LOCUS       NM_016196               4148 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens RNA binding motif protein 19 (RBM19), transcript
            variant 2, mRNA.
ACCESSION   NM_016196 NM_014852 XM_942674 XM_946213 XM_946214 XM_946215
VERSION     NM_016196.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4148)
  AUTHORS   Xie,T., Deng,L., Mei,P., Zhou,Y., Wang,B., Zhang,J., Lin,J.,
            Wei,Y., Zhang,X. and Xu,R.
  TITLE     Genome-wide association study combining pathway analysis for
            typical sporadic amyotrophic lateral sclerosis in Chinese Han
            populations
  JOURNAL   Neurobiol Aging 35 (7), 1778 (2014)
   PUBMED   24529757
REFERENCE   2  (bases 1 to 4148)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 4148)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 4148)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 4148)
  AUTHORS   Lorenzen,J.A., Bonacci,B.B., Palmer,R.E., Wells,C., Zhang,J.,
            Haber,D.A., Goldstein,A.M. and Mayer,A.N.
  TITLE     Rbm19 is a nucleolar protein expressed in crypt/progenitor cells of
            the intestinal epithelium
  JOURNAL   Gene Expr Patterns 6 (1), 45-56 (2005)
   PUBMED   16027046
REFERENCE   6  (bases 1 to 4148)
  AUTHORS   Mayer,A.N. and Fishman,M.C.
  TITLE     Nil per os encodes a conserved RNA recognition motif protein
            required for morphogenesis and cytodifferentiation of digestive
            organs in zebrafish
  JOURNAL   Development 130 (17), 3917-3928 (2003)
   PUBMED   12874115
  REMARK    GeneRIF: Primarily a zebrafish paper but shows an alignment of
            human RBM19
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB096676.1, AL117547.1,
            AC090669.9 and AC009731.6.
            
            On Nov 22, 2018 this sequence version replaced NM_016196.3.
            
            Summary: This gene encodes a nucleolar protein that contains six
            RNA-binding motifs. The encoded protein may be involved in
            regulating ribosome biogenesis. Multiple alternatively spliced
            variants, encoding the same protein, have been identified.[provided
            by RefSeq, Apr 2009].
            
            Transcript Variant: This variant (2) differs in the 3' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL117547.1, SRR1803611.237233.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261741.10/ ENSP00000261741.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                DB096676.1         47-60
            15-1901             AL117547.1         2-1888
            1902-1916           AC090669.9         106764-106778
            1917-2859           AL117547.1         1904-2846
            2860-2860           AC009731.6         59661-59661
            2861-4148           AL117547.1         2848-4135
FEATURES             Location/Qualifiers
     source          1..4148
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.13-q24.21"
     gene            1..4148
                     /gene="RBM19"
                     /gene_synonym="Mrd1"
                     /note="RNA binding motif protein 19"
                     /db_xref="GeneID:9904"
                     /db_xref="HGNC:HGNC:29098"
                     /db_xref="MIM:616444"
     exon            1..134
                     /gene="RBM19"
                     /gene_synonym="Mrd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..2981
                     /gene="RBM19"
                     /gene_synonym="Mrd1"
                     /codon_start=1
                     /product="probable RNA-binding protein 19"
                     /protein_id="NP_057280.2"
                     /db_xref="CCDS:CCDS9172.1"
                     /db_xref="GeneID:9904"
                     /db_xref="HGNC:HGNC:29098"
                     /db_xref="MIM:616444"
                     /translation="MSRLIVKNLPNGMKEERFRQLFAAFGTLTDCSLKFTKDGKFRKF
                     GFIGFKSEEEAQKAQKHFNKSFIDTSRITVEFCKSFGDPAKPRAWSKHAQKPSQPKQP
                     PKDSTTPEIKKDEKKKKVAGQLEKLKEDTEFQEFLSVHQRRAQAATWANDGLDAEPSK
                     GKSKPASDYLNFDSDSGQESEEEGAGEDLEEEASLEPKAAVQKELSDMDYLKSKMVKA
                     GSSSSSEEEESEDEAVHCDEGSEAEEEDSSATPVLQERDSKGAGQEQGMPAGKKRPPE
                     ARAETEKPANQKEPTTCHTVKLRGAPFNVTEKNVMEFLAPLKPVAIRIVRNAHGNKTG
                     YIFVDFSNEEEVKQALKCNREYMGGRYIEVFREKNVPTTKGAPKNTTKSWQGRILGEN
                     EEEEDLAESGRLFVRNLPYTSTEEDLEKLFSKYGPLSELHYPIDSLTKKPKGFAFITF
                     MFPEHAVKAYSEVDGQVFQGRMLHVLPSTIKKEASEDASALGSSSYKKKKEAQDKANS
                     ASSHNWNTLFMGPNAVADAIAQKYNATKSQVFDHETKGSVAVRVALGETQLVQEVRRF
                     LIDNGVSLDSFSQAAAERSKTVILVKNLPAGTLAAQLQETFGHFGSLGRVLLPEGGIT
                     AIVEFLEPLEARKAFRHLAYSKFHHVPLYLEWAPVGVFSSTAPQKKKLQDTPSEPMEK
                     DPAEPETVPDGETPEDENPTEEGADNSSAKMEEEEEEEEEEEESLPGCTLFIKNLNFD
                     TTEEKLKEVFSKVGTVKSCSISKKKNKAGVLLSMGFGFVEYRKPEQAQKALKQLQGHV
                     VDGHKLEVRISERATKPAVTLARKKQVPRKQTTSKILVRNIPFQAHSREIRELFSTFG
                     ELKTVRLPKKMTGTGTHRGFGFVDFLTKQDAKRAFNALCHSTHLYGRRLVLEWADSEV
                     TLQALRRKTAAHFHEPPKKKRSVVLDEILEQLEGSDSDSEEQTLQL"
     exon            135..317
                     /gene="RBM19"
                     /gene_synonym="Mrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            318..437
                     /gene="RBM19"
                     /gene_synonym="Mrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            438..476
                     /gene="RBM19"
                     /gene_synonym="Mrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            477..669
                     /gene="RBM19"
                     /gene_synonym="Mrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            670..938
                     /gene="RBM19"
                     /gene_synonym="Mrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1019
                     /gene="RBM19"
                     /gene_synonym="Mrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1098
                     /gene="RBM19"
                     /gene_synonym="Mrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1170
                     /gene="RBM19"
                     /gene_synonym="Mrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1374
                     /gene="RBM19"
                     /gene_synonym="Mrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1505
                     /gene="RBM19"
                     /gene_synonym="Mrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1627
                     /gene="RBM19"
                     /gene_synonym="Mrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1724
                     /gene="RBM19"
                     /gene_synonym="Mrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1835
                     /gene="RBM19"
                     /gene_synonym="Mrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..2036
                     /gene="RBM19"
                     /gene_synonym="Mrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2166
                     /gene="RBM19"
                     /gene_synonym="Mrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..2342
                     /gene="RBM19"
                     /gene_synonym="Mrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2403
                     /gene="RBM19"
                     /gene_synonym="Mrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2483
                     /gene="RBM19"
                     /gene_synonym="Mrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2539
                     /gene="RBM19"
                     /gene_synonym="Mrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2540..2656
                     /gene="RBM19"
                     /gene_synonym="Mrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2657..2762
                     /gene="RBM19"
                     /gene_synonym="Mrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2763..2883
                     /gene="RBM19"
                     /gene_synonym="Mrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2884..4148
                     /gene="RBM19"
                     /gene_synonym="Mrd1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3492..3497
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM19"
                     /gene_synonym="Mrd1"
                     /note="hexamer: AATAAA"
     polyA_site      3513
                     /gene="RBM19"
                     /gene_synonym="Mrd1"
     regulatory      4122..4127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM19"
                     /gene_synonym="Mrd1"
                     /note="hexamer: AGTAAA"
     polyA_site      4148
                     /gene="RBM19"
                     /gene_synonym="Mrd1"
                     /note="major polyA site"
ORIGIN      
        1 ggctcggtaa agatggcggc gcccagggcg gtagcgtgaa acttggtgga agacgctgac
       61 cagtcgtgtt ggaatcaaaa cagcggggac cctgcgccat gtcgcgactg atcgtgaaga
      121 atctcccgaa tgggatgaag gaggagcgtt tcaggcagct gtttgccgcc ttcggcacgc
      181 tgacagactg cagcctgaag ttcaccaaag atggcaagtt ccgcaagttt ggttttattg
      241 gcttcaagtc cgaggaagag gcccagaagg cacagaagca tttcaacaag agcttcatcg
      301 acacatcccg gatcacagtg gagttctgca agtcattcgg ggacccggcc aaacccagag
      361 cctggagcaa acatgcccag aaaccaagcc agcccaagca gcctccaaaa gactctacta
      421 ctccagaaat taagaaagat gagaagaaga aaaaggtggc aggtcaactg gagaagctga
      481 aggaggatac agagttccag gagtttctgt cagttcatca gaggcgggcg caggcagcca
      541 cttgggcgaa tgatggcctg gatgctgagc cctcgaaagg gaagagcaag ccggccagtg
      601 actacctgaa cttcgactcc gattctgggc aggagagtga ggaggaggga gccggggagg
      661 acctggaaga agaggcaagc ctcgaaccaa aggcagctgt gcagaaggag ctgtcggaca
      721 tggattacct gaaatccaag atggtgaagg ctgggtcgtc ctcttcctcg gaggaagagg
      781 aaagtgaaga tgaagccgtg cactgtgatg aagggagtga ggccgaggaa gaggattcct
      841 ccgccacccc agtcctgcag gaaagagaca gcaagggtgc aggccaagag caagggatgc
      901 cagctgggaa aaagagacca ccggaggcca gagccgagac agagaaacca gcaaaccaga
      961 aggaacccac cacctgccac accgtgaagc tgcggggagc cccgttcaat gtcacagaga
     1021 aaaatgttat ggaattcctg gcacccctga aaccagtggc cattcgaatt gtgagaaacg
     1081 ctcatgggaa taaaacagga tacatctttg tggatttcag caatgaagag gaagtgaagc
     1141 aagctctgaa atgcaaccgg gagtacatgg gtgggcgcta catcgaggtg ttcagggaaa
     1201 agaacgtccc caccaccaag ggtgcaccaa agaataccac caaatcctgg caaggccgga
     1261 tactcgggga gaacgaagag gaggaggacc tggccgaatc cggaaggctc tttgtacgga
     1321 acctgcccta caccagcacc gaggaggatc tggagaagct cttctccaaa tatggtcccc
     1381 tgtctgagct ccactacccc atcgacagcc tgaccaagaa acccaagggt tttgcattca
     1441 tcaccttcat gttccctgag cacgctgtga aggcctactc ggaggtggac gggcaggtat
     1501 tccagggcag gatgctccac gtgttaccat ctaccatcaa gaaggaagcc agcgaggatg
     1561 ccagtgccct gggatcgtcg tcctacaaga agaagaagga ggcccaggac aaagccaaca
     1621 gtgccagctc tcacaactgg aacacactat tcatggggcc gaatgccgtg gccgatgcca
     1681 tcgcacagaa gtacaacgcc accaagagtc aagtgtttga ccacgagacc aagggcagcg
     1741 tggccgtgcg cgtggctctg ggggaaaccc agctcgtcca ggaagtgcgg cgttttctca
     1801 tagacaacgg ggtcagcctg gattccttca gccaggctgc agcagagcga agcaagactg
     1861 tgattctggt caagaacctc ccggcaggca ccctggcggc ccagctgcag gagaccttcg
     1921 gccattttgg cagcctgggc cgcgtgctgc tgccagaggg cggaatcact gccatcgtgg
     1981 agttcctgga gcccctggag gcccgcaagg ccttcaggca tctggcctat tccaagttcc
     2041 atcatgtccc cctctatctg gagtgggctc cagttggcgt cttctccagc acagccccac
     2101 agaagaaaaa gctccaagac acaccttcag aacccatgga aaaggaccca gcagagccag
     2161 aaacagtgcc tgatggcgaa accccagaag atgaaaatcc aacagaggaa ggagcagaca
     2221 actcttcagc aaagatggaa gaggaggagg aggaagagga agaagaagaa gagagcctcc
     2281 caggatgtac tctgtttatt aagaatctca attttgacac aacagaagag aagctgaagg
     2341 aagtgttttc aaaagtgggg acagtgaaga gctgctccat ctccaagaag aagaacaaag
     2401 caggagtgct cctttccatg gggtttggat ttgtggaata caggaagccg gagcaagccc
     2461 agaaagctct caagcagctc cagggtcacg tcgtggacgg ccacaagctg gaagtgagga
     2521 tctcggaacg agccactaag ccagccgtga cattggctcg gaagaaacaa gttcccagaa
     2581 agcagaccac ctccaagatc ctggtgcgga acatcccctt ccaggcccac agccgggaga
     2641 tccgagagct cttcagcacc tttggggagt tgaagacggt ccgcctgcca aagaagatga
     2701 ctgggacagg cacacacaga ggcttcggct ttgtggactt cctcaccaag caggatgcga
     2761 agagagcctt caacgccctg tgtcacagca cccacttgta cgggcggagg ctggtgctgg
     2821 agtgggccga ctccgaggtg accctgcagg ccctgcggcg gaagacggcc gctcactttc
     2881 acgagccccc gaagaaaaag cggtctgtgg tgttggacga gatcctggag cagctggaag
     2941 gcagtgacag cgacagcgag gagcagaccc ttcagctgtg agctggcacc gagagggtgt
     3001 gtggctccgg ggccctgggg accgggacag ccgctccagc ttctgcactc accaccatgt
     3061 gggctggggg gcggggcggg gagcggcagg cggccccacc ctgcactggt ccaaggtcgg
     3121 aggagacagg ggatgaggaa ggcctcaggc cactgcccag cggcccaggc atcctgggtt
     3181 tcaccagtga cgcgttctag cagacactga ctgcgcacct gctctgtagc agacacggaa
     3241 gagtccaagg gagcagccac gttaggaaga gagacttggg aacagctaca cagggagcta
     3301 gaacccctgc tccccctgtc cccaccccag gagagtaagg ggacgagggc cagctctctg
     3361 gcatcaggct gcttggacat gaaaccccgt ctccaagctc aagctgggag accctggccc
     3421 agtttcctta tctccttggg cccagccttc cccttgctag ctagttctta cttcataagg
     3481 ttttagagag aaataaacgc agtaatgcat gaagagtgcc gggcatggtg ctgagccctg
     3541 ttcctgctct ccctccaggg ctgctgagct agaattccca cctatgtctt tccaagggac
     3601 tgttcacggc ttgggacttg gtctctgtcc tgccccatcc tcgtcacttg ggaccacgag
     3661 ccctggttca gtcacccagg gaagcctccc agcggctcat gaagcatcga gctccaagcc
     3721 cagatgccaa gctccctggc tgagctgaat gatgtcactc atggtggacg cgttctgctc
     3781 acgggcccag agccctgtga aatgcatcaa ggtcctctcc gctggccagc agcatcccca
     3841 ggcttctctc aggcgcccgt gttcacattt tctccagcct gagacgcagc ctcccgcctg
     3901 gaagggcctg tgccagcacc aggcagaggg caagacggag agggcagagc aagaactgca
     3961 ctgcatctca ctgcagtctg aatctagaca tcgccattcc ccgaggtgcg acctcagact
     4021 aatgacatcc tggctgagcc tctgtttttc tctctaggaa atgggggtga taattgtgcc
     4081 tacctcagat agacagtgcc agaattaagt gagtcaagcc aagtaaagcc cagagaagat
     4141 tctcatca
//
