LOCUS       NM_005611               4854 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens RB transcriptional corepressor like 2 (RBL2),
            transcript variant 1, mRNA.
ACCESSION   NM_005611
VERSION     NM_005611.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4854)
  AUTHORS   Militi,S., Nibhani,R., Jalali,M. and Pauklin,S.
  TITLE     RBL2-E2F-GCN5 guide cell fate decisions during tissue specification
            by regulating cell-cycle-dependent fluctuations of
            non-cell-autonomous signaling
  JOURNAL   Cell Rep 42 (9), 113146 (2023)
   PUBMED   37725511
  REMARK    GeneRIF: RBL2-E2F-GCN5 guide cell fate decisions during tissue
            specification by regulating cell-cycle-dependent fluctuations of
            non-cell-autonomous signaling.
REFERENCE   2  (bases 1 to 4854)
  AUTHORS   Nakanoh,S., Kadiwala,J., Pinte,L., Morell,C.M., Lenaerts,A.S. and
            Vallier,L.
  TITLE     Simultaneous depletion of RB, RBL1 and RBL2 affects endoderm
            differentiation of human embryonic stem cells
  JOURNAL   PLoS One 17 (11), e0269122 (2022)
   PUBMED   36413521
  REMARK    GeneRIF: Simultaneous depletion of RB, RBL1 and RBL2 affects
            endoderm differentiation of human embryonic stem cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4854)
  AUTHORS   Ullah,F., Khurshid,N., Fatimi,Q., Loidl,P. and Saeed,M.
  TITLE     Mutations in the acetylation hotspots of Rbl2 are associated with
            increased risk of breast cancer
  JOURNAL   PLoS One 17 (4), e0266196 (2022)
   PUBMED   35385527
  REMARK    GeneRIF: Mutations in the acetylation hotspots of Rbl2 are
            associated with increased risk of breast cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4854)
  AUTHORS   Samra,N., Toubiana,S., Yttervik,H., Tzur-Gilat,A., Morani,I.,
            Itzkovich,C., Giladi,L., Abu Jabal,K., Cao,J.Z., Godley,L.A.,
            Mory,A., Baris Feldman,H., Tveten,K., Selig,S. and Weiss,K.
  TITLE     RBL2 bi-allelic truncating variants cause severe motor and
            cognitive impairment without evidence for abnormalities in DNA
            methylation or telomeric function
  JOURNAL   J Hum Genet 66 (11), 1101-1112 (2021)
   PUBMED   33980986
  REMARK    GeneRIF: RBL2 bi-allelic truncating variants cause severe motor and
            cognitive impairment without evidence for abnormalities in DNA
            methylation or telomeric function.
REFERENCE   5  (bases 1 to 4854)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 4854)
  AUTHORS   Hijmans,E.M., Voorhoeve,P.M., Beijersbergen,R.L., van 't Veer,L.J.
            and Bernards,R.
  TITLE     E2F-5, a new E2F family member that interacts with p130 in vivo
  JOURNAL   Mol Cell Biol 15 (6), 3082-3089 (1995)
   PUBMED   7760804
REFERENCE   7  (bases 1 to 4854)
  AUTHORS   Hannon,G.J., Demetrick,D. and Beach,D.
  TITLE     Isolation of the Rb-related p130 through its interaction with CDK2
            and cyclins
  JOURNAL   Genes Dev 7 (12A), 2378-2391 (1993)
   PUBMED   8253384
REFERENCE   8  (bases 1 to 4854)
  AUTHORS   Li,Y., Graham,C., Lacy,S., Duncan,A.M. and Whyte,P.
  TITLE     The adenovirus E1A-associated 130-kD protein is encoded by a member
            of the retinoblastoma gene family and physically interacts with
            cyclins A and E
  JOURNAL   Genes Dev 7 (12A), 2366-2377 (1993)
   PUBMED   8253383
REFERENCE   9  (bases 1 to 4854)
  AUTHORS   Yeung,R.S., Bell,D.W., Testa,J.R., Mayol,X., Baldi,A., Grana,X.,
            Klinga-Levan,K., Knudson,A.G. and Giordano,A.
  TITLE     The retinoblastoma-related gene, RB2, maps to human chromosome
            16q12 and rat chromosome 19
  JOURNAL   Oncogene 8 (12), 3465-3468 (1993)
   PUBMED   8247552
REFERENCE   10 (bases 1 to 4854)
  AUTHORS   Dyson,N., Guida,P., Munger,K. and Harlow,E.
  TITLE     Homologous sequences in adenovirus E1A and human papillomavirus E7
            proteins mediate interaction with the same set of cellular proteins
  JOURNAL   J Virol 66 (12), 6893-6902 (1992)
   PUBMED   1331501
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC034490.1 and X76061.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005611.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034490.1, SRR1660807.171304.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262133.11/ ENSP00000262133.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2887              BC034490.1         23-2909
            2888-3715           X76061.1           2871-3698
            3716-3860           BC034490.1         3738-3882
            3861-4380           X76061.1           3841-4360
            4381-4853           BC034490.1         4402-4874
            4854-4854           X76061.1           4836-4836
FEATURES             Location/Qualifiers
     source          1..4854
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q12.2"
     gene            1..4854
                     /gene="RBL2"
                     /gene_synonym="BRUWAG; P130; Rb2"
                     /note="RB transcriptional corepressor like 2"
                     /db_xref="GeneID:5934"
                     /db_xref="HGNC:HGNC:9894"
                     /db_xref="MIM:180203"
     exon            1..326
                     /gene="RBL2"
                     /gene_synonym="BRUWAG; P130; Rb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..3506
                     /gene="RBL2"
                     /gene_synonym="BRUWAG; P130; Rb2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     retinoblastoma-like protein 2; PRB2; RBR-2;
                     retinoblastoma-like 2; 130 kDa retinoblastoma-associated
                     protein; retinoblastoma-related protein 2"
                     /codon_start=1
                     /product="retinoblastoma-like protein 2 isoform 1"
                     /protein_id="NP_005602.3"
                     /db_xref="CCDS:CCDS10748.1"
                     /db_xref="GeneID:5934"
                     /db_xref="HGNC:HGNC:9894"
                     /db_xref="MIM:180203"
                     /translation="MPSGGDQSPPPPPPPPAAAASDEEEEDDGEAEDAAPPAESPTPQ
                     IQQRFDELCSRLNMDEAARAEAWDSYRSMSESYTLEGNDLHWLACALYVACRKSVPTV
                     SKGTVEGNYVSLTRILKCSEQSLIEFFNKMKKWEDMANLPPHFRERTERLERNFTVSA
                     VIFKKYEPIFQDIFKYPQEEQPRQQRGRKQRRQPCTVSEIFHFCWVLFIYAKGNFPMI
                     SDDLVNSYHLLLCALDLVYGNALQCSNRKELVNPNFKGLSEDFHAKDSKPSSDPPCII
                     EKLCSLHDGLVLEAKGIKEHFWKPYIRKLYEKKLLKGKEENLTGFLEPGNFGESFKAI
                     NKAYEEYVLSVGNLDERIFLGEDAEEEIGTLSRCLNAGSGTETAERVQMKNILQQHFD
                     KSKALRISTPLTGVRYIKENSPCVTPVSTATHSLSRLHTMLTGLRNAPSEKLEQILRT
                     CSRDPTQAIANRLKEMFEIYSQHFQPDEDFSNCAKEIASKHFRFAEMLYYKVLESVIE
                     QEQKRLGDMDLSGILEQDAFHRSLLACCLEVVTFSYKPPGNFPFITEIFDVPLYHFYK
                     VIEVFIRAEDGLCREVVKHLNQIEEQILDHLAWKPESPLWEKIRDNENRVPTCEEVMP
                     PQNLERADEICIAGSPLTPRRVTEVRADTGGLGRSITSPTTLYDRYSSPPASTTRRRL
                     FVENDSPSDGGTPGRMPPQPLVNAVPVQNVSGETVSVTPVPGQTLVTMATATVTANNG
                     QTVTIPVQGIANENGGITFFPVQVNVGGQAQAVTGSIQPLSAQALAGSLSSQQVTGTT
                     LQVPGQVAIQQISPGGQQQKQGQSVTSSSNRPRKTSSLSLFFRKVYHLAAVRLRDLCA
                     KLDISDELRKKIWTCFEFSIIQCPELMMDRHLDQLLMCAIYVMAKVTKEDKSFQNIMR
                     CYRTQPQARSQVYRSVLIKGKRKRRNSGSSDSRSHQNSPTELNKDRTSRDSSPVMRSS
                     STLPVPQPSSAPPTPTRLTGANSDMEEEERGDLIQFYNNIYIKQIKTFAMKYSQANMD
                     APPLSPYPFVRTGSPRRIQLSQNHPVYISPHKNETMLSPREKIFYYFSNSPSKRLREI
                     NSMIRTGETPTKKRGILLEDGSESPAKRICPENHSALLRRLQDVANDRGSH"
     exon            327..457
                     /gene="RBL2"
                     /gene_synonym="BRUWAG; P130; Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            458..658
                     /gene="RBL2"
                     /gene_synonym="BRUWAG; P130; Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            659..723
                     /gene="RBL2"
                     /gene_synonym="BRUWAG; P130; Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            724..852
                     /gene="RBL2"
                     /gene_synonym="BRUWAG; P130; Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1013
                     /gene="RBL2"
                     /gene_synonym="BRUWAG; P130; Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1078
                     /gene="RBL2"
                     /gene_synonym="BRUWAG; P130; Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1265
                     /gene="RBL2"
                     /gene_synonym="BRUWAG; P130; Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1432
                     /gene="RBL2"
                     /gene_synonym="BRUWAG; P130; Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1542
                     /gene="RBL2"
                     /gene_synonym="BRUWAG; P130; Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1646
                     /gene="RBL2"
                     /gene_synonym="BRUWAG; P130; Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1784
                     /gene="RBL2"
                     /gene_synonym="BRUWAG; P130; Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1949
                     /gene="RBL2"
                     /gene_synonym="BRUWAG; P130; Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2061
                     /gene="RBL2"
                     /gene_synonym="BRUWAG; P130; Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2331
                     /gene="RBL2"
                     /gene_synonym="BRUWAG; P130; Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2612
                     /gene="RBL2"
                     /gene_synonym="BRUWAG; P130; Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2613..2789
                     /gene="RBL2"
                     /gene_synonym="BRUWAG; P130; Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2790..2861
                     /gene="RBL2"
                     /gene_synonym="BRUWAG; P130; Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..2967
                     /gene="RBL2"
                     /gene_synonym="BRUWAG; P130; Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2968..3170
                     /gene="RBL2"
                     /gene_synonym="BRUWAG; P130; Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            3171..3335
                     /gene="RBL2"
                     /gene_synonym="BRUWAG; P130; Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            3336..4854
                     /gene="RBL2"
                     /gene_synonym="BRUWAG; P130; Rb2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4835..4840
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBL2"
                     /gene_synonym="BRUWAG; P130; Rb2"
                     /note="hexamer: AATAAA"
     polyA_site      4854
                     /gene="RBL2"
                     /gene_synonym="BRUWAG; P130; Rb2"
                     /note="major polyA site"
ORIGIN      
        1 ggcggacggg cgggcgcttc gccgtttgaa tggctgcggg cccgggccct cacctcacct
       61 gaggtccggc cgcccagggg tgcgctatgc cgtcgggagg tgaccagtcg ccaccgcccc
      121 cgcctccccc tccggcggcg gcagcctcgg atgaggagga ggaggacgac ggcgaggcgg
      181 aagacgccgc gccgcctgcc gagtcgccca cccctcagat ccagcagcgg ttcgacgagc
      241 tgtgcagccg cctcaacatg gacgaggcgg cgcgggccga ggcctgggac agctaccgca
      301 gcatgagcga aagctacacg ctggagggaa atgatcttca ttggttagca tgtgccttat
      361 atgtggcttg cagaaaatct gttccaactg taagcaaagg gacagtggaa ggaaactatg
      421 tatctttaac tagaatcctg aaatgttcag agcagagctt aatcgaattt tttaataaga
      481 tgaagaagtg ggaagacatg gcaaatctac ccccacattt cagagaacgt actgagagat
      541 tagaaagaaa cttcactgtt tctgctgtaa tttttaagaa atatgaaccc atttttcagg
      601 acatctttaa ataccctcaa gaggagcaac ctcgtcagca gcgaggaagg aaacagcggc
      661 gacagccctg tactgtgtct gaaattttcc atttttgttg ggtgcttttt atatatgcaa
      721 aaggtaattt ccccatgatt agtgatgatt tggtcaattc ttatcacctg ctgctgtgtg
      781 ctttggactt agtttatgga aatgcacttc agtgttctaa tcgtaaagaa cttgtgaacc
      841 ctaattttaa aggcttatct gaagattttc atgctaaaga ttctaaacct tcctctgacc
      901 ccccttgtat cattgagaaa ctgtgttcct tacatgatgg cctagttttg gaagcaaagg
      961 ggataaagga acatttctgg aaaccctata ttaggaaact ttatgaaaaa aagctcctta
     1021 agggaaaaga agaaaatctc actgggtttc tagaacctgg gaactttgga gagagtttta
     1081 aagccatcaa taaggcctat gaggagtatg ttttatctgt tgggaattta gatgagcgga
     1141 tatttcttgg agaggatgct gaggaggaaa ttgggactct ctcaaggtgt ctgaacgctg
     1201 gttcaggaac agagactgct gaaagggtgc agatgaaaaa catcttacag cagcattttg
     1261 acaagtccaa agcacttaga atctccacac cactaactgg tgttaggtac attaaggaga
     1321 atagcccttg tgtgactcca gtttctacag ctacgcatag cttgagtcgt cttcacacca
     1381 tgctgacagg cctcaggaat gcaccaagtg agaaactgga acagattctc aggacatgtt
     1441 ccagagatcc aacccaggct attgctaaca gactgaaaga aatgtttgaa atatattctc
     1501 agcatttcca gccagacgag gatttcagta attgtgctaa agaaattgcc agcaaacatt
     1561 ttcgttttgc ggagatgctt tactataaag tattagaatc tgttattgag caggaacaaa
     1621 aaagactagg agacatggat ttatctggta ttctggaaca agatgcgttc cacagatctc
     1681 tcttggcctg ctgccttgag gtcgtcactt tttcttataa gcctcctggg aattttccat
     1741 ttattactga aatatttgat gtgcctcttt atcattttta taaggtgata gaagtattca
     1801 ttagagcaga agatggcctt tgtagagagg tggtaaaaca ccttaatcag attgaagaac
     1861 agatcttaga tcatttggca tggaaaccag agtctccact ctgggaaaaa attagagaca
     1921 atgaaaacag agttcctaca tgtgaagagg tcatgccacc tcagaacctg gaaagggcag
     1981 atgaaatttg cattgctggc tcccctttga ctcccagaag ggtgactgaa gttcgtgctg
     2041 atactggagg acttggaagg agcataacat ctccaaccac attatacgat aggtacagct
     2101 ccccaccagc cagcactacc agaaggcggc tatttgttga gaatgatagc ccctctgatg
     2161 gagggacgcc tgggcgcatg cccccacagc ccctagtcaa tgctgtccct gtgcagaatg
     2221 tatctgggga gactgtttct gtcacaccag ttcctggaca gactttggtc accatggcaa
     2281 ccgccactgt cacagccaac aatgggcaaa cggtaaccat tcctgtgcaa ggtattgcca
     2341 atgaaaatgg agggataaca ttcttccctg tccaagtcaa tgttgggggg caggcacaag
     2401 ctgtgacagg ctccatccag cccctcagtg ctcaggccct ggctggaagt ctgagctctc
     2461 aacaggtgac aggaacaact ttgcaagtcc ctggtcaagt ggccattcaa cagatttccc
     2521 caggtggcca acagcagaag caaggccagt ctgtaaccag cagtagtaat agacccagga
     2581 agaccagctc tttatcgctt ttctttagaa aggtatacca tttagcagct gtccgccttc
     2641 gggatctctg tgccaaacta gatatttcag atgaattgag gaaaaaaatc tggacctgct
     2701 ttgaattctc cataattcag tgtcctgaac ttatgatgga cagacatctg gaccagttat
     2761 taatgtgtgc catttatgtg atggcaaagg tcacaaaaga agataagtcc ttccagaaca
     2821 ttatgcgttg ttataggact cagccgcagg cccggagcca ggtgtataga agtgttttga
     2881 taaaagggaa aagaaaaaga agaaattctg gcagcagtga tagcagaagc catcagaatt
     2941 ctccaacaga actaaacaaa gatagaacca gtagagactc cagtccagtt atgaggtcaa
     3001 gcagcacctt gccagttcca cagcccagca gtgctcctcc cacacctact cgcctcacag
     3061 gtgccaacag tgacatggaa gaagaggaga ggggagacct cattcagttc tacaacaaca
     3121 tctacatcaa acagattaag acatttgcca tgaagtactc acaggcaaat atggatgctc
     3181 ctccactctc tccctatcca tttgtaagaa caggctcccc tcgccgaata cagttgtctc
     3241 aaaatcatcc tgtctacatt tccccacata aaaatgaaac aatgctttct cctcgagaaa
     3301 agattttcta ttacttcagc aacagtcctt caaagagact gagagaaatt aatagtatga
     3361 tacgcacagg agaaactcct actaaaaaga gaggaattct tttggaagat ggaagtgaat
     3421 cacctgcaaa aagaatttgc ccagaaaatc attctgcctt attacgccgt ctccaagatg
     3481 tagctaatga ccgtggttcc cactgaggtt agtctcttgt attaaactct tcacaaaatc
     3541 tgtttagcag cagcctttaa tgcatctaga ttatggagct tttttcctta atccagctga
     3601 tgagttacag cctgttagta acatgagggg acattttggt gagaaatggg acttaactcc
     3661 ttccagtgtc cttagaacat tttaattcat cccaactgtc tttttttccc taccattcag
     3721 tgattactgt caaggctgct tagaatccaa acttggattt ttgactctgg caaagctttt
     3781 agaaatactg caagaaaatg atgtgtaccc aaacgtgagc ataggaggct tctgttgacg
     3841 tactccaaca gaagaactgt gtttcaagtt caatcctacc tgttttgtgg tcagctgtag
     3901 tcctcataaa aagcaaaaca aaaattaggt attttgtcct aaaacacctg gtaggagtgt
     3961 gtgatttttt gcattcctga caaaggagag cacacccagg tttggaggtc ctaggtcatt
     4021 agccctcgtc tcccgttccc tttgtgcaca tcttccctct ccccattcgg tgtggtgcag
     4081 tgtgaaaagt ccttgattgt tcgggtgtgc aatgtctgag tgaacctgta taagtggagg
     4141 cactttaggg ctgtaaaatg catgattttg taacccagat tttgctgtat atttgtgata
     4201 gcactttcta caatgtgaac tttattaaat acaaaacttc caggctaaac atccaatatt
     4261 ttctttaatg cttttatatt tttttaaaat gttaaaaccc ctatagccac cttttgggaa
     4321 tgttttaaat tctccagttt tttgttatat agggatcaac cagctaagaa aagattttaa
     4381 tcaagttgaa ttgaggggat taatatgaaa acttatgacc tcttccttta ggagggagtt
     4441 atctaaaaga aatgtctatt aaggtgatat atttaaaaat atttttgggt gttcctggca
     4501 gtttaaaaaa attggttgga gaatttaggt ttttattagt accatagtac catttataca
     4561 aattagaaaa tgttatttaa cagctgaatt atctatacat atctttatta atcactattg
     4621 ttccagcagt tttcaagtca aattaataat cttattaggg agaaaattca attgtaaatt
     4681 gaatcagtat aaacaaagtt actaggtaac ttcatattgc tgagagaaat atggaactta
     4741 cattgttcaa ttagaatagt gttctgcaaa aatatttata aaacttctca agatactgct
     4801 actgtaattt tatatgaaga taagtgtatt tttcaataaa gcatttataa atta
//
