LOCUS       NM_006328               5367 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens RNA binding motif protein 14 (RBM14), transcript
            variant 1, mRNA.
ACCESSION   NM_006328
VERSION     NM_006328.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5367)
  AUTHORS   Kweon,T.H., Jung,H., Ko,J.Y., Kang,J., Kim,W., Kim,Y., Kim,H.B.,
            Yi,E.C., Ku,N.O., Cho,J.W. and Yang,W.H.
  TITLE     O-GlcNAcylation of RBM14 contributes to elevated cellular O-GlcNAc
            through regulation of OGA protein stability
  JOURNAL   Cell Rep 43 (5), 114163 (2024)
   PUBMED   38678556
  REMARK    GeneRIF: O-GlcNAcylation of RBM14 contributes to elevated cellular
            O-GlcNAc through regulation of OGA protein stability.
REFERENCE   2  (bases 1 to 5367)
  AUTHORS   Yang,Z.Y., Zhao,C., Liu,S.L., Pan,L.J., Zhu,Y.D., Zhao,J.W.,
            Wang,H.K., Ye,Y.Y., Qiang,J., Shi,L.Q., Mei,J.W., Xie,Y., Gong,W.,
            Shu,Y.J., Dong,P. and Xiang,S.S.
  TITLE     NONO promotes gallbladder cancer cell proliferation by enhancing
            oncogenic RNA splicing of DLG1 through interaction with
            IGF2BP3/RBM14
  JOURNAL   Cancer Lett 587, 216703 (2024)
   PUBMED   38341127
  REMARK    GeneRIF: NONO promotes gallbladder cancer cell proliferation by
            enhancing oncogenic RNA splicing of DLG1 through interaction with
            IGF2BP3/RBM14.
REFERENCE   3  (bases 1 to 5367)
  AUTHORS   Wang,Y., Zhu,W., Jang,Y., Sommers,J.A., Yi,G., Puligilla,C.,
            Croteau,D.L., Yang,Y., Kai,M. and Liu,Y.
  TITLE     The RNA-binding motif protein 14 regulates telomere integrity at
            the interface of TERRA and telomeric R-loops
  JOURNAL   Nucleic Acids Res 51 (22), 12242-12260 (2023)
   PUBMED   37930826
  REMARK    GeneRIF: The RNA-binding motif protein 14 regulates telomere
            integrity at the interface of TERRA and telomeric R-loops.
REFERENCE   4  (bases 1 to 5367)
  AUTHORS   Tsuji,K., Kawata,H., Kamiakito,T., Nakaya,T. and Tanaka,A.
  TITLE     RNA-binding protein 14 promotes phase separation to sustain
            prostate specific antigen expression under androgen deprivation in
            human prostate cancer
  JOURNAL   J Steroid Biochem Mol Biol 235, 106407 (2023)
   PUBMED   37806532
  REMARK    GeneRIF: RNA-binding protein 14 promotes phase separation to
            sustain prostate specific antigen expression under androgen
            deprivation in human prostate cancer.
REFERENCE   5  (bases 1 to 5367)
  AUTHORS   Yang,Y., Lee,G.C., Nakagaki-Silva,E., Huang,Y., Peacey,M.,
            Partridge,R., Gooding,C. and Smith,C.W.J.
  TITLE     Cell-type specific regulator RBPMS switches alternative splicing
            via higher-order oligomerization and heterotypic interactions with
            other splicing regulators
  JOURNAL   Nucleic Acids Res 51 (18), 9961-9982 (2023)
   PUBMED   37548402
REFERENCE   6  (bases 1 to 5367)
  AUTHORS   Yang,Z., Sui,Y., Xiong,S., Liour,S.S., Phillips,A.C. and Ko,L.
  TITLE     Switched alternative splicing of oncogene CoAA during embryonal
            carcinoma stem cell differentiation
  JOURNAL   Nucleic Acids Res 35 (6), 1919-1932 (2007)
   PUBMED   17337438
  REMARK    GeneRIF: The switched alternative splicing of CoAA regulates stem
            cell differentiation.
REFERENCE   7  (bases 1 to 5367)
  AUTHORS   Brill,L.M., Salomon,A.R., Ficarro,S.B., Mukherji,M.,
            Stettler-Gill,M. and Peters,E.C.
  TITLE     Robust phosphoproteomic profiling of tyrosine phosphorylation sites
            from human T cells using immobilized metal affinity chromatography
            and tandem mass spectrometry
  JOURNAL   Anal Chem 76 (10), 2763-2772 (2004)
   PUBMED   15144186
REFERENCE   8  (bases 1 to 5367)
  AUTHORS   Auboeuf,D., Dowhan,D.H., Li,X., Larkin,K., Ko,L., Berget,S.M. and
            O'Malley,B.W.
  TITLE     CoAA, a nuclear receptor coactivator protein at the interface of
            transcriptional coactivation and RNA splicing
  JOURNAL   Mol Cell Biol 24 (1), 442-453 (2004)
   PUBMED   14673176
  REMARK    GeneRIF: CoAA regulates transcription-coupled alternative splicing.
REFERENCE   9  (bases 1 to 5367)
  AUTHORS   Iwasaki,T., Chin,W.W. and Ko,L.
  TITLE     Identification and characterization of RRM-containing coactivator
            activator (CoAA) as TRBP-interacting protein, and its splice
            variant as a coactivator modulator (CoAM)
  JOURNAL   J Biol Chem 276 (36), 33375-33383 (2001)
   PUBMED   11443112
  REMARK    GeneRIF: Cloning of the coactivator CoAA gene.
REFERENCE   10 (bases 1 to 5367)
  AUTHORS   Brett,D., Whitehouse,S., Antonson,P., Shipley,J., Cooper,C. and
            Goodwin,G.
  TITLE     The SYT protein involved in the t(X;18) synovial sarcoma
            translocation is a transcriptional activator localised in nuclear
            bodies
  JOURNAL   Hum Mol Genet 6 (9), 1559-1564 (1997)
   PUBMED   9285794
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB044990.1, AK021768.1 and
            AP001157.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_006328.3.
            
            Summary: This gene encodes a ribonucleoprotein that functions as a
            general nuclear coactivator, and an RNA splicing modulator. This
            protein contains two RNA recognition motifs (RRM) at the
            N-terminus, and multiple hexapeptide repeat domain at the
            C-terminus that interacts with thyroid hormone receptor-binding
            protein (TRBP), and is required for transcription activation.
            Alternatively spliced transcript variants encoding different
            isoforms (with opposing effects on transcription) have been
            described for this gene. [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1, also known as CoAA
            or coactivator activator).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.67211.1,
                                           SRR1803612.77287.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310137.5/ ENSP00000311747.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 DB044990.1         49-49
            2-2773              AK021768.1         2-2773
            2774-5367           AP001157.4         46445-49038
FEATURES             Location/Qualifiers
     source          1..5367
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..5367
                     /gene="RBM14"
                     /gene_synonym="COAA; PSP2; SIP; SYTIP1; TMEM137"
                     /note="RNA binding motif protein 14"
                     /db_xref="GeneID:10432"
                     /db_xref="HGNC:HGNC:14219"
                     /db_xref="MIM:612409"
     exon            1..428
                     /gene="RBM14"
                     /gene_synonym="COAA; PSP2; SIP; SYTIP1; TMEM137"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..2101
                     /gene="RBM14"
                     /gene_synonym="COAA; PSP2; SIP; SYTIP1; TMEM137"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane protein 137; paraspeckle protein 2;
                     SYT-interacting protein; synaptotagmin-interacting
                     protein; RRM-containing coactivator activator/modulator"
                     /codon_start=1
                     /product="RNA-binding protein 14 isoform 1"
                     /protein_id="NP_006319.1"
                     /db_xref="CCDS:CCDS8147.1"
                     /db_xref="GeneID:10432"
                     /db_xref="HGNC:HGNC:14219"
                     /db_xref="MIM:612409"
                     /translation="MKIFVGNVDGADTTPEELAALFAPYGTVMSCAVMKQFAFVHMRE
                     NAGALRAIEALHGHELRPGRALVVEMSRPRPLNTWKIFVGNVSAACTSQELRSLFERR
                     GRVIECDVVKDYAFVHMEKEADAKAAIAQLNGKEVKGKRINVELSTKGQKKGPGLAVQ
                     SGDKTKKPGAGDTAFPGTGGFSATFDYQQAFGNSTGGFDGQARQPTPPFFGRDRSPLR
                     RSPPRASYVAPLTAQPATYRAQPSVSLGAAYRAQPSASLGVGYRTQPMTAQAASYRAQ
                     PSVSLGAPYRGQLASPSSQSAAASSLGPYGGAQPSASALSSYGGQAAAASSLNSYGAQ
                     GSSLASYGNQPSSYGAQAASSYGVRAAASSYNTQGAASSLGSYGAQAASYGAQSAASS
                     LAYGAQAASYNAQPSASYNAQSAPYAAQQAASYSSQPAAYVAQPATAAAYASQPAAYA
                     AQATTPMAGSYGAQPVVQTQLNSYGAQASMGLSGSYGAQSAAAATGSYGAAAAYGAQP
                     SATLAAPYRTQSSASLAASYAAQQHPQAAASYRGQPGNAYDGAGQPSAAYLSMSQGAV
                     ANANSTPPPYERTRLSPPRASYDDPYKKAVAMSKRYGSDRRLAELSDYRRLSESQLSF
                     RRSPTKSSLDYRRLPDAHSDYARYSGSYNDYLRAAQMHSGYQRRM"
     exon            429..1893
                     /gene="RBM14"
                     /gene_synonym="COAA; PSP2; SIP; SYTIP1; TMEM137"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..5367
                     /gene="RBM14"
                     /gene_synonym="COAA; PSP2; SIP; SYTIP1; TMEM137"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2745..2750
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM14"
                     /gene_synonym="COAA; PSP2; SIP; SYTIP1; TMEM137"
                     /note="hexamer: AATAAA"
     polyA_site      2776
                     /gene="RBM14"
                     /gene_synonym="COAA; PSP2; SIP; SYTIP1; TMEM137"
                     /note="major polyA site"
ORIGIN      
        1 attcctgagg aggactgccg gtcgttcgga cgtcttgcct gtcgctggag gagaggtccg
       61 ggctctccag gaaggtggct gcggcgacaa aatgaagata ttcgtgggca acgtcgacgg
      121 ggcggatacg actccggagg agctggcagc cctctttgcg ccctacggca cggtcatgag
      181 ctgcgccgtc atgaaacagt tcgccttcgt gcacatgcgc gagaacgcgg gcgcgctgcg
      241 cgccatcgaa gccctgcacg gccacgagct gcggccgggg cgcgcgctcg tggtggagat
      301 gtcgcgccca aggcctctta atacttggaa gattttcgtg ggcaatgtgt cggctgcatg
      361 cacgagccag gaactgcgca gcctcttcga gcgccgcgga cgcgtcatcg agtgtgacgt
      421 ggtgaaagac tacgcgtttg ttcacatgga gaaggaagca gatgccaaag ccgcaatcgc
      481 gcagctcaac ggcaaagaag tgaagggcaa gcgcatcaac gtggaactct ccaccaaggg
      541 tcagaagaag gggcctggcc tggctgtcca gtctggggac aagaccaaga aaccaggggc
      601 tggggatacg gccttccctg gaactggtgg cttctctgcc accttcgact accagcaggc
      661 ttttggcaac agcactggtg gctttgatgg gcaagcccgt cagcccacac cacccttctt
      721 tggtcgcgac cgcagccctc tgcgccgttc acctccccga gcctcttatg tggctcctct
      781 gacggcccag ccagctacct accgggccca gccgtccgtg tcactgggag ctgcctacag
      841 ggcccagcct tctgcctctt tgggtgttgg ctatcggact cagcccatga cagcccaggc
      901 agcctcttac cgcgctcagc cctctgtctc ccttggggca ccatacaggg gccagctggc
      961 tagtcctagc tcccagtctg ctgcagcttc ttcactcggc ccatatggtg gagcccagcc
     1021 ctcagcctcg gccctttcct cctatggggg tcaggcagct gcagcttctt cgctcaactc
     1081 ctatggggct cagggttcct cccttgcctc ctatggtaac cagccatcct cttacggcgc
     1141 ccaggctgcc tcttcctatg gggttcgtgc agctgcttct tcctacaaca cccagggagc
     1201 agcttcctcc ttaggctcct acggggctca ggcagcctcc tatggggccc agtctgcagc
     1261 ctcctcacta gcttatggag cccaggcagc ttcatataat gcccagccct cggcctctta
     1321 caatgcccag tctgccccat atgctgcaca gcaggctgct tcctactctt cccaacctgc
     1381 tgcctatgtg gcacagccag ccacagctgc tgcctatgcc agccagccag cagcctacgc
     1441 cgcacaagcc actaccccaa tggctggctc ctatggggcc cagccggttg tgcagaccca
     1501 gctgaatagt tacggggccc aagcatcaat gggcctttca ggctcctatg gggctcagtc
     1561 ggctgctgcg gccactggct cctatggtgc cgcagcagcc tacggggccc aaccttctgc
     1621 caccctggca gctccttacc gcactcagtc atcagcctca ttggctgctt cctatgctgc
     1681 ccagcagcat ccccaggctg ctgcctccta ccgcggccag ccaggcaatg cctacgatgg
     1741 ggcaggtcag ccgtctgcag cctacctgtc catgtcccag ggggccgttg ccaacgccaa
     1801 cagcaccccg ccgccctatg agcgtacccg cctctcccca ccccgggcca gctacgacga
     1861 tccctacaaa aaggctgtcg ccatgtcgaa aaggtatggt tccgaccggc gtttagccga
     1921 gctctctgat taccgccgtt tatcagagtc gcagctttcg ttccgccgct cgccgacaaa
     1981 gtcctcgctg gattaccgtc gcctgcccga tgcccattcc gattacgcac gctattcggg
     2041 ctcctataat gattacctgc gggcggctca gatgcactct ggctaccagc gccgcatgta
     2101 gggccatcct gggatggggc accacaggga gggagggaga aaagaggtgg gtagggttac
     2161 agatccaggt tataactact ctggcccata cctttcctgg ttgtggtttt tcatgccctc
     2221 taccatgtgg gccttcccca ggagatgatc ctgttaagtg ttcggcagta acctactttg
     2281 ttccttcgcc tcagcagcaa atcttgctac tggctctaga tctgcggttt cccctctacc
     2341 ctgcctcccg tctccccaga atgggaattt cttttatgtt tttatttttt tcctggctcc
     2401 cttttatttt tgtgcgcgat atttaaggtc gtctggatgg ggaagcaacc tgcagctgag
     2461 gtcgccggcg cctttttctt tttagatggg aaggaggcca ggaaagggtc agcttaacca
     2521 tttcctatgt gccaagctgt gccagcagtc cagggtaccc tgactgtccc tctgtagact
     2581 gttgagactg agttcctgtt gggacagtca gttggtatgt atccaagtcc ctgctgacca
     2641 ctaatgttct agctgatggt gagcggcaca gtcccacttc cccatctccc caagtaggtg
     2701 gtgttagaaa accttaattt tttttccctt ttgtatggac tacaaataaa acttggggca
     2761 atttgcagtt tggaaacctg gttgtcattg tcttgattgc attcagtgtc aaaggagcca
     2821 atttgacatc caggaagaca tgatagctaa agggaaggca gtcagagaac ccaggactgg
     2881 tgaggaaagg ggtttgaatg tcggaattag aaggattgcc ctgtggccca gaaggattta
     2941 gctcatcgtc gtcctgctag cctgccatct ttcagacttt ccagggcagg tggcctggtc
     3001 ctcagccctc aacttgagtt agtcacacca aaatgcagta aatgatgccc attttcctct
     3061 gcctgtgctt gaccattttc actgactttt ctccagttca ggaataacct gtgttccaat
     3121 gggatggttc tggggtttgg cctcttagga agtggggaat gggctgctgt ggtatttaca
     3181 ggctagtaga tcctttaggc agtaggctgg aatgagtgct ggggctggga cccagaaagg
     3241 aaccagtagt ggagtggggg taatggcgtt gcctgatact gccctatggt tggaataagg
     3301 aagggcagag aaaacttgaa gcaggtatgg ggcattctgg ccatagagct cgtattttgc
     3361 ctgttgagct gtaccatgga gcatcctcct gtgtcctgcc aacccctgcc attatagtca
     3421 ccggagactc ctttacctat ccctatctgt tagggttttc agatgtcctc tcgctgggtt
     3481 tatatttgaa ggtatagaat ctgggaaagg gtggggtgca agctaaccaa atagggatgc
     3541 tagggttggg tggggaattg aggactcttc tgtgctttta ttgtagggct ggggatcgag
     3601 gatctgggca aaaaatatga catttccaac cagggacaaa atggaggctt gggcttagtg
     3661 atgggtaaat ggaagactgg ttgagtggga tgataatggg agaacttact gatgctcttt
     3721 tgggaaaagg tgctttaaag actcgatttg ggagcctact ggggcaaggc gactggggag
     3781 gtgtacgtgt tagtcaagtg gaggtcaggt gggttatctt ctgcctcctt cactggcttc
     3841 atgtgaactt gcctgtgaca gaatatcttg ccctagatgt cctcttccct cttgccatcg
     3901 tgcaaaagca ttcgatctta tgaccgtgag ttcttatttg tggatgctaa ctggggtaat
     3961 ctcagggagt actggggcca tggctctttc ccttgcttct ctttctgctc actgctttgc
     4021 tttcaggtgc ttagctgctc ctttttattt ctttgcagga ctgggaaagc atgggaggag
     4081 gattttgata agtttcttgt tctctgcgtg gtgatggggt ggtctgaggg ccaagttaat
     4141 aagcctacct ttggttatta ccctggaaaa ttgagggttg atggtagggt tatgattgtg
     4201 gcctgtgtat ttgcaatttt tctttgtcag tgtggctttc tgtcatcttc ctttttctcc
     4261 agtgagggtt ctgccactgt ctcaatccct tggttcctgc aaaaaacagc taaatgtgct
     4321 ctcagggcca gtggtgatgt tctgtgttgc agccccagct cttgaaagtg acctggccca
     4381 gatgagctct gcctgcttgt catctttagg tcctgctgcc cctgctgcct cagccctcag
     4441 gctcctaact gctcaagcca gaaggagcta caaagccaaa tcatttgtca tttttctctg
     4501 gcagattgtt ttaaaatctc cctcccctct tttattttaa ttatgccacc tgtgttaatc
     4561 ctatagcctg cttctttgct ttgtggatta ctgatttcaa gttctataac ttggggaaag
     4621 ttaggttgag tgaatgggag gacagacact gaatgtgtgt tttggaaaaa tggactctct
     4681 atcttcagat tattcagctt ctccacctat cacctctaca acttggcctt cattggagaa
     4741 gttttagttg gcttattcct ggaacaagac cacctagagg cttttagcct tgtcagcctg
     4801 ccctcttctg aggtttggac cttgttttaa attgtgtgca tggtgggctt gagactctct
     4861 tgtaatggag gtaatgggac tatcactgag gggttcagcc tatccaggta ggctaccgtt
     4921 ctagtcatac ccatcactta aattctgcca cagtctgcac agacggttgg tcctccaggc
     4981 atattgtcct attaagccaa ataggtggac atcatgggat ggatgaggtc atcatgaaaa
     5041 cagatttact ggatttatgg acctagtata tactatgtaa cagatggaaa actgaatttt
     5101 acaatctata ggtacctttg aaaggtcata aagggtaaaa gtctatagtt ttccagaaaa
     5161 taattcttaa aactgggttt tatgtctaga tttaaatcat gtatctgtct gtagtgcttc
     5221 aaatgtggcc aggtgtggta gctcacacct gtaattccca gcgctttggg aatttgaggc
     5281 aagaggattg ctagaggcca ggattttgag accagcttcg gcaatacggt gagaccttgt
     5341 ctctaccaaa agaaaagaaa aaaaaaa
//
