LOCUS       NM_022768               3373 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens RNA binding motif protein 15 (RBM15), transcript
            variant 1, mRNA.
ACCESSION   NM_022768
VERSION     NM_022768.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3373)
  AUTHORS   Xie,P., He,J. and Ou,Y.
  TITLE     RBM15 Promotes High Glucose-Induced Lens Epithelial Cell Injury by
            Inducing PRNP N6-Methyladenine Modification During Diabetic
            Cataract
  JOURNAL   Curr Eye Res 49 (11), 1145-1153 (2024)
   PUBMED   39206850
  REMARK    GeneRIF: RBM15 Promotes High Glucose-Induced Lens Epithelial Cell
            Injury by Inducing PRNP N6-Methyladenine Modification During
            Diabetic Cataract.
REFERENCE   2  (bases 1 to 3373)
  AUTHORS   Hu,B., Lin,D., Liu,Z., Chen,R., Liu,J., Wu,Y. and Wang,T.
  TITLE     Identification of RBM15 as a prognostic biomarker in prostate
            cancer involving the regulation of prognostic m6A-related lncRNAs
  JOURNAL   Eur J Med Res 29 (1), 411 (2024)
   PUBMED   39118157
  REMARK    GeneRIF: Identification of RBM15 as a prognostic biomarker in
            prostate cancer involving the regulation of prognostic m6A-related
            lncRNAs.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3373)
  AUTHORS   Park,S.H., Ju,J.S., Woo,H., Yun,H.J., Lee,S.B., Kim,S.H.,
            Gyorffy,B., Kim,E.J., Kim,H., Han,H.D., Eyun,S.I., Lee,J.H. and
            Park,Y.Y.
  TITLE     The m6A writer RBM15 drives the growth of triple-negative breast
            cancer cells through the stimulation of serine and glycine
            metabolism
  JOURNAL   Exp Mol Med 56 (6), 1373-1387 (2024)
   PUBMED   38825643
  REMARK    GeneRIF: The m[6]A writer RBM15 drives the growth of
            triple-negative breast cancer cells through the stimulation of
            serine and glycine metabolism.
REFERENCE   4  (bases 1 to 3373)
  AUTHORS   Wang,R. and Tan,W.
  TITLE     RBM15-Mediated N6-Methyl Adenosine (m6A) Modification of EZH2
            Drives the Epithelial-Mesenchymal Transition of Cervical Cancer
  JOURNAL   Crit Rev Eukaryot Gene Expr 34 (5), 15-29 (2024)
   PUBMED   38842201
  REMARK    GeneRIF: RBM15-Mediated N6-Methyl Adenosine (m6A) Modification of
            EZH2 Drives the Epithelial-Mesenchymal Transition of Cervical
            Cancer.
REFERENCE   5  (bases 1 to 3373)
  AUTHORS   Yuan,J., Guan,W., Li,X., Wang,F., Liu,H. and Xu,G.
  TITLE     RBM15-mediating MDR1 mRNA m6A methylation regulated by the TGF-beta
            signaling pathway in paclitaxel-resistant ovarian cancer
  JOURNAL   Int J Oncol 63 (4) (2023)
   PUBMED   37594126
  REMARK    GeneRIF: RBM15-mediating MDR1 mRNA m[6]A methylation regulated by
            the TGF-beta signaling pathway in paclitaxel-resistant ovarian
            cancer.
REFERENCE   6  (bases 1 to 3373)
  AUTHORS   Hiriart,E., Gruffat,H., Buisson,M., Mikaelian,I., Keppler,S.,
            Meresse,P., Mercher,T., Bernard,O.A., Sergeant,A. and Manet,E.
  TITLE     Interaction of the Epstein-Barr virus mRNA export factor EB2 with
            human Spen proteins SHARP, OTT1, and a novel member of the family,
            OTT3, links Spen proteins with splicing regulation and mRNA export
  JOURNAL   J Biol Chem 280 (44), 36935-36945 (2005)
   PUBMED   16129689
REFERENCE   7  (bases 1 to 3373)
  AUTHORS   Hsiao,H.H., Yang,M.Y., Liu,Y.C., Hsiao,H.P., Tseng,S.B., Chao,M.C.,
            Liu,T.C. and Lin,S.F.
  TITLE     RBM15-MKL1 (OTT-MAL) fusion transcript in an adult acute myeloid
            leukemia patient
  JOURNAL   Am J Hematol 79 (1), 43-45 (2005)
   PUBMED   15849773
  REMARK    GeneRIF: Fusion with MKL1 protein in acute myeloid leukemi.
REFERENCE   8  (bases 1 to 3373)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   9  (bases 1 to 3373)
  AUTHORS   Ma,Z., Morris,S.W., Valentine,V., Li,M., Herbrick,J.A., Cui,X.,
            Bouman,D., Li,Y., Mehta,P.K., Nizetic,D., Kaneko,Y., Chan,G.C.,
            Chan,L.C., Squire,J., Scherer,S.W. and Hitzler,J.K.
  TITLE     Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13)
            of acute megakaryoblastic leukemia
  JOURNAL   Nat Genet 28 (3), 220-221 (2001)
   PUBMED   11431691
REFERENCE   10 (bases 1 to 3373)
  AUTHORS   Mercher,T., Coniat,M.B., Monni,R., Mauchauffe,M., Nguyen Khac,F.,
            Gressin,L., Mugneret,F., Leblanc,T., Dastugue,N., Berger,R. and
            Bernard,O.A.
  TITLE     Involvement of a human gene related to the Drosophila spen gene in
            the recurrent t(1;22) translocation of acute megakaryocytic
            leukemia
  JOURNAL   Proc Natl Acad Sci U S A 98 (10), 5776-5779 (2001)
   PUBMED   11344311
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC042587.1, BC062316.1, AL355488.41 and BC047479.1.
            
            On Jul 21, 2020 this sequence version replaced NM_022768.4.
            
            Summary: Members of the SPEN (Split-end) family of proteins,
            including RBM15, have repressor function in several signaling
            pathways and may bind to RNA through interaction with spliceosome
            components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by
            OMIM, Feb 2009].
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006397.2, AF368063.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369784.9/ ENSP00000358799.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               BC042587.1         872-1074
            204-445             BC062316.1         115-356
            446-446             AL355488.41        25629-25629
            447-2892            BC047479.1         390-2835
            2893-3373           BC062316.1         2804-3284
FEATURES             Location/Qualifiers
     source          1..3373
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..3373
                     /gene="RBM15"
                     /gene_synonym="OTT; OTT1; SPEN"
                     /note="RNA binding motif protein 15"
                     /db_xref="GeneID:64783"
                     /db_xref="HGNC:HGNC:14959"
                     /db_xref="MIM:606077"
     exon            1..2892
                     /gene="RBM15"
                     /gene_synonym="OTT; OTT1; SPEN"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..2963
                     /gene="RBM15"
                     /gene_synonym="OTT; OTT1; SPEN"
                     /note="isoform 1 is encoded by transcript variant 1; one
                     twenty-two; one twenty two protein; putative RNA-binding
                     protein 15; one-twenty two protein 1"
                     /codon_start=1
                     /product="RNA-binding protein 15 isoform 1"
                     /protein_id="NP_073605.4"
                     /db_xref="CCDS:CCDS822.1"
                     /db_xref="GeneID:64783"
                     /db_xref="HGNC:HGNC:14959"
                     /db_xref="MIM:606077"
                     /translation="MRTAGRDPVPRRSPRWRRAVPLCETSAGRRVTQLRGDDLRRPAT
                     MKGKERSPVKAKRSRGGEDSTSRGERSKKLGGSGGSNGSSSGKTDSGGGSRRSLHLDK
                     SSSRGGSREYDTGGGSSSSRLHSYSSPSTKNSSGGGESRSSSRGGGGESRSSGAASSA
                     PGGGDGAEYKTLKISELGSQLSDEAVEDGLFHEFKRFGDVSVKISHLSGSGSGDERVA
                     FVNFRRPEDARAAKHARGRLVLYDRPLKIEAVYVSRRRSRSPLDKDTYPPSASVVGAS
                     VGGHRHPPGGGGGQRSLSPGGAALGYRDYRLQQLALGRLPPPPPPPLPRDLERERDYP
                     FYERVRPAYSLEPRVGAGAGAAPFREVDEISPEDDQRANRTLFLGNLDITVTESDLRR
                     AFDRFGVITEVDIKRPSRGQTSTYGFLKFENLDMSHRAKLAMSGKIIIRNPIKIGYGK
                     ATPTTRLWVGGLGPWVPLAALAREFDRFGTIRTIDYRKGDSWAYIQYESLDAAHAAWT
                     HMRGFPLGGPDRRLRVDFADTEHRYQQQYLQPLPLTHYELVTDAFGHRAPDPLRGARD
                     RTPPLLYRDRDRDLYPDSDWVPPPPPVRERSTRTAATSVPAYEPLDSLDRRRDGWSLD
                     RDRGDRDLPSSRDQPRKRRLPEESGGRHLDRSPESDRPRKRHCAPSPDRSPELSSSRD
                     RYNSDNDRSSRLLLERPSPIRDRRGSLEKSQGDKRDRKNSASAERDRKHRTTAPTEGK
                     SPLKKEDRSDGSAPSTSTASSKLKSPSQKQDGGTAPVASASPKLCLAWQGMLLLKNSN
                     FPSNMHLLQGDLQVASSLLVEGSTGGKVAQLKITQRLRLDQPKLDEVTRRIKVAGPNG
                     YAILLAVPGSSDSRSSSSSAASDTATSTQRPLRNLVSYLKQKQAAGVISLPVGGNKDK
                     ENTGVLHAFPPCEFSQQFLDSPAKALAKSEEDYLVMIIVRGFGFQIGVRYENKKRENL
                     ALTLL"
     exon            2893..3003
                     /gene="RBM15"
                     /gene_synonym="OTT; OTT1; SPEN"
                     /inference="alignment:Splign:2.1.0"
     exon            3004..3373
                     /gene="RBM15"
                     /gene_synonym="OTT; OTT1; SPEN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3349..3354
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM15"
                     /gene_synonym="OTT; OTT1; SPEN"
                     /note="hexamer: AATAAA"
     polyA_site      3373
                     /gene="RBM15"
                     /gene_synonym="OTT; OTT1; SPEN"
                     /note="major polyA site"
ORIGIN      
        1 gagactgtag aagagagagc aattggccaa tgaggactgc ggggcgggac cctgtgccgc
       61 ggcggagtcc aagatggcgg cgtgcggttc cgctgtgtga aacgagcgcg gggcggcggg
      121 ttactcagct ccgcggagac gacctccgac gacccgcaac aatgaaggga aaagagcgct
      181 cgccagtgaa ggccaaacgc tcccgtggtg gtgaggactc gacttcccgc ggtgagcgga
      241 gcaagaagtt agggggctct ggtggcagca atgggagcag cagcggaaag accgatagcg
      301 gcggtgggtc gcggcggagt ctccacctgg acaagtccag cagtcgaggt ggcagccgcg
      361 agtatgatac cggtgggggc agctccagta gccgcttgca tagttatagc tccccgagca
      421 ccaaaaattc ttcgggcggg ggcgaatcgc gcagcagctc ccggggtgga ggcggggagt
      481 cacgttcctc tggggccgcc tcctcagctc ccggcggcgg ggacggcgcg gaatacaaga
      541 ctctgaagat aagcgagttg gggtcccagc ttagtgacga agcggtggag gacggcctgt
      601 ttcatgagtt caaacgcttc ggtgatgtaa gtgtgaaaat cagtcatctg tcgggttctg
      661 gcagcgggga tgagcgggta gcctttgtga acttccggcg gccagaggac gcgcgggcgg
      721 ccaagcatgc cagaggccgc ctggtgctct atgaccggcc tctgaagata gaagctgtgt
      781 atgtgagccg gcgccgcagc cgctcccctt tagacaaaga tacttatcct ccatcagcca
      841 gtgtggtcgg ggcctctgta ggtggtcacc ggcacccccc tggaggtggt ggaggccaga
      901 gatcactttc ccctggtggc gctgctttgg gatacagaga ctaccggctg cagcagttgg
      961 ctcttggccg cctgccccct ccacctccgc caccattgcc tcgagacctg gagagagaaa
     1021 gagactaccc gttctatgag agagtgcgcc ctgcatacag tcttgagcca agggtgggag
     1081 ctggagcagg tgctgctcct ttcagagaag tggatgagat ttcacccgag gatgatcagc
     1141 gagctaaccg gacgctcttc ttgggcaacc tagacatcac tgtaacggag agtgatttaa
     1201 gaagggcgtt tgatcgcttt ggagtcatca cagaagtaga tatcaagagg ccttctcgcg
     1261 gccagactag tacttacggc tttctcaaat ttgagaactt agatatgtct caccgggcca
     1321 aattagcaat gtctggcaaa attataattc ggaatcctat caaaattggt tatggtaaag
     1381 ctacacccac cacccgcctc tgggtgggag gcctgggacc ttgggttcct cttgctgccc
     1441 tggcacgaga atttgatcga tttggcacca tacgcaccat agactaccga aaaggtgata
     1501 gttgggcata tatccagtat gaaagcctgg atgcagcgca tgctgcctgg acccatatgc
     1561 ggggcttccc acttggtggc ccagatcgac gccttagagt agactttgcc gacaccgaac
     1621 atcgttacca gcagcagtat ctgcagcctc tgcccttgac tcattatgag ctggtgacag
     1681 atgcttttgg acatcgggca ccagaccctt tgaggggtgc tcgggatagg acaccaccct
     1741 tactatacag agatcgtgat agggaccttt atcctgactc tgattgggtg ccacccccac
     1801 ccccagtccg agaacgcagc actcggactg cagctacttc tgtgcctgct tacgagccac
     1861 tggatagcct agatcgcagg cgggatggtt ggtccttgga ccgggacaga ggtgatcgag
     1921 atctgcccag cagcagagac cagcctagga agcgaaggct gcctgaggag agtggaggac
     1981 gtcatctgga taggtctcct gagagtgacc gcccacgaaa acgtcactgc gctccttctc
     2041 ctgaccgcag tccagaattg agcagtagcc gggatcgtta caacagcgac aatgatcgat
     2101 cttcccgtct tctcttggaa aggccctctc caatcagaga cagacgaggt agtttggaga
     2161 agagccaggg tgacaagcga gaccgtaaaa actctgcatc agctgaacga gataggaagc
     2221 accggacaac tgctcccact gagggaaaaa gccctctgaa aaaagaagac cgctctgatg
     2281 ggagtgcacc tagcaccagc actgcttcct ccaagctgaa gtccccgtcc cagaaacagg
     2341 atggggggac agcccctgtg gcatcagcct ctcccaaact ctgtttggcc tggcagggca
     2401 tgcttctact gaagaacagc aactttcctt ccaacatgca tctgttgcag ggtgacctcc
     2461 aagtggctag tagtcttctt gtggagggtt caactggagg caaagtggcc cagctcaaga
     2521 tcactcagcg tctccgtttg gaccagccca agttggatga agtaactcga cgcatcaaag
     2581 tagcagggcc caatggttat gccattcttt tggctgtgcc tggaagttct gacagccggt
     2641 cctcctcttc ctcagctgca tcagacactg ccacttctac tcagaggcca cttaggaacc
     2701 ttgtgtccta tttaaagcaa aagcaggcag ccggggtgat cagcctccct gtggggggca
     2761 acaaagacaa ggaaaacacc ggggtccttc atgccttccc accttgtgag ttctcccagc
     2821 agttcctgga ttcccctgcc aaggcactgg ccaaatctga agaagattac ctggtcatga
     2881 tcattgtccg tgggtttggt tttcagatag gagttaggta tgagaacaag aagagagaaa
     2941 acttggcgct gaccctgtta tagtggttat agtggtgtcc ctaaagggag gaaatgattt
     3001 cagcaaaact ggttgaacag cggatgaaga tatggaattc aaagctctaa tggacctttt
     3061 tgaagagaag ttgtggctta tgtggagttt acatgggcct ctgatggaag aaagctaatc
     3121 tgtttagtat ttgtgcattt tactaaaatg gcagcttaaa gttgtgtatc tgctattgtg
     3181 atgccaatgc cggtgtttta agtggaaaaa aaatgacctc tttgatttgt gctgtgtaca
     3241 caagatttct ggaaaagtaa agaaaaaccc tttttatggc tcacacagct taagagtagc
     3301 tgtctctcaa acgtgcgctc acagttgagc tgcttttgtt ttattctaaa taaattgttt
     3361 cttttgagga aaa
//
