LOCUS       NM_033117               4977 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens RNA binding motif protein 18 (RBM18), transcript
            variant 1, mRNA.
ACCESSION   NM_033117
VERSION     NM_033117.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4977)
  AUTHORS   Orvedahl,A., Sumpter,R. Jr., Xiao,G., Ng,A., Zou,Z., Tang,Y.,
            Narimatsu,M., Gilpin,C., Sun,Q., Roth,M., Forst,C.V., Wrana,J.L.,
            Zhang,Y.E., Luby-Phelps,K., Xavier,R.J., Xie,Y. and Levine,B.
  TITLE     Image-based genome-wide siRNA screen identifies selective autophagy
            factors
  JOURNAL   Nature 480 (7375), 113-117 (2011)
   PUBMED   22020285
REFERENCE   2  (bases 1 to 4977)
  AUTHORS   Tsuritani,K., Irie,T., Yamashita,R., Sakakibara,Y., Wakaguri,H.,
            Kanai,A., Mizushima-Sugano,J., Sugano,S., Nakai,K. and Suzuki,Y.
  TITLE     Distinct class of putative 'non-conserved' promoters in humans:
            comparative studies of alternative promoters of human and mouse
            genes
  JOURNAL   Genome Res 17 (7), 1005-1014 (2007)
   PUBMED   17567985
REFERENCE   3  (bases 1 to 4977)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP870502.1, DA308339.1, BC008942.2, AL162424.20, AL389986.1 and
            CA314508.1.
            
            On Nov 22, 2018 this sequence version replaced NM_033117.3.
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes the functional protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL389986.1, AK057676.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000417201.4/ ENSP00000409315.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 BP870502.1         4-4
            2-29                DA308339.1         26-53
            30-1095             BC008942.2         1-1066
            1096-1350           AL162424.20        76485-76739         c
            1351-2589           AL389986.1         1303-2541
            2590-2893           AL162424.20        74942-75245         c
            2894-3044           CA314508.1         19-169              c
            3045-4977           AL162424.20        72858-74790         c
FEATURES             Location/Qualifiers
     source          1..4977
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.2"
     gene            1..4977
                     /gene="RBM18"
                     /note="RNA binding motif protein 18"
                     /db_xref="GeneID:92400"
                     /db_xref="HGNC:HGNC:28413"
     exon            1..126
                     /gene="RBM18"
                     /inference="alignment:Splign:2.1.0"
     exon            127..255
                     /gene="RBM18"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..715
                     /gene="RBM18"
                     /codon_start=1
                     /product="probable RNA-binding protein 18"
                     /protein_id="NP_149108.1"
                     /db_xref="CCDS:CCDS6839.1"
                     /db_xref="GeneID:92400"
                     /db_xref="HGNC:HGNC:28413"
                     /translation="MEAETKTLPLENASILSEGSLQEGHRLWIGNLDPKITEYHLLKL
                     LQKFGKVKQFDFLFHKSGALEGQPRGYCFVNFETKQEAEQAIQCLNGKLALSKKLVVR
                     WAHAQVKRYDHNKNDKILPISLEPSSSTEPTQSNLSVTAKIKAIEAKLKMMAENPDAE
                     YPAAPVYSYFKPPDKKRTTPYSRTAWKSRR"
     exon            256..382
                     /gene="RBM18"
                     /inference="alignment:Splign:2.1.0"
     exon            383..469
                     /gene="RBM18"
                     /inference="alignment:Splign:2.1.0"
     exon            470..555
                     /gene="RBM18"
                     /inference="alignment:Splign:2.1.0"
     exon            556..4977
                     /gene="RBM18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      910..915
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM18"
                     /note="hexamer: AATAAA"
     polyA_site      932
                     /gene="RBM18"
                     /note="major polyA site"
     regulatory      2572..2577
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM18"
                     /note="hexamer: AATAAA"
     polyA_site      2589
                     /gene="RBM18"
                     /note="major polyA site"
     regulatory      4372..4377
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM18"
                     /note="hexamer: AATAAA"
     polyA_site      4395
                     /gene="RBM18"
                     /note="major polyA site"
     regulatory      4941..4946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM18"
                     /note="hexamer: AATAAA"
     polyA_site      4977
                     /gene="RBM18"
ORIGIN      
        1 ttaacgcgtc acgggcggcc tggcagctgg cggcattgag gcggacgcgt ctagaggtcc
       61 gtctgaccgc ggcgtcggga cctggtttcc gggcatgagc tgagagcacc acgccgaggc
      121 cacgagtatt tcatagacat tgatggaagc agaaaccaaa actcttcccc tggagaatgc
      181 atccatcctt tcagagggct ctctgcagga aggacaccga ttatggattg gcaacctgga
      241 ccccaaaatt accgaatacc acctcctcaa gctcctccag aagtttggca aggtaaagca
      301 gtttgacttc ctcttccaca agtcaggtgc tttggaggga cagcctcgag gctactgttt
      361 tgttaacttt gaaactaagc aggaagcaga gcaagccatc cagtgtctca atggcaagtt
      421 ggccctgtcc aagaagctgg tggtgcgatg ggcacatgct caagtaaaga gatatgatca
      481 taacaagaat gataagattc ttccaatcag tctcgagcca tcctcaagca ctgagcctac
      541 tcagtctaac ctaagtgtca ctgcaaagat aaaagccatt gaagcaaaac tgaaaatgat
      601 ggcggaaaat cctgatgcag agtatccagc agcgcctgtt tattcctact ttaagccacc
      661 agataaaaaa aggactactc catattctag aacagcatgg aaatctcgaa gatgatggtt
      721 gtgaattact gtagcagcaa aagcaaattg gtctccacac ctaaaatcgt ctgcctgtgt
      781 actttgtaga tgtgaatggt actattcaac ggagcacaat cacatgttag catttggtaa
      841 cataatgttt ttggatgttc ttatggatgt ttcttcccta aactatgtat ggaattgagc
      901 atcatccaga ataaatagcg ttgtatccca aattgtgatt tgaaccctgg gatgctctaa
      961 ttggctggtt ggtttggatt tgtaactcca gaaacattct atagtgtgcc agagcaaaag
     1021 gcaaatacac aaaatattat ttaaatcagg aaactaaaaa tattaacatc tattaaaaaa
     1081 ttgagcattt ttctacgctc gtgtgtcttt tacaacataa agaaaaagta aaaggcaggg
     1141 agggaagtga gagacagatt ttaaatcatg ttcagaactg ttgttccaga atttactacg
     1201 gcaatccctc caactggact gaaaaagaga aagttcttgg caaaaaggag ctgattcttt
     1261 gaacaaatgt tgtagtaatc tgtttaagaa ttatgcttat tgtttcaaaa tcccaactag
     1321 gaaaacatgg tgtatatctt aaaattgttt gtgttgacaa aactagaatc aaatttaaca
     1381 ttttatacca caacacaagt tctatttgga aattgaactt ttattctata gcaaccattt
     1441 ttttcaaatc taaataacca tgccttctat aataacaaat gttgctatta tcatgggact
     1501 tttaaaatta catttattgc atgggattgt ttttatagca tgagaatgtt ctgtttggaa
     1561 ttatatcatg gtcagtctaa atagaaaaag caaaatttct ttgaaaacct aaacattgct
     1621 atattggtca ctatcaaaca tacaattttc taataattgt gtagcggtct aagtggaaga
     1681 gattgcatta tcttgtgcag gacgaggaga ggacatgcag tgggcacaga aagtcaatgg
     1741 aacagatgcc actgtggcac caagactgta atgactctgt gtggtaggta gttttaaagg
     1801 actgcatgcc ttggaaatga ttcttcactt ggagaacata cttgcctcta gatatgtttg
     1861 tcactctaag catcctgaat ataacaatag agaaagataa gtcaaccaac agatttaggg
     1921 atgtgtttct tcagcacatt ttggtcattt tgatgccaag tttgacatac tgtttaattg
     1981 ggcagcacct ttgctccttt accaggtatg tatcactttg ttactccagg tgccattctt
     2041 ggtgatgaca gaatgtttat cactatcgtt gttagcaaga ggaagctttc aatataggaa
     2101 cttaacatct tcccatgagt ataaatgaat ttaagacatt tgaatcaaaa cttcagtaga
     2161 gggaggtttt agaattcata aaactggttt aaggaaattc tttttacttt tcccaaggtt
     2221 aatcttttta aatatctcta gacatcaaat actttctgta tgtattagct gtgtctgtct
     2281 atgatgcaag taactctcct cctatttggg ggatagttca gagaggtagg agcattatct
     2341 cccatttttc tggtgacttc ttggagtata gaattcacca ttttatccgt aagtcttcaa
     2401 aggattatgg tggactagaa cttacatagt gcaaaatagt cttctatttt taataggaac
     2461 ttagaaaaaa cttagaatta tatatagagt tgtttccttt agaaaccaga gctatttatt
     2521 tgtatttaaa gcactgttta ttatttgtac tgattcttat ccctctgtgt gaataaatgt
     2581 aagacggtgt ccgtgtggtt atatcttctc tcgttcactt actggcatag actgcagttc
     2641 tctgacaggc ttgtttccac tcaggactct ggccagcatg tccacgtggg gtgcttcttc
     2701 taagtgcctt ctctgcagag ggttctggct agagagtcaa actgagaggc aactctcttt
     2761 accctttatg cctgcctacc tctgttgtta gagatgagaa tagagaccag ctgtttccat
     2821 tgcaaatgtc actatttgaa aagaagttgt taatggaaat ctctgcaagt atcgtactgt
     2881 gtttagtctc tcgtggtaga gatttcaaaa gaagaaatgt atgtatccta aatatgctga
     2941 aagcagtctg atgaaaggtt tttaaatttc aggtgttaac ttggtcaact ctttgttagg
     3001 aggttgtctg tactttaagt aaaattattc tttggtttac tggttatttt ggtttgctaa
     3061 aattatgtca cttataattt tgatttatat acaagagtga agaattgaag gaaatactga
     3121 ggagagacgt atgaactatt ttcttcatct caattcctat tttatcaaat gcaaaatgta
     3181 atcctaacca gttgattttc tataattggt atcttagtac tggggaggag tatcacatga
     3241 ggaaagattt ttcaaagcat gtcagctgag gcacaagaat cgcttgaacc caggaggtag
     3301 aggttccagt gagccgagat tgtgccactg cactccagcc tgggcaacag agtgagacac
     3361 cgtctcaaaa aaaacaaaaa caaaacaggt caaaaatcag ttgcacaagt tgtatgaaac
     3421 caggtattct gcagctctgt ctcttgttta ttaagatatg cacagtttct gaatcaacaa
     3481 atatatctgt gattctttta tactactaca taaaagaaca ggagtaattc ttgccttata
     3541 aattaaatgt caaacatttc ctatatgtaa tcatttgttc ctaaaatatg atttagtccc
     3601 agcatgctta tccctgtttt ctctttttct ctccagctcc tatctagttc ttcaacaaat
     3661 cctgtcaact ctaccttcca aatgcctctt gaatccagcc atctcaccac ctccaacact
     3721 accaccattt ttcttaaagc caccatcatc tcttccctgg actattacaa taccttccta
     3781 attatctccc tgcctctgct attgattctt tagggtccgt tttccacaca gtagccaaag
     3841 caatttttaa aaaaattatt ttaaaatgtg attctcttct ttgtggcttt ccatcacagc
     3901 ctagaaaaaa ttgaaagatc tgtaaggccc taatgacctg tccttcacta cgtgtctgac
     3961 cctatagcct actgttctcc ccttgtgcgg tgtactgcag ccacgttggc cttcttgcta
     4021 ttctttgaat acaagggagc ttctacttca aggcatttac attggctgtt gccttagctt
     4081 agaacgctct ttctccagat agccgcagag cccgctctct cacctgactc atgtctctgc
     4141 tcaaatgtta atgatcaaga ggcagtcccc ggcctccctc ttaaaattac aacctgtcac
     4201 tctccaatcc tttcctcacg attttctcaa aagcacttac cgctaaccaa cattatatct
     4261 aaattttttt ttgtctcttt ttattggaat gtaagtttca tgtaagcagg aactgtatat
     4321 cactgctata ccctcagcat ttaaaacaat ggctgtacat catacatact caataaatat
     4381 ttgttggata aactacaaga attctggtat ttgagagcca aagggcctta agagaccatc
     4441 tcatatagcc ccctcattgt ccagatgggg aaaacgggaa cccagagaga caaagcgatt
     4501 tggccagggt cacctggtta atgggagagc tttaggtaga acccaggcct gcaaacatct
     4561 agtccagtgt tcagcaaact ggcctctgcc tcctaatttt gtatagccta caagttaaga
     4621 atgatttttt tttcattttc gagtggttga gaaaaaaagt aaacaaaata tatatactat
     4681 attgtgacat gaaaatgata cgaaattcaa atctcagtgt atgttaataa ctattagaac
     4741 acaaccatgc ccaggcattt acatgtggct gttttcccca tataatagaa gagttgaata
     4801 gttggcaatg aagactgtgg cctacaaaac ctgaaatata tactatcggt ccctttacag
     4861 gaaaaatttg ccaaacccta ctctaaacaa tattccatga ctggaaatgt gttttctaaa
     4921 attctcgtat taatgcagag aataaaagca acagatgtca gaatgatgtg caccgaa
//
