgtcgtca ccgtagccgt agctgggatc
      481 gtcgacatgg tagtgagtcg cgaagtcggg accatcgtcg tgaggatcgt gtgcattaca
      541 ggagtcctcc acttgccact ggttataggt atggacacag taagagtcct catttcagag
      601 agaagagccc agtcagggag ccagttgata atctgagtcc tgaggagcgt gatgcccgca
      661 cagttttctg tatgcagtta gctgcccgaa ttcggcctcg agatctggag gactttttct
      721 ctgctgtagg caaggttcgc gatgtacgta tcatctcaga tcggaactca cgtcgttcta
      781 agggcattgc ctacgtggaa ttctgtgaaa tccagtctgt gccactggcc attgggctga
      841 ctgggcagcg gttgctggga gtgcctatca ttgtacaggc ttcacaggca gagaaaaacc
      901 gactggcagc catggccaac aacctgcaaa agggcaatgg tggaccaatg cgcctctatg
      961 tgggttccct gcacttcaat atcactgaag acatgctccg gggcatcttt gagccctttg
     1021 gtaaaattga taatattgtc ctgatgaagg actcagatac aggccgctct aaaggttatg
     1081 gtttcatcac gttctctgat tctgagtgtg cccggcgggc cctggaacag ttgaatgggt
     1141 ttgagcttgc tggtcgacct atgagggttg gccatgtgac tgagcgactg gatggtggca
     1201 cagacatcac ttttcctgat ggggaccagg agctggatct gggatcagca ggtggacgtt
     1261 ttcagctcat ggcaaaactg gcagaaggcg ctggaatcca actgccaagc actgctgctg
     1321 ctgctgctgc cgccgccgcc caggctgctg ccttgcaact gaatggagca gttcccttgg
     1381 gggccctgaa tccagcagct ctgactgctc tgagtccagc cctgaacctt gcctcccagt
     1441 gtttccagct ctccagcctc tttacccccc agaccatgta aatcagtggc acagtatact
     1501 gcctccttgt gcctctggat cctgccactt cacatctact cttccatggc cccatttctc
     1561 cattttgtgg accaagccat cctgagggca tggacattgt ctctgaggaa attggggcca
     1621 cccttaagat accaagaaaa gctcctgccc atggtcccac tggaaatgga ctctgctgag
     1681 caaagccacc agttgaagag aacagaatcc acacctgcat tgaatacctg tttctccatg
     1741 tgtatcgtct ctgagattac cttcttgccc tttccaacac cttagtgatt cctcaatttc
     1801 tcccccattg ggaaggccat agggcatact gaaggaactg acctctctcc ttttcctgta
     1861 cctttaacct ttagtctgtc aaggaaaacc cttaggacct ctgaatcaag aggactgagt
     1921 ttgtgggtga accttgaagg tgctctttct gctacaaggg ccctgggaga tagcatggac
     1981 gtgcattgag aagccagcct cagaccttag cttgaagcag cttgaggcca gacctactgt
     2041 agcctcagca tcttgctagg aggcatggaa gtgatctatc ctgccaggag gcctcagagt
     2101 gatctgtcct gccaggaggt gtgagagtga tctgtcctgt gaggcattta ggggctttca
     2161 ggaatttagt aaaaggtgga gtatgccttt ccagtatctt ccatcttcct ttgtatactt
     2221 gtccttcctc ccatttcctc cctttggccc gaggtaggag gatggaggga ggctgctact
     2281 ctaccacttc ctgtgtgcct ctactgtggc ctcaaccctg gcaattatag ctactcccat
     2341 cccttacctg ggcatgtgtg agcccttctc actggatttt atacccttgt gtctgtgtac
     2401 ataaatatat atacatatat atatacataa aaactttgta caaaaggcaa gcctcctcct
     2461 tgtggcagct gttgcccatt tgtgtgtggt ctttgttgtg tgtctgacaa cttctcatta
     2521 gcccaactta tgatgtttct agggatataa aacattagta acatcattgt gtttatttat
     2581 ttaaccacct ttagaaagaa aaatgaaaac tcacacctgg gtggggttcc cattctgtat
     2641 ctgcattaca ctgttgatct atggttgtct tctccatcta tcttcatcct aactatctcc
     2701 atcccagcta cccactggac agaattaccc aaacagccaa gttgcagcac caggacagac
     2761 ttagacttaa caggctcctt ctctgtgcct aatgacagat ctttccagca gatggcacta
     2821 tgacagtact gcattctaca cttgtttttt tctagtgggg cggggcgggg aggggggggg
     2881 gttgtgatct tgaagagtta agtaccagag ctaagctgag ctttcttaac tctattggcc
     2941 tttgtacctg cctttgaccc tctttgtagt agcgatccca atccaatatc caaaggggtt
     3001 tgggtcttgt ataacagcag ggttctcctg acctgatgtc tactgttgtt cctctgtcag
     3061 tcccctcaac tcctgctttc catgtggctc tgcctgggat aacacaggcc tgggaccagt
     3121 gaattgtagg gaactgagta ttccagaaat acctctgtga aagggaaggt gcacctacca
     3181 ctgccttaat aataaggggg tgggagagag gctgtctcac ccagcttagg gaccaaatga
     3241 gaaggcctga attcaggggc agggctctgt ggggctcctt ttttgatctc tatggcaaca
     3301 aaatgctaag actttcttat gctaaaaata tggataattg ctgttaggtt ttaatttgtc
     3361 agctctcaga cttctaagcc agtgatgtta gcctctgggg ttgcttttaa cacaaaatca
     3421 tttaaatact tgaagcctgc ttgagtcata aaaggccagt gggactctag ctcctaagtc
     3481 tgtttgctgc ttctgtaaca atagcacaga ctaatttgta aagaaaagag gtgtaggctg
     3541 ggtgcactgg ctcacgcctg taatcccagc actttgggag gccgaggtgg gtggatcacg
     3601 aggtcagttc aagaccagcc tggccaacat ggtgaaactc tgtctctact agaaatacaa
     3661 aaagtagctg ggcatggtgg tgggtgcctg taatcccagc tactcaggag gctgagacag
     3721 gagaatcgct tgagcctggg aggcggaggt tgcagtgagc cgaggatgca ccactgcact
     3781 ccagcctggg caacagagcg agcctccatc tcaaaaaaac agaaaagtgt atttctcaca
     3841 gttctggagg ctgggaattt caagagcatg gtgcctgcat caggtggggg tcatcccatg
     3901 tcagaagggc acaaggtaga aatgagtaca tgagacaaag ggaccatggg ccaaacttgc
     3961 tttataacag ccctctctca tgataacctg ctgtgtgata gtgacattaa tccactcatg
     4021 agggctctgt ccttgtgact cagtcacctc gtattaagcc ccatcttcaa cactgttgca
     4081 ttgggagtca aatttccaat gtgaactttt gggggacaca ttcaaaccac agcatttctg
     4141 attcttccag gcctagatct cacatgatgt tgctgttctc ctggttacca cccccatccc
     4201 ttcccccatc ttatcctagt ttgctttctg gaccggggga aaagggaagg aggatgcact
     4261 atttttaggt agaagctgct ggctatgacc cagcacccct acagttattg atttggcttc
     4321 taatgtatct tgagaagtgc agtgggtacc gtttttgtta gtcatcctga ggccatgaac
     4381 tgggtcttct catggctggc ttggctcctt cagactatta taaatatcca caggccttgc
     4441 ctccctgcct tcctctgctt ggtttcctta tgtttccatc cctagctacc ttggccttcc
     4501 tacactcgga tccttccacc tcagttcttt cttgttctta gttcctcaca tagcctcttg
     4561 ctgggagaga gacaatgttg gaagtaagga cgtatctaag acaatttcca gtcttactcc
     4621 atataaggtg atggtatcta gtgagtgaca gttgctgtcc gtgtgtgact cagtgccttc
     4681 ttgttactca tccctccata cgaggtggtt agagtggaga gaagcgggct gtgaacagac
     4741 tctgggccca gcttaaggta aaagaaactt ccctcaacat ctacctgcac atggtggctg
     4801 gtggcgtagg ggtgacattg tgatctagat cctttgccag catagttaga atttccctac
     4861 cagtcttcag ttctagaaaa gattctcacc tgatttttga cttccagtct atgcttctgt
     4921 attcactaag gtggcagcat ttcctccctg ttctttaaac tgctgtgctc ttgacacagg
     4981 aattctgcct gcttcctcag actcccaaca acccccagat aggagttacc agtagaagca
     5041 gaggcttgac ctgtgaactt ttagtcctgg agcatatcat gaagggaatt gagtaaaaac
     5101 ctgaaggatg gaattatatc acagtccctc ttttccgtgt aatggaaagg ctttagtgaa
     5161 aatcaggcag caacacttgg acagtgaaaa gagactctga aaggtgaggt gacaggaggt
     5221 ggcataatgg tcattgttaa catttatgca aggttggttg taggttaggt gttctaatcg
     5281 tgtattaagt cacaaaatcc tcacaacaat cctctcaagt agtttattat ctttactttg
     5341 taaacaagga aacatatcca aataagttaa ataattttcc ccataagcac aaagttagca
     5401 agttagggat tccaatccaa gtactctcgc ttcagatccc ttgatcttaa ccttacctgc
     5461 ctctcagcac caccatggaa gacaaggcct tggagtcagt gaggaagtgt cacttttcct
     5521 atccctgtac ccatagctct ccgtagactc agaatttttc cactgccatg tctttgctta
     5581 tcttgagtga cagtgtttgt gggtgaacct tgaaggtgct ctttctgcta caagggccct
     5641 gggagatagc atgggcatgt gcattgagaa gccagcctca gaccttatct tgaagcagct
     5701 tgaggccaga cctactgtag gctcagcatc ttgctaggag gcatgggagt gatctaacct
     5761 gccagctatc tctcttcctt tcctccttct gctgatcaaa gtcctgtcct ttaagaccct
     5821 gaagctttcc taggtggagt tgatctctct tttcagtatt ctttgtcctc ttgtgggtca
     5881 tcttactcta cttttattta gtaaataaaa taattgcaat aaaaattatt ttattgaaaa
     5941 ctccattact tgatggttac agcctgatga ggccagactt ggatgtcttt ctcatgattg
     6001 ctttgccttg cacatattaa atgtctgtag aattgaatga atgctgttca ttaaagtgtt
     6061 aaagtcagca ccaggctttc caaaggctgc cccttctagg ctgcttttcc cagcagcctc
     6121 atccattcct tcctcactcc accaggagag aagatgcagc tttactcttt ctgatgttac
     6181 catggtagcc tgtgatactt tctttctaaa gtgctgcttg ccatccacca gagactgatg
     6241 tttccatggc aaccaggtga aggcaatagt cacgagctgg atgcaggaaa ggaattccgg
     6301 tctgagaagc tgcatatctg aatcttctag cttcagacat cctttcccct ctctcataac
     6361 ttttgcgctt tatatccagg actggtttgc tctctggtgt gcccttggtt gagagagctc
     6421 tgtgaaagtg aggtgaagca gaccaaccaa cttagatcac gtgggaaggt gggtgcaagg
     6481 aaagagctga gcaaagatca cttcaaaaag ttggatgaag tctattagtt gttcagatga
     6541 tctgctctca agagccctta aggagttggc tggagtttct ggagagccat taagcagtta
     6601 tttttgagag caatgggtag atggatgagg tgcctgaaga ctggaaagca gccagtcagt
     6661 gccggattgt agaaaggaga aacaatgacc ttggaaatcg gagacccgtc aaacttgcca
     6721 atgttccaga aaggatggga gtttcagtca gctttcaggc atcaggaagc ctacttgctt
     6781 agaattagtg gtgctaagaa ttcgcctcct caactcctga gcataagcaa gctaggggac
     6841 ctccaccctg tagccgagtg tcacactctg gaaccacaca gcatggttca gatccctctt
     6901 ccctcacaaa ctagctgaat aagcttgggt aggttacttc acttctctca cacttcatct
     6961 gtaaaaagga aatgataaca cctatctcat agggatgttg tgagaattca ttgagaaagg
     7021 tttggaactt ggctcattac tgtcctcagt attttcactc ctctggatgc ctactcactt
     7081 gattttctag ctgacttcat tctccccaac tttagagctc aaggtttatg gggaaaagca
     7141 agggcagtgc aatggtgaaa ataaatcttc atttttaaat aaataaattg ttcctgcact
     7201 gaagccccaa gcttacaagg tcttgggtca cacacaacct gcctagtttt caggaaaaca
     7261 gatcccacta gcccaatctc tttatgcttg aggctctgtc cacatagtta gattttaacc
     7321 agatggtttc gaaaaatcaa aatgagcccc cctcacaggt accttcaagg tacctaacac
     7381 cattagcttt gtctggcagg ggaaaaatac cagggcactc agttttgttt tgttttgaga
     7441 cagggtctgg ctctgttgcc catgctggag tacagtggtg ccatcacagc tcactgcagt
     7501 ctcaacctcc tgagctcaaa tgatcctctt gattagctgg aactacaggt atgtgccact
     7561 atgcccagct aagttttgta ttttttgtag agatggggtc ttgctatgtt gcccaggtgg
     7621 tcttgaactc ctgggcttaa gtgatcctcc ctccttagcc tcccaaagtg ctaggattat
     7681 aggtgtgagc caccacaact gcctgagagc accctctgtt accacccttt ccttagcgtc
     7741 tcagcctccc ccaagcacct gtctttgttg gtctccagag cctagcccta cactggcatt
     7801 ttcctttctg aataagtatt ttttttattt atttattttt attttttctt tgagatggag
     7861 tttcgctttt gttgcccagg ctggagtgca atggtgcgat ctcggctcac cgcaacctct
     7921 gcttcctggg ttcaagtgat tctcctgcct cagcctcctg agtagctggg attacaggcg
     7981 tgcgccacca ctcccagcta attttgtatt tttagtggag acagggtttc tccatgttgg
     8041 tcaggctggt ctcgaactcc tgacctcagg tgatccaccc gccttggcct cccaaagtgc
     8101 tgggattaca gtcctgagcc actgcactgg gccttattta tttattttta attaattaat
     8161 taattttttt tgagatggag tcttgctttg tcgcccaggc tggagtgcag tggcgcaatc
     8221 tcgggtcact gcaagctctg cctcccaggt tcatgccatt ctcctgcctc agcctcccaa
     8281 gtagctggga ctacaggcac ctgccactat gcccggctaa ttttttgtat tttttagtag
     8341 agatggggtt tcactgtttt agccaggatg gtttcgatct cctgacctag tgatccgctc
     8401 gcctcggcct cccagagtgc tgggattaca ggcgtgagcc actgcgcccg gctgggcctt
     8461 atttatgtat ttttctgaga cagagtctca tgctatcacc caggctggag tgcagtggca
     8521 tgatctctgc tcactgcgat ctctgctcac ttcaacctct gcttcccggg ttcaagtgat
     8581 tctcccacct cagcctcccg agtagctgga attacaggca cccaccacca tgcctggcta
     8641 atttttgtaa ttttttttag tagaaatagg gtttcaccat gttggccagg ctggtctctc
     8701 tcttgacctc aagtgatcca cccacctcgg cctcccaaag tgctgggatt acaggcgtga
     8761 gccaattgcc cgacctgagt aagtatttta aatcagcaca ggtcctctgc ttaaagtcaa
     8821 gttgtaattt gaacacaaaa atggaaaatc atgcagtaaa ataccatcgt ggagcttcaa
     8881 ttgccaatct gtcccccaac cttccatcag atgacaaaac ccaaaaaagt gttacccgtg
     8941 agtcctatgg aaggcacgtt ggactttgta gaccataact taaattttta tctccaaatg
     9001 gtgctgtgct ttgagagttt agcaagctgc tttgatgcct aaataaaggg ccaggacata
     9061 ggttgcaaaa ggcattacta cttccaccgc ttctctgtat aatgcttgag aaattacaaa
     9121 gatctttgct cttttattta gtcctcatga cttcgctata aggtaggtat tcttcatttt
     9181 agagttggga tagcatagct gagttcagca aaccagacag gttaagagtg acttcatcca
     9241 cagaccccca tccaggaaac atcctgagca ctaattgaaa agcattcaag ggcttactga
     9301 atttgcattc acatctggag ttttcaaggc cactaagctg tggaaacttg acatcaatat
     9361 tcaaatagat gaaaagggac cttaagcata tccatcaggg agtcaccgag atgataaagg
     9421 cctgagaagc agtatgctct tgtccggcat ttgtgtcctt tgacgactgc accatccacc
     9481 caaattttgc tgccttcttt ataggaaggg ccttttcctc atgtggtggg ctgcccactg
     9541 tttcttctct gtgcatttgc tcatgtagtt tgaccacaag gaatgctttt ccttctttct
     9601 ctcaactatc tatagcctac atatccttta aggcccagtt tctaaaatat gtcttccaaa
     9661 tttactgttt cttccattca gaattcctgg agcacatgag gtagccccca gttagataga
     9721 atgtggtatt gtttgctgct attttgcctg ttttgtgctg tatcacctca tccatctccc
     9781 cagcttaatt gcaagctatt tgacgggcag aaattgtgtc ttatttgtat ttgttttccc
     9841 cattgggccc ggcacactga ttggcatatt gcagatgttt agtacttgag agaaacaaaa
     9901 tgtcttctag catttgtgga tgaaagatta aaatgtccag gaaaatttac ttagattgat
     9961 gtggattgaa actatattag attaataaaa agatgtgtgt gtgtgaa
//
