LOCUS       NM_018047               2299 bp    mRNA    linear   PRI 01-MAY-2024
DEFINITION  Homo sapiens RNA binding motif protein 22 (RBM22), mRNA.
ACCESSION   NM_018047
VERSION     NM_018047.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2299)
  AUTHORS   Du,X., Qin,W., Yang,C., Dai,L., San,M., Xia,Y., Zhou,S., Wang,M.,
            Wu,S., Zhang,S., Zhou,H., Li,F., He,F., Tang,J., Chen,J.Y., Zhou,Y.
            and Xiao,R.
  TITLE     RBM22 regulates RNA polymerase II 5' pausing, elongation rate, and
            termination by coordinating 7SK-P-TEFb complex and SPT5
  JOURNAL   Genome Biol 25 (1), 102 (2024)
   PUBMED   38641822
  REMARK    GeneRIF: RBM22 regulates RNA polymerase II 5' pausing, elongation
            rate, and termination by coordinating 7SK-P-TEFb complex and SPT5.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2299)
  AUTHORS   Jimenez-Vacas,J.M., Montero-Hidalgo,A.J., Gomez-Gomez,E.,
            Saez-Martinez,P., Fuentes-Fayos,A.C., Closa,A.,
            Gonzalez-Serrano,T., Martinez-Lopez,A., Sanchez-Sanchez,R.,
            Lopez-Casas,P.P., Sarmento-Cabral,A., Olmos,D., Eyras,E.,
            Castano,J.P., Gahete,M.D. and Luque,R.M.
  TITLE     Tumor suppressor role of RBM22 in prostate cancer acting as a
            dual-factor regulating alternative splicing and transcription of
            key oncogenic genes
  JOURNAL   Transl Res 253, 68-79 (2023)
   PUBMED   36089245
  REMARK    GeneRIF: Tumor suppressor role of RBM22 in prostate cancer acting
            as a dual-factor regulating alternative splicing and transcription
            of key oncogenic genes.
REFERENCE   3  (bases 1 to 2299)
  AUTHORS   Chai,G., Webb,A., Li,C., Antaki,D., Lee,S., Breuss,M.W., Lang,N.,
            Stanley,V., Anzenberg,P., Yang,X., Marshall,T., Gaffney,P.,
            Wierenga,K.J., Chung,B.H., Tsang,M.H., Pais,L.S., Lovgren,A.K.,
            VanNoy,G.E., Rehm,H.L., Mirzaa,G., Leon,E., Diaz,J., Neumann,A.,
            Kalverda,A.P., Manfield,I.W., Parry,D.A., Logan,C.V., Johnson,C.A.,
            Bonthron,D.T., Valleley,E.M.A., Issa,M.Y., Abdel-Ghafar,S.F.,
            Abdel-Hamid,M.S., Jennings,P., Zaki,M.S., Sheridan,E. and
            Gleeson,J.G.
  TITLE     Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause
            Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly
  JOURNAL   Neuron 109 (2), 241-256 (2021)
   PUBMED   33220177
REFERENCE   4  (bases 1 to 2299)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2299)
  AUTHORS   Bertram,K., Agafonov,D.E., Liu,W.T., Dybkov,O., Will,C.L.,
            Hartmuth,K., Urlaub,H., Kastner,B., Stark,H. and Luhrmann,R.
  TITLE     Cryo-EM structure of a human spliceosome activated for step 2 of
            splicing
  JOURNAL   Nature 542 (7641), 318-323 (2017)
   PUBMED   28076346
REFERENCE   6  (bases 1 to 2299)
  AUTHORS   Krebs,J.
  TITLE     The influence of calcium signaling on the regulation of alternative
            splicing
  JOURNAL   Biochim Biophys Acta 1793 (6), 979-984 (2009)
   PUBMED   19133299
  REMARK    Review article
REFERENCE   7  (bases 1 to 2299)
  AUTHORS   Satoh,J., Obayashi,S., Misawa,T., Sumiyoshi,K., Oosumi,K. and
            Tabunoki,H.
  TITLE     Protein microarray analysis identifies human cellular prion protein
            interactors
  JOURNAL   Neuropathol Appl Neurobiol 35 (1), 16-35 (2009)
   PUBMED   18482256
REFERENCE   8  (bases 1 to 2299)
  AUTHORS   Montaville,P., Dai,Y., Cheung,C.Y., Giller,K., Becker,S.,
            Michalak,M., Webb,S.E., Miller,A.L. and Krebs,J.
  TITLE     Nuclear translocation of the calcium-binding protein ALG-2 induced
            by the RNA-binding protein RBM22
  JOURNAL   Biochim Biophys Acta 1763 (11), 1335-1343 (2006)
   PUBMED   17045351
  REMARK    GeneRIF: ALG-2 alone evenly distributed within the cell, whereas in
            the presence of RBM22 the two proteins co-localized within the
            nucleus.
REFERENCE   9  (bases 1 to 2299)
  AUTHORS   Kittler,R., Putz,G., Pelletier,L., Poser,I., Heninger,A.K.,
            Drechsel,D., Fischer,S., Konstantinova,I., Habermann,B.,
            Grabner,H., Yaspo,M.L., Himmelbauer,H., Korn,B., Neugebauer,K.,
            Pisabarro,M.T. and Buchholz,F.
  TITLE     An endoribonuclease-prepared siRNA screen in human cells identifies
            genes essential for cell division
  JOURNAL   Nature 432 (7020), 1036-1040 (2004)
   PUBMED   15616564
REFERENCE   10 (bases 1 to 2299)
  AUTHORS   Hartmuth,K., Urlaub,H., Vornlocher,H.P., Will,C.L., Gentzel,M.,
            Wilm,M. and Luhrmann,R.
  TITLE     Protein composition of human prespliceosomes isolated by a
            tobramycin affinity-selection method
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16719-16724 (2002)
   PUBMED   12477934
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA534416.1, BC003402.1 and
            N23415.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018047.2.
            
            Summary: This gene encodes an RNA binding protein. The encoded
            protein may play a role in cell division and may be involved in
            pre-mRNA splicing. Related pseudogenes exist on chromosomes 6, 7,
            9, 13, 16, 18, and X. [provided by RefSeq, Mar 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK001152.1, SRR3476690.115598.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000199814.9/ ENSP00000199814.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                DA534416.1         46-67
            23-2297             BC003402.1         1-2275
            2298-2299           N23415.1           9-10                c
FEATURES             Location/Qualifiers
     source          1..2299
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.1"
     gene            1..2299
                     /gene="RBM22"
                     /gene_synonym="Cwc2; fSAP47; ZC3H16"
                     /note="RNA binding motif protein 22"
                     /db_xref="GeneID:55696"
                     /db_xref="HGNC:HGNC:25503"
                     /db_xref="MIM:612430"
     exon            1..131
                     /gene="RBM22"
                     /gene_synonym="Cwc2; fSAP47; ZC3H16"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1340
                     /gene="RBM22"
                     /gene_synonym="Cwc2; fSAP47; ZC3H16"
                     /note="functional spliceosome-associated protein 47; zinc
                     finger CCCH domain-containing protein 16"
                     /codon_start=1
                     /product="pre-mRNA-splicing factor RBM22"
                     /protein_id="NP_060517.1"
                     /db_xref="CCDS:CCDS34278.1"
                     /db_xref="GeneID:55696"
                     /db_xref="HGNC:HGNC:25503"
                     /db_xref="MIM:612430"
                     /translation="MATSLGSNTYNRQNWEDADFPILCQTCLGENPYIRMTKEKYGKE
                     CKICARPFTVFRWCPGVRMRFKKTEVCQTCSKLKNVCQTCLLDLEYGLPIQVRDAGLS
                     FKDDMPKSDVNKEYYTQNMEREISNSDGTRPVGMLGKATSTSDMLLKLARTTPYYKRN
                     RPHICSFWVKGECKRGEECPYRHEKPTDPDDPLADQNIKDRYYGINDPVADKLLKRAS
                     TMPRLDPPEDKTITTLYVGGLGDTITETDLRNHFYQFGEIRTITVVQRQQCAFIQFAT
                     RQAAEVAAEKSFNKLIVNGRRLNVKWGRSQAARGKEKEKDGTTDSGIKLEPVPGLPGA
                     LPPPPAAEEEASANYFNLPPSGPPAVVNIALPPPPGIAPPPPPGFGPHMFHPMGPPPP
                     FMRAPGPIHYPSQDPQRMGAHAGKHSSP"
     exon            132..185
                     /gene="RBM22"
                     /gene_synonym="Cwc2; fSAP47; ZC3H16"
                     /inference="alignment:Splign:2.1.0"
     exon            186..215
                     /gene="RBM22"
                     /gene_synonym="Cwc2; fSAP47; ZC3H16"
                     /inference="alignment:Splign:2.1.0"
     exon            216..348
                     /gene="RBM22"
                     /gene_synonym="Cwc2; fSAP47; ZC3H16"
                     /inference="alignment:Splign:2.1.0"
     exon            349..449
                     /gene="RBM22"
                     /gene_synonym="Cwc2; fSAP47; ZC3H16"
                     /inference="alignment:Splign:2.1.0"
     exon            450..622
                     /gene="RBM22"
                     /gene_synonym="Cwc2; fSAP47; ZC3H16"
                     /inference="alignment:Splign:2.1.0"
     exon            623..823
                     /gene="RBM22"
                     /gene_synonym="Cwc2; fSAP47; ZC3H16"
                     /inference="alignment:Splign:2.1.0"
     exon            824..988
                     /gene="RBM22"
                     /gene_synonym="Cwc2; fSAP47; ZC3H16"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1077
                     /gene="RBM22"
                     /gene_synonym="Cwc2; fSAP47; ZC3H16"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1209
                     /gene="RBM22"
                     /gene_synonym="Cwc2; fSAP47; ZC3H16"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..2299
                     /gene="RBM22"
                     /gene_synonym="Cwc2; fSAP47; ZC3H16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2278..2283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM22"
                     /gene_synonym="Cwc2; fSAP47; ZC3H16"
                     /note="hexamer: ATTAAA"
     polyA_site      2299
                     /gene="RBM22"
                     /gene_synonym="Cwc2; fSAP47; ZC3H16"
                     /note="major polyA site"
ORIGIN      
        1 agcctcgggg cttgacggga ttgtggcggt cctctctccc aattcggaag ctacagctac
       61 ctccggacgc tctcaagatg gcgacctctc tgggttccaa cacctacaac aggcagaact
      121 gggaggatgc ggacttcccc attctgtgcc agacatgtct tggagaaaac ccatatatcc
      181 gaatgaccaa agaaaagtat gggaaggaat gcaaaatctg tgccaggcca ttcacagtgt
      241 ttcgctggtg ccctggagtc cgcatgcgtt tcaagaagac tgaagtgtgc caaacctgca
      301 gtaaattgaa gaatgtctgt cagacctgcc tcttagacct agagtatggc ctgcccatcc
      361 aggttcgtga cgcaggattg tcttttaaag atgacatgcc aaagtcagat gtcaacaaag
      421 agtactatac acagaatatg gagagagaga tttctaactc tgatggaaca cggccagttg
      481 gcatgctggg gaaagccaca tctaccagtg acatgctgct caaactggcc cggaccacac
      541 cctactacaa aaggaatcga ccccacattt gctccttctg ggtgaaagga gagtgtaaga
      601 gaggagagga atgtccatac agacatgaga agcctacaga tccagatgac ccccttgctg
      661 atcagaatat taaagaccgt tattacggaa tcaatgatcc tgtagctgac aagcttctaa
      721 agcgggcttc aacaatgcct cggctggacc caccagagga taaaactatc accacactat
      781 atgttggtgg tctaggtgat accattactg agacagattt aagaaatcat ttctaccagt
      841 tcggagagat ccggacgatc actgttgtgc agagacagca gtgtgctttc atccagtttg
      901 ccacacggca ggctgcagaa gtggctgctg agaagtcctt taataagttg attgtaaatg
      961 gccgcagact gaatgtgaaa tggggaagat cccaggcagc cagaggaaaa gaaaaagaga
     1021 aagatggaac tacagactct gggatcaaac tagaacctgt tccaggattg ccaggagctc
     1081 ttcctcctcc tcctgcagca gaagaagaag cctctgccaa ctacttcaac ttgcccccaa
     1141 gtggtcctcc agctgtggtg aacattgctc tgccaccgcc ccctggcatt gctccacccc
     1201 cacccccagg ttttgggcca cacatgttcc acccaatggg accaccccct cctttcatgc
     1261 gggctccagg accaatccac tatccttctc aggaccctca gaggatggga gctcatgctg
     1321 gaaaacacag cagcccctag caccttgtca ccactctggg gctctgtgga agaaagggca
     1381 cttaaaactc ccagtaaatc ttggaataaa tatatttttc cttcccttgt agtttccatg
     1441 gtagctgaat gtgctcagat gtgagcagtc agagactgac agccatgctt tcctatactt
     1501 gttcaaagga tcgatggacc gtaaataagc tgccattaac acatctggtt actgctgtaa
     1561 catgactaat aaaaccgaac gcctgttccc cttacccgtg tgggggacac gcagatgagt
     1621 gaattggaat gtccagcaga gttaccctcc caattatatg ttcattttgt atattttttg
     1681 gtcgggggaa aaattgacct gcagtaaaaa aacctttgac catttttatg tccattggat
     1741 actttccttt ttatcatctt aaaaaaagat aactagtact aatcattgta gtggcctaag
     1801 tgtgatttaa ctcttgaagt cacaccctcc gaaagatgag tagaaaccag caccagcaca
     1861 gcccagatct tctctttcct ctccttttcc tcatttattc ctaaaggaat ctgaccattt
     1921 tacgtctcta cggcccaaaa aaagacaaaa ataaaaattc ctttttattc ctgtcaactg
     1981 gatggaaaca caaatttcat ggagctgtgt accatcgaag aaacctggtg tctggcatga
     2041 aattactgta aagaacttcc tgtaaaacac gttctttaac aaactgaaat gaaaagcatt
     2101 ggagcgtctg aatgaaagac gtgacctcct gctgggactc tgatggtctt cagcattcac
     2161 cttcgtgtgt cttcagtgtc tcattgtcat ccctgcttct gtttggtctt agagtgtttg
     2221 gatataactg aattgtagat ggtaaaggaa atttgatgtg ttttttgttt ttaaataatt
     2281 aaaacgggtc aatttttca
//
