LOCUS       NM_144770               1955 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens RNA binding motif protein 11 (RBM11), transcript
            variant 1, mRNA.
ACCESSION   NM_144770
VERSION     NM_144770.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1955)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1955)
  AUTHORS   Fu,C., Yuan,M., Sun,J., Liu,G., Zhao,X., Chang,W. and Ma,Z.
  TITLE     RNA-Binding Motif Protein 11 (RBM11) Serves as a Prognostic
            Biomarker and Promotes Ovarian Cancer Progression
  JOURNAL   Dis Markers 2021, 3037337 (2021)
   PUBMED   34434291
  REMARK    GeneRIF: RNA-Binding Motif Protein 11 (RBM11) Serves as a
            Prognostic Biomarker and Promotes Ovarian Cancer Progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1955)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1955)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1955)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1955)
  AUTHORS   Pedrotti,S., Busa,R., Compagnucci,C. and Sette,C.
  TITLE     The RNA recognition motif protein RBM11 is a novel tissue-specific
            splicing regulator
  JOURNAL   Nucleic Acids Res 40 (3), 1021-1032 (2012)
   PUBMED   21984414
REFERENCE   7  (bases 1 to 1955)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   8  (bases 1 to 1955)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   9  (bases 1 to 1955)
  AUTHORS   Brun,M.E., Ruault,M., Ventura,M., Roizes,G. and De Sario,A.
  TITLE     Juxtacentromeric region of human chromosome 21: a boundary between
            centromeric heterochromatin and euchromatic chromosome arms
  JOURNAL   Gene 312, 41-50 (2003)
   PUBMED   12909339
REFERENCE   10 (bases 1 to 1955)
  AUTHORS   Gardiner,K., Slavov,D., Bechtel,L. and Davisson,M.
  TITLE     Annotation of human chromosome 21 for relevance to Down syndrome:
            gene structure and expression analysis
  JOURNAL   Genomics 79 (6), 833-843 (2002)
   PUBMED   12036298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB153254.1 and BC030196.1.
            
            On Nov 22, 2018 this sequence version replaced NM_144770.4.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030196.1, SRR5189667.238519.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000400577.4/ ENSP00000383421.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                CB153254.1         28-48
            22-1955             BC030196.1         1-1934
FEATURES             Location/Qualifiers
     source          1..1955
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q11.2"
     gene            1..1955
                     /gene="RBM11"
                     /note="RNA binding motif protein 11"
                     /db_xref="GeneID:54033"
                     /db_xref="HGNC:HGNC:9897"
                     /db_xref="MIM:617937"
     exon            1..126
                     /gene="RBM11"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..876
                     /gene="RBM11"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative RNA-binding protein 11; splicing regulator RBM11"
                     /codon_start=1
                     /product="splicing regulator RBM11 isoform 1"
                     /protein_id="NP_658983.3"
                     /db_xref="CCDS:CCDS46635.1"
                     /db_xref="GeneID:54033"
                     /db_xref="HGNC:HGNC:9897"
                     /db_xref="MIM:617937"
                     /translation="MFPAQEEADRTVFVGNLEARVREEILYELFLQAGPLTKVTICKD
                     REGKPKSFGFVCFKHPESVSYAIALLNGIRLYGRPINVQYRFGSSRSSEPANQSFESC
                     VKINSHNYRNEEMLVGRSSFPMQYFPINNTSLPQEYFLFQKMQWHVYNPVLQLPYYEM
                     TAPLPNSASVSSSLNHVPDLEAGPSSYKWTHQQPSDSDLYQMTAPLPNSASVSSSLNH
                     VPDLEAGPSSYKWTHQQPSDSDLYQMNKRKRQKQTSDSDSSTDNNRGNECSQKFRKSK
                     KKKRY"
     exon            127..289
                     /gene="RBM11"
                     /inference="alignment:Splign:2.1.0"
     exon            290..362
                     /gene="RBM11"
                     /inference="alignment:Splign:2.1.0"
     exon            363..462
                     /gene="RBM11"
                     /inference="alignment:Splign:2.1.0"
     exon            463..1955
                     /gene="RBM11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      950..955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM11"
                     /note="hexamer: AATAAA"
     polyA_site      984
                     /gene="RBM11"
                     /note="major polyA site"
     regulatory      1739..1744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM11"
                     /note="hexamer: AATAAA"
     polyA_site      1756
                     /gene="RBM11"
     regulatory      1933..1938
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM11"
                     /note="hexamer: AATAAA"
     polyA_site      1955
                     /gene="RBM11"
                     /note="major polyA site"
ORIGIN      
        1 cctacttcat tctacggccg agaccggagg atgttccctg ctcaggagga ggccgacagg
       61 accgtgtttg ttgggaattt agaggcccga gttcgggaag agattctgta cgagctgttc
      121 cttcaggcgg ggccactaac caaagtgact atatgcaaag acagagaagg aaagccaaag
      181 tcttttggat ttgtctgctt taaacaccca gaatcggtgt cttatgccat agctttgctg
      241 aatggaattc gtttatatgg aagaccaatt aacgtgcagt atcgatttgg gagttctcgc
      301 tcttctgaac cagctaacca aagttttgag agctgtgtta agataaattc acacaactac
      361 aggaatgaag aaatgttggt gggcagatct tcctttccca tgcagtattt tccaattaat
      421 aatacttctt tacctcaaga atattttctc tttcagaaga tgcagtggca tgtgtataat
      481 ccagtgctgc agcttcctta ctatgaaatg acagctccac ttcctaatag tgcatccgtg
      541 tcttcctcac tgaatcatgt tccagatctt gaggctggac ccagctcata taaatggact
      601 caccaacaac caagtgactc tgacctttat cagatgacag ctccacttcc taatagtgca
      661 tccgtgtctt cctcactgaa tcatgttcca gatcttgagg ctggacccag ctcatataaa
      721 tggactcacc aacaaccaag tgactctgac ctttatcaga tgaataaacg aaagagacaa
      781 aagcaaacaa gtgatagtga tagtagcaca gacaacaaca gaggcaacga atgtagccaa
      841 aagttccgaa agtctaagaa gaagaaaaga tactagtatt acctacaaat gaaacttacc
      901 tacactgatc ttagttctct tatgaaaaaa ataagatgtt atcccatcaa ataaacaatg
      961 tcatggctat cttgtctttt gaaatatgta gtaataagac ttatctctgg tttgctgttc
     1021 aatttttgcc ttgaacgaca aaagctttct aaaaatagta taatgtacca ctttttgtat
     1081 ttgtcatgat atttttgacc cattggcaac aaatagacta ttgtcatttt attagtacca
     1141 atgatgaaat ttcaccaaac tattaatcaa aagtcactta ttgaacacat tgataaagca
     1201 tcatgttccc tttgattatc ccctataacc aacactcaac tacaaatagg ctgggattca
     1261 atgtggagtg gtggatttcc tgaaagaaag tagtgcagat atttaaggat tgcatattgt
     1321 tcctaatgag gatgtaataa acaggcatta gtaccccttt cttttagtac ctaaatatgt
     1381 tgtttctgag ccatattctt cttcaggttt attttataaa gtgaggacat atgataatga
     1441 taccaaagga aagataatta tcatgaaacc aacttttgga tcattccctt tttatacaat
     1501 tgtgtattta tagggatacc ttcctcttct cacatattaa ttgtatgtca ttaaaatcag
     1561 ttggctatgt cagtgtgtat tattcacctc ttttgctagc aaggtttgag atgctatatt
     1621 aacatttaaa tcatgaaaat gagcaagtaa atagaataat attttattaa tgtatgatat
     1681 gtaatactta ttgtctaaat caagtttcct atttttggtt tatttatttt agaagaaaaa
     1741 taaaattatt tgggcatttt tgtttatagc tcattacaaa ctagagtgat gaatatatat
     1801 atttactaaa gctaattgaa agagtcatgc aactcagttg ggaattaacc actcaattca
     1861 atagtaaaag ccatgcttgg atgtttcttt tgcatgttgc ctagcatttt atagatattt
     1921 attatttaaa aaaataaaga tatgttttta atgaa
//
