LOCUS       NM_001204468            3428 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens RNA binding motif protein 10 (RBM10), transcript
            variant 5, mRNA.
ACCESSION   NM_001204468
VERSION     NM_001204468.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3428)
  AUTHORS   Chang,J., Zhang,Y., Zhou,T., Qiao,Q., Shan,J., Chen,Y., Jiang,W.,
            Wang,Y., Liu,S., Wang,Y., Yu,Y., Li,C. and Li,X.
  TITLE     RBM10 C761Y mutation induced oncogenic ASPM isoforms and regulated
            beta-catenin signaling in cholangiocarcinoma
  JOURNAL   J Exp Clin Cancer Res 43 (1), 104 (2024)
   PUBMED   38576051
  REMARK    GeneRIF: RBM10 C761Y mutation induced oncogenic ASPM isoforms and
            regulated beta-catenin signaling in cholangiocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3428)
  AUTHORS   Li,Y., Wei,D., Chen,Z., Chen,Y., Deng,Y., Li,M., Zhao,Y. and Niu,K.
  TITLE     RBM10 regulates the tumorigenic potential of human cancer cells by
            modulating PPM1B and YBX1 activities
  JOURNAL   Exp Cell Res 435 (2), 113932 (2024)
   PUBMED   38246397
  REMARK    GeneRIF: RBM10 regulates the tumorigenic potential of human cancer
            cells by modulating PPM1B and YBX1 activities.
REFERENCE   3  (bases 1 to 3428)
  AUTHORS   Tripathi,S., Sengar,S., Shree,B., Mohapatra,S., Basu,A. and
            Sharma,V.
  TITLE     An RBM10 and NF-kappaB interacting host lncRNA promotes JEV
            replication and neuronal cell death
  JOURNAL   J Virol 97 (12), e0118323 (2023)
   PUBMED   37991381
  REMARK    GeneRIF: An RBM10 and NF-kappaB interacting host lncRNA promotes
            JEV replication and neuronal cell death.
REFERENCE   4  (bases 1 to 3428)
  AUTHORS   Lee,H., Jung,J.H., Ko,H.M., Park,H., Segall,A.M., Sheffmaker,R.L.,
            Wang,J., Frey,W.D., Pham,N., Wang,Y., Zhang,Y., Jackson,J.G.,
            Zeng,S.X. and Lu,H.
  TITLE     RNA-binding motif protein 10 inactivates c-Myc by partnering with
            ribosomal proteins uL18 and uL5
  JOURNAL   Proc Natl Acad Sci U S A 120 (49), e2308292120 (2023)
   PUBMED   38032932
  REMARK    GeneRIF: RNA-binding motif protein 10 inactivates c-Myc by
            partnering with ribosomal proteins uL18 and uL5.
REFERENCE   5  (bases 1 to 3428)
  AUTHORS   Cao,Y., Di,X., Cong,S., Tian,C., Wang,Y., Jin,X., Zhao,M., Zhou,X.,
            Li,R. and Wang,K.
  TITLE     RBM10 recruits METTL3 to induce N6-methyladenosine-MALAT1-dependent
            modification, inhibiting the invasion and migration of NSCLC
  JOURNAL   Life Sci 315, 121359 (2023)
   PUBMED   36608868
  REMARK    GeneRIF: RBM10 recruits METTL3 to induce
            N6-methyladenosine-MALAT1-dependent modification, inhibiting the
            invasion and migration of NSCLC.
REFERENCE   6  (bases 1 to 3428)
  AUTHORS   Martinez-Arribas,F., Agudo,D., Pollan,M., Gomez-Esquer,F.,
            Diaz-Gil,G., Lucas,R. and Schneider,J.
  TITLE     Positive correlation between the expression of X-chromosome RBM
            genes (RBMX, RBM3, RBM10) and the proapoptotic Bax gene in human
            breast cancer
  JOURNAL   J Cell Biochem 97 (6), 1275-1282 (2006)
   PUBMED   16552754
  REMARK    GeneRIF: From these results, it seems that the X-chromosome,
            through its RBM genes, plays a formerly unknown role in the
            regulation of programmed cell death (apoptosis) in breast cancer.
REFERENCE   7  (bases 1 to 3428)
  AUTHORS   Thiselton,D.L., McDowall,J., Brandau,O., Ramser,J., d'Esposito,F.,
            Bhattacharya,S.S., Ross,M.T., Hardcastle,A.J. and Meindl,A.
  TITLE     An integrated, functionally annotated gene map of the DXS8026-ELK1
            interval on human Xp11.3-Xp11.23: potential hotspot for
            neurogenetic disorders
  JOURNAL   Genomics 79 (4), 560-572 (2002)
   PUBMED   11944989
  REMARK    Erratum:[Genomics 2002 Jun;79(6):891]
REFERENCE   8  (bases 1 to 3428)
  AUTHORS   Inoue,A., Takahashi,K.P., Kimura,M., Watanabe,T. and Morisawa,S.
  TITLE     Molecular cloning of a RNA binding protein, S1-1
  JOURNAL   Nucleic Acids Res 24 (15), 2990-2997 (1996)
   PUBMED   8760884
REFERENCE   9  (bases 1 to 3428)
  AUTHORS   Coleman,M.P., Ambrose,H.J., Carrel,L., Nemeth,A.H., Willard,H.F.
            and Davies,K.E.
  TITLE     A novel gene, DXS8237E, lies within 20 kb upstream of UBE1 in
            Xp11.23 and has a different X inactivation status
  JOURNAL   Genomics 31 (1), 135-138 (1996)
   PUBMED   8808293
REFERENCE   10 (bases 1 to 3428)
  AUTHORS   Gorlin,R.J., Cervenka,J., Anderson,R.C., Sauk,J.J. and Bevis,W.D.
  TITLE     Robin's syndrome. A probably X-linked recessive subvariety
            exhibiting persistence of left superior vena cava and atrial septal
            defect
  JOURNAL   Am J Dis Child 119 (2), 176-178 (1970)
   PUBMED   5410571
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB183041.1, BX537969.1,
            AL513366.11 and AW248804.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001204468.1.
            
            Summary: This gene encodes a nuclear protein that belongs to a
            family proteins that contain an RNA-binding motif. The encoded
            protein associates with hnRNP proteins and may be involved in
            regulating alternative splicing. Defects in this gene are the cause
            of the X-linked recessive disorder, TARP syndrome. Alternate
            splicing results in multiple transcript variants.[provided by
            RefSeq, Mar 2011].
            
            Transcript Variant: This variant (5) uses an alternate splice site
            in the 5' coding region and initiates translation at an upstream
            in-frame start codon, compared to variant 1. The encoded isoform
            (5) has a distinct N-terminus and is longer than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX537969.1, SRR18074969.1560657.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                DB183041.1         4-50
            48-2236             BX537969.1         2-2190
            2237-2237           AL513366.11        107237-107237
            2238-2666           BX537969.1         2192-2620
            2667-2667           AL513366.11        110566-110566
            2668-3426           BX537969.1         2622-3380
            3427-3428           AW248804.1         13-14               c
FEATURES             Location/Qualifiers
     source          1..3428
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.3"
     gene            1..3428
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /note="RNA binding motif protein 10"
                     /db_xref="GeneID:8241"
                     /db_xref="HGNC:HGNC:9896"
                     /db_xref="MIM:300080"
     exon            1..296
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..3214
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /note="isoform 5 is encoded by transcript variant 5;
                     RNA-binding protein S1-1; g patch domain-containing
                     protein 9; epididymis secretory sperm binding protein;
                     G-patch domain containing 9; zinc finger RANBP2-type
                     containing 5"
                     /codon_start=1
                     /product="RNA-binding protein 10 isoform 5"
                     /protein_id="NP_001191397.1"
                     /db_xref="CCDS:CCDS75969.1"
                     /db_xref="GeneID:8241"
                     /db_xref="HGNC:HGNC:9896"
                     /db_xref="MIM:300080"
                     /translation="MSGSPSLTARAEKVSVDAGRGGGESLQEASPRLADHGSSSGGGW
                     EVKRSQRLRRGPSSPRRPYQDMEYERRGGRGDRTGRYGATDRSQDDGGENRSRDHDYR
                     DMDYRSYPREYGSQEGKHDYDDSSEEQSAEDSYEASPGSETQRRRRRRHRHSPTGPPG
                     FPRDGDYRDQDYRTEQGEEEEEEEDEEEEEKASNIVMLRMLPQAATEDDIRGQLQSHG
                     VQAREVRLMRNKSSGQSRGFAFVEFSHLQDATRWMEANQHSLNILGQKVSMHYSDPKP
                     KINEDWLCNKCGVQNFKRREKCFKCGVPKSEAEQKLPLGTRLDQQTLPLGGRELSQGL
                     LPLPQPYQAQGVLASQALSQGSEPSSENANDTIILRNLNPHSTMDSILGALAPYAVLS
                     SSNVRVIKDKQTQLNRGFAFIQLSTIVEAAQLLQILQALHPPLTIDGKTINVEFAKGS
                     KRDMASNEGSRISAASVASTAIAAAQWAISQASQGGEGTWATSEEPPVDYSYYQQDEG
                     YGNSQGTESSLYAHGYLKGTKGPGITGTKGDPTGAGPEASLEPGADSVSMQAFSRAQP
                     GAAPGIYQQSAEASSSQGTAANSQSYTIMSPAVLKSELQSPTHPSSALPPATSPTAQE
                     SYSQYPVPDVSTYQYDETSGYYYDPQTGLYYDPNSQYYYNAQSQQYLYWDGERRTYVP
                     ALEQSADGHKETGAPSKEGKEKKEKHKTKTAQQIAKDMERWARSLNKQKENFKNSFQP
                     ISSLRDDERRESATADAGYAILEKKGALAERQHTSMDLPKLASDDRPSPPRGLVAAYS
                     GESDSEEEQERGGPEREEKLTDWQKLACLLCRRQFPSKEALIRHQQLSGLHKQNLEIH
                     RRAHLSENELEALEKNDMEQMKYRDRAAERREKYGIPEPPEPKRRKYGGISTASVDFE
                     QPTRDGLGSDNIGSRMLQAMGWKEGSGLGRKKQGIVTPIEAQTRVRGSGLGARGSSYG
                     VTSTESYKETLHKTMVTRFNEAQ"
     exon            297..438
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            439..622
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            623..853
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            854..923
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            924..997
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1084
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1145
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1322
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1483
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1581
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1669
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1856
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1996
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2114
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2206
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2371
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2521
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..2587
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2776
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..2851
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2852..2958
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2959..3088
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     exon            3089..3428
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3407..3412
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /note="hexamer: AATAAA"
     polyA_site      3428
                     /gene="RBM10"
                     /gene_synonym="DXS8237E; GPATC9; GPATCH9; MINAS-60; S1-1;
                     TARPS; ZRANB5"
                     /note="major polyA site"
ORIGIN      
        1 agtaggtgga tggtggtcgg agcgccgact cccttctcgt cgtcgccatt ttgagctggt
       61 gactgtggcc ggctgggagt aggcggcagt gagtttccct gggagggcag cgcgcttggc
      121 gcttctcccc tccccccgat ctgcctccag tctcggactt ggttgttgcg cgctccggct
      181 ccggctgagc tgggagagtt ggaggaggtg gcggcgggca gaggtgatgt ctgggagccc
      241 ttccttgaca gcccgggccg agaaggtgag cgtcgacgct ggtcgtgggg gcggagagtc
      301 cctgcaggaa gcatcaccca ggctggcaga tcatggtagc agcagcgggg gtggctggga
      361 agtgaaacgg agccagcggc tgaggagggg ccccagcagc ccccgaaggc cctatcagga
      421 catggagtat gaaagacgtg gtggtcgtgg tgacaggact ggccgctatg gagccactga
      481 ccgctcgcag gatgatggtg gggagaaccg cagccgagac cacgactacc gggacatgga
      541 ctaccgttca tatcctcgcg agtatggcag ccaggagggc aagcatgact atgacgactc
      601 atctgaggag cagagtgcgg aggattccta cgaggcctcc ccgggctccg agactcagcg
      661 taggcggcgg cggcggcaca ggcacagccc caccggcccg ccaggcttcc cccgagacgg
      721 cgactatcgg gaccaggact atcggaccga gcaaggggag gaggaggagg aggaggagga
      781 tgaggaggag gaggagaagg ccagtaacat cgtcatgctg aggatgctgc cacaggcagc
      841 cactgaggat gacatccgtg gccagctgca gtcgcacggc gtgcaagcac gggaggttcg
      901 gctgatgcgg aacaaatctt caggtcagag ccggggcttc gccttcgtcg agtttagtca
      961 cttgcaggac gctacacgat ggatggaagc caatcagcac tccctcaaca tcctgggcca
     1021 gaaggtgtcg atgcactaca gtgaccccaa gcccaagatc aatgaggact ggctgtgcaa
     1081 taagtgtggc gtccagaact tcaaacgccg agagaagtgc ttcaaatgtg gcgtgcccaa
     1141 gtcagaggca gagcagaagc tgcccctcgg cacgaggctg gatcagcaga cactgccact
     1201 gggtggccgg gagctgagcc agggcctgct tcccctgccg cagccctacc aggcccaggg
     1261 agtcctggcc tcccaagccc tgtcacaggg ctcggagcca agctcagaga acgccaatga
     1321 caccatcatt ttgcgcaacc tgaacccaca cagcaccatg gattccatcc tgggggccct
     1381 ggcaccctac gcggtgctgt cctcctccaa cgtgcgcgtc ataaaggaca agcagaccca
     1441 actgaaccgc ggctttgcct tcatccagct ctccaccatc gtggaggcag cccagctgct
     1501 gcagatcctg caggccctgc acccaccact cactatcgac ggcaagacca tcaatgttga
     1561 gtttgccaag ggttctaaga gggacatggc ctccaatgaa ggcagtcgca tcagtgctgc
     1621 ctctgtggcc agcactgcca ttgctgcggc ccagtgggcc atctcacagg cctcccaagg
     1681 tggggagggt acctgggcca cctccgagga gccgccggtc gactacagct actaccaaca
     1741 ggatgagggc tatggcaaca gccagggcac agagtcttcc ctctatgccc atggctacct
     1801 caagggcacc aagggccctg gcatcactgg aaccaaaggg gatcccactg gagcaggtcc
     1861 cgaggcctcc ctagagcctg gggccgactc tgtgtcgatg caggctttct ctcgcgccca
     1921 gcctggtgct gctcctggca tctaccaaca atcagccgag gcgagcagta gccagggcac
     1981 tgctgccaac agccagtcgt ataccatcat gtcacccgct gtgctcaaat ctgagctcca
     2041 gagccctacc catcctagtt ctgctctccc accggctacc agccccactg cccaggaatc
     2101 ctacagccag taccctgttc ccgacgtctc tacctaccag tacgatgaga cctccggcta
     2161 ctactatgac ccccagaccg gcctctacta tgaccccaac tcccagtatt actacaatgc
     2221 tcagagccag cagtacctgt actgggatgg ggagaggcgg acctatgttc ccgccctgga
     2281 gcagtcggcc gacggacata aggagacagg ggcaccctcg aaggagggca aagagaagaa
     2341 ggagaagcac aagaccaaga cagctcaaca gattgccaag gacatggaac gctgggcccg
     2401 cagtctcaac aaacaaaaag aaaacttcaa aaatagcttc cagcctatca gctccctgcg
     2461 agatgacgag aggcgggagt cagccactgc agatgctggc tatgccatcc tcgagaagaa
     2521 gggagcacta gccgagagac agcacaccag catggatctc ccgaaattgg ccagtgacga
     2581 ccgcccaagc cctccgcgag gactggtggc agcctacagc ggggagagtg acagtgagga
     2641 ggagcaggag cgtgggggcc ctgagcggga ggagaagctc accgactggc agaagctggc
     2701 ctgtctgctc tgccgacgcc agttccccag caaagaggcg ctcatccggc accagcagct
     2761 ctcagggctc cacaagcaaa accttgagat tcaccggcga gcccacttgt cagaaaacga
     2821 gctagaagca ctagagaaga atgacatgga gcaaatgaag taccgggacc gtgcagctga
     2881 acgcagagaa aagtatggca tccccgagcc gccagagccc aagaggagga agtacggcgg
     2941 catatccaca gcctctgtag acttcgagca gcctactcgg gacgggctgg gcagtgacaa
     3001 cattggcagt cggatgctgc aggccatggg ctggaaagag ggcagcggcc tgggccgcaa
     3061 gaagcagggc attgtaacgc ctatcgaggc ccaaacacgg gtgcggggct ccggcctggg
     3121 tgcacggggc agctcctacg gggtcacctc aaccgagtcc tacaaggaga cactgcacaa
     3181 gacaatggtg acccgcttca acgaggccca gtgagcagct tcaagagcaa cttctccaca
     3241 tgttgggtgt ccatcctggg gcagggaagg acagagtgtt ggatggctgg gacggggcct
     3301 tgctcttgtc ggccagccca ctccccagcc agagagggct tgaccaaatc aaattgaggt
     3361 ggtgactttt gttggaaaat tgggctggga tcacgtcctg ttttgtaata aaagctgaaa
     3421 agtctgca
//
