LOCUS       NM_005676               3397 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens RNA binding motif protein 10 (RBM10), transcript
            variant 1, mRNA.
ACCESSION   NM_005676
VERSION     NM_005676.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3397)
  AUTHORS   Chang,J., Zhang,Y., Zhou,T., Qiao,Q., Shan,J., Chen,Y., Jiang,W.,
            Wang,Y., Liu,S., Wang,Y., Yu,Y., Li,C. and Li,X.
  TITLE     RBM10 C761Y mutation induced oncogenic ASPM isoforms and regulated
            beta-catenin signaling in cholangiocarcinoma
  JOURNAL   J Exp Clin Cancer Res 43 (1), 104 (2024)
   PUBMED   38576051
  REMARK    GeneRIF: RBM10 C761Y mutation induced oncogenic ASPM isoforms and
            regulated beta-catenin signaling in cholangiocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3397)
  AUTHORS   Li,Y., Wei,D., Chen,Z., Chen,Y., Deng,Y., Li,M., Zhao,Y. and Niu,K.
  TITLE     RBM10 regulates the tumorigenic potential of human cancer cells by
            modulating PPM1B and YBX1 activities
  JOURNAL   Exp Cell Res 435 (2), 113932 (2024)
   PUBMED   38246397
  REMARK    GeneRIF: RBM10 regulates the tumorigenic potential of human cancer
            cells by modulating PPM1B and YBX1 activities.
REFERENCE   3  (bases 1 to 3397)
  AUTHORS   Tripathi,S., Sengar,S., Shree,B., Mohapatra,S., Basu,A. and
            Sharma,V.
  TITLE     An RBM10 and NF-kappaB interacting host lncRNA promotes JEV
            replication and neuronal cell death
  JOURNAL   J Virol 97 (12), e0118323 (2023)
   PUBMED   37991381
  REMARK    GeneRIF: An RBM10 and NF-kappaB interacting host lncRNA promotes
            JEV replication and neuronal cell death.
REFERENCE   4  (bases 1 to 3397)
  AUTHORS   Lee,H., Jung,J.H., Ko,H.M., Park,H., Segall,A.M., Sheffmaker,R.L.,
            Wang,J., Frey,W.D., Pham,N., Wang,Y., Zhang,Y., Jackson,J.G.,
            Zeng,S.X. and Lu,H.
  TITLE     RNA-binding motif protein 10 inactivates c-Myc by partnering with
            ribosomal proteins uL18 and uL5
  JOURNAL   Proc Natl Acad Sci U S A 120 (49), e2308292120 (2023)
   PUBMED   38032932
  REMARK    GeneRIF: RNA-binding motif protein 10 inactivates c-Myc by
            partnering with ribosomal proteins uL18 and uL5.
REFERENCE   5  (bases 1 to 3397)
  AUTHORS   Cao,Y., Di,X., Cong,S., Tian,C., Wang,Y., Jin,X., Zhao,M., Zhou,X.,
            Li,R. and Wang,K.
  TITLE     RBM10 recruits METTL3 to induce N6-methyladenosine-MALAT1-dependent
            modification, inhibiting the invasion and migration of NSCLC
  JOURNAL   Life Sci 315, 121359 (2023)
   PUBMED   36608868
  REMARK    GeneRIF: RBM10 recruits METTL3 to induce
            N6-methyladenosine-MALAT1-dependent modification, inhibiting the
            invasion and migration of NSCLC.
REFERENCE   6  (bases 1 to 3397)
  AUTHORS   Martinez-Arribas,F., Agudo,D., Pollan,M., Gomez-Esquer,F.,
            Diaz-Gil,G., Lucas,R. and Schneider,J.
  TITLE     Positive correlation between the expression of X-chromosome RBM
            genes (RBMX, RBM3, RBM10) and the proapoptotic Bax gene in human
            breast cancer
  JOURNAL   J Cell Biochem 97 (6), 1275-1282 (2006)
   PUBMED   16552754
  REMARK    GeneRIF: From these results, it seems that the X-chromosome,
            through its RBM genes, plays a formerly unknown role in the
            regulation of programmed cell death (apoptosis) in breast cancer.
REFERENCE   7  (bases 1 to 3397)
  AUTHORS   Thiselton,D.L., McDowall,J., Brandau,O., Ramser,J., d'Esposito,F.,
            Bhattacharya,S.S., Ross,M.T., Hardcastle,A.J. and Meindl,A.
  TITLE     An integrated, functionally annotated gene map of the DXS8026-ELK1
            interval on human Xp11.3-Xp11.23: potential hotspot for
            neurogenetic disorders
  JOURNAL   Genomics 79 (4), 560-572 (2002)
   PUBMED   11944989
  REMARK    Erratum:[Genomics 2002 Jun;79(6):891]
REFERENCE   8  (bases 1 to 3397)
  AUTHORS   Inoue,A., Takahashi,K.P., Kimura,M., Watanabe,T. and Morisawa,S.
  TITLE     Molecular cloning of a RNA binding protein, S1-1
  JOURNAL   Nucleic Acids Res 24 (15), 2990-2997 (1996)
   PUBMED   8760884
REFERENCE   9  (bases 1 to 3397)
  AUTHORS   Coleman,M.P., Ambrose,H.J., Carrel,L., Nemeth,A.H., Willard,H.F.
            and Davies,K.E.
  TITLE     A novel gene, DXS8237E, lies within 20 kb upstream of UBE1 in
            Xp11.23 and has a different X inactivation status
  JOURNAL   Genomics 31 (1), 135-138 (1996)
   PUBMED   8808293
REFERENCE   10 (bases 1 to 3397)
  AUTHORS   Gorlin,R.J., Cervenka,J., Anderson,R.C., Sauk,J.J. and Bevis,W.D.
  TITLE     Robin's syndrome. A probably X-linked recessive subvariety
            exhibiting persistence of left superior vena cava and atrial septal
            defect
  JOURNAL   Am J Dis Child 119 (2), 176-178 (1970)
   PUBMED   5410571
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB183041.1, BC008733.2 and
            AW248804.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005676.4.
            
            Summary: This gene encodes a nuclear protein that belongs to a
            family proteins that contain an RNA-binding motif. The encoded
            protein associates with hnRNP proteins and may be involved in
            regulating alternative splicing. Defects in this gene are the cause
            of the X-linked recessive disorder, TARP syndrome. Alternate
            splicing results in multiple transcript variants.[provided by
            RefSeq, Mar 2011].
            
            Transcript Variant: This variant (1) encodes isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004181.2, BC008733.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377604.8/ ENSP00000366829.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DB183041.1         4-15
            13-3395             BC008733.2         1-3383
            3396-3397           AW248804.1         13-14               c
FEATURES             Location/Qualifiers
     source          1..3397
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.3"
     gene            1..3397
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /note="RNA binding motif protein 10"
                     /db_xref="GeneID:8241"
                     /db_xref="HGNC:HGNC:9896"
                     /db_xref="MIM:300080"
     exon            1..265
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            266..407
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     CDS             391..3183
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RNA-binding protein S1-1; g patch domain-containing
                     protein 9; epididymis secretory sperm binding protein;
                     G-patch domain containing 9; zinc finger RANBP2-type
                     containing 5"
                     /codon_start=1
                     /product="RNA-binding protein 10 isoform 1"
                     /protein_id="NP_005667.2"
                     /db_xref="CCDS:CCDS14274.1"
                     /db_xref="GeneID:8241"
                     /db_xref="HGNC:HGNC:9896"
                     /db_xref="MIM:300080"
                     /translation="MEYERRGGRGDRTGRYGATDRSQDDGGENRSRDHDYRDMDYRSY
                     PREYGSQEGKHDYDDSSEEQSAEDSYEASPGSETQRRRRRRHRHSPTGPPGFPRDGDY
                     RDQDYRTEQGEEEEEEEDEEEEEKASNIVMLRMLPQAATEDDIRGQLQSHGVQAREVR
                     LMRNKSSGQSRGFAFVEFSHLQDATRWMEANQHSLNILGQKVSMHYSDPKPKINEDWL
                     CNKCGVQNFKRREKCFKCGVPKSEAEQKLPLGTRLDQQTLPLGGRELSQGLLPLPQPY
                     QAQGVLASQALSQGSEPSSENANDTIILRNLNPHSTMDSILGALAPYAVLSSSNVRVI
                     KDKQTQLNRGFAFIQLSTIVEAAQLLQILQALHPPLTIDGKTINVEFAKGSKRDMASN
                     EGSRISAASVASTAIAAAQWAISQASQGGEGTWATSEEPPVDYSYYQQDEGYGNSQGT
                     ESSLYAHGYLKGTKGPGITGTKGDPTGAGPEASLEPGADSVSMQAFSRAQPGAAPGIY
                     QQSAEASSSQGTAANSQSYTIMSPAVLKSELQSPTHPSSALPPATSPTAQESYSQYPV
                     PDVSTYQYDETSGYYYDPQTGLYYDPNSQYYYNAQSQQYLYWDGERRTYVPALEQSAD
                     GHKETGAPSKEGKEKKEKHKTKTAQQIAKDMERWARSLNKQKENFKNSFQPISSLRDD
                     ERRESATADAGYAILEKKGALAERQHTSMDLPKLASDDRPSPPRGLVAAYSGESDSEE
                     EQERGGPEREEKLTDWQKLACLLCRRQFPSKEALIRHQQLSGLHKQNLEIHRRAHLSE
                     NELEALEKNDMEQMKYRDRAAERREKYGIPEPPEPKRRKYGGISTASVDFEQPTRDGL
                     GSDNIGSRMLQAMGWKEGSGLGRKKQGIVTPIEAQTRVRGSGLGARGSSYGVTSTESY
                     KETLHKTMVTRFNEAQ"
     exon            408..591
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            592..822
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            823..892
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            893..966
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1053
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1114
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1291
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1452
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1550
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1638
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1825
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1965
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2083
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2175
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2340
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2490
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2491..2556
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..2745
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2746..2820
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2821..2927
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2928..3057
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            3058..3397
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3376..3381
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /note="hexamer: AATAAA"
     polyA_site      3397
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /note="major polyA site"
ORIGIN      
        1 agtaggtgga tggtggtcgg agcgccgact cccttctcgt cgtcgccatt ttgagctggt
       61 gactgtggcc ggctgggagt aggcggcagt gagtttccct gggagggcag cgcgcttggc
      121 gcttctcccc tccccccgat ctgcctccag tctcggactt ggttgttgcg cgctccggct
      181 ccggctgagc tgggagagtt ggaggaggtg gcggcgggca gaggtgatgt ctgggagccc
      241 ttccttgaca gcccgggccg agaagagtcc ctgcaggaag catcacccag gctggcagat
      301 catggtagca gcagcggggg tggctgggaa gtgaaacgga gccagcggct gaggaggggc
      361 cccagcagcc cccgaaggcc ctatcaggac atggagtatg aaagacgtgg tggtcgtggt
      421 gacaggactg gccgctatgg agccactgac cgctcgcagg atgatggtgg ggagaaccgc
      481 agccgagacc acgactaccg ggacatggac taccgttcat atcctcgcga gtatggcagc
      541 caggagggca agcatgacta tgacgactca tctgaggagc agagtgcgga ggattcctac
      601 gaggcctccc cgggctccga gactcagcgt aggcggcggc ggcggcacag gcacagcccc
      661 accggcccgc caggcttccc ccgagacggc gactatcggg accaggacta tcggaccgag
      721 caaggggagg aggaggagga ggaggaggat gaggaggagg aggagaaggc cagtaacatc
      781 gtcatgctga ggatgctgcc acaggcagcc actgaggatg acatccgtgg ccagctgcag
      841 tcgcacggcg tgcaagcacg ggaggttcgg ctgatgcgga acaaatcttc aggtcagagc
      901 cggggcttcg ccttcgtcga gtttagtcac ttgcaggacg ctacacgatg gatggaagcc
      961 aatcagcact ccctcaacat cctgggccag aaggtgtcga tgcactacag tgaccccaag
     1021 cccaagatca atgaggactg gctgtgcaat aagtgtggcg tccagaactt caaacgccga
     1081 gagaagtgct tcaaatgtgg cgtgcccaag tcagaggcag agcagaagct gcccctcggc
     1141 acgaggctgg atcagcagac actgccactg ggtggccggg agctgagcca gggcctgctt
     1201 cccctgccgc agccctacca ggcccaggga gtcctggcct cccaagccct gtcacagggc
     1261 tcggagccaa gctcagagaa cgccaatgac accatcattt tgcgcaacct gaacccacac
     1321 agcaccatgg attccatcct gggggccctg gcaccctacg cggtgctgtc ctcctccaac
     1381 gtgcgcgtca taaaggacaa gcagacccaa ctgaaccgcg gctttgcctt catccagctc
     1441 tccaccatcg tggaggcagc ccagctgctg cagatcctgc aggccctgca cccaccactc
     1501 actatcgacg gcaagaccat caatgttgag tttgccaagg gttctaagag ggacatggcc
     1561 tccaatgaag gcagtcgcat cagtgctgcc tctgtggcca gcactgccat tgctgcggcc
     1621 cagtgggcca tctcacaggc ctcccaaggt ggggagggta cctgggccac ctccgaggag
     1681 ccgccggtcg actacagcta ctaccaacag gatgagggct atggcaacag ccagggcaca
     1741 gagtcttccc tctatgccca tggctacctc aagggcacca agggccctgg catcactgga
     1801 accaaagggg atcccactgg agcaggtccc gaggcctccc tagagcctgg ggccgactct
     1861 gtgtcgatgc aggctttctc tcgcgcccag cctggtgctg ctcctggcat ctaccaacaa
     1921 tcagccgagg cgagcagtag ccagggcact gctgccaaca gccagtcgta taccatcatg
     1981 tcacccgctg tgctcaaatc tgagctccag agccctaccc atcctagttc tgctctccca
     2041 ccggctacca gccccactgc ccaggaatcc tacagccagt accctgttcc cgacgtctct
     2101 acctaccagt acgatgagac ctccggctac tactatgacc cccagaccgg cctctactat
     2161 gaccccaact cccagtatta ctacaatgct cagagccagc agtacctgta ctgggatggg
     2221 gagaggcgga cctatgttcc cgccctggag cagtcggccg acggacataa ggagacaggg
     2281 gcaccctcga aggagggcaa agagaagaag gagaagcaca agaccaagac agctcaacag
     2341 attgccaagg acatggaacg ctgggcccgc agtctcaaca aacaaaaaga aaacttcaaa
     2401 aatagcttcc agcctatcag ctccctgcga gatgacgaga ggcgggagtc agccactgca
     2461 gatgctggct atgccatcct cgagaagaag ggagcactag ccgagagaca gcacaccagc
     2521 atggatctcc cgaaattggc cagtgacgac cgcccaagcc ctccgcgagg actggtggca
     2581 gcctacagcg gggagagtga cagtgaggag gagcaggagc gtgggggccc tgagcgggag
     2641 gagaagctca ccgactggca gaagctggcc tgtctgctct gccgacgcca gttccccagc
     2701 aaagaggcgc tcatccggca ccagcagctc tcagggctcc acaagcaaaa ccttgagatt
     2761 caccggcgag cccacttgtc agaaaacgag ctagaagcac tagagaagaa tgacatggag
     2821 caaatgaagt accgggaccg tgcagctgaa cgcagagaaa agtatggcat ccccgagccg
     2881 ccagagccca agaggaggaa gtacggcggc atatccacag cctctgtaga cttcgagcag
     2941 cctactcggg acgggctggg cagtgacaac attggcagtc ggatgctgca ggccatgggc
     3001 tggaaagagg gcagcggcct gggccgcaag aagcagggca ttgtaacgcc tatcgaggcc
     3061 caaacacggg tgcggggctc cggcctgggt gcacggggca gctcctacgg ggtcacctca
     3121 accgagtcct acaaggagac actgcacaag acaatggtga cccgcttcaa cgaggcccag
     3181 tgagcagctt caagagcaac ttctccacat gttgggtgtc catcctgggg cagggaagga
     3241 cagagtgttg gatggctggg acggggcctt gctcttgtcg gccagcccac tccccagcca
     3301 gagagggctt gaccaaatca aattgaggtg gtgacttttg ttggaaaatt gggctgggat
     3361 cacgtcctgt tttgtaataa aagctgaaaa gtctgca
//
