LOCUS       NM_001198845            1561 bp    mRNA    linear   PRI 10-JUL-2022
DEFINITION  Homo sapiens RBM14-RBM4 readthrough (RBM14-RBM4), transcript
            variant 1, mRNA.
ACCESSION   NM_001198845
VERSION     NM_001198845.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1561)
  AUTHORS   Prakash T, Sharma VK, Adati N, Ozawa R, Kumar N, Nishida Y,
            Fujikake T, Takeda T and Taylor TD.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1561)
  AUTHORS   Brooks YS, Wang G, Yang Z, Smith KK, Bieberich E and Ko L.
  TITLE     Functional pre- mRNA trans-splicing of coactivator CoAA and
            corepressor RBM4 during stem/progenitor cell differentiation
  JOURNAL   J Biol Chem 284 (27), 18033-18046 (2009)
   PUBMED   19416963
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EU287938.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001198845.1.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring RBM14 (RNA binding motif
            protein 14) and RBM4 (RNA binding motif protein 4) genes.
            Alternative splicing results in multiple transcript variants, one
            of which encodes a fusion protein that shares sequence identity
            with each individual gene product. This fusion protein contains RRM
            and zinc finger domains, and it functions to stimulate
            transcription in a hormone and receptor-dependent manner. [provided
            by RefSeq, Nov 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1), which shares
            sequence identity with the products of both the RBM14 and RBM4
            genes.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU287938.1, SRR1163655.145425.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 5936, 10432
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1561              EU287938.1         5-1565
FEATURES             Location/Qualifiers
     source          1..1561
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..1561
                     /gene="RBM14-RBM4"
                     /gene_synonym="COAZ; PSP2; RBM14; SIP"
                     /note="RBM14-RBM4 readthrough"
                     /db_xref="GeneID:100526737"
                     /db_xref="HGNC:HGNC:38840"
     exon            1..428
                     /gene="RBM14-RBM4"
                     /gene_synonym="COAZ; PSP2; RBM14; SIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1111
                     /gene="RBM14-RBM4"
                     /gene_synonym="COAZ; PSP2; RBM14; SIP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RBM14/RBM4 fusion; transcriptional coactivator CoAZ;
                     RNA-binding protein 14; Paraspeckle protein 2; RNA-binding
                     motif protein 14; RRM-containing coactivator
                     activator/modulator; Synaptotagmin-interacting protein;
                     SYT-interacting protein"
                     /codon_start=1
                     /product="RBM14-RBM4 protein isoform 1"
                     /protein_id="NP_001185774.1"
                     /db_xref="GeneID:100526737"
                     /db_xref="HGNC:HGNC:38840"
                     /translation="MKIFVGNVDGADTTPEELAALFAPYGTVMSCAVMKQFAFVHMRE
                     NAGALRAIEALHGHELRPGRALVVEMSRPRPLNTWKIFVGNVSAACTSQELRSLFERR
                     GRVIECDVVKGKRMHVQLSTSRLRTAPGMGDQSGCYRCGKEGHWSKECPIDRSGRVAD
                     LTEQYNEQYGAVRTPYTMSYGDSLYYNNAYGALDAYYKRCRAARSYEAVAAAAASVYN
                     YAEQTLSQLPQVQNTAMASHLTSTSLDPYDRHLLPTSGAAATAAAAAAAAAAVTAAST
                     SYYGRDRSPLRRATAPVPTVGEGYGYGHESELSQASAAARNSLYDMARYEREQYADRA
                     RYSAF"
     exon            429..1119
                     /gene="RBM14-RBM4"
                     /gene_synonym="COAZ; PSP2; RBM14; SIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1561
                     /gene="RBM14-RBM4"
                     /gene_synonym="COAZ; PSP2; RBM14; SIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1541..1546
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM14-RBM4"
                     /gene_synonym="COAZ; PSP2; RBM14; SIP"
                     /note="hexamer: AATAAA"
     polyA_site      1561
                     /gene="RBM14-RBM4"
                     /gene_synonym="COAZ; PSP2; RBM14; SIP"
                     /note="major polyA site"
ORIGIN      
        1 attcctgagg aggactgccg gtcgttcgga cgtcttgcct gtcgctggag gagaggtccg
       61 ggctctccag gaaggtggct gcggcgacaa aatgaagata ttcgtgggca acgtcgacgg
      121 ggcggatacg actccggagg agctggcagc cctctttgcg ccctacggca cggtcatgag
      181 ctgcgccgtc atgaaacagt tcgccttcgt gcacatgcgc gagaacgcgg gcgcgctgcg
      241 cgccatcgaa gccctgcacg gccacgagct gcggccgggg cgcgcgctcg tggtggagat
      301 gtcgcgccca aggcctctta atacttggaa gattttcgtg ggcaatgtgt cggctgcatg
      361 cacgagccag gaactgcgca gcctcttcga gcgccgcgga cgcgtcatcg agtgtgacgt
      421 ggtgaaaggc aaacgaatgc acgtgcagtt gtccaccagc cggcttagga ctgcgcccgg
      481 gatgggagac cagagcggct gctatcggtg cgggaaagag gggcactggt ccaaagagtg
      541 tccgatagat cgttcaggcc gcgtggcaga cttgaccgag caatataatg agcaatacgg
      601 agcagtgcgt acgccttaca ccatgagcta tggggattca ttgtattaca acaacgcgta
      661 cggagcgctc gatgcctact acaagcgctg ccgtgctgcc cggtcctatg aggcagtggc
      721 agctgcagct gcctccgtgt ataattacgc agagcagacc ctgtcccagc tgccacaagt
      781 ccagaataca gccatggcca gtcacctcac ctccacctct ctcgatccct acgatagaca
      841 cctgttgccg acctcaggag ctgctgccac agctgctgct gcagcagcag ccgctgctgc
      901 tgttactgca gcttccactt catattacgg gcgggatcgg agccccctgc gtcgcgctac
      961 agccccagtc cccactgttg gagagggcta cggttacggg catgagagtg agttgtccca
     1021 agcttcagca gccgcgcgga attctctgta cgacatggcc cggtatgagc gggagcagta
     1081 tgccgatcgg gcgcggtact cagcctttta aagcttgagg tgggatgtgt gtgggctgaa
     1141 attccgagct gcggttgtgc atgagaatac acccttcgtg gtaccccatc tccgggacgt
     1201 tctcggctct gtgcgttcag tccctcagga accgtggacc ttaatttacc ttgctaagtt
     1261 cagaccttct cttcctttcc tttcctttcc tctcctgccc attttcctgt tcttctgtcc
     1321 ttcaatactt ctgtagcttc ccattcatgt tctcttctcc cagcaggcct cattgtgtgc
     1381 agaaactgtg gtgggggctg tgctgtctcc tccctgcctc ctgcctcctg cggctgttgg
     1441 atttgggaat gaccttggtg agagtctcac tgctccaggg tctctttttg gtccaaaggc
     1501 tagacctata gagttggatc actttttttc tttccggtga aataaatggt ttttcaactt
     1561 a
//
