LOCUS       NM_006047               6646 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens RNA binding motif protein 12 (RBM12), transcript
            variant 1, mRNA.
ACCESSION   NM_006047
VERSION     NM_006047.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6646)
  AUTHORS   Gao,C., Zhu,R., Shen,J., Xu,T., She,Y. and Chen,Z.
  TITLE     RBM12 regulates the progression of hepatocellular cancer via
            miR-497-5p/CPNE1 Axis
  JOURNAL   Environ Res 239 (Pt 1), 117203 (2023)
   PUBMED   37793588
  REMARK    GeneRIF: RBM12 regulates the progression of hepatocellular cancer
            via miR-497-5p/CPNE1 Axis.
REFERENCE   2  (bases 1 to 6646)
  AUTHORS   Semesta,K.M., Garces,A. and Tsvetanova,N.G.
  TITLE     The psychosis risk factor RBM12 encodes a novel repressor of
            GPCR/cAMP signal transduction
  JOURNAL   J Biol Chem 299 (9), 105133 (2023)
   PUBMED   37543364
  REMARK    GeneRIF: The psychosis risk factor RBM12 encodes a novel repressor
            of GPCR/cAMP signal transduction.
REFERENCE   3  (bases 1 to 6646)
  AUTHORS   Wakabayashi,A., Kihiu,M., Sharma,M., Thrasher,A.J., Saari,M.S.,
            Quesnel-Vallieres,M., Abdulmalik,O., Peslak,S.A., Khandros,E.,
            Keller,C.A., Giardine,B.M., Barash,Y., Hardison,R.C., Shi,J. and
            Blobel,G.A.
  TITLE     Identification and characterization of RBM12 as a novel regulator
            of fetal hemoglobin expression
  JOURNAL   Blood Adv 6 (23), 5956-5968 (2022)
   PUBMED   35622975
  REMARK    GeneRIF: Identification and characterization of RBM12 as a novel
            regulator of fetal hemoglobin expression.
REFERENCE   4  (bases 1 to 6646)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 6646)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   6  (bases 1 to 6646)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   7  (bases 1 to 6646)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   8  (bases 1 to 6646)
  AUTHORS   Yang,W., Ng,P., Zhao,M., Wong,T.K., Yiu,S.M. and Lau,Y.L.
  TITLE     Promoter-sharing by different genes in human genome--CPNE1 and
            RBM12 gene pair as an example
  JOURNAL   BMC Genomics 9, 456 (2008)
   PUBMED   18831769
  REMARK    GeneRIF: RBM12 shares a promoter and 5'UTR exons with CPNE1. This
            genomic structure is conserved among multiple species.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 6646)
  AUTHORS   Stover,C., Gradl,G., Jentsch,I., Speicher,M.R., Wieser,R. and
            Schwaeble,W.
  TITLE     cDNA cloning, chromosome assignment, and genomic structure of a
            human gene encoding a novel member of the RBM family
  JOURNAL   Cytogenet Cell Genet 92 (3-4), 225-230 (2001)
   PUBMED   11435693
REFERENCE   10 (bases 1 to 6646)
  AUTHORS   Ueki,N., Oda,T., Kondo,M., Yano,K., Noguchi,T. and Muramatsu,M.
  TITLE     Selection system for genes encoding nuclear-targeted proteins
  JOURNAL   Nat Biotechnol 16 (13), 1338-1342 (1998)
   PUBMED   9853615
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB060608.1, AF345332.1,
            AL109827.8 and AA825305.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006047.5.
            
            Summary: This gene encodes a protein that contains several
            RNA-binding motifs, potential transmembrane domains, and
            proline-rich regions. This gene and the gene for copine I overlap
            at map location 20q11.21. Alternative splicing in the 5' UTR
            results in four transcript variants. All variants encode the same
            protein. [provided by RefSeq, Nov 2010].
            
            Transcript Variant: This variant (1) is the predominant transcript.
            All variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.192945.1,
                                           SRR1660809.199569.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155550, SAMEA2467144
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374114.8/ ENSP00000363228.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                DB060608.1         57-76
            21-3613             AF345332.1         1-3593
            3614-6585           AL109827.8         54537-57508         c
            6586-6646           AA825305.1         23-83               c
FEATURES             Location/Qualifiers
     source          1..6646
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.22"
     gene            1..6646
                     /gene="RBM12"
                     /gene_synonym="HRIHFB2091; SCZD19; SWAN"
                     /note="RNA binding motif protein 12"
                     /db_xref="GeneID:10137"
                     /db_xref="HGNC:HGNC:9898"
                     /db_xref="MIM:607179"
     exon            1..141
                     /gene="RBM12"
                     /gene_synonym="HRIHFB2091; SCZD19; SWAN"
                     /inference="alignment:Splign:2.1.0"
     exon            142..226
                     /gene="RBM12"
                     /gene_synonym="HRIHFB2091; SCZD19; SWAN"
                     /inference="alignment:Splign:2.1.0"
     exon            227..6646
                     /gene="RBM12"
                     /gene_synonym="HRIHFB2091; SCZD19; SWAN"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..3047
                     /gene="RBM12"
                     /gene_synonym="HRIHFB2091; SCZD19; SWAN"
                     /note="SH3/WW domain anchor protein in the nucleus"
                     /codon_start=1
                     /product="RNA-binding protein 12"
                     /protein_id="NP_006038.2"
                     /db_xref="CCDS:CCDS13261.1"
                     /db_xref="GeneID:10137"
                     /db_xref="HGNC:HGNC:9898"
                     /db_xref="MIM:607179"
                     /translation="MAVVIRLQGLPIVAGTMDIRHFFSGLTIPDGGVHIVGGELGEAF
                     IVFATDEDARLGMMRTGGTIKGSKVTLLLSSKTEMQNMIELSRRRFETANLDIPPANA
                     SRSGPPPSSGMSSRVNLPTTVSNFNNPSPSVVTATTSVHESNKNIQTFSTASVGTAPP
                     NMGASFGSPTFSSTVPSTASPMNTVPPPPIPPIPAMPSLPPMPSIPPIPVPPPVPTLP
                     PVPPVPPIPPVPSVPPMTPLPPMSGMPPLNPPPVAPLPAGMNGSGAPMNLNNNLNPMF
                     LGPLNPVNPIQMNSQSSVKPLPINPDDLYVSVHGMPFSAMENDVRDFFHGLRVDAVHL
                     LKDHVGRNNGNGLVKFLSPQDTFEALKRNRMLMIQRYVEVSPATERQWVAAGGHITFK
                     QNMGPSGQTHPPPQTLPRSKSPSGQKRSRSRSPHEAGFCVYLKGLPFEAENKHVIDFF
                     KKLDIVEDSIYIAYGPNGKATGEGFVEFRNEADYKAALCRHKQYMGNRFIQVHPITKK
                     GMLEKIDMIRKRLQNFSYDQREMILNPEGDVNSAKVCAHITNIPFSITKMDVLQFLEG
                     IPVDENAVHVLVDNNGQGLGQALVQFKNEDDARKSERLHRKKLNGREAFVHVVTLEDM
                     REIEKNPPAQGKKGLKMPVPGNPAVPGMPNAGLPGVGLPSAGLPGAGLPSTGLPGSAI
                     TSAGLPGAGMPSAGIPSAGGEEHAFLTVGSKEANNGPPFNFPGNFGGSNAFGPPIPPP
                     GLGGGAFGDARPGMPSVGNSGLPGLGLDVPGFGGGPNNLSGPSGFGGGPQNFGNGPGS
                     LGGPPGFGSGPPGLGSAPGHLGGPPAFGPGPGPGPGPGPIHIGGPPGFASSSGKPGPT
                     VIKVQNMPFTVSIDEILDFFYGYQVIPGSVCLKYNEKGMPTGEAMVAFESRDEATAAV
                     IDLNDRPIGSRKVKLVLG"
     regulatory      3528..3533
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM12"
                     /gene_synonym="HRIHFB2091; SCZD19; SWAN"
                     /note="hexamer: AATAAA"
     polyA_site      3548
                     /gene="RBM12"
                     /gene_synonym="HRIHFB2091; SCZD19; SWAN"
                     /note="major polyA site"
     regulatory      5403..5408
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM12"
                     /gene_synonym="HRIHFB2091; SCZD19; SWAN"
                     /note="hexamer: ATTAAA"
     polyA_site      5430
                     /gene="RBM12"
                     /gene_synonym="HRIHFB2091; SCZD19; SWAN"
                     /note="major polyA site"
     regulatory      6594..6599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM12"
                     /gene_synonym="HRIHFB2091; SCZD19; SWAN"
                     /note="hexamer: AATAAA"
     regulatory      6610..6615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM12"
                     /gene_synonym="HRIHFB2091; SCZD19; SWAN"
                     /note="hexamer: AATAAA"
     polyA_site      6616
                     /gene="RBM12"
                     /gene_synonym="HRIHFB2091; SCZD19; SWAN"
                     /note="major polyA site"
     polyA_site      6646
                     /gene="RBM12"
                     /gene_synonym="HRIHFB2091; SCZD19; SWAN"
ORIGIN      
        1 attttgtgaa gcggcgaagg aggtggtggc tgcgttgggc tccgggaagc cgttcgggct
       61 ggggctgtcg gccgcggggc ggaggcactc gcgcgggggg taattcgggg tctgggttct
      121 ggtgccgcgc agctttcccc gtctaaaagt tggttttaat tggttgccca caggattgac
      181 ttggcctcta cttcttgtta aggaaattca tctcttgttt tatcaggtgt gtgtggtttc
      241 agcgcagcat ggctgtggtc atccgtttgc aaggtctccc aattgtggcg gggaccatgg
      301 acattcgcca cttcttctct ggattgacca ttcctgatgg gggcgtgcat attgtagggg
      361 gtgaactggg tgaggctttc atcgtttttg ccactgatga agatgcaagg cttggtatga
      421 tgcgcacagg tggtacaatt aaagggtcaa aagtaacact attgttgagt agtaagacgg
      481 aaatgcagaa tatgattgaa ctgagtcgta ggcgttttga aactgccaac ttagatatac
      541 caccagcaaa tgccagtaga tcaggaccac cacctagctc aggaatgagt agcagggtaa
      601 acttgcccac aacagtatcc aactttaata atccatcacc cagtgtagtt actgccacca
      661 cttctgttca tgaaagcaac aaaaacatac agacattttc cacagccagc gtaggaacag
      721 ctcctccaaa tatgggggct tcctttggga gcccaacgtt tagctcaact gttccaagca
      781 cagcctctcc aatgaacaca gtcccgccgc caccaattcc tccaattcca gcgatgccat
      841 ctctgccacc aatgccatcc attcccccaa ttccagttcc tcctccagta cctacattgc
      901 ctcctgtgcc tcctgtgccc ccgattcccc cagttccttc tgtgccaccc atgaccccac
      961 tgccacccat gtcgggcatg ccgcccttga atccgccacc tgtggcacct ctacctgctg
     1021 gaatgaatgg ctctggagca cctatgaatt tgaacaataa tctgaatcct atgtttcttg
     1081 gtccgttgaa tcctgttaac cctatccaga tgaactctca gagcagtgtg aagccactcc
     1141 ccatcaaccc tgatgatctg tatgtcagtg tgcatggaat gcccttttct gcaatggaaa
     1201 atgatgtcag agattttttt catgggctcc gtgttgatgc agtgcatttg ttgaaagatc
     1261 atgtaggtcg aaataatggg aatggattgg ttaagtttct ctcccctcaa gatacatttg
     1321 aagctttgaa acgaaacaga atgctgatga ttcaacgcta tgtggaagtt agccctgcca
     1381 cagaaagaca gtgggtagct gctggaggcc atatcacttt taagcaaaat atgggacctt
     1441 ctggacaaac tcatccccct cctcagacac ttcccaggtc aaaatcgccc agtgggcaga
     1501 aaagatcaag gtcaagatca ccacatgagg ctggtttttg tgtttacttg aaagggctac
     1561 catttgaagc agaaaacaaa catgtcattg atttttttaa aaagctggat attgtggaag
     1621 atagtattta tatagcttat ggacccaatg ggaaagcaac tggcgaaggc tttgtagagt
     1681 tcagaaatga ggctgactat aaggctgctc tgtgtcgtca taaacagtac atgggcaatc
     1741 gctttattca agttcatcca attactaaga aaggtatgct agaaaagata gatatgattc
     1801 gaaaaagact gcagaacttc agctatgacc agagggaaat gatactaaat ccagaggggg
     1861 atgtcaactc tgccaaagtc tgtgcccaca taacaaatat tccattcagc attacaaaga
     1921 tggatgttct tcagttccta gaaggaatcc cagtggatga aaatgctgta catgttcttg
     1981 ttgataacaa tgggcaaggt ctaggacagg cattggttca gtttaaaaat gaagatgatg
     2041 cacgtaagtc tgaacgctta caccgtaaaa aacttaatgg gagagaagct tttgttcatg
     2101 tagttaccct agaagatatg agagagattg agaaaaatcc ccctgcccaa ggaaaaaagg
     2161 gattaaagat gcctgtgcca ggtaatcctg cagttccagg aatgcccaat gcgggactgc
     2221 ccggtgtggg actgcccagt gcaggacttc ccggtgcagg cctgcccagc acaggactgc
     2281 ctggttcagc aataaccagt gcaggactgc ctggtgcggg aatgcccagt gcaggaatac
     2341 ctagtgcagg aggtgaagag catgccttcc tgactgtagg atcaaaggaa gccaataatg
     2401 ggcctccatt taactttcct ggtaattttg gtggatcaaa tgcctttggg ccaccaatcc
     2461 ctcctccagg attaggaggc ggggcctttg gtgatgctag gcctggtatg ccttcagttg
     2521 gaaacagtgg tttgcctggt ctaggactgg atgttccggg ttttggaggt ggaccaaaca
     2581 atttaagtgg gccatcggga tttggagggg gccctcagaa ttttggaaat ggccctggta
     2641 gcttaggcgg tcccccgggg tttggaagtg gccctcctgg tcttggaagt gcccctgggc
     2701 atttgggtgg gccaccagct tttgggcctg gccccggccc cggccccggc cctggcccaa
     2761 tccatattgg tggtccccct ggctttgcat ctagttctgg aaaaccagga ccgacagtaa
     2821 ttaaagtgca aaacatgccc tttactgtgt ctattgatga gattttagat ttcttttatg
     2881 gctatcaagt aatcccaggc tcagtgtgtt taaaatacaa tgaaaaaggt atgcccacag
     2941 gtgaagccat ggtggccttt gagtctcggg atgaagccac agctgctgtc attgacttaa
     3001 atgacaggcc tataggttca agaaaagtaa aacttgtatt agggtagcca ttcacatcat
     3061 tttttatagg gtagatcttc atattgctgt gattaatgca tccagattgt tttcctagta
     3121 tttccaggtt agaacctgtg gattgtttca attgcatata gcttggtttc cataacatag
     3181 agcattggtt gactgtttac agaagactca ctcaccagga taaacattgc tgtatgttac
     3241 agtaaagcta tctggagaga acacataaat gattttggca taccattaga gaaaccattt
     3301 gtaaaactca aatgaccaca taaagcttat caaggagtct agattggttt tgttttatac
     3361 catatgggat gaagaaaata gaaatgtcag tagaactcat tgagggtgct cttgccagct
     3421 gctgaaaata gaagttggct actctcagaa tttggtttaa agctggacag atttgctttg
     3481 ttatagggta aagctttgtc taaagtcctc attttctttt aaaattgaat aaaatttctg
     3541 tatacagatt cattgtatgt acctttattg cttcttaagg gtccttgctg tatagacagt
     3601 cctgcttcag aagttgctgc tttgtttgtc taattgactc atttgtaaat gagcagaact
     3661 gttttgttgg tttttttccc taaatataaa agtccacact tcgtttgtgc tataacctca
     3721 aactttgatt tctaatgtca cacttaaaac tgtgtggaat aagacttttg ccataaaaat
     3781 aaactatgga gtcctttatc taccagagcc tttttggttt gaccgccacg atttaggtta
     3841 gtcagtttaa aaattgttca tgttgtttgg atggtatcga aaaccagaaa ccacttttaa
     3901 taatgtgttt aagatacttg atttgaagtc cttttcatat ggactaattg tagtatcaat
     3961 ttcctcctgt cccgattatg tgaaattttg gcctttaaac aaagaggggc ccattcataa
     4021 gaaagtgtta tatctaggtt tttaaaactg aagttgaaat tatctttgtt agcagtagta
     4081 gtatagaata aaagatccgt atgctggttc gtagattgat acgtgttagt cctgttattt
     4141 ggaggctttt tggcatagtt gttcgatcag gagcctgttt actaaaagtc ttcatacaga
     4201 gtacaagtgc agccgccaga ggagaaaatt gagattcttg accctttcat actcttttct
     4261 ttggtattca ggacactaag gcaggaggac cacatgagtt ctggttggta agtgtccttg
     4321 tcatgaaaac acttgcctta caaggctcta attatgattt ccctagtcag tgctctgaag
     4381 atgtgtcaca ttatattata aacaatacgg aaggggagat aggtgagatg atatgaaaaa
     4441 caaattttct cactgtcata aaaggctcta attatggtta ctttccttgt gatgaaaaac
     4501 ttggccttac agggctctag ttatggttac tttccctagt caatgctctg aaaatgtgtc
     4561 acattataaa caatacagaa ggagagatag atgagagatc atgaaaacca aattttatct
     4621 tttacatggc ccctttgtct tcgtttgaaa catccccaac atttcctaca aatcagcgta
     4681 gttacaaagg ggtcagtctt ttaaaataag tatttcctat taaactatat atatatacag
     4741 tgcctttttg gtgttgtgag tcagtggaac actgaaatac agcggttgtg taatttaaga
     4801 gtggcaacag tttcatttga taagatttga aaaggctttt tatcactaca atcttagagg
     4861 attgacagta caggattttt gtttaagaga aggattgttt agactcaaga ggtgactatg
     4921 ttgtgggtct tttgataatt catgaataca gatttgcttt gaccgatcac tagatactgc
     4981 ctcctcaatt tcaaaagcaa tataacgttt gtatatgctg tttaatttaa gttaatgtta
     5041 agtaatcatt tctcattcca aagacaatgc aaaaaacttc agcactgctt gagagttgta
     5101 tttcagccac agatattttc tccattggaa agctattttc attttagaaa aatgggttgt
     5161 ttgaagatga aagtctttta tcttttttca caatttattt tggttatatg ttcgtacatt
     5221 cttattaaat atttcataca ctttattgca actactttgt tatttctaca tcttagataa
     5281 atgctgaaaa ggaaaacgat ttcattgttc atctaattaa ataaattaaa agagcggttt
     5341 gtgtagaaat tggagagaac tatgttttat atgaatcaca acagtgctcg ttgtggactg
     5401 taattaaatg ctttgccctc tggaacttga tttttgtgta tctgagattt attaacagtg
     5461 ctaactgcta aggatactgt ttatcttgtt ctgggcattg gagtttcagt ttttaaaaaa
     5521 ttcttgaaaa tgtattctgt gaaactactc atacctctct tcctgcgaat tttctcctaa
     5581 gaactaggtt tggggtagaa atgaattgac attattttct catttgcttt gtatggtatg
     5641 aaggatttgt aaagctttgc tcaaagttgt gtgcatttgt aaacactatc atgatatttt
     5701 caattttatg tgtaaatttt attgtctgtt tttggtgact ctgacattaa tggaagagaa
     5761 tattttccat tagatttaat tttttttcct ctcccttctg attttttttt tattggtgtt
     5821 catttttctt ttgatttaaa ggattagaga aatctacaaa tgtatgtcat aaataagcaa
     5881 atttgtaaac ttttctgaac tttagtgaaa catttagttc acaagcataa tttggaggtg
     5941 tgttctgtgt ttacacagta gtttggatgt acaattatta ttagtggctt tttaaaaaat
     6001 gaaacagtgt taagtgaaat gtagttccta gctttgtact ccaagttgtc aaagcatcaa
     6061 caatgaaaat tcgattagga aactttattt aaaatttcag gtagtaatat tcagtgtagt
     6121 taaggccagt cttaacccac tggatgaaaa tctaggactg tatggaagta agcaaacatt
     6181 acatttttag gtggaaatag tcagccttgc ataaaaacaa ggatgcgtga aagccttaaa
     6241 ttccagctcc cttttactgg agtctgtggt tgtgtacagg tatgggccaa gtgtaaaatc
     6301 tcatcaattt taagaacact cgggaaatga gtaaagaaaa tgtaaaattg ctgctagtca
     6361 aatcttttgg aaagaatttc tggaagtggt cactttaaaa attattttcc acccttgcaa
     6421 aattgccaca tttaaattgt tttactggca gttctatagt agtccagact ttagaaacca
     6481 aacacaacaa aatggcttgt tgccaatatg gccacaacat tgccagcaaa tactgccttg
     6541 gcatcactca gcagaggttt ttgtttataa agatgaagtc ttgaatactg ttcaataaac
     6601 ttgtcaaaaa ataaaacagg ctgatgcttt taatgcttta actgca
//
