LOCUS       NM_001134363            7293 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens RNA binding motif protein 20 (RBM20), mRNA.
ACCESSION   NM_001134363 XM_001716119 XM_291671 XM_939337
VERSION     NM_001134363.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7293)
  AUTHORS   Lin,X.
  TITLE     [Research progress on the expression of the RBM20 gene in dilated
            cardiomyopathy]
  JOURNAL   Zhongguo Dang Dai Er Ke Za Zhi 25 (10), 1084-1088 (2023)
   PUBMED   37905768
  REMARK    GeneRIF: [Research progress on the expression of the RBM20 gene in
            dilated cardiomyopathy].
            Review article
REFERENCE   2  (bases 1 to 7293)
  AUTHORS   Cannie,D.E., Protonotarios,A., Bakalakos,A., Syrris,P.,
            Lorenzini,M., De Stavola,B., Bjerregaard,L., Dybro,A.M., Hey,T.M.,
            Hansen,F.G., Navarro Penalver,M., Crespo-Leiro,M.G.,
            Larranaga-Moreira,J.M., de Frutos,F., Johnson,R., Slater,T.A.,
            Monserrat,L., Sengupta,A., Mestroni,L., Taylor,M.R.G., Sinagra,G.,
            Bilinska,Z., Solla-Ruiz,I., Arana Achaga,X., Barriales-Villa,R.,
            Garcia-Pavia,P., Gimeno,J.R., Dal Ferro,M., Merlo,M., Wahbi,K.,
            Fatkin,D., Mogensen,J., Rasmussen,T.B. and Elliott,P.M.
  TITLE     Risks of Ventricular Arrhythmia and Heart Failure in Carriers of
            RBM20 Variants
  JOURNAL   Circ Genom Precis Med 16 (5), 434-441 (2023)
   PUBMED   37593875
  REMARK    GeneRIF: Risks of Ventricular Arrhythmia and Heart Failure in
            Carriers of RBM20 Variants.
REFERENCE   3  (bases 1 to 7293)
  AUTHORS   Yamamoto,T., Sano,R., Miura,A., Imasaka,M., Naito,Y.,
            Nishiguchi,M., Ihara,K., Otani,N., Kominato,Y., Ohmuraya,M.,
            Kuroyanagi,H. and Nishio,H.
  TITLE     I536T variant of RBM20 affects splicing of cardiac structural
            proteins that are causative for developing dilated cardiomyopathy
  JOURNAL   J Mol Med (Berl) 100 (12), 1741-1754 (2022)
   PUBMED   36198914
  REMARK    GeneRIF: I536T variant of RBM20 affects splicing of cardiac
            structural proteins that are causative for developing dilated
            cardiomyopathy.
REFERENCE   4  (bases 1 to 7293)
  AUTHORS   Sun,M., Jin,Y., Zhang,Y., Gregorich,Z.R., Ren,J., Ge,Y. and Guo,W.
  TITLE     SR Protein Kinases Regulate the Splicing of Cardiomyopathy-Relevant
            Genes via Phosphorylation of the RSRSP Stretch in RBM20
  JOURNAL   Genes (Basel) 13 (9), 1526 (2022)
   PUBMED   36140694
  REMARK    GeneRIF: SR Protein Kinases Regulate the Splicing of
            Cardiomyopathy-Relevant Genes via Phosphorylation of the RSRSP
            Stretch in RBM20.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7293)
  AUTHORS   Linke,W.A. and Bucker,S.
  TITLE     King of hearts: a splicing factor rules cardiac proteins
  JOURNAL   Nat Med 18 (5), 660-661 (2012)
   PUBMED   22561820
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7293)
  AUTHORS   Millat,G., Bouvagnet,P., Chevalier,P., Sebbag,L., Dulac,A.,
            Dauphin,C., Jouk,P.S., Delrue,M.A., Thambo,J.B., Le Metayer,P.,
            Seronde,M.F., Faivre,L., Eicher,J.C. and Rousson,R.
  TITLE     Clinical and mutational spectrum in a cohort of 105 unrelated
            patients with dilated cardiomyopathy
  JOURNAL   Eur J Med Genet 54 (6), e570-e575 (2011)
   PUBMED   21846512
REFERENCE   7  (bases 1 to 7293)
  AUTHORS   Li,D., Morales,A., Gonzalez-Quintana,J., Norton,N., Siegfried,J.D.,
            Hofmeyer,M. and Hershberger,R.E.
  TITLE     Identification of novel mutations in RBM20 in patients with dilated
            cardiomyopathy
  JOURNAL   Clin Transl Sci 3 (3), 90-97 (2010)
   PUBMED   20590677
  REMARK    GeneRIF: Dilated cardiomyopathy in patients with RBM20 mutations is
            associated with advanced disease.
REFERENCE   8  (bases 1 to 7293)
  AUTHORS   Macrae,C.A. and McKenna,W.J.
  TITLE     Splicing and dilated cardiomyopathy one gene to rule them all?
  JOURNAL   J Am Coll Cardiol 54 (10), 942-943 (2009)
   PUBMED   19712805
  REMARK    GeneRIF: RBM20 missense mutation is a novel gene underlying one
            form of dilated cardiomyopathy
REFERENCE   9  (bases 1 to 7293)
  AUTHORS   Brauch,K.M., Karst,M.L., Herron,K.J., de Andrade,M., Pellikka,P.A.,
            Rodeheffer,R.J., Michels,V.V. and Olson,T.M.
  TITLE     Mutations in ribonucleic acid binding protein gene cause familial
            dilated cardiomyopathy
  JOURNAL   J Am Coll Cardiol 54 (10), 930-941 (2009)
   PUBMED   19712804
  REMARK    GeneRIF: RBM20 as a dilated cardiomyopathy gene and reveal a
            mutation hotspot in the RS domain. Individuals in each family
            revealed distinct heterozygous missense mutations in exon 9 of
            RBM20, encoding ribonucleic acid (RNA) binding motif protein 20.
REFERENCE   10 (bases 1 to 7293)
  AUTHORS   Hershberger,R.E. and Jordan,E.
  TITLE     Dilated Cardiomyopathy Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301486
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL359260.20, EU822950.1 and
            KF459660.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001134363.2.
            
            Summary: This gene encodes a protein that binds RNA and regulates
            splicing. Mutations in this gene have been associated with familial
            dilated cardiomyopathy. [provided by RefSeq, Apr 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU822950.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151741, SAMEA2154361
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369519.4/ ENSP00000358532.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AL359260.20        120982-121042
            62-2421             EU822950.1         1-2360
            2422-2422           KF459660.1         171-171
            2423-7293           EU822950.1         2362-7232
FEATURES             Location/Qualifiers
     source          1..7293
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.2"
     gene            1..7293
                     /gene="RBM20"
                     /note="RNA binding motif protein 20"
                     /db_xref="GeneID:282996"
                     /db_xref="HGNC:HGNC:27424"
                     /db_xref="MIM:613171"
     exon            1..310
                     /gene="RBM20"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..3803
                     /gene="RBM20"
                     /note="probable RNA-binding protein 20"
                     /codon_start=1
                     /product="RNA-binding protein 20"
                     /protein_id="NP_001127835.2"
                     /db_xref="CCDS:CCDS44477.1"
                     /db_xref="GeneID:282996"
                     /db_xref="HGNC:HGNC:27424"
                     /db_xref="MIM:613171"
                     /translation="MVLAAAMSQDADPSGPEQPDRVACSVPGARASPAPSGPRGMQQP
                     PPPPQPPPPPQAGLPQIIQNAAKLLDKNPFSVSNPNPLLPSPASLQLAQLQAQLTLHR
                     LKLAQTAVTNNTAAATVLNQVLSKVAMSQPLFNQLRHPSVITGPHGHAGVPQHAAAIP
                     STRFPSNAIAFSPPSQTRGPGPSMNLPNQPPSAMVMHPFTGVMPQTPGQPAVILGIGK
                     TGPAPATAGFYEYGKASSGQTYGPETDGQPGFLPSSASTSGSVTYEGHYSHTGQDGQA
                     AFSKDFYGPNSQGSHVASGFPAEQAGGLKSEVGPLLQGTNSQWESPHGFSGQSKPDLT
                     AGPMWPPPHNQPYELYDPEEPTSDRTPPSFGGRLNNSKQGFIGAGRRAKEDQALLSVR
                     PLQAHELNDFHGVAPLHLPHICSICDKKVFDLKDWELHVKGKLHAQKCLVFSENAGIR
                     CILGSAEGTLCASPNSTAVYNPAGNEDYASNLGTSYVPIPARSFTQSSPTFPLASVGT
                     TFAQRKGAGRVVHICNLPEGSCTENDVINLGLPFGKVTNYILMKSTNQAFLEMAYTEA
                     AQAMVQYYQEKSAVINGEKLLIRMSKRYKELQLKKPGKAVAAIIQDIHSQRERDMFRE
                     ADRYGPERPRSRSPVSRSLSPRSHTPSFTSCSSSHSPPGPSRADWGNGRDSWEHSPYA
                     RREEERDPAPWRDNGDDKRDRMDPWAHDRKHHPRQLDKAELDERPEGGRPHREKYPRS
                     GSPNLPHSVSSYKSREDGYYRKEPKAKSDKYLKQQQDAPGRSRRKDEARLRESRHPHP
                     DDSGKEDGLGPKVTRAPEGAKAKQNEKNKTKRTDRDQEGADDRKENTMAENEAGKEEQ
                     EGMEESPQSVGRQEKEAEFSDPENTRTKKEQDWESESEAEGESWYPTNMEELVTVDEV
                     GEEEDFIVEPDIPELEEIVPIDQKDKICPETCLCVTTTLDLDLAQDFPKEGVKAVGNG
                     AAEISLKSPRELPSASTSCPSDMDVEMPGLNLDAERKPAESETGLSLEDSDCYEKEAK
                     GVESSDVHPAPTVQQMSSPKPAEERARQPSPFVDDCKTRGTPEDGACEGSPLEEKASP
                     PIETDLQNQACQEVLTPENSRYVEMKSLEVRSPEYTEVELKQPLSLPSWEPEDVFSEL
                     SIPLGVEFVVPRTGFYCKLCGLFYTSEETAKMSHCRSAVHYRNLQKYLSQLAEEGLKE
                     TEGADSPRPEDSGIVPRFERKKL"
     exon            311..1394
                     /gene="RBM20"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1456
                     /gene="RBM20"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1548
                     /gene="RBM20"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1646
                     /gene="RBM20"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1787
                     /gene="RBM20"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1919
                     /gene="RBM20"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..1999
                     /gene="RBM20"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2669
                     /gene="RBM20"
                     /inference="alignment:Splign:2.1.0"
     exon            2670..2774
                     /gene="RBM20"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..3435
                     /gene="RBM20"
                     /inference="alignment:Splign:2.1.0"
     exon            3436..3570
                     /gene="RBM20"
                     /inference="alignment:Splign:2.1.0"
     exon            3571..3692
                     /gene="RBM20"
                     /inference="alignment:Splign:2.1.0"
     exon            3693..7293
                     /gene="RBM20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6071..6076
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM20"
                     /note="hexamer: AATAAA"
     polyA_site      6101
                     /gene="RBM20"
                     /note="major polyA site"
     regulatory      7272..7277
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM20"
                     /note="hexamer: AATAAA"
     polyA_site      7293
                     /gene="RBM20"
                     /note="major polyA site"
ORIGIN      
        1 gcgccaccgg gaaggacaag gggactgggc acggggaccc cggccagtga gcgcccgtgg
       61 cccgggaccg cccctccctt gagctctctc gccgcgatcc cgggcgggtc tcgccccgca
      121 tggtgctggc agcagccatg agccaggacg cggaccccag cggtccggag cagccggaca
      181 gagttgcctg cagtgtgcct ggtgcccggg cgtccccggc accctccggc ccgcgaggga
      241 tgcagcagcc gccgccgccg ccccagccac cgcccccgcc ccaagccggc ctaccccaga
      301 tcatccaaaa tgccgccaag ctcctggaca agaacccatt ctcggtcagt aacccgaacc
      361 ctctgcttcc ttcacctgcc agtctccagc tggctcaact gcaggcccag ctcaccctcc
      421 accggctgaa gctggcacag acagctgtca ccaacaacac tgcagccgcc acagtcctga
      481 accaagtcct ctccaaagtg gccatgtccc agcctctctt caatcaactg aggcatccgt
      541 ctgtgatcac tggcccccac ggccatgctg gggttcccca acatgctgca gccataccca
      601 gtacccggtt tccctctaat gcaattgcct tttcaccccc cagccagaca cgaggccccg
      661 gaccctccat gaaccttccc aaccagccac ccagtgccat ggtgatgcat cctttcactg
      721 gggtaatgcc tcagacccct ggccagccag cagtcatctt gggcattggc aagactgggc
      781 ctgctccagc tacagcagga ttctatgagt atggcaaagc cagctctggc cagacatatg
      841 gccctgaaac agatggtcag cctggcttcc tgccatcctc ggcctcaacc tcgggcagtg
      901 tgacctatga agggcactac agccacacag ggcaggatgg tcaagctgcc ttttccaaag
      961 atttttacgg acccaactcc caaggttcac atgtggccag cggatttcca gctgagcagg
     1021 ctgggggcct gaaaagtgag gtcgggccac tgctgcaggg cacaaacagc caatgggaga
     1081 gcccccatgg attctcgggc caaagcaagc ctgatctcac agcaggtccc atgtggcctc
     1141 caccccacaa ccagccctat gagctgtacg accccgagga accaacctca gacaggacac
     1201 ctccttcctt cgggggtcgg cttaacaaca gcaaacaggg ttttatcggt gctgggcgga
     1261 gggccaagga ggaccaggcg ttgctatctg tgcggcccct gcaggctcat gagctgaacg
     1321 actttcacgg tgtggccccc ctccacttgc cgcatatctg tagcatctgt gacaagaagg
     1381 tgtttgattt gaaggactgg gagctgcatg tgaaagggaa gctgcacgct cagaaatgcc
     1441 tggtcttctc tgaaaatgct ggcatccggt gtatacttgg ttcggcagag ggaacattgt
     1501 gtgcttctcc caacagcaca gctgtttata accctgctgg gaatgaagat tatgcctcaa
     1561 atcttggaac atcatacgtg cccattccag caaggtcatt cactcagtca agccccacat
     1621 ttcctttggc ttctgtgggg acaacttttg cacagcggaa aggggctggc cgtgtggtgc
     1681 acatctgcaa tctccctgaa ggaagctgca ctgagaatga cgtcattaac ctggggctgc
     1741 cctttggaaa ggtcactaat tacatcctca tgaagtcgac taatcaggcc tttttagaga
     1801 tggcttacac agaagctgca caggccatgg tccagtatta tcaagaaaaa tctgctgtga
     1861 tcaatggtga gaagttgctc attcggatgt ccaagagata caaggaattg cagctcaaga
     1921 aacccgggaa ggccgtggct gccatcatcc aggacatcca ttcccagagg gagagggaca
     1981 tgttccggga agcagacaga tatggcccag aaaggccgcg gtctcgtagt ccggtgagcc
     2041 ggtcactctc cccgaggtcc cacactccca gcttcacctc ctgcagctct tcccacagcc
     2101 ctccgggccc ctcccgggct gactggggca atggccggga ctcctgggag cactctccct
     2161 atgccaggag ggaggaagag cgagacccgg ctccctggag ggacaacgga gatgacaaga
     2221 gggacaggat ggacccctgg gcacatgatc gcaaacacca cccccggcaa ctggacaagg
     2281 ctgagttgga cgagcgacca gaaggaggga ggccccaccg ggagaagtac ccgagatctg
     2341 ggtctcccaa cctgccccac tctgtgtcca gctacaaaag ccgtgaagac ggctactacc
     2401 ggaaagagcc caaagccaag tcggacaagt atctgaagca gcagcaggat gcccccggga
     2461 ggtccaggag gaaagacgag gccaggctgc gggaaagcag acacccccat ccggatgact
     2521 caggcaagga agatgggctg gggccaaagg tcactagggc ccctgagggc gccaaggcca
     2581 agcagaatga gaaaaataaa accaagagaa ctgatagaga ccaagaagga gctgatgata
     2641 gaaaagaaaa cacaatggca gagaatgagg ctggaaaaga ggaacaggag ggcatggaag
     2701 aaagccctca atcagtgggc agacaggaga aagaagcaga gttctctgat ccggaaaaca
     2761 caaggacaaa gaaggaacaa gattgggaga gtgaaagtga ggcagagggg gagagctggt
     2821 atcccactaa catggaggag ctggtgacag tggacgaggt tggggaagaa gaagatttta
     2881 tcgtggaacc agacatccca gagctggaag aaattgtgcc cattgaccag aaagacaaaa
     2941 tttgcccaga aacatgtctg tgtgtgacaa ccaccttaga cttagacctg gcccaggatt
     3001 tccccaagga aggagtcaag gccgtaggga atggggctgc agaaatcagc ctcaagtcac
     3061 ccagagaact gccctctgct tccacaagct gtcccagtga catggacgtg gaaatgcctg
     3121 gcctaaatct ggatgctgag cggaagccag ctgaaagtga gacaggcctc tccctggagg
     3181 attcagattg ctacgagaag gaggcaaagg gagtggagag ctcagatgtt catccagccc
     3241 ctacagtcca gcaaatgtct tcccctaagc cagcagagga gagggcccgg cagccaagcc
     3301 catttgtgga tgattgcaag accaggggga cccccgaaga tggggcttgt gaaggcagcc
     3361 ccctggagga gaaagccagc ccccccatcg aaactgacct ccaaaaccaa gcttgccaag
     3421 aagtgttgac cccggaaaac tccaggtacg tggaaatgaa atctctggag gtgaggtcac
     3481 cagagtacac tgaagtggaa ctgaaacagc ccctttcttt gccctcttgg gaaccagagg
     3541 atgtgttcag tgaacttagc attcctctag gggtggagtt cgtggttccc aggactggct
     3601 tttattgcaa gctgtgtggg ctgttctaca cgagcgagga gacagcaaag atgagccact
     3661 gccgcagcgc tgtccactac aggaacttac agaaatattt gtcccagctg gccgaggagg
     3721 gcctcaagga gaccgagggg gcagatagcc cgaggccaga ggacagcgga atcgtgccac
     3781 gcttcgaaag gaaaaagctc tgatgcttct gcttctgctg ctactgctgc tgctgcaagg
     3841 ttggaaagga gagcttgctg aagtggggcc ttcctgattc tggggacagg actaaagcct
     3901 gagaggaagg aaaaccaagc agggcacatt gcttgggctt gttcccagag actcagtgaa
     3961 atgcccctga tatgtctcca ggagcaagtc acccaggtgt gtccagccca ctgagggtca
     4021 ccaactctct ccctgctgac tcttgtttct ctcaatcttt caattcgttt ttctctcttt
     4081 tcctcttgtt ctttctctcc ctccctcctt atgtgccaag gatcgtttcc ttttcacaaa
     4141 acccaacttc tcagggattt tcacagtgtt taaattcttg gtaggatata acaggtcagg
     4201 cctagctgag tcaggcaagg aaaaggttta atggaaactc ctgggtcagg cgaacccctg
     4261 cagtgagtct acagcagtat ctctgcctgg tgtcccatgt atcccctgca tgaggagctg
     4321 agtcaggtct gcagtcctgg tgaggggaca tcacggacaa tctgttggca gagctgggag
     4381 ggtcttcatt aacctcttcc tccaactggg ccaccctttt gaaaagcccc tgtttttaat
     4441 aactgtttca tcctctcagt tattctagaa atctgccaga cttatgcctt aaagtaaaat
     4501 taaatgaatt ttagagaaga tgaaaagagc ccttcatttt ggaagctctg ataagtttcc
     4561 tccaaactta ttcccctcct cttgatttca ggagatgtca gggtttttct attctggaca
     4621 atgaatttgg tacagagtca ctgtaattaa atataaaaac agaagcatct tcctccagct
     4681 aaagcagcag ttggcgcggg cttaggttga atgctggcct ctctgcaaag cacagctttg
     4741 gctcgagagg cacagctcca ggctgtggaa aacagagttg tcttgggggt taaatgagct
     4801 tatttaagtc aaggaaacat catctgtcct tgattcagcc ttggtgcctg cactctgggg
     4861 tacaaccacc tcacagtagg atggttttta aatggccccc cagttggggg agaagctaag
     4921 gaaagagaag gctgcagatc caaagagtgg cattgaagtt tgctgggtgt ctgtaggtgg
     4981 accctttcca gctgggcaga tagttgaggg ctccctgggt ttgactgtat gtgcagactt
     5041 tgataccaaa atgttatgaa aagtcgtgat tcccgctgct ctttctggta ctggagggtg
     5101 ggtaccttca ggctgtgggg tctctagcct gatattccat tgaaagggtg tgggataaag
     5161 gtgctggggg aaatgaggct ctgccacagc catagagagg ccctcgggca gttaagaagg
     5221 gagcctggag ctgttttcat gagcagagat actctcctga aagcaccctt catagcttag
     5281 cccaggaaaa ataaaacaag gaagacaggt cactctcccc taggcagttc ctgttgtttc
     5341 tgttcctgac cttgggcagg cagactgaga agggactgtg tagggttttg ttttgttttt
     5401 tttcattttc ctttttatgg catgtgagag catactgtac attctgtcct ctgtactaat
     5461 ggaggaaggg cagagagatt agttcaaggc taacatttta tatcaggtaa ctgaggcaca
     5521 caaagggaac aaatgaagaa cataaaatga tcagtgtaaa cctgaaagca cgcagtcatt
     5581 ggcaagggac aggctcatgg gagctggtga gagagagcag ttaaggcaag caccagggga
     5641 aagcagacca acttgaacag atgtgatgcg gagaggttgg aagaagcaag aaacctgaac
     5701 tcatcatcag gctattaaat aaaatttata ggaggctgtt ggtttggact gagctcctgc
     5761 aataggccca acagaccaaa acaaaaggga gtcactcatg ttgaagttct gtcttccagg
     5821 aaatcaggag agagagagag agaaagaata gccaaatccc caaacaggcc agttttaacc
     5881 agcatgatga agtgtccttg gttttaacct ttataaggaa agcagctttg agatgaccag
     5941 tctggttttt gttctttgtg tctgctttcc tcagcccttt tctgtctata aagccaacct
     6001 cctccgctca gctcatggga acactcattc tattttatag aatgacatgt tgcccaattc
     6061 tagaatcaaa aataaaggcc aactaagatc ttcaaagtaa atttgttgta attttatctt
     6121 ttgagaagac catatggggg ctgctgaaaa gttggtatct caaataaagt ctgaagatca
     6181 cggctcagcc cagattgttc ccctggccaa ctccacaggt ttgaacctgg cattctggac
     6241 accagctatg cctcctccat ttctcagaaa acctttgatc ttgtgtgtct ttcttcctac
     6301 tgaagggaat tgtgggggca gttctttggc cttcttgctg aactttgctg gaaatagccc
     6361 acaattttta tcagaggtta gaactgtaca ttatcagaga gactggacac tttatcccct
     6421 agcaaagtgg gagaagattt taccagctca ttccactcca ccctggcctt cccccacccc
     6481 ccatccccag cagcatttcc atggaaatcc agatggtcgt gtagtgttat ggctctcttg
     6541 tgatagactg gccttcatat tggagagcta gggagagccc ctgggaggga gagagataag
     6601 gcgctatctg ccttcaatca gaaccttcgg tttaaaatca tctaagagtc tatacttgtg
     6661 tgtacatacg tatttatttt tatttatttt tatacaattc cattggcatg gtccttcacc
     6721 gaccctatga tttgcacttt ttatttctat gtgtgccaca cacaatgcag tattaatggc
     6781 aaccaggtaa atattgattt attttttaaa gcttttcttc agtgttttgt caaccatttc
     6841 aaagtgtctc ccaaaaaagg atgctgaaga gcaattgctc ccttaagcaa cagattcata
     6901 tttaccctgg gttaatacaa caaaaggcct gtataattgt cttttcattg ttaacaccca
     6961 aaatagcatc tatctagaca gtatccccaa agaatttgga aaatctgatg gtgtgagcag
     7021 cagccgttag tatcagggtt tcccattctt ggacagtccg aggctgtgac ctgttagata
     7081 attagattat acttgaactg gaccagagtt tgttttttga atttatgaga aaaaccaaaa
     7141 cactaagtta agtttgaact tgtaaagtat tgaaatttgt tgagtgtcct ataaattgtc
     7201 actacttttc ctgatctgta taactgactg caaagtgttt gtttttacaa aagagaaaag
     7261 aaaagatttt taataaagag aatttgaaag ctg
//
