LOCUS       NP_057280                960 aa            linear   PRI 27-APR-2025
DEFINITION  probable RNA-binding protein 19 [Homo sapiens].
ACCESSION   NP_057280 NP_055667 XP_947767 XP_951306 XP_951307 XP_951308
VERSION     NP_057280.2
DBSOURCE    REFSEQ: accession NM_016196.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 960)
  AUTHORS   Xie,T., Deng,L., Mei,P., Zhou,Y., Wang,B., Zhang,J., Lin,J.,
            Wei,Y., Zhang,X. and Xu,R.
  TITLE     Genome-wide association study combining pathway analysis for
            typical sporadic amyotrophic lateral sclerosis in Chinese Han
            populations
  JOURNAL   Neurobiol Aging 35 (7), 1778 (2014)
   PUBMED   24529757
REFERENCE   2  (residues 1 to 960)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (residues 1 to 960)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (residues 1 to 960)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (residues 1 to 960)
  AUTHORS   Lorenzen,J.A., Bonacci,B.B., Palmer,R.E., Wells,C., Zhang,J.,
            Haber,D.A., Goldstein,A.M. and Mayer,A.N.
  TITLE     Rbm19 is a nucleolar protein expressed in crypt/progenitor cells of
            the intestinal epithelium
  JOURNAL   Gene Expr Patterns 6 (1), 45-56 (2005)
   PUBMED   16027046
REFERENCE   6  (residues 1 to 960)
  AUTHORS   Mayer,A.N. and Fishman,M.C.
  TITLE     Nil per os encodes a conserved RNA recognition motif protein
            required for morphogenesis and cytodifferentiation of digestive
            organs in zebrafish
  JOURNAL   Development 130 (17), 3917-3928 (2003)
   PUBMED   12874115
  REMARK    GeneRIF: Primarily a zebrafish paper but shows an alignment of
            human RBM19
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB096676.1, AL117547.1,
            AC090669.9 and AC009731.6.
            
            On Apr 10, 2009 this sequence version replaced NP_057280.1.
            
            Summary: This gene encodes a nucleolar protein that contains six
            RNA-binding motifs. The encoded protein may be involved in
            regulating ribosome biogenesis. Multiple alternatively spliced
            variants, encoding the same protein, have been identified.[provided
            by RefSeq, Apr 2009].
            
            Transcript Variant: This variant (2) differs in the 3' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL117547.1, SRR1803611.237233.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261741.10/ ENSP00000261741.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..960
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.13-q24.21"
     Protein         1..960
                     /product="probable RNA-binding protein 19"
                     /calculated_mol_wt=107201
     Region          2..77
                     /region_name="RRM1_RBM19"
                     /note="RNA recognition motif 1 (RRM1) found in RNA-binding
                     protein 19 (RBM19) and similar proteins; cd12564"
                     /db_xref="CDD:409980"
     Region          85..119
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y4C8.3)"
     Region          149..294
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y4C8.3)"
     Site            174
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:21406692; propagated from
                     UniProtKB/Swiss-Prot (Q9Y4C8.3)"
     Site            176
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:21406692; propagated from
                     UniProtKB/Swiss-Prot (Q9Y4C8.3)"
     Site            180
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:21406692; propagated from
                     UniProtKB/Swiss-Prot (Q9Y4C8.3)"
     Region          294..365
                     /region_name="RRM2_RMB19"
                     /note="RNA recognition motif 2 (RRM2) found in RNA-binding
                     protein 19 (RBM19) and similar proteins; cd12502"
                     /db_xref="CDD:409925"
     Region          400..478
                     /region_name="RRM3_RBM19"
                     /note="RNA recognition motif 3 (RRM3) found in RNA-binding
                     protein 19 (RBM19) and similar proteins; cd12567"
                     /db_xref="CDD:409983"
     Region          491..513
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y4C8.3)"
     Region          587..658
                     /region_name="RRM4_RBM19"
                     /note="RNA recognition motif 4 (RRM4) found in RNA-binding
                     protein 19 (RBM19) and similar proteins; cd12569"
                     /db_xref="CDD:409984"
     Region          667..729
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y4C8.3)"
     Region          730..809
                     /region_name="RRM5_RBM19_like"
                     /note="RNA recognition motif 5 (RRM5) found in RNA-binding
                     protein 19 (RBM19 or RBD-1) and similar proteins; cd12318"
                     /db_xref="CDD:409757"
     Region          832..910
                     /region_name="RRM6_RBM19"
                     /note="RNA recognition motif 6 (RRM6) found in RNA-binding
                     protein 19 (RBM19) and similar proteins; cd12571"
                     /db_xref="CDD:409985"
     Site            936
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21406692; propagated from
                     UniProtKB/Swiss-Prot (Q9Y4C8.3)"
     Site            949
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:20068231,
                     ECO:0007744|PubMed:21406692; propagated from
                     UniProtKB/Swiss-Prot (Q9Y4C8.3)"
     Site            951
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:20068231,
                     ECO:0007744|PubMed:21406692; propagated from
                     UniProtKB/Swiss-Prot (Q9Y4C8.3)"
     CDS             1..960
                     /gene="RBM19"
                     /gene_synonym="Mrd1"
                     /coded_by="NM_016196.4:99..2981"
                     /db_xref="CCDS:CCDS9172.1"
                     /db_xref="GeneID:9904"
                     /db_xref="HGNC:HGNC:29098"
                     /db_xref="MIM:616444"
ORIGIN      
        1 msrlivknlp ngmkeerfrq lfaafgtltd cslkftkdgk frkfgfigfk seeeaqkaqk
       61 hfnksfidts ritvefcksf gdpakpraws khaqkpsqpk qppkdsttpe ikkdekkkkv
      121 agqleklked tefqeflsvh qrraqaatwa ndgldaepsk gkskpasdyl nfdsdsgqes
      181 eeegagedle eeaslepkaa vqkelsdmdy lkskmvkags sssseeeese deavhcdegs
      241 eaeeedssat pvlqerdskg agqeqgmpag kkrppearae tekpanqkep ttchtvklrg
      301 apfnvteknv meflaplkpv airivrnahg nktgyifvdf sneeevkqal kcnreymggr
      361 yievfreknv pttkgapknt tkswqgrilg eneeeedlae sgrlfvrnlp ytsteedlek
      421 lfskygplse lhypidsltk kpkgfafitf mfpehavkay sevdgqvfqg rmlhvlpsti
      481 kkeasedasa lgsssykkkk eaqdkansas shnwntlfmg pnavadaiaq kynatksqvf
      541 dhetkgsvav rvalgetqlv qevrrflidn gvsldsfsqa aaersktvil vknlpagtla
      601 aqlqetfghf gslgrvllpe ggitaivefl eplearkafr hlayskfhhv plylewapvg
      661 vfsstapqkk klqdtpsepm ekdpaepetv pdgetpeden pteegadnss akmeeeeeee
      721 eeeeeslpgc tlfiknlnfd tteeklkevf skvgtvkscs iskkknkagv llsmgfgfve
      781 yrkpeqaqka lkqlqghvvd ghklevrise ratkpavtla rkkqvprkqt tskilvrnip
      841 fqahsreire lfstfgelkt vrlpkkmtgt gthrgfgfvd fltkqdakra fnalchsthl
      901 ygrrlvlewa dsevtlqalr rktaahfhep pkkkrsvvld eileqlegsd sdseeqtlql
//
