LOCUS       NM_001377960            8530 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens RNA binding motif protein 12B (RBM12B), transcript
            variant 1, mRNA.
ACCESSION   NM_001377960 XM_005250915
VERSION     NM_001377960.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8530)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   2  (bases 1 to 8530)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (bases 1 to 8530)
  AUTHORS   Kahle,J.J., Gulbahce,N., Shaw,C.A., Lim,J., Hill,D.E.,
            Barabasi,A.L. and Zoghbi,H.Y.
  TITLE     Comparison of an expanded ataxia interactome with patient medical
            records reveals a relationship between macular degeneration and
            ataxia
  JOURNAL   Hum Mol Genet 20 (3), 510-527 (2011)
   PUBMED   21078624
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010834.19.
            
            On Jan 23, 2020 this sequence version replaced XM_005250915.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.4344224.1,
                                           SRR14038194.891082.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144, SAMEA2467150
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000520560.6/ ENSP00000429807.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AC010834.19        92227-92355         c
            130-197             AC010834.19        91975-92042         c
            198-246             AC010834.19        88653-88701         c
            247-8530            AC010834.19        79501-87784         c
FEATURES             Location/Qualifiers
     source          1..8530
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.1"
     gene            1..8530
                     /gene="RBM12B"
                     /gene_synonym="MGC:33837"
                     /note="RNA binding motif protein 12B"
                     /db_xref="GeneID:389677"
                     /db_xref="HGNC:HGNC:32310"
     exon            1..129
                     /gene="RBM12B"
                     /gene_synonym="MGC:33837"
                     /inference="alignment:Splign:2.1.0"
     exon            130..197
                     /gene="RBM12B"
                     /gene_synonym="MGC:33837"
                     /inference="alignment:Splign:2.1.0"
     exon            198..246
                     /gene="RBM12B"
                     /gene_synonym="MGC:33837"
                     /inference="alignment:Splign:2.1.0"
     exon            247..8530
                     /gene="RBM12B"
                     /gene_synonym="MGC:33837"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..3280
                     /gene="RBM12B"
                     /gene_synonym="MGC:33837"
                     /codon_start=1
                     /product="RNA-binding protein 12B"
                     /protein_id="NP_001364889.1"
                     /db_xref="CCDS:CCDS43755.1"
                     /db_xref="GeneID:389677"
                     /db_xref="HGNC:HGNC:32310"
                     /translation="MAVVIRLLGLPFIAGPVDIRHFFTGLTIPDGGVHIIGGEIGEAF
                     IIFATDEDARRAISRSGGFIKDSSVELFLSSKAEMQKTIEMKRTDRVGRGRPGSGTSG
                     VDSLSNFIESVKEEASNSGYGSSINQDAGFHTNGTGHGNLRPRKTRPLKAENPYLFLR
                     GLPYLVNEDDVRVFFSGLCVDGVIFLKHHDGRNNGDAIVKFASCVDASGGLKCHRSFM
                     GSRFIEVMQGSEQQWIEFGGNAVKEGDVLRRSEEHSPPRGINDRHFRKRSHSKSPRRT
                     RSRSPLGFYVHLKNLSLSIDERDLRNFFRGTDLTDEQIRFLYKDENRTRYAFVMFKTL
                     KDYNTALSLHKTVLQYRPVHIDPISRKQMLKFIARYEKKRSGSLERDRPGHVSQKYSQ
                     EGNSGQKLCIYIRNFPFDVTKVEVQKFFADFLLAEDDIYLLYDDKGVGLGEALVKFKS
                     EEQAMKAERLNRRRFLGTEVLLRLISEAQIQEFGVNFSVMSSEKMQARSQSRERGDHS
                     HLFDSKDPPIYSVGAFENFRHQLEDLRQLDNFKHPQRDFRQPDRHPPEDFRHSSEDFR
                     FPPEDFRHSPEDFRRPREEDFRRPSEEDFRRPWEEDFRRPPEDDFRHPREEDWRRPLE
                     EDWRRPLEEDFRRSPTEDFRQLPEEDFRQPPEEDLRWLPEEDFRRPPEEDWRRPPEED
                     FRRPLQGEWRRPPEDDFRRPPEEDFRHSPEEDFRQSPQEHFRRPPQEHFRRPPPEHFR
                     RPPPEHFRRPPPEHFRRPPPEHFRRPPPEHFRRPPPEHFRRPPQEHFRRPPQEHFRRS
                     REEDFRHPPDEDFRGPPDEDFRHPPDEDFRSPQEEDFRCPSDEDFRQLPEEDLREAPE
                     EDPRLPDNFRPPGEDFRSPPDDFRSHRPFVNFGRPEGGKFDFGKHNMGSFPEGRFMPD
                     PKINCGSGRVTPIKIMNLPFKANVNEILDFFHGYRIIPDSVSIQYNEQGLPTGEAIVA
                     MINYNEAMAAIKDLNDRPVGPRKVKLTLL"
     regulatory      3886..3891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM12B"
                     /gene_synonym="MGC:33837"
                     /note="hexamer: AATAAA"
     polyA_site      3912
                     /gene="RBM12B"
                     /gene_synonym="MGC:33837"
                     /note="major polyA site"
     regulatory      5158..5163
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM12B"
                     /gene_synonym="MGC:33837"
                     /note="hexamer: AATAAA"
     polyA_site      5185
                     /gene="RBM12B"
                     /gene_synonym="MGC:33837"
                     /note="major polyA site"
     regulatory      8507..8512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM12B"
                     /gene_synonym="MGC:33837"
                     /note="hexamer: AATAAA"
     polyA_site      8530
                     /gene="RBM12B"
                     /gene_synonym="MGC:33837"
ORIGIN      
        1 gtccggaccg gaggggcagt gggcgccatc ttcttctggg ctcactgagg gtctacctgt
       61 tttggggagg ctgctgcgac gaagagttcc ctcagcctcc ggccttgtgt gtccgactcg
      121 gcagcagtgc ttccatgtgg tggtgtatgt gcgcttccca gggatcttga gagtgaagat
      181 ctcgaaggat ttcatagtta agttgctttt acagagttaa caggtctcca agaaatttta
      241 aaaaaggtca ttattgctgt ggtttgagct cagcatggct gtagtcatcc gtttactggg
      301 gcttcctttt attgcggggc ctgtggatat tcgtcacttc ttcacgggat tgactattcc
      361 tgatggagga gtgcatataa ttggagggga aattggggag gcttttatta tttttgcaac
      421 agatgaagat gcaagacgtg ccataagtcg ttcaggaggg tttatcaagg attcatctgt
      481 agagctcttt cttagtagca aggcagaaat gcagaagact atagaaatga aaagaactga
      541 tcgtgtagga agagggcgtc caggatctgg gacatcaggg gttgacagcc tgtctaattt
      601 tattgagtct gttaaggaag aagcaagtaa ttctggatat ggctcttcaa ttaatcaaga
      661 tgctgggttt catactaatg gtacaggaca tggtaattta aggccaagaa agacaaggcc
      721 attgaaggcc gagaatcctt acttgtttct acgaggtttg ccttacctag taaatgaaga
      781 tgatgtacgt gtctttttct ctggtttgtg cgtggatgga gtaattttct taaaacatca
      841 tgatggccga aataatggtg atgccatagt aaaatttgct tcatgtgttg atgcttcagg
      901 aggtcttaaa tgtcatagaa gttttatggg ttcaagattt atagaagtaa tgcaaggatc
      961 agaacaacag tggattgagt ttggtggtaa tgcagttaag gagggtgacg ttcttaggag
     1021 atctgaagaa cattctccac caagaggaat taatgataga cattttcgaa aacggtctca
     1081 ttcaaaatct cccagaagaa cacgttctcg ttcccctctt ggattttatg ttcacttaaa
     1141 aaatctgtcc ctcagtattg acgaaagaga tttaagaaat ttctttagag gtactgatct
     1201 gactgatgaa cagattaggt ttttatataa agatgaaaat agaacaagat atgcctttgt
     1261 gatgttcaag actctgaaag actataatac cgctctgagt ttacataaga ctgttttaca
     1321 atatcgtcca gttcatattg atccaatttc tagaaaacaa atgctgaagt tcattgcacg
     1381 ttatgaaaag aagagatcag ggtcactaga gagagatagg cccggacatg tttcacaaaa
     1441 atactctcaa gaaggtaact ctggccagaa actgtgcatc tatataagaa attttccatt
     1501 tgatgttaca aaagttgaag tgcagaagtt ctttgcagac tttcttcttg ctgaggatga
     1561 catttacttg ctttatgatg acaaaggtgt tggtctggga gaagcattag tgaaatttaa
     1621 atcagaagaa caggccatga aagctgaacg tttaaaccga cgaagattcc tagggacaga
     1681 ggtgttatta agacttatat ctgaggcaca aatacaggag tttggtgtaa atttttctgt
     1741 gatgtccagt gaaaaaatgc aagctcgctc acagtcacgt gagcgaggtg accattccca
     1801 tttatttgac tcaaaagacc caccaatata ctcagttggt gcttttgaaa actttagaca
     1861 tcagctagag gacttgaggc aactggataa cttcaagcat ccccagaggg atttccggca
     1921 gcctgacagg caccctccag aagacttccg acactcctca gaggacttta ggttcccccc
     1981 ggaggacttc aggcactccc cagaggactt caggcgacct agggaggaag acttcaggcg
     2041 gccttctgag gaggacttca ggcgcccttg ggaggaagat ttcaggcgcc ctccggagga
     2101 tgacttcagg caccctaggg aggaggactg gaggaggccc cttgaggagg actggaggcg
     2161 gccactggag gaggatttca ggcggtctcc cacggaggac ttcaggcagc tccccgagga
     2221 ggacttcagg caaccccctg aggaggactt aaggtggctc ccagaggaag atttcaggcg
     2281 gccacctgag gaggactgga gacggccccc agaggaggac tttaggcggc ctcttcaggg
     2341 agaatggagg cgaccacccg aggatgactt caggcggccc ccagaggagg atttcaggca
     2401 ttcccctgag gaggacttca ggcagtcacc ccaggagcat ttccggaggc cacctcagga
     2461 gcatttccgt cggccacccc cagagcattt ccggagacca cctccagagc attttaggcg
     2521 gcctccccca gagcacttcc ggcggccacc cccagagcac ttcaggcggc cacccccaga
     2581 gcatttcagg cgcccgcccc cggagcactt ccggagaccg ccccaggagc atttcaggcg
     2641 gccgcctcag gagcatttca ggcgctcccg agaggaagat ttcaggcacc caccagatga
     2701 agacttcagg ggccctcctg atgaagactt taggcaccct cctgatgagg acttcaggag
     2761 cccccaggag gaagatttta gatgcccttc tgatgaggac ttcaggcagc tcccagagga
     2821 agaccttagg gaagctccgg aggaggaccc tagacttcct gacaatttta gacctcctgg
     2881 tgaggatttt aggagcccgc ctgatgattt tagaagtcac cgcccttttg tgaattttgg
     2941 tcgcccagaa ggtggcaagt ttgattttgg aaagcataat atgggaagtt ttcctgaggg
     3001 gagatttatg cctgatccaa aaataaattg tggttcaggt agagtaactc ctattaagat
     3061 aatgaatctt ccatttaaag ctaatgtgaa tgaaatttta gactttttcc atggttacag
     3121 aatcatacct gattcagttt cgatacagta taatgagcaa ggcttaccta caggggaagc
     3181 cattgttgct atgataaact ataatgaagc tatggctgct attaaagatc taaatgatag
     3241 gccagttggg ccccgaaaag ttaagttaac tttgctgtag agagagagca tttctaaatt
     3301 cagttatctt ccttgcagta ttgatggagt aaaatacatt tgttttaaaa aagtgttttt
     3361 tttttaaatt atctaatgaa atattttatt tttgacctgt gaatagaaca aatgtaaata
     3421 gtagaatgtg aatctggttt tcttttgctt gcaaattgcc attctttttt tttttcaaat
     3481 ttaaaattac acatgctgtt tttttctttg atggggagaa agaactcatt ccctgagttc
     3541 attcattttt gttgatgtca tcggtaatct tcaagactta ttgaagtaga gttgtatttg
     3601 gggaagatac attttatatt cacttttttt tttctttctg tagtctacct cttttactca
     3661 aactgtataa ggaaatagtg actgattgtt caggtttggc attttcattg ctacctgcct
     3721 gcagaattaa tgccctcttc cttgtctaag atattactgt gttaagtgtc ctgttaatta
     3781 taaatagttc aaaatggaca gactgtcaac ttgaaattta cttatgtaaa aagcttaggt
     3841 gattcttagg gtttccatgt tcataacttt acaaagcttt ataaaaataa aattgcaact
     3901 taatagagct aattaacttg tatttgtata aaaagaaaaa agaattgcag ctcgatattg
     3961 tgaagttttt caataacttc attaaaccat atttatgatg ggagggacca gacattctat
     4021 agtaataatg tatagtgctg tgtataattc catggtttct tcaacatctt atcaaccaag
     4081 taaaattaat acaagatacg caaaagatag taaaataaga atctaattat aggtgcaagg
     4141 ggactcaggc ttatgctgga agaatctgac aagtggtata gtttgttttt ctaggaagaa
     4201 tttactgatg agtcacataa cttgcatgta atattaggtt ctcatttttt agcttcgaaa
     4261 ctgtgtccat gcaaagactc tataactgtt aagacttgtg tggttgaatt ttgacttctt
     4321 tgatattcag catttagtgc atacattttg caactaggga atttgatttt ctatacccac
     4381 aataatattt atggctaaca tttattaggc acttactatg tgctaggcac tgtaagcact
     4441 ttacatgcat aatctcggta ttccctgtga gtacagggtt aattatttac ctctatttca
     4501 caaatgagat aatgaagtgg gatgaagtgc gaggttaagc aacttgcttg aagtcatagg
     4561 tagtaaatcg tggggccaat tttaacccag acagaccact gactccagtt catgcttttg
     4621 ctgcctcact tttttaagtg gtatttttaa ttaggaagac catgctaaag atactttcaa
     4681 ggataaatga ttattttctc acttcaattg ttggtttaaa attagcataa ataggtaaaa
     4741 ccagcatgct caaacactga gctcaaacat taacattact aataaaaaaa aaaagagtga
     4801 ctttaaaagt ttctttctat ccagggtttc tcttgggata ctcatatggt atattactgg
     4861 cttatatttc aaaattattt tattcaacat gattgacttt ggccttttat aatttacata
     4921 aaacataatt ttcctcagtt ctgtaatcca gattttcccc attgagtaaa taatacaatt
     4981 aaatttacat atggtaattt agacatttaa taggatattg cataggtaga atactttgtc
     5041 agtacttagt tactacctat atgtattttt gtgttacttt tcagtgattt aaagaaatct
     5101 aacagaaatc tgcttaaatt tgttttaaat agtgaatatc ctgcttgcta tggaatgaat
     5161 aaacaggtaa atttgatatg aaaaagcacc tcagtatgat tctttaaagt ataagcttgt
     5221 aagtagctag gataatgtta aattgattgt ttggaatatc caaaccaagc acaatgaaga
     5281 aagtagaaat gatattttta attgagcaaa gattgtatag atggttcatt tggtcaccca
     5341 ttttgaataa tatatggaaa gttaaaaaat gcttctcaga tacaaaggaa taaagctaag
     5401 atgaagctta acgtgaggga ttacttactg tggaattgca tttcaaactg ggctgaggtg
     5461 ggatggtggt ggtagataag aggccagcta gagtaaacat aagctttgta gttttattat
     5521 tttaagagtc agagtcttgt tctgctggcc aggctggagt gcagtggtct gataatggtt
     5581 cactgcagct tctaactcct gggctcaagc tgtcttcctg cctcagcctc ctgagagctg
     5641 ggactacagg tgtgtgccac cttgtctggc taaatttttt attatttgta gagacagagt
     5701 ctcactgtgt tgcccaggct gttctcaaat ttctggcctc aagcaatcct cactccttgg
     5761 tctcccagaa tgtgttggga ttacaggtgt gagccactgt gcccagcctt gtattttgat
     5821 ttttaaatta atttatatga atatttcctt ttaccctata atgtatcagg gcttaatatt
     5881 tttaaacttc attataaaaa gttgattaca gaaagtggta tcttctagtt gggagccatc
     5941 tttgcacatc tctctccaac tctgccttta gtgatatgtc aataacaaat tggccatggc
     6001 aggagtattt tacaccatgg aaagtgataa atgcagcaaa tcaaggaatt cccctcctgt
     6061 tgtcccctca gaaagccagc ttcccagcac ctcatcaatt tcaaatataa aaaaagaata
     6121 gtaaattttc atgtacacat cactcagctt cagtaattgt cgtctcatag ccagtttttc
     6181 ctctcctatc ctcaaggtat accaggtaca ctggaggtgt attctctagc ctgataccca
     6241 gtggcatttg tcttaaagcc aaacattttt gtctagaaat tatctaaaaa aatgtagatc
     6301 atgtctagaa agtcaatccc acaaccaaga gataggtaaa aatcatgtta ggagtgcatt
     6361 tctattaatt tactgagatc actgttaaga gcagtgattc ttgatccata tatcacctgt
     6421 taagtagtga ccttgctgcc tctgtttttg cagtaaatat tagctgttgt ttattgagct
     6481 gtattagata ctatatgatg tataattatg tatgaattaa ctatcattta attctgataa
     6541 tcctagtaaa tgtactacag gttgagtatt cctaatctgg taatctgaaa tttcacatgc
     6601 tccgaaaatc acaaactttt tgagtgccaa catgatgctc aaagaaaatg ctcattgcag
     6661 catttaagat ttcagatttt tgggttagga atgttgaact ggtataatgc aaatactcca
     6721 aaatctgaag aaatccaaag tcttaaatac ttctggtccc aagcacttca gataaaggat
     6781 actcaatttg tattcctatt ttggagataa gagatggaga cttacaggct gggttggttg
     6841 gattggttgc ctgttttttg ttgttgttgt agtggaagct aggaatggtt tttcacattt
     6901 tttaagtgta cttaagtctt acatggttac atagttacct gtataatagt cttgaatttg
     6961 cctaaaccca cgaagaataa cagtatttgc tatctggccc tttaagaagt ttgccaacct
     7021 aggctggtct aaataatgaa aattttacat taatgaaagt attttcatgg atagtattcc
     7081 ttttgttctt agaatatttc tttgaggtag gcagaatgta tgttttattc cagaattact
     7141 gttttacgca gttttaactt tacaaacaag gcaaataatg ctcaagagaa gttgctattt
     7201 agtaagcagc aaaataataa ctctgttgtt ttcccccgaa gtacaaccaa atttaaatac
     7261 tgagtgagga agcagtaaat atccaatgat atcttgagtt tcttaagaat atcaatttag
     7321 ggttttaaaa tgttttaaat attttacaaa aaagtactga aacaactttg tcacttagga
     7381 ctattctcag gaaggagtgc tttgttaaga acagagccat gattgacaaa gtcagaagct
     7441 ttctagaaag tctttatttt tctgttatga ataattgcat tttctaatta tcccaaatga
     7501 ttttataaat tccgtaactt ttatatgcct gcctgggatc catgaaataa aagtattcct
     7561 taccaaaaga gaagcatcag atacactgaa aggctcaatg ttttatattt tcagaaataa
     7621 aagtgactgt ataccctttt attaactata tggtagcttg gtaaaatttt tatagaattt
     7681 ttaatgatct atggtgttct atgatgaggc aacattccac caaattagcc ttccaaaagt
     7741 tgcagtatca tgtataatta tgacagcagt tttgttttaa aaccagagtc agattgaatg
     7801 tagctttttt acagctgaaa tttatgcctt atgtgtattc ataaaacatt gataacttag
     7861 tgtcacatta tctttactct ttggttatac tcttcttgaa aagtaaattt acttatcaaa
     7921 tgataaagtt tcagggaaag ttaaaaaaag ttttttttct taaggcttca tggaatagaa
     7981 ttccatgaat cataatgact acgtaagacc cttttctggt aatgaaagca tggagtctta
     8041 accaaaaagc taagcagaat tgttagatct tttggtttct gtcataatgt actattggaa
     8101 cttcaagtag atatagtaca ttaatatgaa atactttgaa atacaccatc tttaaaaaaa
     8161 aaggcactta cacaaaaatc atgtaacact aggtaggatg ttgaaatgac tggtatgcaa
     8221 tattttttaa agccttcatt tttggtcagc ataagtttcc tttaattatt tttctgtttc
     8281 cagttggact tcactttgag gcttaacata gcaaagtgag tataaagttc tacaatttag
     8341 tcattgtgga tttcaagtca tttatgatga aaatggaaat gtgtagttta cttaagaaaa
     8401 ttttcttctt ctgtaacatc taactcgtca tcctcatcat cttctgcttg ttgatccttt
     8461 cttagtcgac aagtggatac ctgttaaaag ttaacacact ttttaaaata aaaatactaa
     8521 cttaaaaaaa
//
