LOCUS       NM_152856               3163 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens RNA binding motif protein 10 (RBM10), transcript
            variant 2, mRNA.
ACCESSION   NM_152856
VERSION     NM_152856.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3163)
  AUTHORS   Chang,J., Zhang,Y., Zhou,T., Qiao,Q., Shan,J., Chen,Y., Jiang,W.,
            Wang,Y., Liu,S., Wang,Y., Yu,Y., Li,C. and Li,X.
  TITLE     RBM10 C761Y mutation induced oncogenic ASPM isoforms and regulated
            beta-catenin signaling in cholangiocarcinoma
  JOURNAL   J Exp Clin Cancer Res 43 (1), 104 (2024)
   PUBMED   38576051
  REMARK    GeneRIF: RBM10 C761Y mutation induced oncogenic ASPM isoforms and
            regulated beta-catenin signaling in cholangiocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3163)
  AUTHORS   Li,Y., Wei,D., Chen,Z., Chen,Y., Deng,Y., Li,M., Zhao,Y. and Niu,K.
  TITLE     RBM10 regulates the tumorigenic potential of human cancer cells by
            modulating PPM1B and YBX1 activities
  JOURNAL   Exp Cell Res 435 (2), 113932 (2024)
   PUBMED   38246397
  REMARK    GeneRIF: RBM10 regulates the tumorigenic potential of human cancer
            cells by modulating PPM1B and YBX1 activities.
REFERENCE   3  (bases 1 to 3163)
  AUTHORS   Tripathi,S., Sengar,S., Shree,B., Mohapatra,S., Basu,A. and
            Sharma,V.
  TITLE     An RBM10 and NF-kappaB interacting host lncRNA promotes JEV
            replication and neuronal cell death
  JOURNAL   J Virol 97 (12), e0118323 (2023)
   PUBMED   37991381
  REMARK    GeneRIF: An RBM10 and NF-kappaB interacting host lncRNA promotes
            JEV replication and neuronal cell death.
REFERENCE   4  (bases 1 to 3163)
  AUTHORS   Lee,H., Jung,J.H., Ko,H.M., Park,H., Segall,A.M., Sheffmaker,R.L.,
            Wang,J., Frey,W.D., Pham,N., Wang,Y., Zhang,Y., Jackson,J.G.,
            Zeng,S.X. and Lu,H.
  TITLE     RNA-binding motif protein 10 inactivates c-Myc by partnering with
            ribosomal proteins uL18 and uL5
  JOURNAL   Proc Natl Acad Sci U S A 120 (49), e2308292120 (2023)
   PUBMED   38032932
  REMARK    GeneRIF: RNA-binding motif protein 10 inactivates c-Myc by
            partnering with ribosomal proteins uL18 and uL5.
REFERENCE   5  (bases 1 to 3163)
  AUTHORS   Cao,Y., Di,X., Cong,S., Tian,C., Wang,Y., Jin,X., Zhao,M., Zhou,X.,
            Li,R. and Wang,K.
  TITLE     RBM10 recruits METTL3 to induce N6-methyladenosine-MALAT1-dependent
            modification, inhibiting the invasion and migration of NSCLC
  JOURNAL   Life Sci 315, 121359 (2023)
   PUBMED   36608868
  REMARK    GeneRIF: RBM10 recruits METTL3 to induce
            N6-methyladenosine-MALAT1-dependent modification, inhibiting the
            invasion and migration of NSCLC.
REFERENCE   6  (bases 1 to 3163)
  AUTHORS   Martinez-Arribas,F., Agudo,D., Pollan,M., Gomez-Esquer,F.,
            Diaz-Gil,G., Lucas,R. and Schneider,J.
  TITLE     Positive correlation between the expression of X-chromosome RBM
            genes (RBMX, RBM3, RBM10) and the proapoptotic Bax gene in human
            breast cancer
  JOURNAL   J Cell Biochem 97 (6), 1275-1282 (2006)
   PUBMED   16552754
  REMARK    GeneRIF: From these results, it seems that the X-chromosome,
            through its RBM genes, plays a formerly unknown role in the
            regulation of programmed cell death (apoptosis) in breast cancer.
REFERENCE   7  (bases 1 to 3163)
  AUTHORS   Thiselton,D.L., McDowall,J., Brandau,O., Ramser,J., d'Esposito,F.,
            Bhattacharya,S.S., Ross,M.T., Hardcastle,A.J. and Meindl,A.
  TITLE     An integrated, functionally annotated gene map of the DXS8026-ELK1
            interval on human Xp11.3-Xp11.23: potential hotspot for
            neurogenetic disorders
  JOURNAL   Genomics 79 (4), 560-572 (2002)
   PUBMED   11944989
  REMARK    Erratum:[Genomics 2002 Jun;79(6):891]
REFERENCE   8  (bases 1 to 3163)
  AUTHORS   Inoue,A., Takahashi,K.P., Kimura,M., Watanabe,T. and Morisawa,S.
  TITLE     Molecular cloning of a RNA binding protein, S1-1
  JOURNAL   Nucleic Acids Res 24 (15), 2990-2997 (1996)
   PUBMED   8760884
REFERENCE   9  (bases 1 to 3163)
  AUTHORS   Coleman,M.P., Ambrose,H.J., Carrel,L., Nemeth,A.H., Willard,H.F.
            and Davies,K.E.
  TITLE     A novel gene, DXS8237E, lies within 20 kb upstream of UBE1 in
            Xp11.23 and has a different X inactivation status
  JOURNAL   Genomics 31 (1), 135-138 (1996)
   PUBMED   8808293
REFERENCE   10 (bases 1 to 3163)
  AUTHORS   Gorlin,R.J., Cervenka,J., Anderson,R.C., Sauk,J.J. and Bevis,W.D.
  TITLE     Robin's syndrome. A probably X-linked recessive subvariety
            exhibiting persistence of left superior vena cava and atrial septal
            defect
  JOURNAL   Am J Dis Child 119 (2), 176-178 (1970)
   PUBMED   5410571
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB183041.1 and BC003089.1.
            
            On May 31, 2019 this sequence version replaced NM_152856.2.
            
            Summary: This gene encodes a nuclear protein that belongs to a
            family proteins that contain an RNA-binding motif. The encoded
            protein associates with hnRNP proteins and may be involved in
            regulating alternative splicing. Defects in this gene are the cause
            of the X-linked recessive disorder, TARP syndrome. Alternate
            splicing results in multiple transcript variants.[provided by
            RefSeq, Mar 2011].
            
            Transcript Variant: This variant (2) lacks an in-frame exon and
            uses and alternate splice site in the coding region, compared to
            variant 1. The encoded isoform (2) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003089.1, GQ900942.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                DB183041.1         4-61
            59-3163             BC003089.1         1-3105
FEATURES             Location/Qualifiers
     source          1..3163
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.3"
     gene            1..3163
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /note="RNA binding motif protein 10"
                     /db_xref="GeneID:8241"
                     /db_xref="HGNC:HGNC:9896"
                     /db_xref="MIM:300080"
     exon            1..265
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            266..407
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     CDS             391..2949
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /note="isoform 2 is encoded by transcript variant 2;
                     RNA-binding protein S1-1; g patch domain-containing
                     protein 9; epididymis secretory sperm binding protein;
                     G-patch domain containing 9; zinc finger RANBP2-type
                     containing 5"
                     /codon_start=1
                     /product="RNA-binding protein 10 isoform 2"
                     /protein_id="NP_690595.1"
                     /db_xref="CCDS:CCDS78478.1"
                     /db_xref="GeneID:8241"
                     /db_xref="HGNC:HGNC:9896"
                     /db_xref="MIM:300080"
                     /translation="MEYERRGGRGDRTGRYGATDRSQDDGGENRSRDHDYRDMDYRSY
                     PREYGSQEGKHDYDDSSEEQSAEIRGQLQSHGVQAREVRLMRNKSSGQSRGFAFVEFS
                     HLQDATRWMEANQHSLNILGQKVSMHYSDPKPKINEDWLCNKCGVQNFKRREKCFKCG
                     VPKSEAEQKLPLGTRLDQQTLPLGGRELSQGLLPLPQPYQAQGVLASQALSQGSEPSS
                     ENANDTIILRNLNPHSTMDSILGALAPYAVLSSSNVRVIKDKQTQLNRGFAFIQLSTI
                     EAAQLLQILQALHPPLTIDGKTINVEFAKGSKRDMASNEGSRISAASVASTAIAAAQW
                     AISQASQGGEGTWATSEEPPVDYSYYQQDEGYGNSQGTESSLYAHGYLKGTKGPGITG
                     TKGDPTGAGPEASLEPGADSVSMQAFSRAQPGAAPGIYQQSAEASSSQGTAANSQSYT
                     IMSPAVLKSELQSPTHPSSALPPATSPTAQESYSQYPVPDVSTYQYDETSGYYYDPQT
                     GLYYDPNSQYYYNAQSQQYLYWDGERRTYVPALEQSADGHKETGAPSKEGKEKKEKHK
                     TKTAQQIAKDMERWARSLNKQKENFKNSFQPISSLRDDERRESATADAGYAILEKKGA
                     LAERQHTSMDLPKLASDDRPSPPRGLVAAYSGESDSEEEQERGGPEREEKLTDWQKLA
                     CLLCRRQFPSKEALIRHQQLSGLHKQNLEIHRRAHLSENELEALEKNDMEQMKYRDRA
                     AERREKYGIPEPPEPKRRKYGGISTASVDFEQPTRDGLGSDNIGSRMLQAMGWKEGSG
                     LGRKKQGIVTPIEAQTRVRGSGLGARGSSYGVTSTESYKETLHKTMVTRFNEAQ"
     exon            408..591
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            592..661
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            662..735
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            736..822
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            823..883
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1060
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1218
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1316
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1404
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1591
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1731
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1849
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1941
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2106
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2256
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..2322
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2511
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..2586
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2587..2693
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2694..2823
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2824..3163
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3142..3147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /note="hexamer: AATAAA"
     polyA_site      3163
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /note="major polyA site"
ORIGIN      
        1 agtaggtgga tggtggtcgg agcgccgact cccttctcgt cgtcgccatt ttgagctggt
       61 gactgtggcc ggctgggagt aggcggcagt gagtttccct gggagggcag cgcgcttggc
      121 gcttctcccc tccccccgat ctgcctccag tctcggactt ggttgttgcg cgctccggct
      181 ccggctgagc tgggagagtt ggaggaggtg gcggcgggca gaggtgatgt ctgggagccc
      241 ttccttgaca gcccgggccg agaagagtcc ctgcaggaag catcacccag gctggcagat
      301 catggtagca gcagcggggg tggctgggaa gtgaaacgga gccagcggct gaggaggggc
      361 cccagcagcc cccgaaggcc ctatcaggac atggagtatg aaagacgtgg tggtcgtggt
      421 gacaggactg gccgctatgg agccactgac cgctcgcagg atgatggtgg ggagaaccgc
      481 agccgagacc acgactaccg ggacatggac taccgttcat atcctcgcga gtatggcagc
      541 caggagggca agcatgacta tgacgactca tctgaggagc agagtgcgga gatccgtggc
      601 cagctgcagt cgcacggcgt gcaagcacgg gaggttcggc tgatgcggaa caaatcttca
      661 ggtcagagcc ggggcttcgc cttcgtcgag tttagtcact tgcaggacgc tacacgatgg
      721 atggaagcca atcagcactc cctcaacatc ctgggccaga aggtgtcgat gcactacagt
      781 gaccccaagc ccaagatcaa tgaggactgg ctgtgcaata agtgtggcgt ccagaacttc
      841 aaacgccgag agaagtgctt caaatgtggc gtgcccaagt cagaggcaga gcagaagctg
      901 cccctcggca cgaggctgga tcagcagaca ctgccactgg gtggccggga gctgagccag
      961 ggcctgcttc ccctgccgca gccctaccag gcccagggag tcctggcctc ccaagccctg
     1021 tcacagggct cggagccaag ctcagagaac gccaatgaca ccatcatttt gcgcaacctg
     1081 aacccacaca gcaccatgga ttccatcctg ggggccctgg caccctacgc ggtgctgtcc
     1141 tcctccaacg tgcgcgtcat aaaggacaag cagacccaac tgaaccgcgg ctttgccttc
     1201 atccagctct ccaccatcga ggcagcccag ctgctgcaga tcctgcaggc cctgcaccca
     1261 ccactcacta tcgacggcaa gaccatcaat gttgagtttg ccaagggttc taagagggac
     1321 atggcctcca atgaaggcag tcgcatcagt gctgcctctg tggccagcac tgccattgct
     1381 gcggcccagt gggccatctc acaggcctcc caaggtgggg agggtacctg ggccacctcc
     1441 gaggagccgc cggtcgacta cagctactac caacaggatg agggctatgg caacagccag
     1501 ggcacagagt cttccctcta tgcccatggc tacctcaagg gcaccaaggg ccctggcatc
     1561 actggaacca aaggggatcc cactggagca ggtcccgagg cctccctaga gcctggggcc
     1621 gactctgtgt cgatgcaggc tttctctcgc gcccagcctg gtgctgctcc tggcatctac
     1681 caacaatcag ccgaggcgag cagtagccag ggcactgctg ccaacagcca gtcgtatacc
     1741 atcatgtcac ccgctgtgct caaatctgag ctccagagcc ctacccatcc tagttctgct
     1801 ctcccaccgg ctaccagccc cactgcccag gaatcctaca gccagtaccc tgttcccgac
     1861 gtctctacct accagtacga tgagacctcc ggctactact atgaccccca gaccggcctc
     1921 tactatgacc ccaactccca gtattactac aatgctcaga gccagcagta cctgtactgg
     1981 gatggggaga ggcggaccta tgttcccgcc ctggagcagt cggccgacgg acataaggag
     2041 acaggggcac cctcgaagga gggcaaagag aagaaggaga agcacaagac caagacagct
     2101 caacagattg ccaaggacat ggaacgctgg gcccgcagtc tcaacaaaca aaaagaaaac
     2161 ttcaaaaata gcttccagcc tatcagctcc ctgcgagatg acgagaggcg ggagtcagcc
     2221 actgcagatg ctggctatgc catcctcgag aagaagggag cactagccga gagacagcac
     2281 accagcatgg atctcccgaa attggccagt gacgaccgcc caagccctcc gcgaggactg
     2341 gtggcagcct acagcgggga gagtgacagt gaggaggagc aggagcgtgg gggccctgag
     2401 cgggaggaga agctcaccga ctggcagaag ctggcctgtc tgctctgccg acgccagttc
     2461 cccagcaaag aggcgctcat ccggcaccag cagctctcag ggctccacaa gcaaaacctt
     2521 gagattcacc ggcgagccca cttgtcagaa aacgagctag aagcactaga gaagaatgac
     2581 atggagcaaa tgaagtaccg ggaccgtgca gctgaacgca gagaaaagta tggcatcccc
     2641 gagccgccag agcccaagag gaggaagtac ggcggcatat ccacagcctc tgtagacttc
     2701 gagcagccta ctcgggacgg gctgggcagt gacaacattg gcagtcggat gctgcaggcc
     2761 atgggctgga aagagggcag cggcctgggc cgcaagaagc agggcattgt aacgcctatc
     2821 gaggcccaaa cacgggtgcg gggctccggc ctgggtgcac ggggcagctc ctacggggtc
     2881 acctcaaccg agtcctacaa ggagacactg cacaagacaa tggtgacccg cttcaacgag
     2941 gcccagtgag cagcttcaag agcaacttct ccacatgttg ggtgtccatc ctggggcagg
     3001 gaaggacaga gtgttggatg gctgggacgg ggccttgctc ttgtcggcca gcccactccc
     3061 cagccagaga gggcttgacc aaatcaaatt gaggtggtga cttttgttgg aaaattgggc
     3121 tgggatcacg tcctgttttg taataaaagc tgaaaagtct gca
//
